Cervus canadensis (wapiti): 122440167
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Entry
122440167 CDS
T07554
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
ccad
Cervus canadensis (wapiti)
Pathway
ccad00310
Lysine degradation
ccad01100
Metabolic pathways
ccad05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
ccad00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
122440167 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
122440167 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
ccad03036
]
122440167 (DOT1L)
Enzymes [BR:
ccad01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
122440167 (DOT1L)
Chromosome and associated proteins [BR:
ccad03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
122440167 (DOT1L)
HMT complexes
Dot1-containing complex
122440167 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
122440167
NCBI-ProteinID:
XP_043321988
LinkDB
All DBs
Position
4:complement(85838596..85890539)
Genome browser
AA seq
1716 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVVFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKAAVPADTPVDSGAEEEKAGTAAVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSAT
NPERKPKKTQSALDLLHAQTVSRAASPLPQDAHRPPHSPFYQLPPSVQRPTPEQLLLAPT
PPALHRLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKGNRELRSQSLRLL
KARCEELKLDWSTLSLENLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDEALTLQLRGKPEAEPGRLHLELDCARFSLPPFSSLSPELSMNGHAAGYELCSAL
GRPSPKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKLVLRRHLS
QDHAASGKAAASELHPRAEHAKENGLPYQSPGITNGIKLSPQDPRPSSPTALQMGEKGPE
KGVKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKARSTPSPGPPA
RESSSTLEKQVAANAHGTGGSASGSKSLALAPTGYAYTGSVAISGALAGSPAPLGPGTEP
PALDESSSSGSLFATVGSRSSTPQHPPLLTQPRACGSASPAPQLSASPRLGALGPLPDSG
KGDLPCEASFSDPESEAKRRIVFTISAGASSAKQSPSSKHSPLPSGARGDGGQGHGPDSR
KRGRRKRASAGTPSLSSSVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAIS
SPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEPGSEDEPGSARIERKI
ATISLESKSPPKTLENAGGSLTGRKAPLASEPVNSSKWKSTFSPISDLGLAKAADSPLQA
ASALSHNSLFAFRPGLEEPSAADAKLATHSRKSFPGTLPGAGGLSPSSLPASSFALGGGL
AADLSLHSFSDGASLSHKAPEAAGLGAPLSFPGPRGKEGGAAESGPFANKRQLDGLGPKG
EGGLPTCGPPDKASTAHSKAGKGREREPDVKNGHNLFMAAAAAPPAGLLSGPGLAPAASS
AGGAAPSVQTHRPFLGTFAPGPQFALGPMSLQANLGPSVLQSLFSSVPAAGLVHVSTAAT
RLTNSHAMGSFSSGVAGGAVGGVFNHAVPPASAHPFGASFGSGAACGSTTLSLTPLQAVA
SPPASSFQAPSSAEPRPPPPPPHLGQPPPGQPALHAPPHPNTTLPSPPALLPANSEPVLL
QNLASLPANQAFLPASSAASLPPANASLSIKLASLPHKVSRPSLTVHHQPLPGLALAQAQ
ATPVNPQASSTGPPAVWVSLGMPPPYAARLAGVKPQ
NT seq
5151 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atcagatgggtctgtgaagaaatcccggatctcaagcttgctatggagaattacgtttta
attgactacgataccaaaagctttgagagtatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggcaccacacagcccatgaagctgaacaca
cggccgtccacggggctcctgcggcacatcctgcagcaggtctacaaccactcagtgacc
gaccctgagaagctcaacaactatgagcccttctccccagaggtgtatggggagacctcc
ttcgacctggtcgcccagatgatcgatgagatcaagatgactgaagatgacctgttcgtg
gacctgggcagtggggtgggccaggtcgtgctgcaggttgctgcggccaccaactgcaaa
catcactatggtgtagagaaagctgacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagaga
ggggacttcctctcggaggagtggagagaacggattgctaacacaagtgttgtatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcaaacatg
aaggaaggtggcagaatcgtgtcctcgaagccctttgcgcctctgaacttcagaataaac
agtagaaacttgagtgacattggcaccatcatgcgtgtcgtggagctgtcgccgctaaaa
ggctcggtgtcgtggacggggaagccagtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctaaaaaatccaaaactcagggaggaacaagaggca
gctcggcgccggcagcaacgggagaacaagagcaacacaaccacgcccaccaaggtgccc
gagagcaaggcagctgtgcccgcggacacccccgtggactctggtgctgaggaggagaaa
gctgggacggccgctgtcaagaagccatctccctccaaggcccggaagaagaagctgaac
aagaagggccggaagatggcgggtcggaagcgcgggcgccccaagaagatgagtgccacc
aaccccgagcgcaagcccaagaagacccagagcgcactggacctgctgcacgcccagact
gtatcacgagcggcctcccccttgccgcaggatgcgcacaggccacctcacagcccattc
taccagctacctcccagcgtgcagcggcctacccccgagcagctgctgctggcacccacc
ccgcccgccctgcacaggctgctagagtccttcaagattcagtacctacagttcctggca
tacacgaagacccctcagtacaaggccaacctgcagcagctgctggaccaggagaaggag
aagaatgcccggttgctaggcgcagcgcagcagctgttcggccactgtcaagctcagaag
gaagagatcaagaggctcttccagcagaaactggacgagctgggagtgaaggcgctgacc
tacaacgacctgatccaagcgcagaaggagatctcggctcacaaccagcaattgagggaa
cagacagagcagctggagaagggcaaccgggagctgaggagccagagcctgagactgctc
aaggcacggtgtgaggagctgaagctggactggtccacgctgtccctggagaatctgctg
aaggagaagcaggccctgaagagccagatctcagagaagcagaggcactgcctggagctg
cagatcagcattgtggagctagagaagagccaacggcagcaggagttgctgcagctcaag
tcctgtgtgccacctgatgaggcgctgaccctgcagcttcgtggaaagccagaggccgag
cctggccggctgcacttagagctggactgcgcccgcttctccctgccgcccttcagcagc
ttgagccccgagctctccatgaatggccacgcggccggctatgagctctgcagcgcactg
ggtcggccctcgcccaagcagaacaccccccagtacctggcctccccactagaccaggag
gtcgtgccctgcacccccagccacagtggccggccacgactggagaagctgtctgggctg
gccctgcctgactacaccaggctatcccctgccaagctggtgctgcggcgccatctgagc
caggaccacgcggccagcggcaaggcagctgctagtgagctgcacccacgagccgagcat
gccaaggagaacgggctcccttaccagagccctggcatcaccaacggcatcaagctgagc
ccacaagacccccgaccttcatcccccacggctttacagatgggagagaagggccccgag
aagggtgtgaaggagcgtgcctacgccagcagtggggaggccatcaccagcctgcccgtc
agcatcccgctgagcaccgtgcagcccagcaagctgcccgtcagcatccctctggccagc
gtggtgctgcccagccgcgccgagaaggcgagaagcacacccagccctgggccgccggcc
cgagagtcgtcatccacgctggagaagcaggtggctgctaacgcccatggtaccgggggc
agtgcttccgggagcaagagcctcgccctggctcccacaggatatgcatacaccggctcg
gtggccatcagtggggccctagcgggcagcccggcacccctcggccctggaaccgagccc
ccagccctggacgagtcctccagctctggaagcctctttgccaccgtggggtcccgcagc
tccaccccgcagcacccgcccctgctgacgcagccacgtgcctgtggctcggcctcaccg
gccccccagctctccgccagcccccggctaggcgccctgggcccgcttcctgactctggc
aaaggggacctgccctgtgaggccagcttctcagaccctgagagcgaagccaagaggagg
atcgtcttcaccatctcggcaggcgccagcagcgccaagcagtcaccttccagcaaacac
agccctctgccttcgggtgcccgcggggatggtggccagggccatgggccagacagccgc
aagcggggccggaggaagcgggcatcagcggggacccccagcctgagctcgagtgtgtcc
cccaagcgccgggccttgccatctgttgctgggcttttcacgcagtcttcagggtccccc
ctgaacctcaactccatggtcagcaacatcaaccagcccctggagatcacagccatctcg
tcccctgagagctccctaaagagctcacccgtcccctaccaggacaacgaccaaccaccc
gtgctcaagaaggagaagcccctgagccagaccaatggcgcccactactccccgctgacc
tcggatgaggagccaggctctgaggatgagcccggcagtgccagaattgagagaaaaatt
gcaacaatctccttagaaagcaagtctccaccaaaaaccttggaaaatgcaggtggcagc
ctaacgggaaggaaggcaccgctggccagcgagccagtcaacagcagcaagtggaagtcc
accttctcgcccatctccgacctgggcctggccaaggcagccgacagcccactgcaggct
gcctccgctctgagccacaactccctgttcgctttccggcccggcctggaggagcccagt
gcggccgatgccaagctggccacccactccaggaagagcttcccgggcacactgccgggg
gcgggcgggctgagccccagtagccttcctgccagcagcttcgccctgggcgggggccta
gcagctgacctcagtttacacagcttcagtgatggtgcttctctctcccacaaggccccc
gaggcagctggcctgggtgcccccctgagcttccccggcccacggggcaaggagggtggc
gccgcagagtctggcccctttgcgaacaagcggcagctggacggactgggcccgaaaggc
gaggggggccttcccacgtgcggacccccagacaaggcctcaacagcgcatagcaaggcc
ggcaagggtcgtgagcgcgagcccgatgtcaagaacggccacaacctgttcatggccgcc
gccgccgcaccccctgcaggcctcctcagtggcccaggtcttgccccagcggcatcctcg
gcaggtggcgcagccccgtccgtgcagacccaccgccccttcctgggcacctttgccccc
gggccacagtttgcgctgggccccatgtcgctacaggccaacctgggcccgtctgtgctg
cagtccctgttcagctccgtgcccgccgccggcctggttcacgtctcgaccgccgccacc
agactgaccaactcgcacgccatgggcagcttctcctccggggtggccggcggcgcagtt
ggaggtgtctttaaccacgcggtgcctcccgcctccgcccatccgtttggagccagtttc
ggcagtggggctgcatgtggcagcaccacgctgagcttaaccccgctgcaggcggtggcc
agccccccggcctcttcctttcaggccccgtcctctgcggagccgaggccgcccccaccc
cctccgcacctgggccagccccctccggggcagcccgccctccatgcacccccccatcct
aacaccaccttgccttctccccctgcgctgctcccagctaactctgagcccgtgcttctg
cagaacctcgcatccctccctgctaaccaagctttcttacccgcctcttctgctgcctct
ctgccgcctgctaacgcctctctgtccatcaagctcgcctccctcccacacaaggtgtcc
cgcccctccttgacggtgcaccaccagcccctgcctgggctggccctggcccaggcccag
gccacgcccgtgaacccacaggccagctccacggggccgcccgccgtgtgggtttccctt
ggcatgccgcctccgtatgccgcgcgccttgcgggggttaagccgcaataa
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