KEGG   Heterocephalus glaber (naked mole-rat): 106007524
Entry
106007524         CDS       T02812                                 
Symbol
Mapk14
Name
(RefSeq) mitogen-activated protein kinase 14
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
hgl  Heterocephalus glaber (naked mole-rat)
Pathway
hgl01522  Endocrine resistance
hgl04010  MAPK signaling pathway
hgl04015  Rap1 signaling pathway
hgl04068  FoxO signaling pathway
hgl04071  Sphingolipid signaling pathway
hgl04114  Oocyte meiosis
hgl04148  Efferocytosis
hgl04218  Cellular senescence
hgl04261  Adrenergic signaling in cardiomyocytes
hgl04370  VEGF signaling pathway
hgl04380  Osteoclast differentiation
hgl04550  Signaling pathways regulating pluripotency of stem cells
hgl04611  Platelet activation
hgl04613  Neutrophil extracellular trap formation
hgl04620  Toll-like receptor signaling pathway
hgl04621  NOD-like receptor signaling pathway
hgl04622  RIG-I-like receptor signaling pathway
hgl04625  C-type lectin receptor signaling pathway
hgl04657  IL-17 signaling pathway
hgl04658  Th1 and Th2 cell differentiation
hgl04659  Th17 cell differentiation
hgl04660  T cell receptor signaling pathway
hgl04664  Fc epsilon RI signaling pathway
hgl04668  TNF signaling pathway
hgl04670  Leukocyte transendothelial migration
hgl04714  Thermogenesis
hgl04722  Neurotrophin signaling pathway
hgl04723  Retrograde endocannabinoid signaling
hgl04728  Dopaminergic synapse
hgl04750  Inflammatory mediator regulation of TRP channels
hgl04912  GnRH signaling pathway
hgl04914  Progesterone-mediated oocyte maturation
hgl04917  Prolactin signaling pathway
hgl04926  Relaxin signaling pathway
hgl04932  Non-alcoholic fatty liver disease
hgl04933  AGE-RAGE signaling pathway in diabetic complications
hgl04935  Growth hormone synthesis, secretion and action
hgl04936  Alcoholic liver disease
hgl05014  Amyotrophic lateral sclerosis
hgl05020  Prion disease
hgl05022  Pathways of neurodegeneration - multiple diseases
hgl05132  Salmonella infection
hgl05133  Pertussis
hgl05135  Yersinia infection
hgl05140  Leishmaniasis
hgl05142  Chagas disease
hgl05145  Toxoplasmosis
hgl05152  Tuberculosis
hgl05161  Hepatitis B
hgl05163  Human cytomegalovirus infection
hgl05167  Kaposi sarcoma-associated herpesvirus infection
hgl05169  Epstein-Barr virus infection
hgl05170  Human immunodeficiency virus 1 infection
hgl05171  Coronavirus disease - COVID-19
hgl05205  Proteoglycans in cancer
hgl05208  Chemical carcinogenesis - reactive oxygen species
hgl05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hgl05415  Diabetic cardiomyopathy
hgl05417  Lipid and atherosclerosis
hgl05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    106007524 (Mapk14)
   04015 Rap1 signaling pathway
    106007524 (Mapk14)
   04370 VEGF signaling pathway
    106007524 (Mapk14)
   04668 TNF signaling pathway
    106007524 (Mapk14)
   04068 FoxO signaling pathway
    106007524 (Mapk14)
   04071 Sphingolipid signaling pathway
    106007524 (Mapk14)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    106007524 (Mapk14)
  09143 Cell growth and death
   04114 Oocyte meiosis
    106007524 (Mapk14)
   04218 Cellular senescence
    106007524 (Mapk14)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    106007524 (Mapk14)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    106007524 (Mapk14)
   04613 Neutrophil extracellular trap formation
    106007524 (Mapk14)
   04620 Toll-like receptor signaling pathway
    106007524 (Mapk14)
   04621 NOD-like receptor signaling pathway
    106007524 (Mapk14)
   04622 RIG-I-like receptor signaling pathway
    106007524 (Mapk14)
   04625 C-type lectin receptor signaling pathway
    106007524 (Mapk14)
   04660 T cell receptor signaling pathway
    106007524 (Mapk14)
   04658 Th1 and Th2 cell differentiation
    106007524 (Mapk14)
   04659 Th17 cell differentiation
    106007524 (Mapk14)
   04657 IL-17 signaling pathway
    106007524 (Mapk14)
   04664 Fc epsilon RI signaling pathway
    106007524 (Mapk14)
   04670 Leukocyte transendothelial migration
    106007524 (Mapk14)
  09152 Endocrine system
   04912 GnRH signaling pathway
    106007524 (Mapk14)
   04914 Progesterone-mediated oocyte maturation
    106007524 (Mapk14)
   04917 Prolactin signaling pathway
    106007524 (Mapk14)
   04926 Relaxin signaling pathway
    106007524 (Mapk14)
   04935 Growth hormone synthesis, secretion and action
    106007524 (Mapk14)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    106007524 (Mapk14)
  09156 Nervous system
   04728 Dopaminergic synapse
    106007524 (Mapk14)
   04723 Retrograde endocannabinoid signaling
    106007524 (Mapk14)
   04722 Neurotrophin signaling pathway
    106007524 (Mapk14)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    106007524 (Mapk14)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    106007524 (Mapk14)
  09159 Environmental adaptation
   04714 Thermogenesis
    106007524 (Mapk14)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    106007524 (Mapk14)
   05208 Chemical carcinogenesis - reactive oxygen species
    106007524 (Mapk14)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    106007524 (Mapk14)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    106007524 (Mapk14)
   05161 Hepatitis B
    106007524 (Mapk14)
   05171 Coronavirus disease - COVID-19
    106007524 (Mapk14)
   05163 Human cytomegalovirus infection
    106007524 (Mapk14)
   05167 Kaposi sarcoma-associated herpesvirus infection
    106007524 (Mapk14)
   05169 Epstein-Barr virus infection
    106007524 (Mapk14)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    106007524 (Mapk14)
   05135 Yersinia infection
    106007524 (Mapk14)
   05133 Pertussis
    106007524 (Mapk14)
   05152 Tuberculosis
    106007524 (Mapk14)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    106007524 (Mapk14)
   05140 Leishmaniasis
    106007524 (Mapk14)
   05142 Chagas disease
    106007524 (Mapk14)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    106007524 (Mapk14)
   05020 Prion disease
    106007524 (Mapk14)
   05022 Pathways of neurodegeneration - multiple diseases
    106007524 (Mapk14)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    106007524 (Mapk14)
   05418 Fluid shear stress and atherosclerosis
    106007524 (Mapk14)
   05415 Diabetic cardiomyopathy
    106007524 (Mapk14)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    106007524 (Mapk14)
   04932 Non-alcoholic fatty liver disease
    106007524 (Mapk14)
   04933 AGE-RAGE signaling pathway in diabetic complications
    106007524 (Mapk14)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    106007524 (Mapk14)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hgl01001]
    106007524 (Mapk14)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     106007524 (Mapk14)
Protein kinases [BR:hgl01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   106007524 (Mapk14)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Kdo APH NAD_binding_8
Other DBs
NCBI-GeneID: 106007524
NCBI-ProteinID: XP_004846752
UniProt: A0A0N8ETG7
LinkDB
Position
Un
AA seq 360 aa
MSQERPKFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFSDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPAPLDQEEMES
NT seq 1083 nt   +upstreamnt  +downstreamnt
atgtctcaggagaggcccaagttctacaggcaggagctgaacaagacggtctgggaggtg
cccgagcgttaccagaacctgtccccagtgggctccggcgcctatggctctgtgtgtgct
gcttttgacacaaaaactgggttgcgtgtggcagtgaagaagctgtccagaccatttcag
tccatcattcatgccaaaaggacctaccgagagctgcggttacttaaacatatgaaacat
gaaaatgtgattggtctgttggacgtctttacacctgcaaggtctctggaggagttcagt
gatgtgtatctggtgacccatctcatgggggcagatctgaacaacatcgtgaaatgtcag
aagctcacggatgaccatgttcagttcctcatctaccagattctccgaggtctcaagtac
atacattcagccgacatcatccacagggacctcaagcccagtaatctagctgtgaatgaa
gactgcgagctgaagattctggattttggactggctcggcacactgatgacgaaatgaca
ggatacgtggccaccaggtggtacagggctcctgagatcatgctgaattggatgcattac
aaccagacagtggacatctggtcagtgggatgcataatggccgagctgttgactggaaga
acattgtttcctggtacagaccatattgatcagttgaagctcattttaagactcgttgga
accccaggggctgagcttttgaagaaaatctcctcagagtctgcaagaaactatattcag
tcattgacccagatgccgaagatgaactttgcaaatgtatttattggtgccaatcccctg
gctgtcgacctgctggagaagatgcttgtgttggactcggataagagaatcacggcagcc
caagcccttgcacatgcctactttgctcagtaccatgatcctgatgatgaaccagtggcc
gatccttatgatcagtcctttgaaagccgggacctcctcatagatgaatggaaaagcttg
acctatgacgaggtcatcagctttgtgccagcaccccttgaccaagaagagatggagtcc
tga

DBGET integrated database retrieval system