Homo sapiens (human): 1111
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Entry
1111 CDS
T01001
Symbol
CHEK1, CHK1, OZEMA21
Name
(RefSeq) checkpoint kinase 1
KO
K02216
serine/threonine-protein kinase CHEK1 [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04110
Cell cycle
hsa04115
p53 signaling pathway
hsa04218
Cellular senescence
hsa05166
Human T-cell leukemia virus 1 infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05203
Viral carcinogenesis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06230
Cell cycle (cancer)
nt06506
Double-strand break repair
Element
N00455
CDC25-Cell cycle G2/M
N00456
HIV Vpr to CDC25-cell cycle G2M
N00459
WEE1-Cell cycle G2/M
N00499
ATR-p21-Cell cycle G2/M
N00500
HTLV-1 Tax to p21-cell cycle G2/M
N01451
ATR signaling
Disease
H01897
Oocyte/zygote/embryo maturation arrest
Drug target
Prexasertib:
D11206
Rabusertib:
D10397
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
1111 (CHEK1)
04115 p53 signaling pathway
1111 (CHEK1)
04218 Cellular senescence
1111 (CHEK1)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
1111 (CHEK1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
1111 (CHEK1)
05170 Human immunodeficiency virus 1 infection
1111 (CHEK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
1111 (CHEK1)
09182 Protein families: genetic information processing
03400 DNA repair and recombination proteins [BR:
hsa03400
]
1111 (CHEK1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
1111 (CHEK1)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: CAMK group
CAMKL family
1111 (CHEK1)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic type
Check point factors
Other check point factors
1111 (CHEK1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Kinase-like
ABC1
Pkinase_fungal
Motif
Other DBs
NCBI-GeneID:
1111
NCBI-ProteinID:
NP_001107593
OMIM:
603078
HGNC:
1925
Ensembl:
ENSG00000149554
UniProt:
O14757
B4DT73
Structure
PDB
LinkDB
All DBs
Position
11:125625136..125681124
Genome browser
AA seq
476 aa
AA seq
DB search
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
NT seq
1431 nt
NT seq
+upstream
nt +downstream
nt
atggcagtgccctttgtggaagactgggacttggtgcaaaccctgggagaaggtgcctat
ggagaagttcaacttgctgtgaatagagtaactgaagaagcagtcgcagtgaagattgta
gatatgaagcgtgccgtagactgtccagaaaatattaagaaagagatctgtatcaataaa
atgctaaatcatgaaaatgtagtaaaattctatggtcacaggagagaaggcaatatccaa
tatttatttctggagtactgtagtggaggagagctttttgacagaatagagccagacata
ggcatgcctgaaccagatgctcagagattcttccatcaactcatggcaggggtggtttat
ctgcatggtattggaataactcacagggatattaaaccagaaaatcttctgttggatgaa
agggataacctcaaaatctcagactttggcttggcaacagtatttcggtataataatcgt
gagcgtttgttgaacaagatgtgtggtactttaccatatgttgctccagaacttctgaag
agaagagaatttcatgcagaaccagttgatgtttggtcctgtggaatagtacttactgca
atgctcgctggagaattgccatgggaccaacccagtgacagctgtcaggagtattctgac
tggaaagaaaaaaaaacatacctcaacccttggaaaaaaatcgattctgctcctctagct
ctgctgcataaaatcttagttgagaatccatcagcaagaattaccattccagacatcaaa
aaagatagatggtacaacaaacccctcaagaaaggggcaaaaaggccccgagtcacttca
ggtggtgtgtcagagtctcccagtggattttctaagcacattcaatccaatttggacttc
tctccagtaaacagtgcttctagtgaagaaaatgtgaagtactccagttctcagccagaa
ccccgcacaggtctttccttatgggataccagcccctcatacattgataaattggtacaa
gggatcagcttttcccagcccacatgtcctgatcatatgcttttgaatagtcagttactt
ggcaccccaggatcctcacagaacccctggcagcggttggtcaaaagaatgacacgattc
tttaccaaattggatgcagacaaatcttatcaatgcctgaaagagacttgtgagaagttg
ggctatcaatggaagaaaagttgtatgaatcaggttactatatcaacaactgataggaga
aacaataaactcattttcaaagtgaatttgttagaaatggatgataaaatattggttgac
ttccggctttctaagggtgatggattggagttcaagagacacttcctgaagattaaaggg
aagctgattgatattgtgagcagccagaagatttggcttcctgccacatga
Homo sapiens (human): 11200
Help
Entry
11200 CDS
T01001
Symbol
CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, TPDS4, hCds1
Name
(RefSeq) checkpoint kinase 2
KO
K06641
serine/threonine-protein kinase CHEK2 [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04110
Cell cycle
hsa04115
p53 signaling pathway
hsa04218
Cellular senescence
hsa05166
Human T-cell leukemia virus 1 infection
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
Element
N00455
CDC25-Cell cycle G2/M
Disease
H00020
Colorectal cancer
H00036
Osteosarcoma
H00881
Li-Fraumeni syndrome
H02624
Tumor predisposition syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
11200 (CHEK2)
04115 p53 signaling pathway
11200 (CHEK2)
04218 Cellular senescence
11200 (CHEK2)
09160 Human Diseases
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
11200 (CHEK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
11200 (CHEK2)
09182 Protein families: genetic information processing
03400 DNA repair and recombination proteins [BR:
hsa03400
]
11200 (CHEK2)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
11200 (CHEK2)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: CAMK group
RAD53 family
11200 (CHEK2)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic type
Check point factors
Other check point factors
11200 (CHEK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
FHA
Kinase-like
Kdo
ABC1
Haspin_kinase
YrbL-PhoP_reg
Pkinase_fungal
RIO1
APH
Motif
Other DBs
NCBI-GeneID:
11200
NCBI-ProteinID:
NP_009125
OMIM:
604373
HGNC:
16627
Ensembl:
ENSG00000183765
UniProt:
O96017
Structure
PDB
LinkDB
All DBs
Position
22:complement(28687743..28741834)
Genome browser
AA seq
543 aa
AA seq
DB search
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
NT seq
1632 nt
NT seq
+upstream
nt +downstream
nt
atgtctcgggagtcggatgttgaggctcagcagtctcatggcagcagtgcctgttcacag
ccccatggcagcgttacccagtcccaaggctcctcctcacagtcccagggcatatccagc
tcctctaccagcacgatgccaaactccagccagtcctctcactccagctctgggacactg
agctccttagagacagtgtccactcaggaactctattctattcctgaggaccaagaacct
gaggaccaagaacctgaggagcctacccctgccccctgggctcgattatgggcccttcag
gatggatttgccaatcttgaatgtgtgaatgacaactactggtttgggagggacaaaagc
tgtgaatattgctttgatgaaccactgctgaaaagaacagataaataccgaacatacagc
aagaaacactttcggattttcagggaagtgggtcctaaaaactcttacattgcatacata
gaagatcacagtggcaatggaacctttgtaaatacagagcttgtagggaaaggaaaacgc
cgtcctttgaataacaattctgaaattgcactgtcactaagcagaaataaagtttttgtc
ttttttgatctgactgtagatgatcagtcagtttatcctaaggcattaagagatgaatac
atcatgtcaaaaactcttggaagtggtgcctgtggagaggtaaagctggctttcgagagg
aaaacatgtaagaaagtagccataaagatcatcagcaaaaggaagtttgctattggttca
gcaagagaggcagacccagctctcaatgttgaaacagaaatagaaattttgaaaaagcta
aatcatccttgcatcatcaagattaaaaacttttttgatgcagaagattattatattgtt
ttggaattgatggaagggggagagctgtttgacaaagtggtggggaataaacgcctgaaa
gaagctacctgcaagctctatttttaccagatgctcttggctgtgcagtaccttcatgaa
aacggtattatacaccgtgacttaaagccagagaatgttttactgtcatctcaagaagag
gactgtcttataaagattactgattttgggcactccaagattttgggagagacctctctc
atgagaaccttatgtggaacccccacctacttggcgcctgaagttcttgtttctgttggg
actgctgggtataaccgtgctgtggactgctggagtttaggagttattctttttatctgc
cttagtgggtatccacctttctctgagcataggactcaagtgtcactgaaggatcagatc
accagtggaaaatacaacttcattcctgaagtctgggcagaagtctcagagaaagctctg
gaccttgtcaagaagttgttggtagtggatccaaaggcacgttttacgacagaagaagcc
ttaagacacccgtggcttcaggatgaagacatgaagagaaagtttcaagatcttctgtct
gaggaaaatgaatccacagctctaccccaggttctagcccagccttctactagtcgaaag
cggccccgtgaaggggaagccgagggtgccgagaccacaaagcgcccagctgtgtgtgct
gctgtgttgtga
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