Heterocephalus glaber (naked mole-rat): 101706002
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Entry
101706002 CDS
T02812
Symbol
Mapk12
Name
(RefSeq) mitogen-activated protein kinase 12
KO
K04441
p38 MAP kinase [EC:
2.7.11.24
]
Organism
hgl
Heterocephalus glaber (naked mole-rat)
Pathway
hgl01522
Endocrine resistance
hgl04010
MAPK signaling pathway
hgl04015
Rap1 signaling pathway
hgl04068
FoxO signaling pathway
hgl04071
Sphingolipid signaling pathway
hgl04114
Oocyte meiosis
hgl04148
Efferocytosis
hgl04218
Cellular senescence
hgl04261
Adrenergic signaling in cardiomyocytes
hgl04370
VEGF signaling pathway
hgl04380
Osteoclast differentiation
hgl04550
Signaling pathways regulating pluripotency of stem cells
hgl04611
Platelet activation
hgl04613
Neutrophil extracellular trap formation
hgl04620
Toll-like receptor signaling pathway
hgl04621
NOD-like receptor signaling pathway
hgl04622
RIG-I-like receptor signaling pathway
hgl04625
C-type lectin receptor signaling pathway
hgl04657
IL-17 signaling pathway
hgl04658
Th1 and Th2 cell differentiation
hgl04659
Th17 cell differentiation
hgl04660
T cell receptor signaling pathway
hgl04664
Fc epsilon RI signaling pathway
hgl04668
TNF signaling pathway
hgl04670
Leukocyte transendothelial migration
hgl04714
Thermogenesis
hgl04722
Neurotrophin signaling pathway
hgl04723
Retrograde endocannabinoid signaling
hgl04728
Dopaminergic synapse
hgl04750
Inflammatory mediator regulation of TRP channels
hgl04912
GnRH signaling pathway
hgl04914
Progesterone-mediated oocyte maturation
hgl04917
Prolactin signaling pathway
hgl04926
Relaxin signaling pathway
hgl04932
Non-alcoholic fatty liver disease
hgl04933
AGE-RAGE signaling pathway in diabetic complications
hgl04935
Growth hormone synthesis, secretion and action
hgl04936
Alcoholic liver disease
hgl05014
Amyotrophic lateral sclerosis
hgl05020
Prion disease
hgl05022
Pathways of neurodegeneration - multiple diseases
hgl05132
Salmonella infection
hgl05133
Pertussis
hgl05135
Yersinia infection
hgl05140
Leishmaniasis
hgl05142
Chagas disease
hgl05145
Toxoplasmosis
hgl05152
Tuberculosis
hgl05161
Hepatitis B
hgl05163
Human cytomegalovirus infection
hgl05167
Kaposi sarcoma-associated herpesvirus infection
hgl05169
Epstein-Barr virus infection
hgl05170
Human immunodeficiency virus 1 infection
hgl05171
Coronavirus disease - COVID-19
hgl05205
Proteoglycans in cancer
hgl05208
Chemical carcinogenesis - reactive oxygen species
hgl05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hgl05415
Diabetic cardiomyopathy
hgl05417
Lipid and atherosclerosis
hgl05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
hgl00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
101706002 (Mapk12)
04015 Rap1 signaling pathway
101706002 (Mapk12)
04370 VEGF signaling pathway
101706002 (Mapk12)
04668 TNF signaling pathway
101706002 (Mapk12)
04068 FoxO signaling pathway
101706002 (Mapk12)
04071 Sphingolipid signaling pathway
101706002 (Mapk12)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
101706002 (Mapk12)
09143 Cell growth and death
04114 Oocyte meiosis
101706002 (Mapk12)
04218 Cellular senescence
101706002 (Mapk12)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
101706002 (Mapk12)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
101706002 (Mapk12)
04613 Neutrophil extracellular trap formation
101706002 (Mapk12)
04620 Toll-like receptor signaling pathway
101706002 (Mapk12)
04621 NOD-like receptor signaling pathway
101706002 (Mapk12)
04622 RIG-I-like receptor signaling pathway
101706002 (Mapk12)
04625 C-type lectin receptor signaling pathway
101706002 (Mapk12)
04660 T cell receptor signaling pathway
101706002 (Mapk12)
04658 Th1 and Th2 cell differentiation
101706002 (Mapk12)
04659 Th17 cell differentiation
101706002 (Mapk12)
04657 IL-17 signaling pathway
101706002 (Mapk12)
04664 Fc epsilon RI signaling pathway
101706002 (Mapk12)
04670 Leukocyte transendothelial migration
101706002 (Mapk12)
09152 Endocrine system
04912 GnRH signaling pathway
101706002 (Mapk12)
04914 Progesterone-mediated oocyte maturation
101706002 (Mapk12)
04917 Prolactin signaling pathway
101706002 (Mapk12)
04926 Relaxin signaling pathway
101706002 (Mapk12)
04935 Growth hormone synthesis, secretion and action
101706002 (Mapk12)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
101706002 (Mapk12)
09156 Nervous system
04728 Dopaminergic synapse
101706002 (Mapk12)
04723 Retrograde endocannabinoid signaling
101706002 (Mapk12)
04722 Neurotrophin signaling pathway
101706002 (Mapk12)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
101706002 (Mapk12)
09158 Development and regeneration
04380 Osteoclast differentiation
101706002 (Mapk12)
09159 Environmental adaptation
04714 Thermogenesis
101706002 (Mapk12)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
101706002 (Mapk12)
05208 Chemical carcinogenesis - reactive oxygen species
101706002 (Mapk12)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
101706002 (Mapk12)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
101706002 (Mapk12)
05161 Hepatitis B
101706002 (Mapk12)
05171 Coronavirus disease - COVID-19
101706002 (Mapk12)
05163 Human cytomegalovirus infection
101706002 (Mapk12)
05167 Kaposi sarcoma-associated herpesvirus infection
101706002 (Mapk12)
05169 Epstein-Barr virus infection
101706002 (Mapk12)
09171 Infectious disease: bacterial
05132 Salmonella infection
101706002 (Mapk12)
05135 Yersinia infection
101706002 (Mapk12)
05133 Pertussis
101706002 (Mapk12)
05152 Tuberculosis
101706002 (Mapk12)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
101706002 (Mapk12)
05140 Leishmaniasis
101706002 (Mapk12)
05142 Chagas disease
101706002 (Mapk12)
09164 Neurodegenerative disease
05014 Amyotrophic lateral sclerosis
101706002 (Mapk12)
05020 Prion disease
101706002 (Mapk12)
05022 Pathways of neurodegeneration - multiple diseases
101706002 (Mapk12)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
101706002 (Mapk12)
05418 Fluid shear stress and atherosclerosis
101706002 (Mapk12)
05415 Diabetic cardiomyopathy
101706002 (Mapk12)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
101706002 (Mapk12)
04932 Non-alcoholic fatty liver disease
101706002 (Mapk12)
04933 AGE-RAGE signaling pathway in diabetic complications
101706002 (Mapk12)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
101706002 (Mapk12)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hgl01001
]
101706002 (Mapk12)
Enzymes [BR:
hgl01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.24 mitogen-activated protein kinase
101706002 (Mapk12)
Protein kinases [BR:
hgl01001
]
Serine/threonine kinases: CMGC group
MAPK family [OT]
101706002 (Mapk12)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
APH
Kdo
Haspin_kinase
UvrD_C
Kinase-like
Motif
Other DBs
NCBI-GeneID:
101706002
NCBI-ProteinID:
XP_004845386
LinkDB
All DBs
Position
Un
AA seq
373 aa
AA seq
DB search
MSSPPPLRKGFYRQEVAKTLWAVRAEYRDLQPAGSGAYGAVCSAVDSRSGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDEFTDFYLVMPFMGTDLGKLM
KHETLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVHKLQSAEAKNYMKGLPELEKKDFASVLTNASPMACDPPPAVNLLEKMLVL
DAEERVTAAEALAHPYFESLHDTEEEPKAQKYDDSFDDMDRTLDEWKRVTYKEVLSFKPP
RQLGARAAKETAL
NT seq
1122 nt
NT seq
+upstream
nt +downstream
nt
atgagctcgccgccgcccctgcgcaagggcttctaccgccaggaggtggccaagacgctg
tgggcggtgcgcgccgagtaccgggacctgcagcccgcgggctcgggagcgtacggcgct
gtgtgctcggccgtggacagtcgctctggcgccaaggtggccatcaagaagctgtaccgg
cctttccagtccgagctgttcgccaagcgtgcctaccgcgagttgcgtctgctcaagcac
atgcgccacgagaacgtgatcgggctcctggatgtgttcactcctgacgagacactggat
gagttcactgacttctatctggtaatgccgttcatgggcaccgatctaggcaagctcatg
aagcacgagacactgagtgaagaccggatccagttccttgtgtatcagatgctgaagggg
ctgaagtatatccacgctgctgggatcatccacagggacctgaagcccggcaacctggct
gtgaatgaggactgtgagctgaagatcttggactttggcctggcccgacaggcagacagc
gaaatgacaggatatgtagtgacccggtggtaccgggcacctgaagtcatcttgaattgg
atgcgctacacacagacggtggacatctggtcagtgggctgcatcatggcggagatgatt
acagggaagacgttattcaagggcagtgaccacctggaccagttgaaggagatcatgaag
gtgacagggactcctcccgctgagtttgtgcacaaactgcagagtgcagaggctaagaac
tacatgaagggcctccctgagctggagaagaaggactttgcctctgtcctgaccaacgca
agccccatggcctgtgaccctcccccagctgtgaacctcctagagaagatgctggtgctg
gatgcagaggagcgggtgacagcggctgaggcactggctcacccctattttgagtccttg
catgacacggaagaggagcccaaggcccagaagtatgatgactcctttgatgacatggac
cgcaccctggatgagtggaagcgtgtcacttataaagaagtgctcagcttcaagcctccc
aggcagctgggggccagggccgccaaggagacagccctgtga
DBGET
integrated database retrieval system