Haemophilus influenzae R2846 (nontypeable): R2846_0554
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Entry
R2846_0554 CDS
T01980
Symbol
thrA
Name
(GenBank) Aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
hie
Haemophilus influenzae R2846 (nontypeable)
Pathway
hie00260
Glycine, serine and threonine metabolism
hie00261
Monobactam biosynthesis
hie00270
Cysteine and methionine metabolism
hie00300
Lysine biosynthesis
hie01100
Metabolic pathways
hie01110
Biosynthesis of secondary metabolites
hie01120
Microbial metabolism in diverse environments
hie01230
Biosynthesis of amino acids
Module
hie_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
hie_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
hie00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
R2846_0554 (thrA)
00270 Cysteine and methionine metabolism
R2846_0554 (thrA)
00300 Lysine biosynthesis
R2846_0554 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
R2846_0554 (thrA)
Enzymes [BR:
hie01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
R2846_0554 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
R2846_0554 (thrA)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
NAD_binding_3
ACT_7
ACT
Motif
Other DBs
NCBI-ProteinID:
ADO95980
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All DBs
Position
559957..562404
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AA seq
815 aa
AA seq
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MRVLKFGGTSLANPERFSQAAKLIEQAHLEEQAAGVLSAPAKITNHLVALSEKAALNQST
DTHFNEAIEIFYNIINGLHAENNQFDLNGTKALIDAEFAQIKGLLEEIRQAGKVEDAVKA
TIDCRGEKLSIAMMKAWFEARGYSVHIVDPVKQLLAKGGYLESSVEIEESTKRVDAASIA
KDKVVLMAGFTAGNEKGELVLLGRNGSDYSAACLAACLGASVCEIWTDVDGVYTCDPRLV
PDARLLPTLSYREAMELSYFGAKVIHPRTIGPLLPQNIPCVIKNTGNPSAPGSIIDGNVK
SESLQVKGITNLDNLAMFNVSGPGMQGMVGMASRVFSAMSGAGISVILITQSSSEYSISF
CVPVKSAEVAKTVLETEFANELNEHQLESIEVIKDLSIISVVGDGMKQAKGIAARFFSAL
AQANISIVAIAQGSSERSISAVVPQNKAIEAVKATHQALFNNKKVVDMFLVGVGGVGGEL
IEQVKRQKEYLAKKNVEIRVCAIANSNRMLLDENGLNLEDWKNDLENATQPSDFDVLLSF
IKLHHVVNPVFVDCTSAESVAGLYARALKEGFHVVTPNKKANTRELVYYNELRQNAQASQ
HKFLYETNVGAGLPVIENLQNLLAAGDELEYFEGILSGSLSFIFGKLEEGLSLSEVTALA
REKGFTEPDPRDDLSGQDVARKLLILAREAGIELELSDVEVEGVLPKGFSDGKSADEFMA
MLPQLDEEFKTRVATAKAEGKVLRYVGKISEGKCKVSIVAVDLNNPLYKVKDGENALAFY
TRYYQPIPLLLRGYGAGNAVTAAGIFADILRTLQH
NT seq
2448 nt
NT seq
+upstream
nt +downstream
nt
atgcgcgtacttaaatttggcggcacttcgcttgcaaatccggaacgtttttcccaagcg
gcgaaattgatcgagcaagctcatttagaagagcaggctgcaggtgttttatcagcacca
gccaaaataaccaaccatctcgtcgccctttctgaaaaagctgcattaaatcaatcaacc
gatacgcatttcaacgaagcaatcgaaattttctataacatcattaatggcttacatgcc
gaaaataatcaattcgacttaaatggcaccaaggcacttattgatgctgaatttgctcaa
atcaaaggattattagaagaaattcgtcaggcaggaaaagtagaagatgcagttaaagcg
accattgattgccgtggggaaaaactttctattgcaatgatgaaagcttggtttgaagca
cgtggctatagcgtacatattgtggatccggtcaagcaattattagcaaaaggcggttat
cttgagtcttcagttgaaattgaagaatcaacaaaacgtgttgatgcagcaagtattgca
aaagataaagtggtgctgatggcaggttttactgcgggtaatgaaaaaggcgagttggta
ttgctcggtcgtaatggctcagactattctgcagcctgtttagccgcttgtttaggcgca
agtgtatgcgaaatttggaccgatgtggacggcgtttatacttgcgatccgcgtttagtg
cctgatgcacgtttattaccaacgctttcttatcgtgaagcgatggaactctcttatttc
ggtgcgaaagtgattcatcctcgtacgattgggccattgttgccacaaaatattccttgt
gtcattaaaaatacaggaaatccttctgcgccaggttcgattattgatggcaatgtgaaa
tcagaaagtttgcaagttaaaggtatcactaacttagacaatttggcgatgtttaatgtg
tcaggccctggtatgcaaggtatggtaggcatggcatctcgcgtattttcagccatgtca
ggtgcaggcatttcagttattttaattactcagtcttcgtctgaatatagtattagtttc
tgtgtgcctgtgaaatctgcagaagtagcgaaaaccgtactagaaacggagtttgctaat
gaattaaatgaacatcaattagaatcaattgaagtgattaaagatttatccattatttct
gttgtgggcgatggaatgaagcaagcgaaaggcattgctgctcgtttcttctcggcatta
gcgcaggcaaacattagcattgtggcgattgcacaaggatctagcgaacgttcaatttct
gcggttgtgccgcaaaataaagccattgaagcggtgaaggctacccatcaggcgcttttc
aataataaaaaagtcgtggatatgtttttagtgggcgttggcggagtaggcggagaatta
attgagcaggtaaagcgtcaaaaggagtatctagcaaagaagaatgttgaaattcgagtt
tgtgctattgcgaattccaaccgtatgttgcttgatgaaaatggattaaatttagaggat
tggaaaaacgatttagaaaatgcgactcagccatcagattttgatgtattgctttctttc
attaaattacatcatgtggtgaatccagtatttgtagattgtacttcagccgaatctgta
gcagggctttatgctcgtgcgttaaaagaaggtttccatgtggttacgccaaacaaaaaa
gcgaatacacgagaattagtttattacaatgagttacgccaaaatgcccaagcaagccag
cataaatttttatatgaaaccaatgtaggtgcgggcttgccagttattgaaaatctccaa
aacttacttgcagcaggtgatgagcttgaatattttgaagggattttatctggctcgctt
tcctttatttttggtaagttggaagaaggactttctctttcagaagtaaccgcacttgcg
cgtgaaaaaggctttactgagccagatcctcgagatgatctttctggacaagatgtagca
cgcaaattattaattcttgctcgtgaagcgggaattgaacttgaactttcagatgttgaa
gttgaaggtgtattgccgaaaggcttctccgatggaaaatctgcagatgagtttatggca
atgttgccacagcttgacgaggagtttaaaactcgcgttgccacagctaaagcagaaggc
aaagtattgcgttatgttggaaaaattagtgaaggaaaatgcaaagtatccatcgttgcg
gtagatctgaataatccactttataaagtgaaagatggtgaaaatgccttggcattttat
actcgttattatcaaccgattccacttttattacgtggttatggcgcaggtaatgcagtt
actgcggcaggtatctttgcagatattttaagaacattacaacattaa
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