KEGG   Homo sapiens (human): 1022
Entry
1022              CDS       T01001                                 
Symbol
CDK7, CAK, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15
Name
(RefSeq) cyclin dependent kinase 7
  KO
K02202  cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03022  Basal transcription factors
hsa03420  Nucleotide excision repair
hsa04110  Cell cycle
Network
nt06502  Nucleotide excision repair
  Element
N01425  Global genome NER
N01430  Transcription-coupled NER
Drug target
Alvocidib (DG02041): D02880 D09868
Zotiraciclib (DG03058): D11599 D11600
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03022 Basal transcription factors
    1022 (CDK7)
  09124 Replication and repair
   03420 Nucleotide excision repair
    1022 (CDK7)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1022 (CDK7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1022 (CDK7)
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    1022 (CDK7)
   03019 Messenger RNA biogenesis [BR:hsa03019]
    1022 (CDK7)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    1022 (CDK7)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     1022 (CDK7)
    2.7.11.23  [RNA-polymerase]-subunit kinase
     1022 (CDK7)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  CDK family
   1022 (CDK7)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Basal transcription factors
    TFIIH
     1022 (CDK7)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA processing factors
   5' end processing
    Capping factors
     1022 (CDK7)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    TFIIH complex
     1022 (CDK7)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like Seadorna_VP7 ABC1 Haspin_kinase FTA2 APH Pkinase_fungal
Other DBs
NCBI-GeneID: 1022
NCBI-ProteinID: NP_001790
OMIM: 601955
HGNC: 1778
Ensembl: ENSG00000134058
UniProt: P50613 A0A0S2Z3F9
Structure
LinkDB
Position
5:69234795..69277430
AA seq 346 aa
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
NT seq 1041 nt   +upstreamnt  +downstreamnt
atggctctggacgtgaagtctcgggcaaagcgttatgagaagctggacttccttggggag
ggacagtttgccaccgtttacaaggccagagataagaacaccaaccaaattgtcgccatt
aagaaaatcaaacttggacatagatcagaagctaaagatggtataaatagaaccgcctta
agagagataaaattattacaggagctaagtcatccaaatataattggtctccttgatgct
tttggacataaatctaatattagccttgtctttgattttatggaaactgatctagaggtt
ataataaaggataatagtcttgtgctgacaccatcacacatcaaagcctacatgttgatg
actcttcaaggattagaatatttacatcaacattggatcctacatagggatctgaaacca
aacaacttgttgctagatgaaaatggagttctaaaactggcagattttggcctggccaaa
tcttttgggagccccaatagagcttatacacatcaggttgtaaccaggtggtatcgggcc
cccgagttactatttggagctaggatgtatggtgtaggtgtggacatgtgggctgttggc
tgtatattagcagagttacttctaagggttccttttttgccaggagattcagaccttgat
cagctaacaagaatatttgaaactttgggcacaccaactgaggaacagtggccggacatg
tgtagtcttccagattatgtgacatttaagagtttccctggaatacctttgcatcacatc
ttcagtgcagcaggagacgacttactagatctcatacaaggcttattcttatttaatcca
tgtgctcgaattacggccacacaggcactgaaaatgaagtatttcagtaatcggccaggg
ccaacacctggatgtcagctgccaagaccaaactgtccagtggaaaccttaaaggagcaa
tcaaatccagctttggcaataaaaaggaaaagaacagaggccttagaacaaggaggattg
cccaagaaactaattttttaa

KEGG   Homo sapiens (human): 902
Entry
902               CDS       T01001                                 
Symbol
CCNH, CAK, CycH, p34, p37
Name
(RefSeq) cyclin H
  KO
K06634  cyclin H
Organism
hsa  Homo sapiens (human)
Pathway
hsa03022  Basal transcription factors
hsa03420  Nucleotide excision repair
hsa04110  Cell cycle
Network
nt06502  Nucleotide excision repair
  Element
N01425  Global genome NER
N01430  Transcription-coupled NER
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03022 Basal transcription factors
    902 (CCNH)
  09124 Replication and repair
   03420 Nucleotide excision repair
    902 (CCNH)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    902 (CCNH)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    902 (CCNH)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    902 (CCNH)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Basal transcription factors
    TFIIH
     902 (CCNH)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    TFIIH complex
     902 (CCNH)
SSDB
Motif
Pfam: Cyclin_C_2 Cyclin_N Cyclin_C CycT2-like_C
Other DBs
NCBI-GeneID: 902
NCBI-ProteinID: NP_001230
OMIM: 601953
HGNC: 1594
Ensembl: ENSG00000134480
UniProt: P51946
Structure
LinkDB
Position
5:complement(87311471..87412930)
AA seq 323 aa
MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYY
EKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNV
SSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPI
LENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKE
NRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDD
DYVSKKSKHEEEEWTDDDLVESL
NT seq 972 nt   +upstreamnt  +downstreamnt
atgtaccacaacagtagtcagaagcggcactggaccttctccagcgaggagcagctggca
agactgcgggctgacgccaaccgcaaattcagatgcaaagccgtggccaacgggaaggtt
cttccgaatgatccagtctttcttgagcctcatgaagaaatgacactctgcaaatactat
gagaaaaggttattggaattctgttcggtgtttaagccagcaatgccaagatctgttgtg
ggtacggcttgtatgtatttcaaacgtttttatcttaataactcagtaatggaatatcac
cccaggataataatgctcacttgtgcatttttggcctgcaaagtagatgaattcaatgta
tctagtcctcagtttgttggaaacctccgggagagtcctcttggacaggagaaggcactt
gaacagatactggaatatgaactacttcttatacagcaacttaatttccaccttattgtc
cacaatccttacagaccatttgagggcttcctcatcgacttaaagacccgctatcccata
ttggagaatccagagattttgaggaaaacagctgatgactttcttaatagaattgcattg
acggatgcttaccttttatacacaccttcccaaattgccctgactgccattttatctagt
gcctccagggctggaattactatggaaagttatttatcagagagtctgatgctgaaagag
aacagaacttgcctgtcacagttactagatataatgaaaagcatgagaaacttagtaaag
aagtatgaaccacccagatctgaagaagttgctgttctgaaacagaagttggagcgatgt
cattctgctgagcttgcacttaacgtaatcacgaagaagaggaaaggctatgaagatgat
gattacgtctcaaagaaatccaaacatgaggaggaagaatggactgatgacgacctggta
gaatctctctaa

KEGG   Homo sapiens (human): 4331
Entry
4331              CDS       T01001                                 
Symbol
MNAT1, CAP35, MAT1, RNF66, TFB3
Name
(RefSeq) MNAT1 component of CDK activating kinase
  KO
K10842  CDK-activating kinase assembly factor MAT1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03022  Basal transcription factors
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
  Element
N01425  Global genome NER
N01430  Transcription-coupled NER
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03022 Basal transcription factors
    4331 (MNAT1)
  09124 Replication and repair
   03420 Nucleotide excision repair
    4331 (MNAT1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    4331 (MNAT1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    4331 (MNAT1)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Basal transcription factors
    TFIIH
     4331 (MNAT1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    TFIIH complex
     4331 (MNAT1)
SSDB
Motif
Pfam: MAT1 zf-C3HC4_5 zf-RING_5 zf-C3HC4 zf-RING_UBOX zf-RING_2 zf-C3HC4_2 zf-UDP TRAF3_RING DZR_2 DNA_ligase_ZBD zinc-ribbons_6 zf-P11 LMBR1 zf-RING_4 Poty_PP DUF1272
Other DBs
NCBI-GeneID: 4331
NCBI-ProteinID: NP_002422
OMIM: 602659
HGNC: 7181
Ensembl: ENSG00000020426
UniProt: P51948 A0A024R688
Structure
LinkDB
Position
14:60734761..60969965
AA seq 309 aa
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV
QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK
KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK
QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK
LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA
FSGLFWQPS
NT seq 930 nt   +upstreamnt  +downstreamnt
atggacgatcagggttgccctcggtgtaagaccaccaaatatcggaacccctccttgaag
ctgatggtgaatgtgtgcggacacactctctgtgaaagttgtgtagatttactgtttgtg
agaggagctggaaactgccctgagtgtggtactccactcagaaagagcaacttcagggta
caactctttgaagatcccactgttgacaaggaggttgagatcaggaaaaaagtgctaaag
atatacaataaaagggaagaagattttcctagtctaagagaatacaatgatttcttggaa
gaagtggaagaaattgttttcaacttgaccaacaatgtggatttggacaacaccaaaaag
aaaatggagatataccaaaaggaaaacaaagatgttattcagaaaaataaattaaagctg
actcgagaacaggaagaactggaagaagctttagaagtggaacgacaggaaaatgaacaa
agaagattatttatacaaaaagaagaacaactgcagcagattctaaaaaggaagaataag
caggcttttttagatgagctggagagttctgatctccctgttgctctgcttttggctcag
cataaagatagatctacccaattagaaatgcaacttgagaaacccaaacctgtaaaacca
gtgacgttttccacaggcatcaaaatgggtcaacatatttcactggcacctattcacaag
cttgaagaagctctgtatgaataccagccactgcagatagagacatatggaccacatgtt
cctgagcttgagatgctaggaagacttgggtatttaaaccatgtcagagctgcctcacca
caggaccttgctggaggctatacttcttctcttgcttgtcacagagcactacaggatgca
ttcagtgggcttttctggcagcccagttaa

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