KEGG   Castor canadensis (American beaver): 109681514
Entry
109681514         CDS       T04791                                 
Symbol
Chuk
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1
  KO
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Organism
ccan  Castor canadensis (American beaver)
Pathway
ccan01523  Antifolate resistance
ccan04010  MAPK signaling pathway
ccan04014  Ras signaling pathway
ccan04062  Chemokine signaling pathway
ccan04064  NF-kappa B signaling pathway
ccan04068  FoxO signaling pathway
ccan04150  mTOR signaling pathway
ccan04151  PI3K-Akt signaling pathway
ccan04210  Apoptosis
ccan04380  Osteoclast differentiation
ccan04620  Toll-like receptor signaling pathway
ccan04621  NOD-like receptor signaling pathway
ccan04622  RIG-I-like receptor signaling pathway
ccan04623  Cytosolic DNA-sensing pathway
ccan04625  C-type lectin receptor signaling pathway
ccan04657  IL-17 signaling pathway
ccan04658  Th1 and Th2 cell differentiation
ccan04659  Th17 cell differentiation
ccan04660  T cell receptor signaling pathway
ccan04662  B cell receptor signaling pathway
ccan04668  TNF signaling pathway
ccan04920  Adipocytokine signaling pathway
ccan04936  Alcoholic liver disease
ccan05010  Alzheimer disease
ccan05132  Salmonella infection
ccan05135  Yersinia infection
ccan05142  Chagas disease
ccan05145  Toxoplasmosis
ccan05160  Hepatitis C
ccan05161  Hepatitis B
ccan05162  Measles
ccan05163  Human cytomegalovirus infection
ccan05164  Influenza A
ccan05165  Human papillomavirus infection
ccan05166  Human T-cell leukemia virus 1 infection
ccan05167  Kaposi sarcoma-associated herpesvirus infection
ccan05168  Herpes simplex virus 1 infection
ccan05169  Epstein-Barr virus infection
ccan05170  Human immunodeficiency virus 1 infection
ccan05171  Coronavirus disease - COVID-19
ccan05200  Pathways in cancer
ccan05208  Chemical carcinogenesis - reactive oxygen species
ccan05212  Pancreatic cancer
ccan05215  Prostate cancer
ccan05220  Chronic myeloid leukemia
ccan05221  Acute myeloid leukemia
ccan05222  Small cell lung cancer
ccan05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ccan05417  Lipid and atherosclerosis
ccan05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccan00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109681514 (Chuk)
   04014 Ras signaling pathway
    109681514 (Chuk)
   04064 NF-kappa B signaling pathway
    109681514 (Chuk)
   04668 TNF signaling pathway
    109681514 (Chuk)
   04068 FoxO signaling pathway
    109681514 (Chuk)
   04151 PI3K-Akt signaling pathway
    109681514 (Chuk)
   04150 mTOR signaling pathway
    109681514 (Chuk)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    109681514 (Chuk)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    109681514 (Chuk)
   04621 NOD-like receptor signaling pathway
    109681514 (Chuk)
   04622 RIG-I-like receptor signaling pathway
    109681514 (Chuk)
   04623 Cytosolic DNA-sensing pathway
    109681514 (Chuk)
   04625 C-type lectin receptor signaling pathway
    109681514 (Chuk)
   04660 T cell receptor signaling pathway
    109681514 (Chuk)
   04658 Th1 and Th2 cell differentiation
    109681514 (Chuk)
   04659 Th17 cell differentiation
    109681514 (Chuk)
   04657 IL-17 signaling pathway
    109681514 (Chuk)
   04662 B cell receptor signaling pathway
    109681514 (Chuk)
   04062 Chemokine signaling pathway
    109681514 (Chuk)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    109681514 (Chuk)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    109681514 (Chuk)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109681514 (Chuk)
   05208 Chemical carcinogenesis - reactive oxygen species
    109681514 (Chuk)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109681514 (Chuk)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    109681514 (Chuk)
   05221 Acute myeloid leukemia
    109681514 (Chuk)
   05220 Chronic myeloid leukemia
    109681514 (Chuk)
   05215 Prostate cancer
    109681514 (Chuk)
   05222 Small cell lung cancer
    109681514 (Chuk)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109681514 (Chuk)
   05170 Human immunodeficiency virus 1 infection
    109681514 (Chuk)
   05161 Hepatitis B
    109681514 (Chuk)
   05160 Hepatitis C
    109681514 (Chuk)
   05171 Coronavirus disease - COVID-19
    109681514 (Chuk)
   05164 Influenza A
    109681514 (Chuk)
   05162 Measles
    109681514 (Chuk)
   05168 Herpes simplex virus 1 infection
    109681514 (Chuk)
   05163 Human cytomegalovirus infection
    109681514 (Chuk)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109681514 (Chuk)
   05169 Epstein-Barr virus infection
    109681514 (Chuk)
   05165 Human papillomavirus infection
    109681514 (Chuk)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    109681514 (Chuk)
   05135 Yersinia infection
    109681514 (Chuk)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    109681514 (Chuk)
   05142 Chagas disease
    109681514 (Chuk)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109681514 (Chuk)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109681514 (Chuk)
   05418 Fluid shear stress and atherosclerosis
    109681514 (Chuk)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    109681514 (Chuk)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    109681514 (Chuk)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccan01001]
    109681514 (Chuk)
Enzymes [BR:ccan01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     109681514 (Chuk)
Protein kinases [BR:ccan01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   109681514 (Chuk)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo TBK1_ULD
Other DBs
NCBI-GeneID: 109681514
NCBI-ProteinID: XP_020011900
UniProt: A0A250YL28
LinkDB
Position
Unknown
AA seq 745 aa
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELELKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIMHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMTGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDPTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPSDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
VQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIRYAEVGVIGYLEDQIMSLHTE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPADHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEIALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGAVTPHASAWLPPTLAECEHPLSCVVTPQDGETLPQMIEENLNCLGHL
STIIREANEEQGSSMMNLDWSWLAE
NT seq 2238 nt   +upstreamnt  +downstreamnt
atggagcggcccccggggctgcggccgggcgcgggcgggccctgggagatgcgggagcgg
cttggcaccggaggattcggaaatgtctgtctgtaccagcatcgggaacttgaactcaaa
atagcaattaagtcttgtcgcctggagttaagtaccaaaaatagagaacgatggtgccac
gaaatccagatcatgaagaagttgaaccatgccaatgttgtaaaggcctgtgatgttcct
gaggaactgaattttttgattaatgatgtacctcttctggcaatggaatactgttctgga
ggagatctccggaagctactcaacaaaccagaaaattgttgtggacttaaagaaagccag
atactttctttgctgagtgatataggatctgggattcgatatttgcatgaaaataaaatt
atacatcgagatctaaaacctgaaaatatagttctacaggatgttggtggaaagataatg
cataaaataattgatctgggatatgccaaagatgttgatcaaggaagtctctgtacatct
tttgtgggaacactgcagtatctggccccagagctctttgagaataagccttacacagct
actgttgattattggagctttgggaccatggtatttgaatgtattgccggatatagacct
tttttacatcatctgcagccatttacctggcatgagaagattaagaagaaggatcctaag
tgtatatttgcgtgtgaagagatgacaggagaagttcggtttagtagccatttacctcaa
ccaaatagcctttgtagtttaatagtagaacccatggaaaactggctacagctgatgctg
aattgggacccacagcaaagagggggccctgttgaccctactttgaagcagccaagatgc
tttgtattaatggatcacattctgaatttaaagatagtgcacatcctaaatatgacttct
gcaaagataatttcttttctgttaccatctgatgaaagtcttcattcactacagtctcgt
attgagcgtgaaactggaataaatactggttctcaagaactgctttcagagacaggaatt
tctctggatcctcggaaaccagcctctcagtgtgttctagatggagttagaggctgtgat
agttacatggtttacttgtttgataaaagcaagactgtatatgaagggccatttgcttcc
agaagtttatctgattgtgtaaattatattgtacaagacagcaaaatacagcttccaatt
gtacagttacgtaaagtatgggctgaggcagtacactacgtgtctggactaaaagaagac
tacagcaggctgtttcagggacaaagagcagcaatgttaagtcttcttagatataatgct
aacttgacaaaaatgaagaatactttgatatcagcatcacagcaactgaaagctaaactg
gagttttttcacaaaagcattcaacttgacttggagagatacagtgaacaaatgacttat
gggatatcttcagaaaaaatgctaaaagcatggaaagaaatggaagaaaaggccatccgc
tatgctgaggttggtgtcattggatacctagaggatcagattatgtctttacacactgaa
atcatggaactacagaagagcccttatggaagacgtcagggagacttgatggaatctctg
gagcaacgtgccattgatctttataagcagttaaagcacagacctgcagatcattcctac
agtgacagcacagagatggtgaagatcattgtgcatactgtacagagtcaggaccgtgtt
ctcaaggagctgtttggtcatctgagcaagttgttgggctgtaagcagaagattattgat
ctactccccaaagtggaaatcgccctcagtaacatcaaagaagctgacaatactgtcatg
tttatgcagggaaagaggcagaaagaaatatggcatctccttaaaattgcctgtacacag
agttctgcccgctcccttgtggggtccagtctagaaggtgcagtaacccctcacgcatca
gcatggctacccccgaccttagcagaatgtgaacaccctctgtcatgcgtggtaactcct
caagatggggaaactttaccacaaatgatagaagaaaatttgaactgtctcggccattta
agtactattattcgtgaagcaaatgaggaacagggcagtagcatgatgaatcttgattgg
agttggttagcagaatga

DBGET integrated database retrieval system