Heterocephalus glaber (naked mole-rat): 101704336 Help Entry 101704336         CDS       T02812                                  Symbol Notch1 Name (RefSeq) notch 1   KO K02599   Notch 1 Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl01522   Endocrine resistance hgl04330   Notch signaling pathway hgl04658   Th1 and Th2 cell differentiation hgl04919   Thyroid hormone signaling pathway hgl05020   Prion disease hgl05165   Human papillomavirus infection hgl05200   Pathways in cancer hgl05206   MicroRNAs in cancer hgl05224   Breast cancer Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04330 Notch signaling pathway     101704336 (Notch1)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     101704336 (Notch1)   09152 Endocrine system    04919 Thyroid hormone signaling pathway     101704336 (Notch1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101704336 (Notch1)    05206 MicroRNAs in cancer     101704336 (Notch1)   09162 Cancer: specific types    05224 Breast cancer     101704336 (Notch1)   09172 Infectious disease: viral    05165 Human papillomavirus infection     101704336 (Notch1)   09164 Neurodegenerative disease    05020 Prion disease     101704336 (Notch1)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101704336 (Notch1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  EGF hEGF EGF_CA EGF_2 Ank_2 Ank NOD Notch NODP Ank_4 Ank_3 Ank_5 EGF_3 DL-JAG_EGF-like JAG1-like_EGF2 Motif Other DBs NCBI-GeneID:  101704336 NCBI-ProteinID:  XP_004848987 LinkDB All DBs Position Un AA seq 2559 aa AA seqDB search MPRLPAPLVCLALLPALAARGLRCSQPGVTACQNGGRCEVHNDTEACVCIGPYVGQLCQD RNPCLSNPCKNAGTCHVLDRGATVDYTCSCSLGFSGPLCLTPLDNACLSGPCRNGGTCDL LTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGHCLPFEASYICGCRPGFHGPTCRQDV NECSQTPGLCRHGGTCHNEVGSFRCACRPTHTGTHCELPYVPCSPSPCQNGGTCRPTGET THECACLPGFTGQNCEENVDDCPGNSCRNGGACVDGVNTYNCRCPPEWTGQYCTEDVDEC QLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFNGATCHDRVASFYC ECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECALG ANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECISNPCQNDATCLDQIGEFQCICM PGYEGVYCEVNTDECASSPCLHNGRCLDRVSEFLCECPTGFSGHLCQHDVDECASTPCRN GARCLDGPNTYTCVCTEGYTGTHCEVDINECEPDPCHYGSCKDGIAAFTCLCQPGYTGHH CETNINECASQPCHHGGTCQDRDNAYLCLCLKGTTGPNCEINLDDCTSSPCDAGTCLDKI DGYECACEPGYTGSMCNINIDECAGSPCHNGGTCEDGVNGFTCHCPEGYHDPTCLSEVNE CSSNPCIHGTCRDSLNGYQCDCDPGWSGTNCDINNNECESNPCVNGGTCRDMTSGYVCTC WEGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCPLPYTGTKCELVLAPCAPSPCK NSGVCRESEDYESFSCVCPSGWQGQTCEVDINECVKSPCRNGASCQNTNGDYRCHCQAGY TGRDCEADVDDCRPNPCHNGGSCTDGVNVAFCDCLPGFQGAFCEEDINECASSPCRNGAN CTDCVDSYTCTCPAGFNGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQ HDINECDSRPCLHGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSSPCKNGGQCWQTST LYRCECHSGWTGLYCDVPSVSCEVAAKQQGIDVTHLCQHGGLCVDAGNTHHCRCQAGYTG SYCEEEVDECSPSPCQNGATCTDYLGGYSCKCMAGYHGANCSEEINECLSQPCQNGGTCI DLTNTYKCSCPRGTQGVHCEINVDDCSPLLDPAFRSPKCFNNGTCVDQVGGYTCTCPPGF VGERCEGDVNECLSNPCDPRGTQNCVQRVNDFHCECRAGHTGRRCESVIDGCKGKPCKNG GACAVAANTARGFICRCPAGFEGATCENDARTCGNLRCLNGGTCISGPRSPTCLCLGTFT GPECQFPASSPCVGGNPCYNQGTCEPTAESPFYRCLCPAKFNGLLCHILDYSFAGGTGRD IPPPQVEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFDDPWKNCSQSLQCWKY FSDGHCDSQCNSAGCLFDGFDCQHTEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGL DCAEHVPERLAAGALVVVVLLPPEQLRNNSFHFLRELSRVLHTNVVFKRDAQGQQMIFPY YGREEELHKHPIKRSATGWAPPGALLGQAAASLLPSRASRRRRRELDPMDVRGSIVYLEI DNRQCVQLSSQCFQSTTDVAAFLGALASLGNLNLPYKIEAVQSETVEPPAPSQLHLMYLV GAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNM SDGALMDDNQNEWGDEDLEGKKFRFEEPVVLPDLDDQTDHRQWTQQHLDAADLRVSAMAP TPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASL HNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQIL IRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNN VDAALVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDI AQERMHHDIVRLLDEYNLVRSPQLHGAGLSGTPTLSPTLCSPNGYLGNLKPAVQGKKARK PSTKGLTCSAKEAKDLKARRKKSQDGKGCLLDSSSMLSPVDSLESPHGYLSDVASPPLLP SPFQQSPSLPLGHLPGMPDTHLGINHLNVAAKPEMAALGGGGRLAFEPGPPRLSHLPVAS STSTVLGTSGSGAANFTVGTAAGLNGQCEWLSRLQNGMVSGQYNPLRGAVAPGTPSTQAP ALQHGMMGPLHSSLSANTLSQMISYQGLPSTRLATQPHLVQAQQVPQVQQQNLQVQPPGL QPPPNIQQPQGLQPPPPSQPHLGVGSVANGHLGRSFLGGEPSQADVQPLGPSSLTVHTIL PQEGQNLPTPLPASLVPPMTTAQFLTPPSQHSYSSSPVDSTPSHQLQVPEHPFLTPSPES PDQWSSSSPQSNISDWSEGVCSPPTSMQSQIAHIPEAFK NT seq 7680 nt NT seq  +upstreamnt  +downstreamnt atgccgaggctcccggcccccctggtgtgcctggcgctgctgcctgcgctcgctgctaga ggcctgcgctgctcccagcccggcgtgactgcctgccagaacggtgggaggtgtgaagtg cacaacgacacagaggcctgcgtctgcatcgggccctacgtgggccagctatgccaggac cgcaacccctgcctcagcaacccctgcaagaatgctgggacctgccacgtgctggaccgg ggcgccaccgtggactacacctgcagctgctccctggggttctccgggcccctctgtctg acgcccctggacaacgcctgcctgtctgggccctgccgcaacgggggcacctgtgacctg ctcacgctcacagagtacaagtgccgctgcccccccggctggtcagggaagtcgtgccag caggctgacccgtgtgcctccaacccctgtgccaatggtggccactgcttgccctttgag gcctcctacatctgcggctgccggcccggcttccatggccccacctgccgccaggacgtg aacgagtgcagccagacaccggggctgtgccgccacgggggcacctgccacaacgaggtg ggctccttccgctgcgcctgccgccccacacacaccggcacccactgcgagctgccctac gttccctgcagcccctcgccctgccagaacggggggacctgccgccccacaggggagacc acccacgagtgtgcctgcctgccaggcttcactggccagaactgcgaggagaatgtggat gactgcccaggaaacagctgcaggaacgggggtgcctgtgtggatggtgtgaacacctac aactgccgctgcccgccagagtggacaggtcagtactgcacggaggacgtggacgagtgc cagctcatgcccaatgcctgccagaacgggggcacctgccacaacacccacggtggctac aactgtgtgtgtgtcaatggctggacgggtgaggactgcagcgagaacatcgacgactgc gccagtgccgcctgctttaatggcgccacctgccacgaccgtgtggcttccttctactgc gagtgtccccatggccgcaccggcctgctgtgccacctgaatgatgcctgcatcagcaac ccctgcaacgagggctccaactgtgacaccaaccctgtcaatggcaaggccatctgcacc tgcccctcaggctacacagggccggcctgcagccaggatgtggatgaatgcgcgctgggt gccaacccctgtgagcatgcgggcaagtgcatcaacaccctgggctccttcgagtgccag tgtctgcagggctacactggcccccgctgtgagatcgacgtcaacgagtgcatctccaac ccgtgtcagaatgacgccacctgccttgaccagatcggggagttccagtgcatctgcatg cccggctatgagggggtgtactgcgaggtcaacacagatgagtgcgccagcagcccctgc ctgcacaacggacgctgtctggacagggtcagcgagttcctgtgcgagtgtcccaccggc ttcagcgggcatctgtgtcagcacgacgtggacgagtgtgccagcacgccctgcaggaac ggtgccaggtgtctggatgggcccaacacctacacttgcgtgtgcacagaagggtacaca gggacacactgcgaggtggacatcaacgagtgcgagcctgacccctgccactacggctcc tgcaaggatggcatcgctgccttcacctgcctgtgccagccgggctacaccggccaccac tgtgagaccaacatcaacgagtgtgccagccagccctgccaccacgggggcacctgccag gaccgcgacaatgcctacctctgcctctgcctcaagggcaccacaggacccaactgtgag atcaacctggacgactgcactagcagcccctgcgatgcgggcacctgcctggacaagatc gatggctacgagtgtgcctgcgagccgggctacacagggagcatgtgcaacatcaacatc gacgagtgcgcgggcagcccctgccacaacgggggcacctgcgaggacggcgtcaacggc ttcacctgccattgccccgagggctaccacgaccccacgtgcctgtccgaggtcaacgag tgcagcagcaacccctgcatacacgggacctgccgggacagcctcaacgggtaccagtgt gactgtgaccccgggtggagcgggacgaactgtgacatcaacaacaacgagtgcgagtct aacccgtgcgtgaatggcggcacctgcagagacatgaccagcggctacgtgtgcacgtgc tgggagggcttcagcggccccaactgccagaccaacatcaatgagtgcgcgtccaacccg tgtctgaaccagggcacgtgcatcgacgacgtggccgggtacaagtgcaactgcccgctg ccctacacaggaaccaagtgtgagctggtgctggccccgtgtgctcccagcccctgcaag aacagcggagtgtgcagggagtccgaggactatgagagcttttcctgtgtctgtcccagc ggctggcaggggcagacctgcgaggtcgacatcaacgagtgtgtgaagagcccgtgccgc aatggtgcgtcctgtcagaacaccaacggggactatcggtgccactgccaggccggctac acggggcgcgactgcgaggctgatgtggacgactgccggcccaacccctgtcacaatggg ggctcctgcaccgatggcgtcaatgtggccttttgcgactgcctgcccggcttccagggc gccttctgcgaggaggacatcaacgagtgtgccagcagcccctgtcgcaatggcgccaac tgcaccgactgtgtggacagctacacgtgcacctgccctgcgggcttcaacggcatccac tgtgagaacaacacgcctgactgcacggagagctcctgcttcaatggtggcacctgcgtg gatggcatcaattccttcacctgcctgtgtccgcccggcttcacgggcagctactgccag cacgacatcaacgagtgcgactcaaggccctgcctgcatggtggcacctgccaggacagc tacggcacctacaagtgcacctgcccacagggctacaccggcctcaactgccagaacctc gtgcgctggtgtgactcctccccctgcaaaaatgggggccagtgctggcagaccagcacc ctgtaccgctgcgagtgccacagcggctggaccggcctctactgcgatgtgcccagcgtc tcctgcgaggtagccgcaaagcagcaaggcatcgatgtcacccacctgtgccagcacgga ggactctgtgtggatgcgggcaacacccaccactgccgctgccaggccggctacacgggc agctactgcgaagaagaggtggacgagtgctcacctagcccctgccagaatggggccacc tgcactgactacctgggtggctactcctgcaagtgcatggctggctaccatggggccaac tgctccgaggagatcaacgagtgcctgtcccaaccctgccagaatggaggcacctgcatc gacctcaccaacacctacaagtgctcctgcccacggggcacgcagggtgtgcactgcgag atcaacgtggacgactgcagcccgctcctcgatcccgctttccgcagccccaagtgcttc aacaacggcacctgcgtggaccaggtgggcggctacacctgcacctgcccgcctggcttc gtgggcgagcggtgcgagggcgacgtcaatgagtgcctgtccaacccgtgtgaccctcgc ggcacccagaactgtgtgcagcgcgtcaacgacttccactgcgagtgccgcgcgggccac accgggcgccgctgcgagtcggtcatcgatggctgcaaggggaagccctgcaagaacggg ggtgcctgtgccgtggctgccaacaccgcccgcggcttcatctgcaggtgccccgcgggc ttcgagggcgccacttgcgagaacgatgcgcggacttgcggcaacctgcgctgcctcaac ggcggcacatgcatctcgggcccgagaagccccacctgcctgtgcctgggcaccttcacg ggccccgagtgccagttcccggccagcagcccctgcgtaggtggcaatccctgctacaac cagggcacctgcgagcccacggccgagagccccttctaccgctgcctgtgccccgccaag ttcaacgggctcctgtgccacatcctggactacagctttgcaggtggcactgggcgtgac atccccccgccgcaagtggaagaggcctgcgagctgcccgagtgccaggaggacgcgggc aacaaggtctgcagcctgcagtgcaacaaccacgcctgtggctgggacggcggcgactgc tcgctcaacttcgacgacccctggaagaactgctcccagtccctgcagtgctggaagtac ttcagcgacggccactgcgacagccagtgcaactcggctggctgcctctttgacggcttc gactgccagcacacggagggccagtgcaaccccctgtacgaccagtactgcaaggaccac ttcagtgacgggcactgcgaccagggctgcaacagcgcggagtgtgagtgggatgggctg gattgtgcggagcacgtgcctgagcggctggcggccggcgcgctggtggtggtggtgctg ctgcctcccgagcagcttcgcaacaactccttccacttcctgcgcgagctcagccgcgta ctgcacaccaacgtggtcttcaagcgcgacgctcagggccagcagatgatcttcccctac tacggccgtgaggaggagctgcacaagcaccccatcaagcgctctgccacaggctgggcc ccgccgggtgccctccttggccaggctgccgcctcgctgctccccagcagggcaagcagg cgccggcgcagagagctggaccccatggacgtccgcggatccatcgtctacctggagatc gacaaccggcagtgcgtgcagttgtcctcgcagtgcttccagagtaccaccgacgtggcc gcattcctgggtgcgctcgcctcgctgggcaacctcaacctcccctacaagatcgaggcc gtgcagagtgagacagtggagccgccggcgccctcacagctgcacctcatgtacctggtc ggggccgccttcgtgctcctcttcttcgtgggctgcggggtgctgttgtcccgcaagcgc cggcgccagcatggccagctctggttccccgagggcttcaaggtgtcggaggccagcaag aagaagcgacgagagcccctcggcgaggactccgtgggcctcaagcccctgaagaacatg tcggacggcgccctcatggatgacaaccagaatgagtggggggacgaggacctggagggc aagaagtttcggtttgaggaaccggtggttcttcctgacctggatgaccagacggaccac cggcagtggacccagcagcatctggacgccgccgacctgcgtgtgtctgccatggcaccc acaccgccgcagggcgaggtcgacgctgactgcatggatgtgaatgtgcgcgggcctgat ggcttcaccccgctcatgatcgcctcctgcagcggagggggcctggagacgggcaacagc gaggaggaggaggatgcgccggccgtcatctccgacttcatctaccagggtgccagcctg cacaaccagaccgaccgcaccggcgagaccgccctgcacctggctgcgcgctactcacgc tctgacgctgccaagcgcctgctggaggccagtgcggatgccaacatccaggacaatatg ggacgcaccccgctgcacgcggccgtgtctgctgatgcacagggtgtcttccagatcctg atccggaaccgagccacggacctagatgcccgcatgcacgacggcacgacgccgctgatc ctggcggcccgcctggccgtggagggcatgctggaggacctcatcaactcgcacgccgac gtcaatgccgtggatgacctgggcaagtcggccctgcactgggctgccgctgtgaacaac gtggatgctgcgctggtgctgctgaagaacggggccaacaaggacatgcagaacaacaag gaggagacacctctgttcctggccgcccgggagggcagctatgagactgccaaggtgctg ctggaccactttgccaaccgggacatcactgaccacatggaccgcctgccgcgggacatt gcccaggagcgcatgcaccacgacatcgtgcggctcctggatgagtacaacctggtgcgc agtccccagctgcacggcgccggcctgagtggcacgcctaccctgtcacccacactctgc tcacccaacggctacctgggcaacctcaagcctgctgtgcagggcaagaaggcccgcaag cccagcaccaagggcctgacctgcagcgccaaggaggccaaagacctcaaggcacggagg aagaagtcgcaggacggcaagggctgcctgctggacagttcgagcatgctgtcgcccgtg gactcgctggagtcaccccacggctacttgtcggatgtggcttcaccgcccctcctgccc tccccattccagcagtctccatccctgcctctcggtcacttgcccggcatgcccgacacc cacctgggcatcaaccacctgaatgtggcagccaagcccgagatggcggcgctgggtggg ggtggccggctggcctttgagcccgggcccccgcgcctctcccacctgccggtggcctcc agcaccagcacggtcctgggcaccagcggcagcggggctgcgaatttcaccgtgggcaca gcggccggcctgaatggccagtgcgagtggctgtcccggctgcagaacggcatggtctct ggccagtacaacccactgcggggagcggtggccccaggcacacccagcacgcaggccccc gccctgcagcatggcatgatgggcccactgcacagcagcctctctgccaacaccctgtcc cagatgatcagctaccagggcctgccctccacgcggctggccacccagccccacctggtg caggcccagcaggtacctcaggtgcagcagcaaaacttacaggtgcagccaccaggcctt cagccaccaccaaatatccagcaaccgcagggtctgcagccgccgccaccatcgcaacca cacctcggtgtgggctcagtggccaatgggcacctgggccgcagcttcctgggtggggag ccgagccaggcggacgtgcagccactgggccccagcagtctgaccgtgcacaccatcctg ccccaggagggccagaacctgcccacgccgctgccggcttcactggtcccgcccatgacc acagcccagttcctgaccccgccctcccagcacagctactcctcctcacccgtggacagc acccccagccaccagctgcaggtgccggagcaccccttcctcaccccgtcccctgagtcc cccgaccagtggtcaagctcgtcgccacagtccaacatctccgactggtccgagggcgtc tgcagcccacccaccagcatgcagtcccagatcgcccacattccagaggcgttcaagtaa

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