Escherichia coli O127 H6 E2348/69 (EPEC): E2348C_4244
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Entry
E2348C_4244 CDS
T00796
Symbol
metL
Name
(GenBank) fused aspartokinase II/homoserine dehydrogenase II
KO
K12525
bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:
2.7.2.4
1.1.1.3
]
Organism
ecg
Escherichia coli O127:H6 E2348/69 (EPEC)
Pathway
ecg00260
Glycine, serine and threonine metabolism
ecg00261
Monobactam biosynthesis
ecg00270
Cysteine and methionine metabolism
ecg00300
Lysine biosynthesis
ecg01100
Metabolic pathways
ecg01110
Biosynthesis of secondary metabolites
ecg01120
Microbial metabolism in diverse environments
ecg01230
Biosynthesis of amino acids
Module
ecg_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
ecg_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
ecg_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
ecg00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
E2348C_4244 (metL)
00270 Cysteine and methionine metabolism
E2348C_4244 (metL)
00300 Lysine biosynthesis
E2348C_4244 (metL)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
E2348C_4244 (metL)
Enzymes [BR:
ecg01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
E2348C_4244 (metL)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
E2348C_4244 (metL)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
NAD_binding_3
HTH_11
Motif
Other DBs
NCBI-ProteinID:
CAS11792
UniProt:
B7UNR0
LinkDB
All DBs
Position
4444797..4447229
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AA seq
810 aa
AA seq
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MSVIAQAGAKGRQLHKFGGSSLADVKCYLRVAGIMAEYSQPDDMMVVSAAGSTTNQLINW
LKLSQTDRLSAHQVQQTLRRYQCDLISGLLPAEEADNLISAFVSDLERLAALLDSGINDA
VYAEVVGHGEVWSARLMSAVLNQQGLPSAWLDAREFLRAERAAQPQVDEGLSYPLLQQLL
VQHPGKRLVVTGFISRNNAGETVLLGRNGSDYSATQIGALAGVSRVTIWSDVAGVYSADP
RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSGSEIDLQLRCSYTPDQGSTRIER
VLASGTGARIVTSHDDVCLIEFQVPASQDFKLAHKEIDQILKRAQVRPLAVGVHNDRQLL
QFCYTSEVADSALKILDEAGLPGELRLRQGLALVAMVGAGVTRNPLHCHRFWQQLKGQPV
EFTWQSDDGISLVAVLRTGPTESLIQGLHQSVFRAEKRIGLVLFGKGNIGSRWLELFARE
QSTLSARTGFEFVLAGVVDSRRSLLSYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPY
DDLVVLDVTASQQLADQYLDFASHGFHVISANKLAGASDSNKYRQIHDAFEKTGRHWLYN
ATVGAGLPINHTVRDLIDSGDTILSISGIFSGTLSWLFLQFDGSVPFTELVDQAWQQGLT
EPDPRDDLSGKDVMRKLVILAREAGYNIEPDQVRVESLVPAHCEGGSIDHFFENGDELNE
QMVQRLEAAREMGLVLRYVARFDANGKARVGVEAVREDHPLASLLPCDNVFAIESRWYRD
NPLVIRGPGAGRDVTAGAIQSDINRLAQLL
NT seq
2433 nt
NT seq
+upstream
nt +downstream
nt
atgagtgtgattgcgcaggcaggggcgaaaggtcgtcaactgcataaatttggtggcagt
agtctggctgatgtgaagtgttatttgcgtgtcgcgggcattatggcggagtactctcag
cctgacgatatgatggtggtttccgccgccggtagcaccactaaccagttgattaactgg
ttgaaactaagccagaccgatcgtctctctgcgcatcaggttcaacaaacattacgtcgt
tatcagtgcgatctgattagcggcctgctacccgccgaagaagccgataacctcattagc
gcttttgtcagcgatcttgagcgcctggcggcgttgctcgacagcggtattaacgatgcg
gtgtatgcggaagtggtgggccacggtgaagtgtggtcggcgcgcctgatgtctgcggtg
cttaatcaacaagggctgccatcggcctggcttgatgcccgcgagtttttacgcgctgaa
cgcgctgcgcaaccgcaggttgatgaagggctttcgtacccgttgctgcaacagctactg
gtacaacatccgggcaaacgtctggtggtgaccgggtttatcagccgtaacaacgccggt
gaaacggtgctgcttgggcgtaacggttccgactattccgcgacacaaatcggtgcgctg
gcgggtgtttctcgcgtaaccatctggagtgacgtcgccggggtatatagcgccgacccg
cgtaaagtgaaagatgcctgcctgctgccgttgctgcgtctggatgaagccagcgaactg
gcgcgtctggcggctcccgttcttcatgcccgtactttacagcccgtttctggcagcgaa
atcgacctgcaactgcgctgtagctacacgccggatcaaggttccacgcgcattgaacgc
gtgctggcctccggtactggtgcgcgtattgtcaccagccatgatgatgtctgcttgatt
gagtttcaggtgcccgccagccaggatttcaaactggcgcataaagagatcgaccagatc
ctgaaacgtgctcaggtgcgcccactggcggttggcgtgcataacgatcgccagttgctg
caattttgctacacctcagaagtggccgacagtgcgctgaaaatcctcgacgaagcggga
ttacctggcgaactgcgcctgcgtcaggggctggcgctggtggcgatggttggggcgggc
gtcacccgtaacccgctgcattgccaccgcttctggcagcaactgaaaggccagccggtc
gagtttacctggcagtctgatgatggcatcagcctggtggcagtactgcgcaccggcccg
accgaaagcctgattcaggggctgcatcagtccgtcttccgcgcggaaaaacgcatcggc
ctggtattgttcggtaagggcaatatcggttcccgctggctggaactgttcgcccgtgag
cagagtacgctttcggcacgtaccggctttgaatttgtgctggcaggcgtggtggacagc
cgccgcagcctgttgagctatgacgggctggacgccagccgcgcgttagccttcttcaac
gatgaagcggtcgagcaggatgaagagtcgctgttcctgtggatgcgcgcccacccgtat
gatgatttagtggtgctggacgttaccgccagccagcagctcgctgaccagtatcttgat
ttcgccagccacggtttccacgtcatcagtgccaacaaactggcaggagcgagcgacagc
aataaatatcgccagatccacgacgccttcgaaaaaaccgggcgtcactggctgtacaat
gccactgtcggtgcgggtttgccgatcaaccataccgtgcgcgatctgatcgacagcggc
gataccattttgtcgatcagtgggatcttctctggcacgctctcctggctgttcctgcaa
ttcgacggtagcgtgccgtttaccgaactggtggatcaggcgtggcagcagggcttaacc
gagcctgacccgcgtgatgacctttccggcaaagacgtgatgcgcaagctggtgattctg
gcgcgtgaagcgggttacaacattgaaccggaccaggtacgtgttgaatcactggtacct
gcccattgcgaaggcggcagcatcgaccatttctttgaaaatggcgatgaacttaacgag
cagatggtgcaacgactggaagcggcccgcgaaatggggctggtgctgcgctacgtggcg
cgtttcgatgccaatggcaaagcgcgtgtgggcgtggaagcggtgcgtgaagaccatccg
ctggcatcactactgccatgcgataacgtctttgccatcgaaagccgctggtatcgcgac
aacccgctggtgatccgcgggccaggtgcagggcgcgacgtcaccgccggggcgattcag
tcggatatcaaccggctggcgcagttgttgtag
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