Haemophilus influenzae 477: NTHI477_01119
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Entry
NTHI477_01119 CDS
T03720
Symbol
thrA
Name
(GenBank) Aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
hiw
Haemophilus influenzae 477
Pathway
hiw00260
Glycine, serine and threonine metabolism
hiw00261
Monobactam biosynthesis
hiw00270
Cysteine and methionine metabolism
hiw00300
Lysine biosynthesis
hiw01100
Metabolic pathways
hiw01110
Biosynthesis of secondary metabolites
hiw01120
Microbial metabolism in diverse environments
hiw01230
Biosynthesis of amino acids
Module
hiw_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
hiw_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
hiw00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
NTHI477_01119 (thrA)
00270 Cysteine and methionine metabolism
NTHI477_01119 (thrA)
00300 Lysine biosynthesis
NTHI477_01119 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
NTHI477_01119 (thrA)
Enzymes [BR:
hiw01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
NTHI477_01119 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
NTHI477_01119 (thrA)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
NAD_binding_3
ACT_7
ACT
CCB1
Motif
Other DBs
NCBI-ProteinID:
AJO88122
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All DBs
Position
complement(1152977..1155424)
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AA seq
815 aa
AA seq
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MRVLKFGGTSLANPERFSQAAKLIEQAHLEEQAAGVLSAPAKITNHLVALSEKAALNQPT
DTHFNEAIEIFYNIINGLHTENNQFDLNGTKALIDAEFVQIKGLLEEIRQAGKVEDAVKA
TIDCRGEKLSIAMMKAWFEARGYRVHIVDPVKQLLAKGGYLESSVEIEESTKRVDAANIE
KDKVVLMAGFTAGNEKGELVLLGRNGSDYSAACLAACLGASVCEIWTDVDGVYTCDPRLV
PDARLLPTLSYREAMELSYFGAKVIHPRTIGPLLPQNIPCVIKNTGNPSAPGSIIDGNVK
SESLQVKGITNLDNLAMFNVSGPGMQGMVGMASRVFSAMSGAGISVILITQSSSEYSISF
CVPVKSAEVAKTVLETEFANELNEHQLEPIEVIKDLSIISVVGDGMKKAKGIAARFFSAL
AQANISIVAIAQGSSERSISAVVPQNKAIEAVKATHQALFNNKKVVDMFLVGVGGVGGEL
IEQVKSQKEYLAKKNVEIRVCAIANSNRMLLDENGLNLEDWKTDLENATQPSDFDVLLSF
IKLHHVVNPVFVDCTSAESVAGLYARALKEGFHVVTPNKKANTRELAYYNELRQNAQESQ
HKFLYETNVGAGLPVIENLQNLLAAGDELEYFEGILSGSLSFIFGKLEEGFSLSEVTALA
REKGFTEPDPRDDLSGQDVARKLLILAREAGMALDLSGVEIEGVLPKGFSEGKSADEFMT
MLPQLDEEFKARVSTAKAEGKVLRYVGKIYEGKCKVSIVAVDQNNPLYKVKDGENALAFY
TRYYQPIPLLLRGYGAGNAVTAAGIFADILRTLQH
NT seq
2448 nt
NT seq
+upstream
nt +downstream
nt
atgcgcgtacttaaatttggcggcacttcgcttgcaaatccggaacgtttttcccaagct
gcgaaattgatcgagcaagctcatttagaagagcaggctgctggtgttttatcagcacca
gccaaaataactaatcatcttgtcgccctttctgaaaaagctgcattaaatcaaccaact
gatacacatttcaacgaagcaatcgaaattttctataacatcatcaatggtttacatacc
gaaaataatcaattcgacttaaatggcaccaaagcccttattgatgctgaatttgttcaa
attaaaggattactagaggaaattcgtcaggcaggaaaagtagaagatgcagttaaagcg
accattgattgccgtggtgaaaaactttctatcgcaatgatgaaagcttggtttgaagcg
cgtggctatcgcgtacatattgtggatcctgtcaaacaattattagcaaaaggcggttat
cttgagtcttctgttgaaattgaagaatcaacaaaacgtgttgatgcagcaaatatcgaa
aaagataaagtggtgctgatggcaggttttactgcaggtaatgaaaaaggcgaattggtg
ttgctaggtcgtaatggctcagactattctgctgcctgtttagccgcttgtttaggcgca
agcgtatgcgaaatttggaccgatgtggatggcgtttatacttgcgatccgcgtttagtg
cctgatgcacgtttattaccaacgctttcttatcgtgaagcgatggaactttcttatttc
ggtgcgaaagtgattcatcctcgtacgattggcccattgttgcctcaaaatattccttgt
gtcattaaaaatacaggaaatccttctgcgccgggttcgattattgatggcaatgtgaaa
tcagaaagtttgcaagttaaaggtattactaacttagacaatttggctatgtttaatgta
tcaggccctggtatgcaaggcatggtaggcatggcatctcgcgtattttcagctatgtca
ggcgcaggtatttcagtcatcttaattacccagtcttcatctgaatatagtattagtttc
tgcgtgccagtgaaatctgcagaagtcgcaaaaaccgtgttagaaactgagtttgctaat
gaattaaacgaacatcaattagaaccaattgaagtgattaaagatttgtctattatttct
gtggtgggcgatggaatgaagaaagcaaaaggtattgctgctcgtttcttctctgcgtta
gcacaggcaaatattagcattgtggcaattgcacaaggttctagcgaacgttcaatttct
gcagttgtgccgcaaaataaagcgattgaagcagtgaaagctacccatcaggcacttttc
aataataaaaaagtcgtggatatgtttttagtgggcgttggtggcgtcggcggagaatta
atagagcaggtaaagagccaaaaggagtatttagcaaagaagaatgttgaaattcgtgtc
tgtgctatagcaaattctaatcgtatgttacttgatgaaaatggattaaatttagaggat
tggaaaaccgatttagaaaatgcgactcagccatcagattttgatgtattgctttctttc
attaaattacatcatgtggtaaaccctgtatttgtagattgtacttcggcggagtctgtc
gcagggctttatgctcgcgcattaaaagaaggtttccatgtggtcacaccaaataaaaaa
gcgaatacacgagaattagcatattacaatgaattacgtcaaaacgctcaagaaagccag
cataaattcttgtatgaaactaatgtgggcgcaggtttaccagttattgaaaatcttcaa
aacttacttgctgcgggcgatgagcttgagtattttgaaggtattttatctggctccctt
tcctttatttttggtaaattagaagaaggattttctctttcagaagtcaccgcacttgcg
cgtgaaaaaggctttactgagcccgatcctcgagatgatctttctggacaagatgtcgca
cgaaaattattaattcttgctcgtgaagctggaatggcacttgatctttcaggtgttgaa
attgaaggtgtattgccgaaaggcttctctgaaggaaaatctgcagatgaatttatgaca
atgttgccacagcttgatgaagaatttaaagctcgtgtttccaccgctaaagctgaaggt
aaagtattgcgttatgttggaaaaatttatgaaggtaaatgcaaagtatccattgttgca
gtggatcagaataacccactttataaagtaaaagatggcgaaaatgctttagcattttac
actcgttattatcaaccgattccacttttattacgtggttatggtgctggaaatgcggtt
actgcggcaggtatctttgcagatattttaagaacattacaacattaa
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