KEGG   Hipposideros armiger (great roundleaf bat): 109376563
Entry
109376563         CDS       T04661                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hai  Hipposideros armiger (great roundleaf bat)
Pathway
hai01521  EGFR tyrosine kinase inhibitor resistance
hai01522  Endocrine resistance
hai04010  MAPK signaling pathway
hai04012  ErbB signaling pathway
hai04068  FoxO signaling pathway
hai04270  Vascular smooth muscle contraction
hai04650  Natural killer cell mediated cytotoxicity
hai04720  Long-term potentiation
hai04726  Serotonergic synapse
hai04730  Long-term depression
hai04810  Regulation of actin cytoskeleton
hai04910  Insulin signaling pathway
hai04914  Progesterone-mediated oocyte maturation
hai04928  Parathyroid hormone synthesis, secretion and action
hai05010  Alzheimer disease
hai05022  Pathways of neurodegeneration - multiple diseases
hai05034  Alcoholism
hai05160  Hepatitis C
hai05161  Hepatitis B
hai05200  Pathways in cancer
hai05205  Proteoglycans in cancer
hai05208  Chemical carcinogenesis - reactive oxygen species
hai05210  Colorectal cancer
hai05211  Renal cell carcinoma
hai05212  Pancreatic cancer
hai05213  Endometrial cancer
hai05214  Glioma
hai05215  Prostate cancer
hai05218  Melanoma
hai05219  Bladder cancer
hai05220  Chronic myeloid leukemia
hai05221  Acute myeloid leukemia
hai05223  Non-small cell lung cancer
hai05224  Breast cancer
hai05225  Hepatocellular carcinoma
hai05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:hai00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109376563 (ARAF)
   04012 ErbB signaling pathway
    109376563 (ARAF)
   04068 FoxO signaling pathway
    109376563 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109376563 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    109376563 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109376563 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    109376563 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    109376563 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    109376563 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    109376563 (ARAF)
   04720 Long-term potentiation
    109376563 (ARAF)
   04730 Long-term depression
    109376563 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109376563 (ARAF)
   05205 Proteoglycans in cancer
    109376563 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    109376563 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109376563 (ARAF)
   05212 Pancreatic cancer
    109376563 (ARAF)
   05225 Hepatocellular carcinoma
    109376563 (ARAF)
   05226 Gastric cancer
    109376563 (ARAF)
   05214 Glioma
    109376563 (ARAF)
   05221 Acute myeloid leukemia
    109376563 (ARAF)
   05220 Chronic myeloid leukemia
    109376563 (ARAF)
   05218 Melanoma
    109376563 (ARAF)
   05211 Renal cell carcinoma
    109376563 (ARAF)
   05219 Bladder cancer
    109376563 (ARAF)
   05215 Prostate cancer
    109376563 (ARAF)
   05213 Endometrial cancer
    109376563 (ARAF)
   05224 Breast cancer
    109376563 (ARAF)
   05223 Non-small cell lung cancer
    109376563 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    109376563 (ARAF)
   05160 Hepatitis C
    109376563 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109376563 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    109376563 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    109376563 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109376563 (ARAF)
   01522 Endocrine resistance
    109376563 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hai01001]
    109376563 (ARAF)
Enzymes [BR:hai01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     109376563 (ARAF)
Protein kinases [BR:hai01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   109376563 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 109376563
NCBI-ProteinID: XP_019488098
EnsemblRapid: ENSHARG00000020180
UniProt: A0A8B7QK92
LinkDB
Position
Unknown
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTSWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSVQDLSVASRQHETPSNRPPNEPL
TPQGPSSCTQHHDPEHFPFSTPANAPLQRIRSTSTPNVHMVSTTAPMDSSLIQLTTQSFN
TDAAGSRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcaacgcacagtagtgactgtccgggatggcatgagt
gtctatgactctttagacaaggccctcaaggtgcggggtctcaatcaggattgctgcgtg
gtctaccggctcatcaaggggcgaaagacagtcacttcctgggacacagccattgccccc
ctggatggcgaggagctcattgtggaggtcctcgaagatgtccctctgaccatgcacaat
tttgtacggaagacattcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccgacagttctaccacagtgtccaggat
ttgtccgtagcctccagacagcatgagactccctcgaaccgccccccgaatgagccgcta
acccctcagggtcccagctcctgtacccagcaccatgaccctgagcacttccccttctct
accccggctaatgcccccctccagcgcatccgctccacgtccacccccaacgtccatatg
gttagcaccacagcccccatggactccagcctcatccagctcacgacccagagtttcaac
actgatgctgctggtagtagaggtggtggtgatggagcaccccgggggagccccagtccg
gctagcgtgtcctcggggaggaagtccccacattccaagtccccatcagaacaacgggag
cggaagtccttggctgatgataagaagaaagtgaagaatctggggtaccgggactcgggc
tattactgggaggtgccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggaaccgtgtttcgcgggcggtggcatggcgatgtggctgtgaaggtgctcaaggtg
gcccaacccacagctgagcaagcccaggccttcaagaacgagatgcaggtgctcaggaag
acacgacacgtcaacatcttgctgttcatgggcttcatgacccggcctgggttcgccatc
atcacacagtggtgtgagggctccagtctctaccaccacctccatgttgccgacacacgt
tttgacatggtccagctcatagatgtggcccggcagactgcccagggcatggactaccta
catgccaagaacatcatccatcgagacctcaagtcgaacaacatctttttacacgaggga
ctcacagtgaagatcggtgattttggcctggccacagtgaagacgcggtggagcggggct
cagcccttggagcagccgtcaggctctgtgctgtggatggcggctgaagtgatccgtatg
caggacccgaacccctacagcttccagtcagatgtctacgcctatggggttgtgctgtat
gagctcatgactggctccctgccttatagccacattggcagccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggagcggcccctcttc
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcaccgcacccaggctgatgagttacccgcctgcctactcagc
gcagcccgccttgtgccttag

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