KEGG   Heterocephalus glaber (naked mole-rat): 101706002
Entry
101706002         CDS       T02812                                 
Symbol
Mapk12
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
hgl  Heterocephalus glaber (naked mole-rat)
Pathway
hgl01522  Endocrine resistance
hgl04010  MAPK signaling pathway
hgl04015  Rap1 signaling pathway
hgl04068  FoxO signaling pathway
hgl04071  Sphingolipid signaling pathway
hgl04114  Oocyte meiosis
hgl04148  Efferocytosis
hgl04218  Cellular senescence
hgl04261  Adrenergic signaling in cardiomyocytes
hgl04370  VEGF signaling pathway
hgl04380  Osteoclast differentiation
hgl04550  Signaling pathways regulating pluripotency of stem cells
hgl04611  Platelet activation
hgl04613  Neutrophil extracellular trap formation
hgl04620  Toll-like receptor signaling pathway
hgl04621  NOD-like receptor signaling pathway
hgl04622  RIG-I-like receptor signaling pathway
hgl04625  C-type lectin receptor signaling pathway
hgl04657  IL-17 signaling pathway
hgl04658  Th1 and Th2 cell differentiation
hgl04659  Th17 cell differentiation
hgl04660  T cell receptor signaling pathway
hgl04664  Fc epsilon RI signaling pathway
hgl04668  TNF signaling pathway
hgl04670  Leukocyte transendothelial migration
hgl04714  Thermogenesis
hgl04722  Neurotrophin signaling pathway
hgl04723  Retrograde endocannabinoid signaling
hgl04728  Dopaminergic synapse
hgl04750  Inflammatory mediator regulation of TRP channels
hgl04912  GnRH signaling pathway
hgl04914  Progesterone-mediated oocyte maturation
hgl04917  Prolactin signaling pathway
hgl04926  Relaxin signaling pathway
hgl04932  Non-alcoholic fatty liver disease
hgl04933  AGE-RAGE signaling pathway in diabetic complications
hgl04935  Growth hormone synthesis, secretion and action
hgl04936  Alcoholic liver disease
hgl05014  Amyotrophic lateral sclerosis
hgl05020  Prion disease
hgl05022  Pathways of neurodegeneration - multiple diseases
hgl05132  Salmonella infection
hgl05133  Pertussis
hgl05135  Yersinia infection
hgl05140  Leishmaniasis
hgl05142  Chagas disease
hgl05145  Toxoplasmosis
hgl05152  Tuberculosis
hgl05161  Hepatitis B
hgl05163  Human cytomegalovirus infection
hgl05167  Kaposi sarcoma-associated herpesvirus infection
hgl05169  Epstein-Barr virus infection
hgl05170  Human immunodeficiency virus 1 infection
hgl05171  Coronavirus disease - COVID-19
hgl05205  Proteoglycans in cancer
hgl05208  Chemical carcinogenesis - reactive oxygen species
hgl05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hgl05415  Diabetic cardiomyopathy
hgl05417  Lipid and atherosclerosis
hgl05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101706002 (Mapk12)
   04015 Rap1 signaling pathway
    101706002 (Mapk12)
   04370 VEGF signaling pathway
    101706002 (Mapk12)
   04668 TNF signaling pathway
    101706002 (Mapk12)
   04068 FoxO signaling pathway
    101706002 (Mapk12)
   04071 Sphingolipid signaling pathway
    101706002 (Mapk12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    101706002 (Mapk12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    101706002 (Mapk12)
   04218 Cellular senescence
    101706002 (Mapk12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    101706002 (Mapk12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101706002 (Mapk12)
   04613 Neutrophil extracellular trap formation
    101706002 (Mapk12)
   04620 Toll-like receptor signaling pathway
    101706002 (Mapk12)
   04621 NOD-like receptor signaling pathway
    101706002 (Mapk12)
   04622 RIG-I-like receptor signaling pathway
    101706002 (Mapk12)
   04625 C-type lectin receptor signaling pathway
    101706002 (Mapk12)
   04660 T cell receptor signaling pathway
    101706002 (Mapk12)
   04658 Th1 and Th2 cell differentiation
    101706002 (Mapk12)
   04659 Th17 cell differentiation
    101706002 (Mapk12)
   04657 IL-17 signaling pathway
    101706002 (Mapk12)
   04664 Fc epsilon RI signaling pathway
    101706002 (Mapk12)
   04670 Leukocyte transendothelial migration
    101706002 (Mapk12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    101706002 (Mapk12)
   04914 Progesterone-mediated oocyte maturation
    101706002 (Mapk12)
   04917 Prolactin signaling pathway
    101706002 (Mapk12)
   04926 Relaxin signaling pathway
    101706002 (Mapk12)
   04935 Growth hormone synthesis, secretion and action
    101706002 (Mapk12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101706002 (Mapk12)
  09156 Nervous system
   04728 Dopaminergic synapse
    101706002 (Mapk12)
   04723 Retrograde endocannabinoid signaling
    101706002 (Mapk12)
   04722 Neurotrophin signaling pathway
    101706002 (Mapk12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101706002 (Mapk12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101706002 (Mapk12)
  09159 Environmental adaptation
   04714 Thermogenesis
    101706002 (Mapk12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    101706002 (Mapk12)
   05208 Chemical carcinogenesis - reactive oxygen species
    101706002 (Mapk12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101706002 (Mapk12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101706002 (Mapk12)
   05161 Hepatitis B
    101706002 (Mapk12)
   05171 Coronavirus disease - COVID-19
    101706002 (Mapk12)
   05163 Human cytomegalovirus infection
    101706002 (Mapk12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101706002 (Mapk12)
   05169 Epstein-Barr virus infection
    101706002 (Mapk12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101706002 (Mapk12)
   05135 Yersinia infection
    101706002 (Mapk12)
   05133 Pertussis
    101706002 (Mapk12)
   05152 Tuberculosis
    101706002 (Mapk12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101706002 (Mapk12)
   05140 Leishmaniasis
    101706002 (Mapk12)
   05142 Chagas disease
    101706002 (Mapk12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    101706002 (Mapk12)
   05020 Prion disease
    101706002 (Mapk12)
   05022 Pathways of neurodegeneration - multiple diseases
    101706002 (Mapk12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101706002 (Mapk12)
   05418 Fluid shear stress and atherosclerosis
    101706002 (Mapk12)
   05415 Diabetic cardiomyopathy
    101706002 (Mapk12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    101706002 (Mapk12)
   04932 Non-alcoholic fatty liver disease
    101706002 (Mapk12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101706002 (Mapk12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    101706002 (Mapk12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hgl01001]
    101706002 (Mapk12)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     101706002 (Mapk12)
Protein kinases [BR:hgl01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   101706002 (Mapk12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase UvrD_C Kinase-like
Other DBs
NCBI-GeneID: 101706002
NCBI-ProteinID: XP_004845386
LinkDB
Position
Un
AA seq 373 aa
MSSPPPLRKGFYRQEVAKTLWAVRAEYRDLQPAGSGAYGAVCSAVDSRSGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDEFTDFYLVMPFMGTDLGKLM
KHETLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVHKLQSAEAKNYMKGLPELEKKDFASVLTNASPMACDPPPAVNLLEKMLVL
DAEERVTAAEALAHPYFESLHDTEEEPKAQKYDDSFDDMDRTLDEWKRVTYKEVLSFKPP
RQLGARAAKETAL
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgagctcgccgccgcccctgcgcaagggcttctaccgccaggaggtggccaagacgctg
tgggcggtgcgcgccgagtaccgggacctgcagcccgcgggctcgggagcgtacggcgct
gtgtgctcggccgtggacagtcgctctggcgccaaggtggccatcaagaagctgtaccgg
cctttccagtccgagctgttcgccaagcgtgcctaccgcgagttgcgtctgctcaagcac
atgcgccacgagaacgtgatcgggctcctggatgtgttcactcctgacgagacactggat
gagttcactgacttctatctggtaatgccgttcatgggcaccgatctaggcaagctcatg
aagcacgagacactgagtgaagaccggatccagttccttgtgtatcagatgctgaagggg
ctgaagtatatccacgctgctgggatcatccacagggacctgaagcccggcaacctggct
gtgaatgaggactgtgagctgaagatcttggactttggcctggcccgacaggcagacagc
gaaatgacaggatatgtagtgacccggtggtaccgggcacctgaagtcatcttgaattgg
atgcgctacacacagacggtggacatctggtcagtgggctgcatcatggcggagatgatt
acagggaagacgttattcaagggcagtgaccacctggaccagttgaaggagatcatgaag
gtgacagggactcctcccgctgagtttgtgcacaaactgcagagtgcagaggctaagaac
tacatgaagggcctccctgagctggagaagaaggactttgcctctgtcctgaccaacgca
agccccatggcctgtgaccctcccccagctgtgaacctcctagagaagatgctggtgctg
gatgcagaggagcgggtgacagcggctgaggcactggctcacccctattttgagtccttg
catgacacggaagaggagcccaaggcccagaagtatgatgactcctttgatgacatggac
cgcaccctggatgagtggaagcgtgtcacttataaagaagtgctcagcttcaagcctccc
aggcagctgggggccagggccgccaaggagacagccctgtga

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