Escherichia coli O17 K52 H18 UMN026 (ExPEC): ECUMN_4470
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Entry
ECUMN_4470 CDS
T00831
Symbol
metL
Name
(GenBank) fused aspartokinase II; homoserine dehydrogenase II
KO
K12525
bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:
2.7.2.4
1.1.1.3
]
Organism
eum
Escherichia coli O17:K52:H18 UMN026 (ExPEC)
Pathway
eum00260
Glycine, serine and threonine metabolism
eum00261
Monobactam biosynthesis
eum00270
Cysteine and methionine metabolism
eum00300
Lysine biosynthesis
eum01100
Metabolic pathways
eum01110
Biosynthesis of secondary metabolites
eum01120
Microbial metabolism in diverse environments
eum01230
Biosynthesis of amino acids
Module
eum_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
eum_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
eum_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
eum00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
ECUMN_4470 (metL)
00270 Cysteine and methionine metabolism
ECUMN_4470 (metL)
00300 Lysine biosynthesis
ECUMN_4470 (metL)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
ECUMN_4470 (metL)
Enzymes [BR:
eum01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
ECUMN_4470 (metL)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
ECUMN_4470 (metL)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
NAD_binding_3
HTH_11
Motif
Other DBs
NCBI-ProteinID:
CAR15596
UniProt:
B7NFN9
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All DBs
Position
4616526..4618958
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AA seq
810 aa
AA seq
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MSVIAQAGAKGRQLHKFGGSSLADVKCYLRVAGIMAEYSQPDDMMVVSAAGSTTNQLINW
LKLSQTDRLSAHQIQQTLRRYQCDLISGLLPAEEADSLISAFISDLERLAALLDSGINDA
VYAEVVGHGEVWSARLMSAVLNQQGLSAAWLDAREFLRAERAAQPQVDEGLSYPLLQQLL
VQHPGKRLVVTGFISRNNAGETVLLGRNGSDYSATQIGALAGVSRVTIWSDVAGVYSADP
RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSGSEIDLQLRCSYTPDQGSTRIER
VLASGTGARIVTSHDDVCLIEFQVPASQDFKLAHKEIDQILKRAQVRPLAVGVHNDRQLL
QFCYTSEVADSALKILDEAGLPGELRLRQGLALVAMVGAGVTRNPLHCHRFWQQLKGQPV
EFTWQSDDGISLVAVLRTGPTESLIQGLHQSVFRAEKRIGLVLFGKGNIGSRWLELFARE
QSTLSARTGFEFVLAGVVDSRRSLLSYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPY
DDLVVLDVTASQLLADQYLDFASHGFHVISANKLAGASDSNKYRQIHDAFEKTGRHWLYN
ATVGAGLPINHTVRDLIDSGDTILSISGIFSGTLSWLFLQFDGSVPFTELVDQAWQQGLT
EPDPRDDLSGKDVMRKLVILAREAGYDIEPDQVRVESLVPAHCEGGSIDHFFENGDELNE
QMVQRLEAAREMGLVLRYVARFDANGKARVGVEAVREDHPLASLLPCDNVFAIESRWYRD
NPLVIRGPGAGRDVTAGAIQSDINRLAQLL
NT seq
2433 nt
NT seq
+upstream
nt +downstream
nt
atgagtgtgattgcgcaggcaggggcgaaaggtcgtcaactgcataaatttggtggcagt
agtctggctgatgtgaagtgttatttgcgtgtcgcgggcattatggcggagtactctcag
cctgacgatatgatggtggtttccgccgccggtagcaccactaaccagctgattaactgg
ttgaaactaagccagaccgatcgtctctctgcgcatcagattcaacaaacgctgcgtcgc
tatcagtgcgatctgattagcggcctgctacccgccgaagaagccgatagcctcattagt
gcctttatcagcgatcttgagcgcctggcggcgctgctcgacagcggtattaacgacgcg
gtgtatgcggaagtggtgggccacggcgaagtgtggtcggcgcgcctgatgtctgcggtg
cttaatcaacaagggctgtcagcggcctggcttgatgcccgcgagtttttacgcgctgaa
cgcgctgcgcaaccgcaggttgatgaagggctttcttacccgttgctgcaacagctactg
gtacaacatccaggcaaacgtctggtggtgaccgggtttatcagccgtaacaacgccggt
gaaacggtgctgctggggcgtaacggttccgactattccgcgacacaaatcggtgcgctg
gcgggtgtttctcgtgtaaccatctggagcgacgtcgccggggtatacagtgccgacccg
cgtaaagtgaaagatgcctgtctgctgccattgctgcgtctggatgaggccagcgaactg
gcgcgtctggcggctcccgttcttcacgcccgtactttacagccagtttctggcagcgaa
atcgacctgcaactgcgctgtagctacacgccggatcaaggttccacgcgcattgaacgc
gtgctggcctccggtactggtgcgcgtattgtcaccagccatgatgatgtctgcttgatt
gagtttcaggtgcccgccagccaggatttcaaactggcgcataaagagatcgaccagatc
ctgaaacgtgctcaggtgcgcccactggcggttggcgtgcataacgatcgccagttgctg
caattttgctacacctcagaagtggccgacagtgcgctgaaaatcctcgacgaagcggga
ttacctggcgaactgcgtctgcgtcaggggctggcgctggtggcgatggttggtgcaggc
gtcacccgtaacccgctacattgccaccgcttctggcagcaactgaaaggccagccggtc
gaatttacctggcagtcggatgacggcatcagcctggtggcagtactgcgcaccgggccg
accgaaagcctgattcagggtctgcatcagtccgtctttcgcgcggaaaaacgcatcggc
ctggtattgttcggcaagggcaatatcggttcccgctggctggaactgttcgcccgtgag
cagagcacgctttcggcgcgtaccggctttgaatttgtgctggcaggcgtggtggacagc
cgccgcagcctgttgagctatgacgggctggacgccagccgcgcgttagccttcttcaac
gatgaagcggtcgagcaggatgaagagtcgctgttcctgtggatgcgcgcccatccgtat
gatgatttagtggtgttggacgttaccgccagccagctgcttgctgatcagtatctcgat
tttgccagccacggtttccacgtcatcagtgccaacaaactggcaggagccagcgacagc
aataaatatcgccagatccacgacgccttcgaaaaaaccgggcgtcactggctgtacaat
gccactgtcggtgcgggcttgccgatcaaccacaccgtgcgcgatctgatcgacagcggc
gatactattttgtcgatcagcgggatcttctctggcacgctctcctggctgttcctgcaa
ttcgacggtagcgtgccgtttaccgagctggtggatcaggcgtggcagcagggcttaacc
gagcctgatccgcgtgatgacctttccggcaaagacgtgatgcgcaagctggtgattctg
gcgcgtgaagcgggttacgacatcgaaccagatcaggtgcgcgtggaatcgctggtgcct
gcccattgcgaaggcggtagcatcgaccatttctttgaaaacggcgatgaacttaacgag
cagatggtgcaacggctggaagcggcccgcgaaatggggctggtgctgcgctacgtggcg
cgtttcgatgccaatggcaaagcgcgtgtgggcgtggaagcggtgcgtgaagaccatccg
ctggcatcactgctgccgtgcgataacgtctttgccatcgaaagccgctggtatcgcgat
aaccctctggtgatccgtgggcctggcgcggggcgcgacgtcaccgcaggggcgattcag
tcggatattaaccggctggcgcagttgttgtaa
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