Cavia porcellus (domestic guinea pig): 100722908 Help Entry 100722908         CDS       T07777                                  Symbol Jak2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism cpoc  Cavia porcellus (domestic guinea pig) Pathway cpoc01521   EGFR tyrosine kinase inhibitor resistance cpoc04062   Chemokine signaling pathway cpoc04148   Efferocytosis cpoc04151   PI3K-Akt signaling pathway cpoc04217   Necroptosis cpoc04550   Signaling pathways regulating pluripotency of stem cells cpoc04630   JAK-STAT signaling pathway cpoc04658   Th1 and Th2 cell differentiation cpoc04659   Th17 cell differentiation cpoc04725   Cholinergic synapse cpoc04917   Prolactin signaling pathway cpoc04920   Adipocytokine signaling pathway cpoc04933   AGE-RAGE signaling pathway in diabetic complications cpoc04935   Growth hormone synthesis, secretion and action cpoc05140   Leishmaniasis cpoc05145   Toxoplasmosis cpoc05152   Tuberculosis cpoc05161   Hepatitis B cpoc05164   Influenza A cpoc05167   Kaposi sarcoma-associated herpesvirus infection cpoc05168   Herpes simplex virus 1 infection cpoc05200   Pathways in cancer cpoc05207   Chemical carcinogenesis - receptor activation cpoc05235   PD-L1 expression and PD-1 checkpoint pathway in cancer cpoc05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:cpoc00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     100722908 (Jak2)    04151 PI3K-Akt signaling pathway     100722908 (Jak2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     100722908 (Jak2)   09143 Cell growth and death    04217 Necroptosis     100722908 (Jak2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     100722908 (Jak2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     100722908 (Jak2)    04659 Th17 cell differentiation     100722908 (Jak2)    04062 Chemokine signaling pathway     100722908 (Jak2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     100722908 (Jak2)    04917 Prolactin signaling pathway     100722908 (Jak2)    04935 Growth hormone synthesis, secretion and action     100722908 (Jak2)   09156 Nervous system    04725 Cholinergic synapse     100722908 (Jak2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100722908 (Jak2)    05207 Chemical carcinogenesis - receptor activation     100722908 (Jak2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     100722908 (Jak2)   09172 Infectious disease: viral    05161 Hepatitis B     100722908 (Jak2)    05164 Influenza A     100722908 (Jak2)    05168 Herpes simplex virus 1 infection     100722908 (Jak2)    05167 Kaposi sarcoma-associated herpesvirus infection     100722908 (Jak2)   09171 Infectious disease: bacterial    05152 Tuberculosis     100722908 (Jak2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     100722908 (Jak2)    05140 Leishmaniasis     100722908 (Jak2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     100722908 (Jak2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     100722908 (Jak2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100722908 (Jak2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:cpoc01001]     100722908 (Jak2) Enzymes [BR:cpoc01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      100722908 (Jak2) Protein kinases [BR:cpoc01001]  Non-receptor tyrosine kinases   JAK family [OT]    100722908 (Jak2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F1 Jak1_Phl SH2 Kdo ABC1 FERM_C_FAK1 Kinase-like RIO1 Pkinase_fungal Motif Other DBs NCBI-GeneID:  100722908 NCBI-ProteinID:  XP_003472309 Ensembl:  ENSCPOG00000014653 LinkDB All DBs Position Unknown AA seq 1042 aa AA seqDB search MEMACLMMTEMEATSTFPVHQNGDIPGNTNSVKQVDPVLQVYLYHSLGKAEGDYLKFPTG EYVAEEICVAACKACGITPVYHNMFALMSETERIWYPPNHVFHIDESSRHNVLYRIRFYF PHWYCSGNNRTYRYGISRGAEAPLLDDFVMSYLFAQYLINLETLQSAFYTEQFEVKEPGR GPSGEEIFATIIITGNGGIQWSRGRHKENETLTEQDLQLYCDFPDIIDVSVKQANQEGSN ESRIVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPTVLENIQ SNCHGPYFYFYFTFRMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK HCLITKNENREYNLSGTKKNFSNLKDLLNCYQMETVRSDSIIFQFTKCCPPKPKDKSNLL VFRTNGVSDVSTSPTLQRHNNVNQMVFHKIRNEDLIFNESLGQGTFTKIFKGIRREVGDY GQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVK FGSLDTYLKKNKNSINILWKLEVAKQLAWAMHFLEEKNRIHGNVCAKNILLIREEDRKTG NPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGG DKPLSALDSQRKLQFYEDRHQLPAPKWTELANLINNCMDYEPDFRPSFRAIIRDLNSLFT PDYELLTENDMLPNTRMTASLSSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDP LEDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIME YLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV KIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTY IEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNV NQRPSFKDLSFRVDQIRDNMSG NT seq 3129 nt NT seq  +upstreamnt  +downstreamnt atggaaatggcttgcctaatgatgacagaaatggaagctacatccacatttccagtacat cagaatggtgatattcctggaaatactaattctgtgaagcaagtcgatccagtccttcag gtgtatctttatcattcccttgggaaagctgagggagattatctgaagtttccaactgga gagtatgttgcagaagaaatttgtgttgctgcttgtaaagcctgtggcatcacacctgtg tatcataatatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaatcat gtcttccatatagatgaatcatccaggcataatgtactctacagaataagattttacttt cctcactggtattgcagtggaaacaacagaacctatcggtatggaatatctcgaggtgct gaagctcctcttcttgatgattttgtcatgtcttacctttttgctcagtatcttataaat ctggagactcttcagtctgccttctacacagaacaatttgaagtaaaagaacctggaaga ggtccttcaggtgaggagatttttgcaaccattataataactggaaacggtggaattcag tggtcaagagggagacataaagaaaatgagacactgacagaacaggatttacagttgtat tgtgattttcctgatattattgatgtcagtgttaagcaagcaaatcaggaaggctcaaat gaaagtagaattgtaactatccataagcaagatggtaaaaatttggaaattgaactgagt tcattaagggaagctttgtcttttgtgtcattgattgacggatattatagactgactgca gatgctcatcattacctctgtaaagaggtggcaccccctacagtgcttgagaacatacag agcaactgtcatgggccctatttctatttctattttacctttagaatggattttgccatc agtaaattgaagaaagcgggtaatcagactggactttatgtacttcggtgcagccctaag gactttaataaatattttctgacttttgctgttgagcgagaaaatgtcattgaatataaa cattgcttgattacaaaaaatgagaatagagaatacaacctcagtgggaccaagaagaac ttcagtaatcttaaagatcttttgaattgctaccaaatggaaactgttcgctcagacagt ataattttccagtttactaaatgctgtcccccaaaaccaaaagataaatcaaaccttcta gtctttagaaccaatggtgtttctgatgtatcaacttcaccaacattacagaggcataat aatgtgaaccaaatggtatttcacaaaatcagaaacgaagatttgatatttaatgaaagc cttggccaagggactttcacaaaaatttttaaaggaataaggagagaagtaggagactat ggtcagctgcatgaaacagaagttcttttgaaagttctggataaagcacatagaaactat tcagagtctttttttgaagcagcaagcatgatgagtcagctttctcacaagcatttggtt ttaaattatggtgtatgtgtctgtggagaggagaatattctcgttcaggagtttgtaaaa tttggatcattagatacatacttgaaaaagaataaaaattctataaatatattgtggaaa cttgaagtggctaaacagttggcatgggctatgcattttctagaagaaaaaaaccgtatt catgggaatgtatgtgccaaaaatattctacttatcagagaagaagacaggaagacagga aatcctcctttcatcaaacttagtgatcctggcattagtattacagttttaccaaaggac attcttcaggagagaataccatgggtaccaccagaatgcattgaaaatcctaaaaatcta aatttggcaacagacaaatggagctttggtactactttgtgggaaatctgcagtggagga gataaacctctgagtgctctagattctcaaagaaaattacagttttatgaagataggcac cagcttcctgcaccaaaatggacagaattagcaaaccttataaataattgtatggattat gaaccagattttaggccttctttcagagccatcatacgagatcttaacagtttattcact ccagattatgaactgttaacagaaaatgacatgttaccaaacacgaggatgactgcttca ttgtcttctggtgcttttgaagatagagaccctacacagtttgaagaaagacacttaaaa tttctacagcaacttggcaagggtaattttggaagtgtggagatgtgccggtatgaccct ctagaggataatactggggaggtggtagctgtaaaaaagctccagcacagtaccgaggag cacctcagagattttgaaagggaaattgaaatcttgaaatccctacagcatgataacatt gtaaagtacaaaggagtctgctacagtgctgggcggcgtaatctaagattaattatggaa tatttaccatatgggagtttacgagactacctccaaaaacacaaagaacggatagatcac aaaaaacttctgcaatatacatctcagatatgcaagggtatggagtaccttggcacaaaa aggtatatacacagagatctggcaacaagaaatatattggtggagaatgagaacagagtt aaaattggagattttggattaaccaaagtcttgccacaagacaaagaatactacaaagtg aaagaacctggtgaaagtcccatattctggtatgctccagaatctctgacagagagcaag ttttctgtggcctcagatgtttggagttttggagtagttctttatgaacttttcacatat attgagaagagtaaaagtccaccagcagagttcatgcgtatgattggcaatgacaaacaa ggacagatgattgtgttccatttgatagaactcctaaagaataatggaagattaccacga ccagatggatgcccagatgagatttatatgatcatgacagaatgctggaacaataacgta aaccagcgcccctcctttaaggacctatcatttcgagtggatcaaataagggacaacatg agtggatga

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