Hyaena hyaena (striped hyena): 120242313
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Entry
120242313 CDS
T07257
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
hhv
Hyaena hyaena (striped hyena)
Pathway
hhv00310
Lysine degradation
hhv01100
Metabolic pathways
hhv05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
hhv00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
120242313 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
120242313 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hhv03036
]
120242313 (DOT1L)
Enzymes [BR:
hhv01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
120242313 (DOT1L)
Chromosome and associated proteins [BR:
hhv03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
120242313 (DOT1L)
HMT complexes
Dot1-containing complex
120242313 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
120242313
NCBI-ProteinID:
XP_039103911
LinkDB
All DBs
Position
Unknown
AA seq
1689 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKAAVPADTPMDSGAEEEKAGATAIKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTA
NPERKPKKSQTALDLLHGQASSQTAAPSPQDAYKSPHSPFYQLPPSVQRHAPAPDRPLLA
ATPPALQKLLESFKIQYLQFLAYTKTAQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQA
QKEEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLQKDNRELRSQSLQ
LLKARCEELRLDWSTLSLESLLKEKQALRSQISEKQRHCLELQISIVELEKSQRQQELLQ
LKSCVPPDDALSAHLRGKGALGREPEAEPGRLHLDLDCSRFPLPHFSSASPELSMNGHAA
GYELCGTLSRPSSKQNTPQYLASPLDQEAVPCTPSHSSRPRLEKVSGLALPDYTRLSPAK
LVLRRHLSQDHAAGGKAASGELHPRAEHAKENGLAYQSPGIKLSPQDPRPPSPVALPMTG
ERASEKGLKERAYASGGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAERVRSTPS
PVPQTRESSTLEKQMGASAHGAGGKGPAPAPAGFYTGSVAVSPAPLASGVEPGAFDEVPG
PGGLFASMGSCGSTPQHPPLLPQPRGSGAASPAHPLCASPRLSSAAQGPFPDGSKGDLPS
EAGFSDPESEAKRRIVFTISAGGGSAKQSPPSKPSPLPAGSRGDSSQGHGQDSRKRGRRK
RAAAGAPSLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPESLK
SSPVPYQDSDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSARIERKIATISLES
RSPPKTLENGGGLAGRKPTPASEPTNSSKWKSTFSPISDLGLAKCADSPLQAGSALSQSS
LFTFRPPLEEPSPADAKLAAHPRKSFPGSLSGAGGLSPSGNPPNGFTFSGGLAADLSLHS
FSDGASLSHKAPEAAGLGAPLSFPAPRGKDGAAEPGPFVNKRQLDGAGGPKGREAGEPGP
AACGPPDKAPLAHGKPGKGRDREPDLKNGHNLFISAAAVPPGGLLSGPGLATAASSVASA
APSAQTHRPFLGTFAPGPQFALGPMSLQANLGSSVLQSLFGSVPAASLVHVSSAATRLTN
SHAMGSFPSGVAGGAVGGVFNHAVPSASAHPFGASFGSGAACRSGTLSLTPLQAVAGAPP
PPPPGQPALPAPPPPNAALPPAPALLPANSEPALLQSLASLPANQAFLPASSAASLQPAN
ASLSVKLASLPHKAPRPSFTVHHQPLPGLALAQAAPVIPQASSTGPSAVWVSLGMPPPCA
ARLAGVKPR
NT seq
5070 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcacgaaatcatcgagacc
atccggtgggtctgtgaagagatcccagacctcaagcttgctatggagaactacgtttta
atcgactacgataccaaaagcttcgaaagcatgcagaggctctgtgacaagtacaaccgc
gccatcgacagcatccaccagctgtggaaggggaccactcagcccatgaaactgaacacc
cggccgtccaacgggctcctgcggcacatcctgcagcaggtgtacaaccactcggtgacg
gaccctgagaagctcaacaactacgagcccttctccccggaggtttatggggagacctcc
tttgacttggtcgcgcagatgatcgacgagatcaagatgacggaggacgacctatttgtg
gacctgggcagcggagtgggccaggtcgtcctgcaggtcgccgcggccaccaattgcaaa
catcactatggcgtggagaaagccgacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtacggaaaaaagcatgcagaatacacactggagaga
ggcgacttcctctcggaggagtggagggagcggattgccaacacaagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcgaacatg
aaggaaggtgggagaatcgtgtcctcaaagccctttgcgcctctgaacttcagaataaac
agcagaaacttgagcgacatcggcaccatcatgcgcgtcgtagagctctcgcccctgaaa
ggctccgtgtcctggacggggaagccagtctcctactacctgcacaccattgaccgcacc
atacttgaaaactatttttctagtctgaaaaatccaaaactcagggaggaacaagaggcg
gctcggcgccggcagcagcgagaaaacaagagcaacacgaccactcccaccaaggtgccc
gagagcaaggccgccgtgcccgccgacacccccatggattccggtgccgaggaggagaag
gctggggcgaccgccatcaaaaagccgtccccttccaaggctcggaagaagaagctgaac
aagaaggggcggaagatggccggccggaagcgcgggcgccccaagaaaatgagcactgcg
aaccccgagcgcaagcccaagaagagccagaccgcactggacctcctgcacggccaggcc
tcgtcgcagacggcggcgccctcgccccaggatgcgtacaagtcacctcatagcccgttc
tatcagctacctcccagcgtgcagcggcacgcccccgcccccgaccggccgctgctggca
gccaccccacccgcactgcagaagctgctagaatccttcaagattcagtacttgcagttc
ttggcgtacaccaagaccgcccagtacaaggccagcctgcagcagctgctggaccaggag
aaggagaagaacgcccggctgctgggcgctgcgcagcagctgtttggccactgccaggcc
cagaaggaggagatcaagaggctcttccagcagaagctggacgagctgggggtgaaggcg
ctgacctacaacgacctgattcaggcacagaaggagatctcggctcacaaccagcagctg
agggaacagacggagcagctgcagaaggacaacagggagctgaggagccagagcctgcag
ctgctcaaggctcggtgtgaggagctgaggctggactggtcgacgctgtccctggagagc
ctgctgaaggagaagcaggccctgaggagccagatctccgagaagcagaggcactgtctg
gagctgcagatcagcatcgtggagctggagaagagccagcggcagcaggagctcctgcag
ctgaagtcctgcgtgccgcccgacgacgctctgtcggcgcacctgcgcgggaaaggcgcc
ctgggccgggagccagaggcggagcccggccggctgcacctcgacctggactgctccagg
ttccccctgccccacttcagcagcgcgagcccagagctctccatgaacggccacgcggcc
ggctatgagctgtgcggcacgctgagccggccctcatccaagcagaacaccccccagtac
ctggcctccccgctggaccaggaggccgtgccctgcacccccagccacagcagccgccca
cggctcgagaaggtgtccggcctggccctgcccgactacaccaggctctccccagccaag
ctggtgctaaggcgccacctgagccaggaccacgcggccggcggcaaggcggcctccgga
gagctgcacccacgagccgagcatgccaaggagaacggccttgcgtaccagagcccgggc
atcaagctgagccctcaggaccctcggcccccgtcccccgtggccttaccgatgacaggg
gagagggccagcgagaagggtttgaaggagcgcgcctatgccagcggcggggaggccatc
accagcctgccggtcagcatcccgctcagcaccgtgcagcccagcaagctgcccgtcagc
attcccctggccagcgtggtgctgcccagccgcgccgagagagtgagaagcacccccagc
ccggtgccgcagacccgcgagtcctccacgcttgagaagcagatgggcgctagcgcgcac
ggggctggcggcaaaggccccgccccagctcctgcaggcttctacacgggctcggtggcc
gtcagcccagcgcccctggcttccggagtcgagcccggcgcctttgacgaggtccccggc
ccgggcggcctgttcgccagcatgggctcttgcggctccaccccacagcacccgcccctg
ctgccacagccccgcggctccggcgcggcctcgcccgcccacccgctctgcgccagcccc
cggctcagcagtgccgcccagggtcccttccctgatggcagcaaaggggaccttccatct
gaggccggcttctcagaccctgagagcgaagccaagcggaggatcgtcttcaccatctcg
gctggcggtggcagtgctaaacagtcgccgcccagcaagcccagccccctgcccgcgggc
agccgtggggacagtagccagggccacggccaggacagccgcaagcggggcaggaggaag
cgggcggcagcgggggcccccagcctgagctcaggcgtgtcgcccaagcgccgggccctg
ccgtccgtggctggcctcttcacacagtcttcagggtcccccctgaacctcaactccatg
gtcagcaacattaaccagcctttggaaatcacggccatttcgtcccccgagagcctgaag
agctcccctgtcccctaccaggacagcgaccagccgcccgtcctcaagaaggagaagccc
ctgagccagaccaacggggcccactactccccactgacctcggacgaggagcagggctcc
gaggacgagccgggcagcgccagaattgagagaaagattgccacaatctccttagaaagc
agatctcctccgaaaaccttggaaaacggtggtggcctggccgggaggaagccgacccct
gccagcgagcccaccaacagcagcaagtggaagtccaccttctcacccatttccgacctc
ggcctggccaagtgcgccgacagcccgctgcaggccggctccgccctgagccagagctcc
ctgttcactttccggcccccgctggaggagcccagcccggctgacgccaagctggctgcc
caccccaggaagagctttcccggcagcctgtcaggggcaggcgggctgagcccaagcggc
aaccctcccaacggcttcaccttcagcgggggcctggccgcagacctcagtttacacagc
ttcagtgatggtgcttctctctcccacaaggccccagaggcggcaggcctgggcgccccc
ctgagctttcccgccccccggggcaaggacggcgccgcagagcccggcccctttgtgaac
aagaggcagctggacggagcaggcggccccaagggcagggaggcaggcgagccgggccca
gcggcatgcgggcccccggacaaggccccgctggcgcacggcaagccgggcaagggccgg
gaccgtgagcctgacctgaagaacggccacaacctcttcatttccgccgccgccgtgccc
cccgggggcctcctcagcggcccgggcctcgccacagcggcgtcctcggtggccagcgct
gccccctccgcccagacgcaccgccccttcctgggcacgtttgcccccggcccgcagttc
gccctgggccccatgtcccttcaggccaacctgggctcgtctgtgctgcagtccctgttc
ggctccgtgccggccgccagcctggtgcacgtctcatccgccgcaaccagactgaccaac
tcgcacgccatgggcagctttccctccggggtggcaggcggcgcagttggaggtgtcttt
aaccacgcggtgccttccgcctccgctcatccgtttggagccagtttcggcagcggggct
gcgtgtcgcagcggcacgctgagcttaacccccctgcaggcggtggccggcgccccgccc
ccgccccctccggggcagcccgccctccccgcgccccctccccctaacgccgccttgcct
cccgcccccgcactgctccccgctaactctgagcccgcgcttctgcagagcctcgcgtcc
ctcccggctaaccaggctttcttacccgcctcctctgccgcctctctgcagcctgctaac
gcctctctgtccgtcaagctcgcctccctcccgcacaaggctccccgcccctccttcacg
gtgcaccaccagcccctgcccgggctggccctggcccaggccgcgcccgtgatcccgcag
gccagctccacgggcccgtccgccgtgtgggtttcccttggcatgccgcctccgtgtgcc
gcgcgcctcgcgggggttaagccacgataa
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