Heterocephalus glaber (naked mole-rat): 101715782 Help Entry 101715782         CDS       T02812                                  Symbol Tyk2 Name (RefSeq) tyrosine kinase 2   KO K11219   non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl04217   Necroptosis hgl04380   Osteoclast differentiation hgl04620   Toll-like receptor signaling pathway hgl04621   NOD-like receptor signaling pathway hgl04630   JAK-STAT signaling pathway hgl04658   Th1 and Th2 cell differentiation hgl04659   Th17 cell differentiation hgl05145   Toxoplasmosis hgl05160   Hepatitis C hgl05161   Hepatitis B hgl05162   Measles hgl05164   Influenza A hgl05165   Human papillomavirus infection hgl05167   Kaposi sarcoma-associated herpesvirus infection hgl05168   Herpes simplex virus 1 infection hgl05169   Epstein-Barr virus infection hgl05171   Coronavirus disease - COVID-19 Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101715782 (Tyk2)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     101715782 (Tyk2)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     101715782 (Tyk2)    04621 NOD-like receptor signaling pathway     101715782 (Tyk2)    04658 Th1 and Th2 cell differentiation     101715782 (Tyk2)    04659 Th17 cell differentiation     101715782 (Tyk2)   09158 Development and regeneration    04380 Osteoclast differentiation     101715782 (Tyk2)  09160 Human Diseases   09172 Infectious disease: viral    05161 Hepatitis B     101715782 (Tyk2)    05160 Hepatitis C     101715782 (Tyk2)    05171 Coronavirus disease - COVID-19     101715782 (Tyk2)    05164 Influenza A     101715782 (Tyk2)    05162 Measles     101715782 (Tyk2)    05168 Herpes simplex virus 1 infection     101715782 (Tyk2)    05167 Kaposi sarcoma-associated herpesvirus infection     101715782 (Tyk2)    05169 Epstein-Barr virus infection     101715782 (Tyk2)    05165 Human papillomavirus infection     101715782 (Tyk2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     101715782 (Tyk2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hgl01001]     101715782 (Tyk2) Enzymes [BR:hgl01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      101715782 (Tyk2) Protein kinases [BR:hgl01001]  Non-receptor tyrosine kinases   JAK family [OT]    101715782 (Tyk2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 Kinase-like Kdo FERM_C_FAK1 ABC1 Motif Other DBs NCBI-GeneID:  101715782 NCBI-ProteinID:  XP_004865547 LinkDB All DBs Position Un AA seq 1184 aa AA seqDB search MPLCHRGGSEKGSQPARDEVQPLATTGGLQVLLHWAGSSGGQPWVTFGEVSLTAEEICIR VAHRIGITPACFNLFALFDAEAQVWLPPNHILEVSADTRQTLYFRMRFYFRNWHGMNPQE PPVYRCGLPGAEASSEQAEQGVQVLDPASFEYLFEQGKYEFVNDVVSLRELSSEEEIHHF KNESLGMAFLHLCHLALCRSVPLEEVAKEISFTRCIPRSFRQQIRQYNMLTRLRLRSVFR RFLHAFQPNHLSQQVVMVKYLATLEHLAPRFGAECIPVHHLELLFQADREPCYIRDSGQP PEADPMSAPGPPTHEVLVTGTRGIQWRPVQPESSSANGSDSWNPKARLPGKKASAHEEAG KQPVDKPQEPSWTYFCDFQDITHVVLKECRISIHRQDNKCLELSLSSPAAALSFAALVDG YFRLTTDSSHYLCHEVAPPRLVLSIQDGIHGPLLEPFVRAKLQLEEGVYLIHWSTSHLER LILTVGQRDPTPGGSGVQSVRLRKFPIERQAGGFVLEGWGRSFASVRDLRMALQGCSLRA GDDCFSLRQCCLPQPGEISNLIIIRGPRASTRQLNLSQLSFHRVQQDDITQLSHLGQGTR TNVYEGLLRVGTPEEDKEDSMGPVEPSGGCGQELRVVLKVLDPGHHDITLAFYETASLMS QVSHAHLAFLHGVCVRGSENVMVTEFVEHGPLDVWLRRERGCVPLAWKLVVAQQLASALS YLEDKNLVHGNVCGRNILLARLGLADGTSPFIKLSDPGVGLAALSREERVERIPWTAPES LLAGASSLSTTTDKWGFGATLLEICFNGEVPLQGHTPSEKERFYQKQHQLPKPLCPELAS ITSQCLSYEQAQRPSFRTILRDLTRLQPHSLVDVSALNPDSPASDPTVFHKRYLRKIRDL GEGHFGKVSLYCYDPNNDGTGEMVAVKSLKAGGGPQLSSGWRREIDILRTLYHEHIVKYK GCCEDQGEKSVQLVMEYVPLGSLRDYLPRHSVGLAQLLLFAQQICEGMAYLHGQHYIHRD LAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLQECKFYYASD VWSFGVTLYELLTHCDSSQSPPSKFMELIGITQGQMTVLRLTELLARGERLPWPDRCPRE IYLLMKNCWEAEASFRPTFQNLVPILKSEQEKYQGQAPSLFSVC NT seq 3555 nt NT seq  +upstreamnt  +downstreamnt atgcccctgtgtcatcgaggaggctctgagaagggcagccagcctgccagggatgaagtg cagcccttggccaccacgggaggcctgcaggtccttctgcactgggctggctccagtggt gggcagccctgggtcaccttcggtgaggtctcgctgacggctgaggagatctgcatccgg gtcgcacacagaatcggcatcacaccagcctgctttaatctctttgctctctttgatgct gaggcccaagtgtggctgcccccaaaccacattctggaagtttctgcagacacaagacag acgctgtatttccgcatgaggttttacttccggaactggcatggcatgaatccgcaggag ccacctgtgtaccgctgtggactcccaggggctgaggcatcctcagaacaagcagaacaa ggggtacaagtcttagatccagcctcttttgagtacctctttgagcagggcaagtatgag tttgtgaatgatgtggtgtcgctgcgggagctgtcaagtgaggaggagatccaccacttt aagaatgagagtctaggcatggcctttctgcacctctgccacctcgctctctgccgcagt gtccccctggaggaggtggccaaggagatcagcttcacgcgctgcatcccgcgctccttc cggcagcagatccgccagtacaatatgctgacccggctgcgccttcggagtgtcttccga cgcttcctgcatgccttccagccaaaccacctgtcccagcaggttgtcatggtcaagtac cttgccaccctggagcatctggcaccccgctttggtgccgaatgcatccctgtgcatcac ctggagctcctattccaggccgacagggagccctgctatatccgggacagtgggcagccc ccagaagctgaccccatgtcggcccctggaccccccacccatgaggtgctggtcacgggt accaggggcatccagtggcgcccggtacagccagagagttccagtgccaatggcagtgac agctggaatccgaaagccaggctgcctgggaaaaaggccagtgcccatgaggaggcaggc aagcagccagtggacaagccacaggagccctcttggacctacttctgtgacttccaggac atcacccatgtggtcctgaaggaatgtcgcatcagcatccaccggcaggacaataagtgc ctggagctgagcctgtcctccccggctgctgccctgtcctttgcggcgctggtggacggc tacttccgcctgactaccgactccagccactacctgtgccatgaggtggctcctccgagg ctggtcctgagcatccaggacggcatccacggacccctgctggagccgtttgtgcgggcc aagctgcagctggaagagggcgtctacctcatccactggagcaccagccaccttgagcgc ctcatcctcacggtgggccagcgtgacccgacccctggcggcagtggtgtgcagagtgtg cgcctccgcaagttccccattgagcggcaagccgggggctttgtgctggagggctggggc cgctccttcgccagcgtgcgggacctgcggatggccctgcagggctgctctctgcgggct ggggacgactgcttctccctgcgccagtgctgcctgccccagccaggagagatctccaac ctcatcatcattcgggggcctcgggccagcacccggcagctcaacctcagccagctcagc ttccacagggtacagcaggatgacatcacccagctgtcacacttgggccagggcacaagg accaacgtgtatgagggtctgctgcgagtggggacgcccgaggaggacaaagaggacagc atgggccctgtggagcccagtgggggctgtgggcaggagctgcgtgtggtgctgaaggtg ctggacccaggtcaccacgacatcacgctggccttctacgagacagccagcctcatgagc caggtgtcccatgcacacctggccttcctgcatggcgtatgcgtgcgcggctccgagaac gtcatggtgacggagttcgtggagcatgggcccctggacgtgtggctgcggcgggagcgg ggctgtgtgcccctggcctggaagctggtggtggcccagcagctggccagtgccctcagc tacctggaggacaagaacctggtgcacgggaatgtgtgtggccggaacatcctcctggcc cggctggggctggcagatggcaccagcccattcatcaagctcagcgacccaggcgtgggg ctggccgccctctccagggaggagcgggtggaacgcatcccctggactgcgcccgagtcc ctgcttgctggggccagcagcctgagcacaaccacagacaagtggggcttcggtgccacc ctgctggagatctgcttcaacggcgaggtgcccctgcagggccacaccccctccgagaaa gagcgcttctaccagaagcagcatcagctgcccaagcctttgtgcccagagctggcctca atcaccagccagtgcctgagctacgagcaggcccagcggccatccttccgcaccatcctg cgcgacctcactcggctgcagccccacagtctagtagatgtctcagctctgaaccccgac tcacctgcgtcagaccccaccgtttttcataagcgctatttgagaaagatccgagatttg ggagagggtcactttggcaaggtcagcctgtactgctacgacccaaacaacgatggcact ggcgagatggtggcagtgaaatccctcaaggcgggcggcgggccccagctcagctcgggc tggaggcgggagatcgacatccttcgcactctgtaccacgagcacattgtcaagtacaag ggctgctgtgaggaccaaggagagaagtcggtgcagctcgtcatggagtacgtgccgctg ggcagcctccgggactacctgccccggcacagcgtcggccttgcccagctgctgctgttc gcccagcagatctgcgagggcatggcctacctgcatgggcagcactacatccacagagac ctggcggcgcgcaacgtgctgctggacaacgacaggctggtgaagatcggggattttggc cttgccaaggccgtgcctgaaggccacgagtactaccgcgtgcgcgaggacggggacagt cccgtgttctggtacgcccccgagtgcctccaggagtgtaagttttactacgcgtcggac gtctggtccttcggggtcacactctatgagctgctgacgcactgtgactccagccagagc cccccctcgaaattcatggagctcataggcatcacccagggccagatgactgtgctgagg ctcacagagttgctggcgcgaggggagaggctgccgtggccagacagatgtccccgggag atctacctcctcatgaagaactgctgggaggccgaggcctcgttccgtcccaccttccag aaccttgtccccatcctcaagtcggagcaagagaaataccaaggccaggccccctcgttg ttcagtgtgtgctga

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