KEGG   Canis lupus familiaris (dog): 488084
Entry
488084            CDS       T01007                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00562  Inositol phosphate metabolism
cfa01100  Metabolic pathways
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa01522  Endocrine resistance
cfa01524  Platinum drug resistance
cfa04012  ErbB signaling pathway
cfa04014  Ras signaling pathway
cfa04015  Rap1 signaling pathway
cfa04024  cAMP signaling pathway
cfa04062  Chemokine signaling pathway
cfa04066  HIF-1 signaling pathway
cfa04068  FoxO signaling pathway
cfa04070  Phosphatidylinositol signaling system
cfa04071  Sphingolipid signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04140  Autophagy - animal
cfa04150  mTOR signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04152  AMPK signaling pathway
cfa04210  Apoptosis
cfa04211  Longevity regulating pathway
cfa04213  Longevity regulating pathway - multiple species
cfa04218  Cellular senescence
cfa04360  Axon guidance
cfa04370  VEGF signaling pathway
cfa04380  Osteoclast differentiation
cfa04510  Focal adhesion
cfa04550  Signaling pathways regulating pluripotency of stem cells
cfa04611  Platelet activation
cfa04613  Neutrophil extracellular trap formation
cfa04620  Toll-like receptor signaling pathway
cfa04625  C-type lectin receptor signaling pathway
cfa04630  JAK-STAT signaling pathway
cfa04650  Natural killer cell mediated cytotoxicity
cfa04660  T cell receptor signaling pathway
cfa04662  B cell receptor signaling pathway
cfa04664  Fc epsilon RI signaling pathway
cfa04666  Fc gamma R-mediated phagocytosis
cfa04668  TNF signaling pathway
cfa04670  Leukocyte transendothelial migration
cfa04722  Neurotrophin signaling pathway
cfa04725  Cholinergic synapse
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04810  Regulation of actin cytoskeleton
cfa04910  Insulin signaling pathway
cfa04914  Progesterone-mediated oocyte maturation
cfa04915  Estrogen signaling pathway
cfa04917  Prolactin signaling pathway
cfa04919  Thyroid hormone signaling pathway
cfa04923  Regulation of lipolysis in adipocytes
cfa04926  Relaxin signaling pathway
cfa04929  GnRH secretion
cfa04930  Type II diabetes mellitus
cfa04931  Insulin resistance
cfa04932  Non-alcoholic fatty liver disease
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04935  Growth hormone synthesis, secretion and action
cfa04960  Aldosterone-regulated sodium reabsorption
cfa04973  Carbohydrate digestion and absorption
cfa05010  Alzheimer disease
cfa05017  Spinocerebellar ataxia
cfa05020  Prion disease
cfa05100  Bacterial invasion of epithelial cells
cfa05132  Salmonella infection
cfa05135  Yersinia infection
cfa05142  Chagas disease
cfa05146  Amoebiasis
cfa05160  Hepatitis C
cfa05161  Hepatitis B
cfa05162  Measles
cfa05163  Human cytomegalovirus infection
cfa05164  Influenza A
cfa05165  Human papillomavirus infection
cfa05166  Human T-cell leukemia virus 1 infection
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05168  Herpes simplex virus 1 infection
cfa05169  Epstein-Barr virus infection
cfa05170  Human immunodeficiency virus 1 infection
cfa05171  Coronavirus disease - COVID-19
cfa05200  Pathways in cancer
cfa05203  Viral carcinogenesis
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
cfa05207  Chemical carcinogenesis - receptor activation
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05210  Colorectal cancer
cfa05211  Renal cell carcinoma
cfa05212  Pancreatic cancer
cfa05213  Endometrial cancer
cfa05214  Glioma
cfa05215  Prostate cancer
cfa05218  Melanoma
cfa05220  Chronic myeloid leukemia
cfa05221  Acute myeloid leukemia
cfa05222  Small cell lung cancer
cfa05223  Non-small cell lung cancer
cfa05224  Breast cancer
cfa05225  Hepatocellular carcinoma
cfa05226  Gastric cancer
cfa05230  Central carbon metabolism in cancer
cfa05231  Choline metabolism in cancer
cfa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cfa05415  Diabetic cardiomyopathy
cfa05417  Lipid and atherosclerosis
cfa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    488084 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    488084 (PIK3CA)
   04014 Ras signaling pathway
    488084 (PIK3CA)
   04015 Rap1 signaling pathway
    488084 (PIK3CA)
   04370 VEGF signaling pathway
    488084 (PIK3CA)
   04630 JAK-STAT signaling pathway
    488084 (PIK3CA)
   04668 TNF signaling pathway
    488084 (PIK3CA)
   04066 HIF-1 signaling pathway
    488084 (PIK3CA)
   04068 FoxO signaling pathway
    488084 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    488084 (PIK3CA)
   04072 Phospholipase D signaling pathway
    488084 (PIK3CA)
   04071 Sphingolipid signaling pathway
    488084 (PIK3CA)
   04024 cAMP signaling pathway
    488084 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    488084 (PIK3CA)
   04152 AMPK signaling pathway
    488084 (PIK3CA)
   04150 mTOR signaling pathway
    488084 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    488084 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    488084 (PIK3CA)
   04218 Cellular senescence
    488084 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    488084 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    488084 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    488084 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    488084 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    488084 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    488084 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    488084 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    488084 (PIK3CA)
   04660 T cell receptor signaling pathway
    488084 (PIK3CA)
   04662 B cell receptor signaling pathway
    488084 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    488084 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    488084 (PIK3CA)
   04670 Leukocyte transendothelial migration
    488084 (PIK3CA)
   04062 Chemokine signaling pathway
    488084 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    488084 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    488084 (PIK3CA)
   04929 GnRH secretion
    488084 (PIK3CA)
   04915 Estrogen signaling pathway
    488084 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    488084 (PIK3CA)
   04917 Prolactin signaling pathway
    488084 (PIK3CA)
   04926 Relaxin signaling pathway
    488084 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    488084 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    488084 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    488084 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    488084 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    488084 (PIK3CA)
   04722 Neurotrophin signaling pathway
    488084 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    488084 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    488084 (PIK3CA)
   04380 Osteoclast differentiation
    488084 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    488084 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    488084 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    488084 (PIK3CA)
   05206 MicroRNAs in cancer
    488084 (PIK3CA)
   05205 Proteoglycans in cancer
    488084 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    488084 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    488084 (PIK3CA)
   05203 Viral carcinogenesis
    488084 (PIK3CA)
   05230 Central carbon metabolism in cancer
    488084 (PIK3CA)
   05231 Choline metabolism in cancer
    488084 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    488084 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    488084 (PIK3CA)
   05212 Pancreatic cancer
    488084 (PIK3CA)
   05225 Hepatocellular carcinoma
    488084 (PIK3CA)
   05226 Gastric cancer
    488084 (PIK3CA)
   05214 Glioma
    488084 (PIK3CA)
   05221 Acute myeloid leukemia
    488084 (PIK3CA)
   05220 Chronic myeloid leukemia
    488084 (PIK3CA)
   05218 Melanoma
    488084 (PIK3CA)
   05211 Renal cell carcinoma
    488084 (PIK3CA)
   05215 Prostate cancer
    488084 (PIK3CA)
   05213 Endometrial cancer
    488084 (PIK3CA)
   05224 Breast cancer
    488084 (PIK3CA)
   05222 Small cell lung cancer
    488084 (PIK3CA)
   05223 Non-small cell lung cancer
    488084 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    488084 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    488084 (PIK3CA)
   05161 Hepatitis B
    488084 (PIK3CA)
   05160 Hepatitis C
    488084 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    488084 (PIK3CA)
   05164 Influenza A
    488084 (PIK3CA)
   05162 Measles
    488084 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    488084 (PIK3CA)
   05163 Human cytomegalovirus infection
    488084 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    488084 (PIK3CA)
   05169 Epstein-Barr virus infection
    488084 (PIK3CA)
   05165 Human papillomavirus infection
    488084 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    488084 (PIK3CA)
   05135 Yersinia infection
    488084 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    488084 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    488084 (PIK3CA)
   05142 Chagas disease
    488084 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    488084 (PIK3CA)
   05017 Spinocerebellar ataxia
    488084 (PIK3CA)
   05020 Prion disease
    488084 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    488084 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    488084 (PIK3CA)
   05415 Diabetic cardiomyopathy
    488084 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    488084 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    488084 (PIK3CA)
   04931 Insulin resistance
    488084 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    488084 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    488084 (PIK3CA)
   01524 Platinum drug resistance
    488084 (PIK3CA)
   01522 Endocrine resistance
    488084 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    488084 (PIK3CA)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     488084 (PIK3CA)
Membrane trafficking [BR:cfa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    488084 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 488084
NCBI-ProteinID: XP_022270060
Ensembl: ENSCAFG00000011212
VGNC: 44555
LinkDB
Position
34:16743641..16822678
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacggctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgagaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaaacagaagtatactctgaaaatcaaccatgactgtgttccagaacaagta
attgctgaagcaatcagaaaaaaaactagaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtatgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttgga
aggatgcccaatttgatgttgatggctaaagaaagcctttactcccaattgccaatggac
tgtttcacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagcgcactcagaataaaaatcctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatttatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgttaacactcaaagagtaccttgttctaat
cccaggtggaatgaatggctaaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtcggtg
tctcgggaagcaggatttagttattcccatgcaggactgagtaacagactggctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctctc
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtccgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaagctatggag
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatacttaacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tacgaacaatatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcattttttcttttggcatttaaaatctgagatgcacaataaaacggtt
agtcagaggtttggcctgcttttggagtcctattgccgtgcttgtgggatgtatttgaag
cacctaaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctacaaggttttctatctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacgacaagatatgctaacacttcaaataattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcagatt
cagtgcaaaggtggcctgaaaggtgcactgcagttcaacagccacacactacaccagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggaccat
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaggaatgcacaaaaacaagagaatttgagaggttt
caggagatgtgttacaaggcttacctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
accattaagcagcatgctttgaactga

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