Equus caballus (horse): 100052935
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Entry
100052935 CDS
T01058
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
ecb
Equus caballus (horse)
Pathway
ecb05012
Parkinson disease
ecb05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
ecb00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
100052935 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
100052935 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ecb01001
]
100052935 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ecb04131
]
100052935 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
ecb04147
]
100052935 (LRRK2)
Enzymes [BR:
ecb01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100052935 (LRRK2)
Protein kinases [BR:
ecb01001
]
Serine/threonine kinases: TKL group
LRRK family
100052935 (LRRK2)
Membrane trafficking [BR:
ecb04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
100052935 (LRRK2)
Exosome [BR:
ecb04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
100052935 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Roc
LRR_8
COR
LRR_4
Ras
LRR_9
Arf
nSTAND3
AAA_22
Ank_2
T2SSE
LRR_6
ABC_tran
GTP_EFTU
AAA_7
TrwB_AAD_bind
PduV-EutP
G-alpha
MMR_HSR1
AAA_16
Kdo
NACHT
cobW
SRPRB
Septin
MobB
WD40_like
FtsK_SpoIIIE
AAA_29
ResIII
TsaE
TniB
SRP54
AAA_23
Motif
Other DBs
NCBI-GeneID:
100052935
NCBI-ProteinID:
XP_014596461
Ensembl:
ENSECAG00000010288
VGNC:
19801
LinkDB
All DBs
Position
6:60222667..60358448
Genome browser
AA seq
2528 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLKNVQEGKQIETLVQILEDMLVFTYADHASKLFQGKN
VHVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPDTMQSLMGPQDIGHDWEVLGVHQLIL
KMLTVHNASVNLSTVGLKALELLLTSGKITLLILDEESDIFLLIFDAMRTFSASDEVQKL
GCKALHVLFERVSEEQLTEFVENKDYMILLSALKNFKDEEEVVLHVLHCLHSLAIPCNNV
EVLMSGNVRCYNIVVEAMKAFPVSEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
QQYSKNATLQIAALSCLALLTETIFLNQDLEEKNESQENEEEEEEEKLFWLEACYKALTW
HRKNKHVQEAACWALNNLLMYQNSLHKKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASA
NALSTLLEQNVNFRKILLSKGIYLNVLELMRKHIHSPEVAESGCKMLDHLFEGSNPSLDT
MAAVAPKIMAVMKSHETSLSVQLEALRAILHFIVPGMPEESREDTEYQQKLNMVKKQCFR
NDLHKLVLAALNRFIGNPGIQKCGLKVISSIAHFPDALEVLSLEGAIDLILHTLQMYPDD
QEIQCLGLSLVGCLITKKNLCFGTGHLLAKILVSSLQRFKDIAEVQSKGFQAVLAILELS
VSFSKLLVQHAFDSVIFHQLSSSIMEQKDQQFLNLCCKCFAKLAMDDELKSVMLERACDQ
NNSIMVECLLLLGADANRAKEATSLICQVCEKASSPKLVELLLNSGSREQDVRKALTISI
GKGDSQIISLLLRRLALDLANNSICLGGFCMGKIEPSWLGPLFPDKTSNLRKEMNIGSTL
ARMVLRYQMKSAAEEGAASGSEGNISEEVLDKFDEWTFIPDTFVDSVFGQSDDLDSEGSE
GSFLVKKKSNSINVGELYRDPALQRYSPNLQRHSISLGPFFDHEDLLKQKRKKLSSDDSL
RSSKLQSHTRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISGHLEHLEKLELH
QNALANFPQRLCETLKCLTHLDLHSNKFTSFPSYLLKMNCIANLDVSRNDIGPLVVLDPA
VKCPTLKQFNLSYNQLSSLPENLNDVVEKLEQLVLEGNKISGLCSPLSLKELKILNLSKN
HISSLSEDFLEACPKVESFSARMNSLAAMSFLPSSMTSLKLSQNRFTCVPEAILNLPHLR
SLDMSSNEIQYLPSPAHWKSLNLRELLFSHNQISILDLSEKAYAWSRVEKLHLSHNKLKE
IPPEIGCLENLTSLDVSYNLELTSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDII
RFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQ
IRGKRKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIK
ARASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAK
LRKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVINRKRLLQLVKE
NQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPRWLCKVMAQILTVKVEGCP
KHPKGIISRRDVEKFLSKKKRFPKGYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPV
IELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIY
LNWSPEAYCLVGSEVLDNHLESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEID
ICGEGETLLKKWALYSFNDGEEHQKILLDDLMRKAEEGDLLVNPDQPRLTIPISQIAPDL
ILADLPRNIMLNSDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQ
ELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVA
DGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFR
APEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVREY
GCAPWPMVEKLIKNCLKENPQERPTSAQVFDILNSAELICLMRHITIPKNLIVECMVASN
HNSKNASIWLGCGHPDKGQLSFLDLNTERYTSEEVTDSRILCLALVHLPVEKESWIVSGT
QSGMLLVINTEDEKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGNLAIFEDKS
VKCKGAAPLKTLNIGTVSTPLMCLSESMNSTEKSIMWGGCGTKIFSFSEDFTIQKLIETR
TNQLFSYTAFSDSNIIAVVVDTALYVAKKNSPFVEVRDKKTEKLCELIDCVHFLKEEMVK
VNKDSKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIIRIIHNFCDSVRVMM
TAQLGSLKNAMLVLGYNRKSTDGTQQQKEIQSCLSVWDINLPHEVQNLEKHIEVRKELAE
KMRRISVE
NT seq
7587 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcaggggtgcgaggaggaggacgaggaaactctgaagaagttg
atagtcaggctgaagaatgtccaggaaggaaaacagatagagacgctggtccaaattctg
gaggatatgctggtgtttacgtacgccgaccacgcctccaagttatttcaaggcaaaaat
gtccacgtgcctctgttgatcgtcttggactcgtacatgagagtcgctagtgtacagcag
gtgggttggtcacttttatgcaaattaatagaaatctgtccagatacaatgcaaagctta
atgggaccccaggatattggacacgattgggaagtccttggggttcaccaactgattctt
aaaatgctcacagttcataatgccagtgtaaacctgtcaacagttggactgaaggcctta
gagctactcctaacttcaggtaaaatcactttgctaatattggatgaagaaagcgatatt
ttcttgttaattttcgatgccatgcgcacattttcagccagtgacgaagtgcagaaactt
ggatgcaaagctttacatgtgctgtttgagagagtttcagaggagcaactgactgaattt
gttgagaataaagattacatgatattgctaagtgcattaaaaaattttaaagatgaagag
gaagttgtgcttcatgtcctgcactgtttgcattccctagcaattccttgcaataatgtt
gaagtcctcatgagcggcaacgtcagatgttataatattgtggtagaagccatgaaagca
ttccctgtcagtgaaaaaattcaagaagtgagttgctgcttgctccataggcttacatta
ggtaatttttttaatatcctggtactgaatgaggtacatgaatttgtggtgaaagccgtg
cagcagtattcaaagaatgcgacgttacaaatcgcagcgctcagctgtttagcactcctc
actgagaccattttcttaaatcaagacttagaggaaaagaatgagagtcaggagaatgaa
gaggaggaggaagaagagaaattgttctggctggaagcctgttacaaagcattaacatgg
catagaaagaataagcatgtgcaggaggccgcatgctgggcattaaataatctccttatg
taccaaaacagtttacacaagaagattggagatgaagacggccagttcccagctcatagg
gaagtgatgctctccatgctgatgcattcttcgtcaaaagaagtcttccaggcctctgcg
aatgcattgtcgactctgttagaacaaaacgttaatttcagaaaaatcctgttgtcaaaa
ggaatatacctgaacgtattggagttaatgcggaagcacatacattcccctgaagtggct
gaaagtggctgtaaaatgctagatcatctatttgaaggaagtaacccttccctggataca
atggcagcagtggcccccaaaataatggcagttatgaaaagtcatgagacgtcattgtca
gtgcagctggaggcacttcgagctattttacatttcatagttccaggcatgccagaagaa
tccagggaagatactgaatatcaacagaaactaaatatggttaaaaagcagtgtttccgg
aatgatcttcacaaactggtccttgcagctttgaacaggttcattggaaatcctgggatt
cagaaatgtggattaaaagtaatttcttctatagcacattttcctgatgcgttagaggtg
ttatccctggaaggtgccattgatttgatacttcatacactgcagatgtatccggacgac
caagaaattcagtgtctgggtttaagtcttgtaggatgcttgattacaaagaagaattta
tgcttcggaactgggcatctcctggcaaaaattctggtttccagcttacaacgatttaag
gatattgctgaagttcagagtaaaggatttcaggcagtcttggcaatattggaactgtca
gtgtctttttccaagctgctggtccagcatgcctttgactcggtaatattccatcagctg
tcttccagtatcatggaacaaaaggatcaacagtttctaaacctttgttgcaagtgcttt
gcaaaattagctatggatgatgagttaaagagtgtgatgctagagagagcatgtgatcag
aacaacagcatcatggttgaatgcttgcttctcttgggagccgatgccaatcgagcaaag
gaggcaacttctttaatttgtcaggtatgtgagaaagcgagcagtcccaaattggtggag
ctgttactgaatagtggttcccgtgaacaagatgtacggaaagcgctgacaataagcatt
gggaaaggcgacagccaaatcatcagtttactcttaaggaggcttgccctggatctggcc
aataatagcatttgccttggaggattttgtatgggaaaaattgaaccatcttggcttggt
cctttatttccagataagacatctaatttaagaaaagaaatgaatataggatccaccctg
gcaagaatggtgctcagatatcagatgaaaagtgctgccgaggaaggagcagcctcaggc
agcgagggcaatatttctgaagaagtacttgataaatttgatgaatggaccttcattcct
gacacttttgtggacagtgtgtttggtcaaagtgatgacctggatagtgaaggaagtgaa
ggctcttttcttgtgaaaaagaaatcaaattcaattaatgtaggagaactttaccgagat
cctgccttgcagcgttactctccaaatttgcagaggcattccatttcattgggacccttt
tttgatcatgaagatttactgaagcaaaaaagaaaaaaattgtcttcagatgattcactc
aggtcatcaaaacttcaatcccatacgaggcattcagacagcatttcttcactggcttct
gagagagaatatattacatcattagacctttcagcaaatgaactaagagatattgatgcc
cttagccagaaatgctgtataagtggtcatttggagcatcttgaaaagctggagcttcac
cagaacgcactcgcgaactttccacaacgactatgtgaaactctgaagtgtttgacacat
ttggacttgcacagtaataaattcacatcatttccctcttacttgttgaaaatgaattgt
atcgccaaccttgacgtctctcggaatgacattggacccttggtagttttggatcctgcg
gtgaagtgcccgaccttgaaacagtttaacctgtcgtataatcagctgtcttctcttcct
gagaacctcaatgatgtggtagagaaattggaacagctcgttttagaaggaaataaaata
tcaggactatgttcccccttgagcctgaaggaactgaagattttaaaccttagtaaaaac
cacatttcatccctgtcggaggactttctggaggcgtgtcctaaagtggagagtttcagc
gccagaatgaattctcttgctgcaatgtcttttttgccttcttccatgacaagcctaaaa
ttatctcaaaacagatttacatgtgttccagaagcaattttaaatcttccacacttgcgg
tccttagatatgagcagcaatgaaattcaatatctaccaagtccagcacactggaaatct
ttgaacttaagggaactcttgtttagtcataatcaaatcagcatcttggacttgagtgaa
aaagcatatgcgtggtctagagtagagaaactacatctttcccataataaactgaaagag
attcctcctgagattggctgtctcgaaaatctgacatctcttgatgttagttacaacttg
gaactgacgtcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttg
gatgaattgcgtcttaattttgattttaaacatataggatgtaaagccaaagacatcata
aggtttcttcagcagcggttaaaaaaggccgtgccctataaccgaatgaaacttatgatt
gtggggaatactgggagtggtaaaaccaccttattgcagcagttaatgaaaaccaagaaa
tcagatcttgggatgcagagcgccacagttggcatagatgtgaaagactggcctatccaa
ataagaggcaaacgcaagaaagacctcattctaaatgtgtgggattttgcaggtcgtgag
gaattctacagcactcatccccactttatgacccagcgagcactgtaccttgctgtctat
gacctcagcaaagggcaagctgaagtcgatgccatgaaaccgtggctcttcaatataaag
gctcgtgcttcctcttcccccgtgattctcgttggcacacatttggatgtttctgacgag
aagcagcgcaaagcctgcatcagtaaaatcaccaaggagctcttgaacaagcgagggttt
cctgcaatacgggattaccactttgtgaatgccactgaggaatccgatgctttggcaaaa
cttcggaaaaccatcataaatgagagccttaatttcaagatccgagatcagcctgttgtt
gggcagctgattccagactgctatgtggaacttgagaaaatcattttatcagagcgtaaa
aatgtgccaattgaatttcctgtaattaaccggaaacgattattacaactcgtgaaagaa
aaccaactgcagttagatgaaaatgagcttcctcatgcagttcacttcctaaatgaatca
ggggtccttcttcattttcaagacccagcactgcagttaagtgacttatattttgtggaa
cccaggtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctgtcca
aaacatccgaagggaattatttcacgtagagatgtggaaaaatttctttcgaagaaaaag
agatttccaaagggctacatgtcacagtattttaaactcctagaaaaattccagattgcc
ttgccaataggagaagaatatttgctggttccaagcagtttgtctgaccacaggccggta
atagagcttccccattgtgagaactctgaaattatcattcgactatatgaaatgccttat
tttcccatgggattttggtcgagattaatcaatcgattacttgaaatttcaccttacatg
ctttcaggaagagaaagagcacttcgcccaaacagaatgtactggcgacaaggcatctac
ttgaattggtctccagaagcttattgtctggtaggatctgaagtcttagacaatcaccta
gagagtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttttgggccaa
gttgtggaccacattgattctctcatggaagaatggtttcctggcttattggagattgat
atttgtggtgaaggagaaactctgttgaagaagtgggcattatatagttttaatgatggt
gaagagcatcaaaaaatcttacttgatgatttgatgaggaaagcagaagaaggagacctc
ctagtgaatccagaccaaccacggctcaccattccaatatctcagattgcccctgatttg
attttggctgacctgcctagaaatattatgttgaatagtgatgaactggaatttgaacaa
gctccagagtttcttttaggtgatggcagttttggctcagtttatcgagcagcctacgaa
ggagaagaagtggctgtgaagatttttaataaacatacctcgcttagactgttaagacaa
gagctggtggtgctttgccatctccaccaccccagcttaatatctttgctggcggctggg
attcgtcctcgaatgttggtcatggagttggcctccaaagggtccctggatcgcctgctt
cagcaagacaaggccagtctcaccagaaccctgcagcacaggatcgcactccatgtggct
gatggcttgagatacctccactcggccatgattatttaccgtgatttgaagccccacaac
gtgctgcttttcaccctgtatcccaatgctgccatcattgccaagattgcggactacggc
attgctcagtactgctgtagaatggggataaaaacatcagaaggcacaccagggtttcgt
gcacctgaagttgctagaggaaatgttatttataaccaacaggctgatgtttattcattt
ggtttactactctatgacattttgacaactggaggcagaatagcagagggtttgaagttt
ccaaatgagtttgatgaattggcaatacaaggaaaattacctgatccagttagagaatat
ggttgtgccccatggcctatggttgagaagttaattaagaactgtttgaaagaaaaccct
caagaaaggcctacttctgcccaggtgtttgacattttgaattcagctgagttaatctgc
ctgatgagacatataacaatacctaaaaacttgattgttgaatgcatggttgcctcaaat
cataacagcaagaatgcaagcatttggctgggctgtgggcaccctgacaaaggacagctt
tcgttccttgacttaaatactgaaagatacacttctgaggaagttactgatagtagaata
ctgtgcctagccttggtgcatcttcctgtcgaaaaggaaagctggattgtgtctgggaca
cagtctggtatgctcctggtcatcaataccgaagatgagaaaaaaagacatacccttgaa
aagatgactgattctgttacttgcttgtattgcaattccttttccaagcaaagcaagcaa
aaaaattttcttttggtgggaactgctgatggcaacttagcgatttttgaagataaatct
gttaagtgtaaaggagctgctcctttgaagacactaaatataggcactgttagcactcca
ctgatgtgtttgagtgaatccatgaattcaactgaaaaaagcattatgtggggaggatgt
ggcacaaaaatcttctcattttctgaagatttcaccattcagaaactcattgagaccagg
acaaatcagctgttttcttacacagccttcagtgattccaacatcatagcagtggtggtc
gacacggctctctatgttgctaagaaaaatagcccatttgtggaagtgcgggataagaaa
actgaaaaactctgcgaactaatagactgtgtgcactttttaaaggaagaaatggtaaaa
gtaaacaaagactcgaaacacaaaatgtcttattctgggagagtgaaaactctctgccta
cagaagaacactgccctctggataggaactggaggaggccatattttactccttgatctt
tcaactcgtcgaattatacgtataattcacaacttttgtgattctgttagagtcatgatg
acagcacagttaggaagtcttaaaaatgccatgctggttttggggtataaccggaaaagt
accgacggtacacaacagcaaaaagagatacagtcttgcttgtctgtttgggacatcaat
cttccacatgaagtgcaaaatttagaaaaacatattgaagtgagaaaagaattagctgaa
aaaatgagaagaatatctgttgaataa
DBGET
integrated database retrieval system
