Hyaena hyaena (striped hyena): 120223505
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Entry
120223505 CDS
T07257
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
hhv
Hyaena hyaena (striped hyena)
Pathway
hhv00270
Cysteine and methionine metabolism
hhv00480
Glutathione metabolism
hhv01100
Metabolic pathways
hhv01240
Biosynthesis of cofactors
hhv04216
Ferroptosis
Module
hhv_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
hhv00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
120223505 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
120223505 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
120223505 (GCLC)
Enzymes [BR:
hhv01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
120223505 (GCLC)
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Paralog
GFIT
Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
120223505
NCBI-ProteinID:
XP_039077608
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All DBs
Position
Unknown
AA seq
637 aa
AA seq
DB search
MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKRVQLVLSGEEVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSLLGENQALCTITSFPRLGCPGFTLPEFKPNPLEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFMETFPEDEEAAKASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNSYRISKSRYDSIDSYLSECGEKYNDIDLTIDKEIYEQLLQ
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
RGKFYFRKDICKGGNNVVDGYGKAQNSSDLATEDYALMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFISNHPDYKQDSVITDEMNYS
LILKCNQIADELCECPELLGPGFRKVKYSGSKTDPSN
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccaaggttcgccgctgagctgggaggagaccaagcgccacgccgac
cacgtgcggcggcacgggatcctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaagtggggcgacgaggtggaatacatgttggtgtcttttgatcat
gaaaataagagagtccagttggtcctgtctggagaggaagttcttgagactctacaagaa
aagggagaaaggacaaacccaaaccatcctaccctgtggagaccagagtacggcagttac
atgattgaaggcacacctggacagccgtacggaggaacaatgtccgagttcaacacagtt
gaagacaacatgagaaaacgccggaaggaggcaacctctttattaggagaaaatcaggct
ctttgcacaataacttcgtttcccagattaggctgtcctgggttcacgctgccagagttc
aaacccaacccactggaaggaggtgcttctaagtccctcttctttcctgatgaagccata
aacaagcatccccgtttcagtaccctaacaagaaatatccgacacaggagaggagagaag
gttgtcatcaatgtaccaatatttaaggacaagaatacaccgtctccatttatggaaacg
tttcctgaggatgaggaggcagcaaaggcttctaagcctgatcatatatacatggatgcc
atgggatttgggatgggtaattgctgtcttcaggtaacgttccaagcctgcagcatatct
gaggccagatacctttatgatcagctggccactatatgtccaattgtcatggctttgagt
gctgcgtctcccttttaccgaggctatgtatcagacattgattgtcgctggggagtgatt
tctgcatctgtagatgatagaactcgggaggagagaggactggagccactgaagaacaat
agctataggatcagtaaatcccgatatgattcaatagacagttatttatctgagtgtggg
gagaaatacaatgacatcgacttgacaattgataaagaaatctacgaacagttgctgcag
gaaggcattgatcatctcctggcccagcatgttgctcacctcttcattagagacccactg
actctattcgaagagaaaatacacttggatgatgccaatgagtcggaccatttcgagaac
attcagtccacgaattggcagacgatgagatttaagccccctcctcctaactccgacatt
ggatggagagtagaattccgacccatggaggttcagttaacagactttgagaactctgcg
tatgtggtgttcgtggtgctgcttaccagagtgatcctttcatacaaactggattttctc
attccactatcaaaggttgatgaaaacatgaaagttgcacagaaacgagatgctgtcctg
cggggaaagttttatttcaggaaagatatttgcaaaggtgggaacaatgtggtggatggt
tacggcaaggcccagaacagctcggacctggccacggaggactatgccctgatgagcata
gacaccatcatcaatgggaaggagggtgtgtttcctgggctgatcccaattctgaactct
taccttgaaaacatggaggtggatgtggacaccagatgtagtattctcaactacctaaag
ctaattaagaaaagagcatccggagaactaatgacagttgccagatggatgagagagttt
atctccaaccatcctgactataagcaagacagtgtaatcaccgatgaaatgaactacagc
ctcatcttaaagtgtaatcaaattgcagatgaattgtgtgagtgcccggagttgcttgga
ccagggtttaggaaagtaaaatatagcggaagtaaaacggacccttccaactag
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