Canis lupus familiaris (dog): 488084
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Entry
488084 CDS
T01007
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
KO
K00922
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:
2.7.1.153
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa00562
Inositol phosphate metabolism
cfa01100
Metabolic pathways
cfa01521
EGFR tyrosine kinase inhibitor resistance
cfa01522
Endocrine resistance
cfa01524
Platinum drug resistance
cfa04012
ErbB signaling pathway
cfa04014
Ras signaling pathway
cfa04015
Rap1 signaling pathway
cfa04024
cAMP signaling pathway
cfa04062
Chemokine signaling pathway
cfa04066
HIF-1 signaling pathway
cfa04068
FoxO signaling pathway
cfa04070
Phosphatidylinositol signaling system
cfa04071
Sphingolipid signaling pathway
cfa04072
Phospholipase D signaling pathway
cfa04140
Autophagy - animal
cfa04150
mTOR signaling pathway
cfa04151
PI3K-Akt signaling pathway
cfa04152
AMPK signaling pathway
cfa04210
Apoptosis
cfa04211
Longevity regulating pathway
cfa04213
Longevity regulating pathway - multiple species
cfa04218
Cellular senescence
cfa04360
Axon guidance
cfa04370
VEGF signaling pathway
cfa04380
Osteoclast differentiation
cfa04510
Focal adhesion
cfa04550
Signaling pathways regulating pluripotency of stem cells
cfa04611
Platelet activation
cfa04613
Neutrophil extracellular trap formation
cfa04620
Toll-like receptor signaling pathway
cfa04625
C-type lectin receptor signaling pathway
cfa04630
JAK-STAT signaling pathway
cfa04650
Natural killer cell mediated cytotoxicity
cfa04660
T cell receptor signaling pathway
cfa04662
B cell receptor signaling pathway
cfa04664
Fc epsilon RI signaling pathway
cfa04666
Fc gamma R-mediated phagocytosis
cfa04668
TNF signaling pathway
cfa04670
Leukocyte transendothelial migration
cfa04722
Neurotrophin signaling pathway
cfa04725
Cholinergic synapse
cfa04750
Inflammatory mediator regulation of TRP channels
cfa04810
Regulation of actin cytoskeleton
cfa04910
Insulin signaling pathway
cfa04914
Progesterone-mediated oocyte maturation
cfa04915
Estrogen signaling pathway
cfa04917
Prolactin signaling pathway
cfa04919
Thyroid hormone signaling pathway
cfa04923
Regulation of lipolysis in adipocytes
cfa04926
Relaxin signaling pathway
cfa04929
GnRH secretion
cfa04930
Type II diabetes mellitus
cfa04931
Insulin resistance
cfa04932
Non-alcoholic fatty liver disease
cfa04933
AGE-RAGE signaling pathway in diabetic complications
cfa04935
Growth hormone synthesis, secretion and action
cfa04960
Aldosterone-regulated sodium reabsorption
cfa04973
Carbohydrate digestion and absorption
cfa05010
Alzheimer disease
cfa05017
Spinocerebellar ataxia
cfa05020
Prion disease
cfa05100
Bacterial invasion of epithelial cells
cfa05132
Salmonella infection
cfa05135
Yersinia infection
cfa05142
Chagas disease
cfa05146
Amoebiasis
cfa05160
Hepatitis C
cfa05161
Hepatitis B
cfa05162
Measles
cfa05163
Human cytomegalovirus infection
cfa05164
Influenza A
cfa05165
Human papillomavirus infection
cfa05166
Human T-cell leukemia virus 1 infection
cfa05167
Kaposi sarcoma-associated herpesvirus infection
cfa05168
Herpes simplex virus 1 infection
cfa05169
Epstein-Barr virus infection
cfa05170
Human immunodeficiency virus 1 infection
cfa05171
Coronavirus disease - COVID-19
cfa05200
Pathways in cancer
cfa05203
Viral carcinogenesis
cfa05205
Proteoglycans in cancer
cfa05206
MicroRNAs in cancer
cfa05207
Chemical carcinogenesis - receptor activation
cfa05208
Chemical carcinogenesis - reactive oxygen species
cfa05210
Colorectal cancer
cfa05211
Renal cell carcinoma
cfa05212
Pancreatic cancer
cfa05213
Endometrial cancer
cfa05214
Glioma
cfa05215
Prostate cancer
cfa05218
Melanoma
cfa05220
Chronic myeloid leukemia
cfa05221
Acute myeloid leukemia
cfa05222
Small cell lung cancer
cfa05223
Non-small cell lung cancer
cfa05224
Breast cancer
cfa05225
Hepatocellular carcinoma
cfa05226
Gastric cancer
cfa05230
Central carbon metabolism in cancer
cfa05231
Choline metabolism in cancer
cfa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
cfa05415
Diabetic cardiomyopathy
cfa05417
Lipid and atherosclerosis
cfa05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
488084 (PIK3CA)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
488084 (PIK3CA)
04014 Ras signaling pathway
488084 (PIK3CA)
04015 Rap1 signaling pathway
488084 (PIK3CA)
04370 VEGF signaling pathway
488084 (PIK3CA)
04630 JAK-STAT signaling pathway
488084 (PIK3CA)
04668 TNF signaling pathway
488084 (PIK3CA)
04066 HIF-1 signaling pathway
488084 (PIK3CA)
04068 FoxO signaling pathway
488084 (PIK3CA)
04070 Phosphatidylinositol signaling system
488084 (PIK3CA)
04072 Phospholipase D signaling pathway
488084 (PIK3CA)
04071 Sphingolipid signaling pathway
488084 (PIK3CA)
04024 cAMP signaling pathway
488084 (PIK3CA)
04151 PI3K-Akt signaling pathway
488084 (PIK3CA)
04152 AMPK signaling pathway
488084 (PIK3CA)
04150 mTOR signaling pathway
488084 (PIK3CA)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
488084 (PIK3CA)
09143 Cell growth and death
04210 Apoptosis
488084 (PIK3CA)
04218 Cellular senescence
488084 (PIK3CA)
09144 Cellular community - eukaryotes
04510 Focal adhesion
488084 (PIK3CA)
04550 Signaling pathways regulating pluripotency of stem cells
488084 (PIK3CA)
09142 Cell motility
04810 Regulation of actin cytoskeleton
488084 (PIK3CA)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
488084 (PIK3CA)
04613 Neutrophil extracellular trap formation
488084 (PIK3CA)
04620 Toll-like receptor signaling pathway
488084 (PIK3CA)
04625 C-type lectin receptor signaling pathway
488084 (PIK3CA)
04650 Natural killer cell mediated cytotoxicity
488084 (PIK3CA)
04660 T cell receptor signaling pathway
488084 (PIK3CA)
04662 B cell receptor signaling pathway
488084 (PIK3CA)
04664 Fc epsilon RI signaling pathway
488084 (PIK3CA)
04666 Fc gamma R-mediated phagocytosis
488084 (PIK3CA)
04670 Leukocyte transendothelial migration
488084 (PIK3CA)
04062 Chemokine signaling pathway
488084 (PIK3CA)
09152 Endocrine system
04910 Insulin signaling pathway
488084 (PIK3CA)
04923 Regulation of lipolysis in adipocytes
488084 (PIK3CA)
04929 GnRH secretion
488084 (PIK3CA)
04915 Estrogen signaling pathway
488084 (PIK3CA)
04914 Progesterone-mediated oocyte maturation
488084 (PIK3CA)
04917 Prolactin signaling pathway
488084 (PIK3CA)
04926 Relaxin signaling pathway
488084 (PIK3CA)
04935 Growth hormone synthesis, secretion and action
488084 (PIK3CA)
04919 Thyroid hormone signaling pathway
488084 (PIK3CA)
09154 Digestive system
04973 Carbohydrate digestion and absorption
488084 (PIK3CA)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
488084 (PIK3CA)
09156 Nervous system
04725 Cholinergic synapse
488084 (PIK3CA)
04722 Neurotrophin signaling pathway
488084 (PIK3CA)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
488084 (PIK3CA)
09158 Development and regeneration
04360 Axon guidance
488084 (PIK3CA)
04380 Osteoclast differentiation
488084 (PIK3CA)
09149 Aging
04211 Longevity regulating pathway
488084 (PIK3CA)
04213 Longevity regulating pathway - multiple species
488084 (PIK3CA)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
488084 (PIK3CA)
05206 MicroRNAs in cancer
488084 (PIK3CA)
05205 Proteoglycans in cancer
488084 (PIK3CA)
05207 Chemical carcinogenesis - receptor activation
488084 (PIK3CA)
05208 Chemical carcinogenesis - reactive oxygen species
488084 (PIK3CA)
05203 Viral carcinogenesis
488084 (PIK3CA)
05230 Central carbon metabolism in cancer
488084 (PIK3CA)
05231 Choline metabolism in cancer
488084 (PIK3CA)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
488084 (PIK3CA)
09162 Cancer: specific types
05210 Colorectal cancer
488084 (PIK3CA)
05212 Pancreatic cancer
488084 (PIK3CA)
05225 Hepatocellular carcinoma
488084 (PIK3CA)
05226 Gastric cancer
488084 (PIK3CA)
05214 Glioma
488084 (PIK3CA)
05221 Acute myeloid leukemia
488084 (PIK3CA)
05220 Chronic myeloid leukemia
488084 (PIK3CA)
05218 Melanoma
488084 (PIK3CA)
05211 Renal cell carcinoma
488084 (PIK3CA)
05215 Prostate cancer
488084 (PIK3CA)
05213 Endometrial cancer
488084 (PIK3CA)
05224 Breast cancer
488084 (PIK3CA)
05222 Small cell lung cancer
488084 (PIK3CA)
05223 Non-small cell lung cancer
488084 (PIK3CA)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
488084 (PIK3CA)
05170 Human immunodeficiency virus 1 infection
488084 (PIK3CA)
05161 Hepatitis B
488084 (PIK3CA)
05160 Hepatitis C
488084 (PIK3CA)
05171 Coronavirus disease - COVID-19
488084 (PIK3CA)
05164 Influenza A
488084 (PIK3CA)
05162 Measles
488084 (PIK3CA)
05168 Herpes simplex virus 1 infection
488084 (PIK3CA)
05163 Human cytomegalovirus infection
488084 (PIK3CA)
05167 Kaposi sarcoma-associated herpesvirus infection
488084 (PIK3CA)
05169 Epstein-Barr virus infection
488084 (PIK3CA)
05165 Human papillomavirus infection
488084 (PIK3CA)
09171 Infectious disease: bacterial
05132 Salmonella infection
488084 (PIK3CA)
05135 Yersinia infection
488084 (PIK3CA)
05100 Bacterial invasion of epithelial cells
488084 (PIK3CA)
09174 Infectious disease: parasitic
05146 Amoebiasis
488084 (PIK3CA)
05142 Chagas disease
488084 (PIK3CA)
09164 Neurodegenerative disease
05010 Alzheimer disease
488084 (PIK3CA)
05017 Spinocerebellar ataxia
488084 (PIK3CA)
05020 Prion disease
488084 (PIK3CA)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
488084 (PIK3CA)
05418 Fluid shear stress and atherosclerosis
488084 (PIK3CA)
05415 Diabetic cardiomyopathy
488084 (PIK3CA)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
488084 (PIK3CA)
04932 Non-alcoholic fatty liver disease
488084 (PIK3CA)
04931 Insulin resistance
488084 (PIK3CA)
04933 AGE-RAGE signaling pathway in diabetic complications
488084 (PIK3CA)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
488084 (PIK3CA)
01524 Platinum drug resistance
488084 (PIK3CA)
01522 Endocrine resistance
488084 (PIK3CA)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
cfa04131
]
488084 (PIK3CA)
Enzymes [BR:
cfa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase
488084 (PIK3CA)
Membrane trafficking [BR:
cfa04131
]
Endocytosis
Rab GTPases and associated proteins
Rab associated proteins
488084 (PIK3CA)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PI3Ka
PI3_PI4_kinase
PI3K_C2
PI3K_rbd
PI3K_p85B
DUF2321
ABC1
Ribosomal_S15
Motif
Other DBs
NCBI-GeneID:
488084
NCBI-ProteinID:
XP_022270060
Ensembl:
ENSCAFG00000011212
VGNC:
44555
LinkDB
All DBs
Position
34:16743641..16822678
Genome browser
AA seq
1068 aa
AA seq
DB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq
3207 nt
NT seq
+upstream
nt +downstream
nt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacggctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgagaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaaacagaagtatactctgaaaatcaaccatgactgtgttccagaacaagta
attgctgaagcaatcagaaaaaaaactagaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtatgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttgga
aggatgcccaatttgatgttgatggctaaagaaagcctttactcccaattgccaatggac
tgtttcacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagcgcactcagaataaaaatcctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatttatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgttaacactcaaagagtaccttgttctaat
cccaggtggaatgaatggctaaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtcggtg
tctcgggaagcaggatttagttattcccatgcaggactgagtaacagactggctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctctc
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtccgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaagctatggag
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatacttaacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tacgaacaatatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcattttttcttttggcatttaaaatctgagatgcacaataaaacggtt
agtcagaggtttggcctgcttttggagtcctattgccgtgcttgtgggatgtatttgaag
cacctaaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctacaaggttttctatctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacgacaagatatgctaacacttcaaataattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcagatt
cagtgcaaaggtggcctgaaaggtgcactgcagttcaacagccacacactacaccagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggaccat
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaggaatgcacaaaaacaagagaatttgagaggttt
caggagatgtgttacaaggcttacctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
accattaagcagcatgctttgaactga
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integrated database retrieval system