Echinops telfairi (small Madagascar hedgehog): 101640736
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Entry
101640736 CDS
T08707
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
etf
Echinops telfairi (small Madagascar hedgehog)
Pathway
etf00310
Lysine degradation
etf01100
Metabolic pathways
etf05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
etf00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
101640736 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
101640736 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
etf03036
]
101640736 (DOT1L)
Enzymes [BR:
etf01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
101640736 (DOT1L)
Chromosome and associated proteins [BR:
etf03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
101640736 (DOT1L)
HMT complexes
Dot1-containing complex
101640736 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DOT1
Motif
Other DBs
NCBI-GeneID:
101640736
NCBI-ProteinID:
XP_030744151
LinkDB
All DBs
Position
Unknown
AA seq
1662 aa
AA seq
DB search
MHADKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDS
IHQLWKGTTQPMKLNTRPCTGLLRHILQQVYNHSVSDPEKLNNYEPFSPEVYGETSFDLV
AQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRK
WMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGG
RIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILEN
YFSSLKNPKLRDSGAEDDKAGATTVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTAN
PERRPKKSQSPLDLLPTQTTPQTAPPSPQDAYKSPHSPFYQLPPAVQRHASSPLLAAPTP
PALQKLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKVRLAYLGCAXXXLSTCVPVRPQ
LGVKALTYHDLIQAQKEISAHNQQLKEQTEQLEKDNRALQGQSLQLLKARCEELQLDWPT
LSLEKLLKEKQALKSQISEKQRRCLELQISIVELEKSQRQQELLQLKSYVPADEAPAGHL
RGKGAPGREPETEPGRLPLELDCARFSLPPLSSLSPELSMNGHGTGYELHGTLSRPSSKQ
NTPQYLASALDQEVVPCTPGHGARARVDKLASLALPDYTRLSPAKIVLRRHLGQDPSAHG
RGAAGELPPRAEHIRENGLSYQSPCATGSARLSPQDPRPASPTASQMAGEKGSGEKGVKE
RSYGSGGEPITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARNTPSPVHPSRDAST
FDKQIGANAHGVAGSAATSRGLGLAAAGFYAGSVAVSGALAGSPAPVVSAPEPATFDESS
GSGSLFATMSSRSSTPQHPSLLAQARGSGPASPAHQLTASPRLGGPSQGPLTDAPSDTGF
SDPESEAKRRIVFTVVAGTGGARPSPSSRHSPLATSRGDSGQGHGQDSRKRGRRKRSSTG
TPSLSSAVSPKRRAPSSVAGLFTQSSGSPLNLNSMVNNINQPLAITAISSPEHSLKSSPA
PCQDPDQPPVLKKERPLGPSSGAHYSPLTSDEEPGSEDEPGSARIERKIATISLESKSPP
KTLENGGSLGSRKPTPAGEPVNSSKWKSTFSPISDLGLAKAADSPLQASSVLGPSSLFAF
RPALEEATAPDAKGTTHPRKGFPASLAGVDGPSPSTNTPNGFTLGGALAADLSLHSFSDG
ASLAHKAPEMAGLGFPSQRGKETGGPDANPFLSKRPPDGLGSLKGEASKARETGELAGAS
DKAALPPGAKASRGRDRELDFTHGHNLFISATAVSPGGLLNGPGLAPAAPSTGSHAPSAQ
THRPFLGTFTPGTQFTLGPMSLQANLGSVASSSVLQSLFSAVPAAAGLVHVSSAATRLTN
SHTMATFSSGVTGGTVGGVFNHAVPSASSHPLGAGLGGGAVCGSATLGLAPLQAVVSASP
ASFQAPSSVETRPSLLPPAAHLGRPPPPPPTAPASTPAPAQLGLAAAPPNTALPPPPLLA
PSSEPVLLQGLTALPANHAFLPHSSAASLPPTNASLSFKLAALPHKAARPSLTVHHQPLP
RLALAPAAPLPPQASPATPAAVWVSLGMPPPYAAHLSGVKPR
NT seq
4989 nt
NT seq
+upstream
nt +downstream
nt
atgcatgctgacaaacaccacgatgctgctcatgaaatcatcgagaccatccgatgggtc
tgtgaagaaatcccggacctcaagctggccatggagaactatgtgctcattgactatgac
accaaaagcttcgagagcatgcagcggctatgcgacaagtataaccgggccatcgacagc
atccaccagctgtggaaggggaccacacagcccatgaagctcaacacacggccgtgcacg
gggctgctgcgccacatcctgcagcaggtctacaaccactcggtcagtgaccctgagaag
cttaacaactatgagcccttctcgcccgaggtctatggtgagacctcctttgacctggtg
gcgcagatgatcgatgagatcaagatgaccgaggatgacctctttgtggacctgggcagt
ggagtgggccaggtggtgctccaggtcgccgcagccaccaactgtaagcatcactacggc
gtcgagaaagccgacatcccagccaagtatgcggagacaatggacagagagttcaggaag
tggatgaaatggtatggaaaaaagcatgccgaatacacactggaaagaggcgactttctc
tctgaagagtggcgggagcgcatcgccaacacgagtgttatatttgtgaataattttgcc
tttggtcctgaggtggatcaccagctgaaggagaggtttgcaaacatgaaggaaggtggc
agaatcgtgtcctccaaaccctttgcacctctcaacttcagaataaacagcagaaacttg
agtgacatcggcaccatcatgcgcgtcgtggagctgtcgcccctgaagggctccgtttcc
tggacagggaagccggtctcctactacctgcacaccattgaccggaccatacttgaaaac
tatttttctagtctgaaaaatccaaaactcagggactctggtgctgaggacgacaaagcc
ggggccaccactgtcaaaaagccatccccctccaaagcccgcaagaagaagctgaacaag
aagggccggaagatggctggccgcaagcgcgggcgccccaagaaaatgagcactgcgaac
cccgaacgcaggcccaagaagagccagagcccactggacctcctgccgacccagaccaca
ccccagaccgccccgccctcgcctcaggatgcgtacaagtcacctcacagccccttctac
cagctacctccggccgtgcagcggcacgcgtccagcccgttgctggcggcacccaccccg
ccagcgctgcagaagctgctagagtccttcaagatccagtacctgcaattcctggcttac
accaagacgccgcagtacaaggccaacctgcagcagctgctggaccaggagaaggtgagg
ctcgcctacctgggttgtgcnnnnnnnnnnttgtcgacctgtgtccctgtccgtccccag
ctgggtgtcaaggcgctgacctaccacgacctgatccaagcgcagaaggagatctctgca
cacaaccagcagttgaaggagcagacagagcagttggagaaggacaaccgggcgctgcag
ggccagagcctgcagctgctcaaggcccgctgtgaggagctgcagctggactggcccacc
ctgtccctggagaagctgctgaaggagaagcaggccctcaagagccagatctcagagaag
cagcggcgctgcctggagctgcagatcagcatcgtggagctagagaagagccagcggcag
caggagctcctgcagctcaagtcgtatgtgcctgcggacgaggcaccggccgggcacctg
cgcggaaagggtgcaccaggccgggagcctgagaccgagccgggccgcctccccctggag
ctggactgcgcccggttctcactgccgcccttgagcagcctgagccctgagctctccatg
aatggccacgggacaggctacgagctgcacggcaccctcagccggccctcgtccaagcag
aacacgccgcagtacttggcctcagccctggaccaggaggtggtgccctgcacgcctggc
cacggggcccgggcccgagtggacaagctggccagcctggccctgcccgactacacgcgc
ctctccccggccaagatcgtgctgcggcgccaccttggccaggacccctctgcccatggg
agaggggctgccggcgagctgcctccacgagcggagcacatccgggagaatggcctcagc
taccagagcccctgtgccacaggcagtgccagactgagcccgcaggacccccggcccgcg
tctcccacggcctcgcagatggcaggggagaagggcagcggtgagaagggcgtgaaggag
cgctcctacggcagcggcggcgagcccatcaccagcctgcccgtcagcatccccctcagc
actgtgcagcccaacaaactgcccgtcagcatccctctggccagtgtggtcctgcccagc
cgggccgagcgggcgaggaacacacccagcccagtgcacccgagccgagacgcttccacc
ttcgacaagcagattggtgctaatgcccatggcgtggcgggcagcgcggccacaagcaga
ggcctgggcctggctgctgcaggcttctacgcaggctcggtggccgtcagcggggccctg
gcaggcagccctgcgcctgtggtgtcagcgcccgagcccgccacgttcgatgagtcctcg
ggctctggcagcctcttcgccactatgagctcacgcagctccaccccgcagcatccctcc
ctgttggcccaggcccgaggatctggcccagcctcccctgcccaccagctcacagcaagc
ccccggctcgggggcccttcccagggcccgctcactgatgctcccagtgatacaggcttc
tctgaccccgagagtgaggccaagcgcaggatcgtctttaccgtcgtggctggcacaggt
ggtgcccggccctcgccctccagcaggcacagccccctggccaccagccgtggggacagt
gggcagggccatgggcaggacagccgcaagcggggtcgcaggaagcgctcatcgaccggc
actcccagcctgagctccgcagtgtcccccaagcgccgggccccctcctctgtcgctggg
ctcttcacacagtcttcagggtcccccctgaatctcaactctatggtcaacaacatcaac
cagcccctggccatcacggccatctcctcccccgagcattccctgaagagctcgccagcc
ccctgccaggacccggaccagccacctgtactcaagaaagagaggcccctgggcccgagc
agcggggcccactactccccgctgacatccgacgaggagccgggctcggaggacgagcca
ggcagtgccaggattgagagaaaaattgcaaccatctctttagaaagcaaatctcccccg
aaaaccttggagaatggtggtagcttgggcagccggaagccaacaccagctggagagcca
gtcaacagcagcaagtggaagtccaccttctcccccatctcggacctgggtctggccaag
gcggctgacagccccctgcaggctagctctgtgctcggccccagctccctgtttgccttc
cggcccgctctggaggaagccactgcccccgatgccaaggggaccacgcacccccggaag
ggcttcccggcttccctggctggggtggacgggcccagccctagcaccaacacccccaac
gggttcaccctgggcggggccctggctgccgacctcagtttacacagcttcagcgacggt
gcttctctcgcccacaaagcccccgagatggccgggctgggcttcccctcccagcggggc
aaggagactggtggccccgacgccaaccctttcctgagcaagcggccacccgatgggctg
ggcagcctgaagggtgaggccagcaaggcccgtgagaccggcgagctggctggggcctca
gacaaagctgcactgccgcccggggcgaaggcaagccgaggccgggaccgcgaactcgac
ttcacccatggccacaacctcttcatctcggccaccgctgtgtcccccggcggcctactc
aacggcccgggcctggccccggcagcaccctccacaggcagccacgcgccctctgcccag
acacaccgccccttcctgggcaccttcactcctggcacgcagtttaccctgggccccatg
tcactgcaggccaacctaggctcggtggccagctcgtctgtgctgcagtccctgttcagt
gccgtgccggccgccgcgggcctggtgcacgtgtcgtctgcggccaccaggctcaccaac
tcgcacaccatggccaccttctcttccggagtcacaggcggaactgtcggaggtgtcttt
aaccacgcggtgccttctgcctcttcgcatccgctcggagccggtctcggcggcggggcc
gtctgtggcagcgccactctgggcttggccccgctgcaggcggtggtcagcgcctccccc
gcttcctttcaggccccgtcctctgtcgagacccggccgtccctgctgcctcctgctgca
cacctgggccggcctcccccgcctccccccaccgctcctgcttctactcctgctcctgcg
cagctcggcctggccgccgctccgcctaacactgccttgcctcctccgccgctgctggcg
cctagctcagagcctgtgctgctgcagggcctcacggcgctccccgctaaccatgctttc
ttgccgcactcctcggccgcctccctgccacccactaacgcctctttgtccttcaagctc
gctgccctgccgcacaaggccgcccgcccctccctcactgtccaccaccaacctctgccc
cggctggccctagccccggctgcacccctccctccgcaggccagccccgccacgcccgcc
gcggtctgggtgtcccttggcatgccgcctccttatgccgcgcacctttcgggggttaag
ccacgataa
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