Equus asinus (ass): 106824091
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Entry
106824091 CDS
T04645
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase
KO
K00501
tyrosine 3-monooxygenase [EC:
1.14.16.2
]
Organism
eai
Equus asinus (ass)
Pathway
eai00350
Tyrosine metabolism
eai00790
Folate biosynthesis
eai01100
Metabolic pathways
eai04728
Dopaminergic synapse
eai04917
Prolactin signaling pathway
eai05012
Parkinson disease
eai05030
Cocaine addiction
eai05031
Amphetamine addiction
eai05034
Alcoholism
Module
eai_M00042
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:
eai00001
]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
106824091 (TH)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
106824091 (TH)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
106824091 (TH)
09156 Nervous system
04728 Dopaminergic synapse
106824091 (TH)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
106824091 (TH)
09165 Substance dependence
05030 Cocaine addiction
106824091 (TH)
05031 Amphetamine addiction
106824091 (TH)
05034 Alcoholism
106824091 (TH)
Enzymes [BR:
eai01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16.2 tyrosine 3-monooxygenase
106824091 (TH)
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Motif
Pfam:
Biopterin_H
TH_ACT
TOH_N
LTP_2
Motif
Other DBs
NCBI-GeneID:
106824091
NCBI-ProteinID:
XP_044606214
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Position
17:45981467..45989192
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AA seq
496 aa
AA seq
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MPTPSAAAPQAKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIEDARKEREKAEAAAAAAA
AEPGEPLEAAAVVERDGKAVLNLLFTLRTAKPSSLSRAVKAFETFEAQIHHLETRPAQRP
QAGGPHLEYFVRCEVPSPDLPALLSSVRRVAEDVRGAGENKVLWFPRKVSELDKCHHLVT
KFDPDLDLDHPGFSDQAYRQRRKLIADIAFQYKHGDPIPRVEYTAEEIATWKEVYTTLKG
LYATHACREHLEAFELLERFSGYREDNIPQLEDVSRFLKERSGFQLRPVAGLLSARDFLA
SLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDE
EIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHSLSEEPEIRAFDPDAAAVQP
YQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFAVKFDPYTLAIDVLDSPHAIRRSLEG
VQDELHALANALSTIG
NT seq
1491 nt
NT seq
+upstream
nt +downstream
nt
atgcccactcccagcgccgccgcgccgcaggccaagggcttccggagggccgtctctgag
ctggacgccaagcaggccgaggccatcatgtccccgcggttcatcgggcggcggcagagc
ctcatcgaggacgcgcgcaaggagcgcgagaaagcggaggcggcggcggccgcggcggca
gcggagccgggggagcccctggaggcggcggcggtggtcgagagggacgggaaggctgtg
ctgaacctactcttcaccctgaggaccgccaagccctcctcgctgtcccgcgcggtgaag
gcctttgagacattcgaagcccaaattcaccacctggagacccggcccgcccagaggccg
caggcagggggaccccacctggagtactttgtgcgctgtgaggtgcccagccccgacctg
cccgccctgctcagctccgtgcgccgggtggcagaggacgtgcgtggcgctggagagaac
aaggtcctctggttcccaaggaaagtttccgagctagacaagtgccaccacctggtcacc
aagtttgatcctgacctggacttggatcatccgggcttctcagaccaggcgtaccgccag
cgcaggaagctgattgccgacatagccttccagtacaagcatggtgaccctattccccgc
gtggagtacacggccgaggagattgccacctggaaggaggtctacaccaccctcaagggc
ctctacgccacgcacgcctgccgcgagcacctggaggccttcgagctgctggaacgcttc
agcggctaccgggaggacaacatcccccagctggaggacgtctcccgattcctgaaggag
cgctctggcttccagctgcggcccgtggccggcctgctgtctgcccgggacttcctggcc
agcctggccttccgtgtgttccagtgcacccagtacatccgccatgcctcgtcgcccatg
cactccccagagccggactgctgccacgagctgctgggacatgtgcccatgctggccgac
cggacctttgcccaattctcccaggacatcggcctcgcatccctgggggcatcggacgag
gaaattgagaagctgtccacgctgtactggttcacggtggagtttgggctgtgcaaacag
aacggcgaggtgaaggcctacggtgcggggctgctgtcctcctatggggagctcctgcac
tccctgtcagaggagcccgagatccgggcctttgaccccgacgctgcggccgtgcagccc
taccaggaccagacctaccagtccgtctacttcgtgtcggagagtttcagcgatgccaaa
gacaagctcaggagctacgcctcccgcatccaacgcccctttgccgtgaagtttgacccg
tacacgctggccatcgacgtgctggacagtccccacgccatccggcgctccctggagggt
gtccaggacgagctgcacgccctcgccaatgcgctgagcaccatcggctag
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