Heterocephalus glaber (naked mole-rat): 101715472 Help Entry 101715472         CDS       T02812                                  Symbol Jak3 Name (RefSeq) Janus kinase 3   KO K11218   Janus kinase 3 [EC:2.7.10.2] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl04062   Chemokine signaling pathway hgl04151   PI3K-Akt signaling pathway hgl04217   Necroptosis hgl04550   Signaling pathways regulating pluripotency of stem cells hgl04630   JAK-STAT signaling pathway hgl04658   Th1 and Th2 cell differentiation hgl04659   Th17 cell differentiation hgl05161   Hepatitis B hgl05162   Measles hgl05166   Human T-cell leukemia virus 1 infection hgl05169   Epstein-Barr virus infection hgl05200   Pathways in cancer hgl05203   Viral carcinogenesis hgl05223   Non-small cell lung cancer hgl05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101715472 (Jak3)    04151 PI3K-Akt signaling pathway     101715472 (Jak3)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     101715472 (Jak3)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     101715472 (Jak3)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     101715472 (Jak3)    04659 Th17 cell differentiation     101715472 (Jak3)    04062 Chemokine signaling pathway     101715472 (Jak3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101715472 (Jak3)    05203 Viral carcinogenesis     101715472 (Jak3)   09162 Cancer: specific types    05223 Non-small cell lung cancer     101715472 (Jak3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101715472 (Jak3)    05161 Hepatitis B     101715472 (Jak3)    05162 Measles     101715472 (Jak3)    05169 Epstein-Barr virus infection     101715472 (Jak3)   09163 Immune disease    05340 Primary immunodeficiency     101715472 (Jak3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hgl01001]     101715472 (Jak3) Enzymes [BR:hgl01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      101715472 (Jak3) Protein kinases [BR:hgl01001]  Non-receptor tyrosine kinases   JAK family [OT]    101715472 (Jak3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl ABC1 Haspin_kinase Motif Other DBs NCBI-GeneID:  101715472 NCBI-ProteinID:  XP_004873384 LinkDB All DBs Position Un AA seq 1101 aa AA seqDB search MVPPSEETPLISQRSCSLSSSEAGALHVLLPPRGPGPTQRLSFSYGDHLAEELCVRAAKA SGILPVYHSLFALASEDLSCWFPPSHIFSVEDLGTQILVYRLRFYFPSWFGLEKCHRFGL RKDLASAIVDLPVLEHLFFQHRSDLVSGRLAVGLGLKEQGECLSLAVLDLARMAREQGRT PQEVLRTVSYKSCLPRGLRDLIQGLSFLTRKRIRRTVRRALHRVAACQADRHSLMAKYIL DLERLDPAQATETFCVGLPWTASGQDARGLLQVAGGSGIAWSPREHEPFQQFCDFPEIVD VSVKQAPRAGPAGEHRLVTVTRADNQILEAEFPALPAALSFVALVDGYFRLTCDPRHFFC KEVAPPRLLEEVAEHCHGPITLDFAIHKLKARGSVPGTYVLRRSPQDFDSFLLTACVQTP MGPDYKGCLIRRDPTGSFCLVGLSQPHGSLRELLSACREGGLHVDGAALSLTTCCAPTPK EKSNLIVVRRGCGPATTAHAQLPVLSQLTFHKIPPPSLQRHENLGHGSFTKIYRGCRHEC VDGEALETEVLLKVLDVEHRSFVESFLEAASLMSQVSYPHLVLLHGVCMAGDSIIVQELV ALGAIDTYLLKRGHLVPASWKLQVTKQLACALNYLEDKGLPHGNVSARKVLLAREGADGS PPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLDEARMLGLEADKWGFGATVWEVFSGAP MPTRALEPAEKLRFYEERRQLPAPRWAELAALIRQCMDYEPGRRPSFRAVIRDLNSLSTS DYELLSDPTPGALAPRDGPWSGAQQYAGQDPTIFEERHLKYISQLGKGNFGSVELCRYDP LGDNTGALVAVKQLQHSGPDQQRDFQREVQILKALQSEFIVKYRGVSYGPGRQSLRLVME YLPCGCLRDFLRRHRPRLDAGRLLLFATQICKGMEYLGACRCVHRDLAARNILVESETHV KIADFGLAKLLPLDKDYYVVREPGQSPIFWFAPESLADNVFSRQSDVWSFGVVLYELFTF GDPGCSPSAEFLRMMGCERDAPALCRLLELLAEGRRLPAPAACPAEVQELISQCWAPSPQ DRPTFSTLGPQLEALWSGSRG NT seq 3306 nt NT seq  +upstreamnt  +downstreamnt atggtgcccccgagtgaggagacgcccctgatctctcagcgctcctgcagcctctcatcc tcagaggccggggccctgcatgtgctgctgcctcctcgggggcctggccccacccagcgc ctgtccttctcctatggggaccacttagctgaggagctgtgtgtgcgagctgccaaggcc agtggcatcctgcctgtgtaccactctctcttcgcactggcctcggaggacctgtcttgc tggttccccccaagccacatcttctccgtggaggacttgggcacgcaaatcttggtctac aggctccggttttacttccccagctggtttgggctggagaaatgtcaccgcttcgggctc cgaaaggacctggccagcgccattgttgacctgcctgtcctggaacacctcttcttccag caccgcagcgacctggtgagcgggcgcctcgctgtgggcctcgggctcaaggagcagggc gaatgcctcagcctggccgtcctggacctggcccggatggcccgtgagcagggccggacg ccacaggaggtgctgcgcactgtcagctacaagtcctgcctaccccgcggcctgcgcgac ctcatccagggcctgagcttcctgacgcgcaagcgcatccgcaggacggtgcgccgcgcc ctgcaccgcgtggccgcctgccaggccgaccggcactcactcatggccaagtacatcttg gacctggagcggctggacccagcccaggccacggagaccttctgcgtggggctcccgtgg acagcgagcggccaggacgcacgcgggctgctccaagtggccgggggcagcggcatagcc tggagccccagggagcacgagcccttccagcagttctgcgacttccccgagattgtggac gtcagcgtcaagcaggccccacgcgcgggcccggccggcgagcaccgcctggtcaccgtc acgcgcgccgacaaccagatcctggaggccgagttcccagcgctgcccgccgcgctgtcc ttcgtggcgctcgtggacggctacttccgcctgacgtgcgacccgcgacacttcttctgc aaggaggtggcgcccccgcggctgctggaggaggtggctgagcactgccacggccccatc accctggacttcgccatccacaagttgaaggcccggggctcagtcccgggcacctacgtg ctccgccgcagccctcaggactttgacagctttctgctcacggcctgtgtccaaacaccc atgggccccgactacaagggctgcctcatccgccgggaccccactgggagcttctgcctg gttggcctcagccagccgcacggcagcctcagggagctcctgtccgcctgccgcgagggc gggctgcacgtggacggcgcggccctgagcctcaccacctgctgtgcccccacgcccaaa gagaagtccaacctgatcgtggtgcggagaggctgcggcccggccaccacggcgcacgcg cagctcccagtgctgagccagctgaccttccacaagatccctccgccgagcctgcagcgg cacgagaacctgggccatggctccttcaccaagatttaccgaggctgtcgccacgagtgc gtggacggggaggccctggagaccgaggtgctgctgaaggtgctggacgtggagcacagg agctttgtggagtccttcctggaagcagccagtttgatgagccaggtgtcctacccgcat ctcgtgttgctgcatggcgtgtgcatggctggagacagcatcatagtgcaggagctcgta gccctaggcgccattgacacctacctgctcaagcgcggccacctggtgcccgccagctgg aagctgcaggtgactaagcagctggcctgcgccctcaactatttggaggacaaaggcctc cctcatggcaacgtctcagctcggaaggtgctgctggcccgggagggtgctgatgggagc ccgccgtttatcaagctcagcgaccctggcgtcagccccactgtgctgagcctggagatg ctgaccgacaggatcccctgggtggcccccgagtgtctggacgaggcccggatgcttggc ctggaggcggacaagtggggctttggagccacggtctgggaggtcttcagcggggccccc atgcccacccgcgcgctggagcccgccgagaaactcaggttctacgaggagcggcggcag ctgcccgcgccccggtgggcggagctggccgcactgatccgccagtgcatggactacgag ccgggccgcaggccgagcttccgcgcggtcatccgggacctcaacagcctcagcacctca gattacgagcttctctccgaccccacgcccggcgccctggcgccccgggacgggccctgg agcggcgcccagcaatacgcgggccaggaccccacgatcttcgaggagcggcacctcaag tacatctcgcagttgggcaagggcaacttcggcagcgtggagctgtgccgctacgacccg ctgggggacaacacgggcgccctggtggccgtgaagcagctgcagcacagcgggccggac cagcagagggacttccagcgggaggtgcagatcctcaaggcgctgcaaagcgagttcatc gtcaagtaccgtggcgtcagctatggccccggccggcagagcctgcgcctggtgatggag tacctaccttgcggctgcctgcgcgacttcctgcggcgccaccgcccgcgcctggacgcg ggccgcctgctgctcttcgccacgcagatctgcaagggcatggagtacctgggcgcctgt cgctgtgtgcaccgggacctggccgcgcgcaacatcctggtggagagcgagacgcacgtc aagatcgccgacttcgggcttgccaagctgctgccgctcgacaaggactactacgtggtg cgcgagccgggccagagccccatcttctggttcgcgcccgagtccctggcggacaacgtc ttctcgcgccagtcggacgtgtggagttttggcgtggtgctgtacgagctcttcaccttc ggggacccgggctgcagcccctcagccgagttcctgcgcatgatgggctgtgagcgggac gcccctgccctgtgccgcctgctggagctgctggccgagggtcgcaggctgcccgcacct gctgcctgccccgcggaggtccaagagctcataagccagtgctgggcgcccagcccgcag gaccggccgacctttagcaccctgggcccccagctggaggcgctgtggagcggaagccgg gggtag

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