KEGG   Homo sapiens (human): 221613
Entry
221613            CDS       T01001                                 
Symbol
H2AC1, H2AA, H2AFR, HIST1H2AA, HISTH2AA, TH2A, bA317E16.2
Name
(RefSeq) H2A clustered histone 1
  KO
K11251  histone H2A
Organism
hsa  Homo sapiens (human)
Pathway
hsa03082  ATP-dependent chromatin remodeling
hsa04217  Necroptosis
hsa04613  Neutrophil extracellular trap formation
hsa05034  Alcoholism
hsa05322  Systemic lupus erythematosus
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03082 ATP-dependent chromatin remodeling
    221613 (H2AC1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    221613 (H2AC1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    221613 (H2AC1)
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    221613 (H2AC1)
  09165 Substance dependence
   05034 Alcoholism
    221613 (H2AC1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    221613 (H2AC1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    221613 (H2AC1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Nucleosome assembly factors
   Histones
    221613 (H2AC1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   221613 (H2AC1)
SSDB
Motif
Pfam: Histone_H2A_C Histone CBFD_NFYB_HMF
Other DBs
NCBI-GeneID: 221613
NCBI-ProteinID: NP_734466
OMIM: 613499
HGNC: 18729
Ensembl: ENSG00000164508
UniProt: Q96QV6
Structure
LinkDB
Position
6:complement(25726063..25726562)
AA seq 131 aa
MSGRGKQGGKARAKSKSRSSRAGLQFPVGRIHRLLRKGNYAERIGAGAPVYLAAVLEYLT
AEILELAGNASRDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK
TESHHHKAQSK
NT seq 396 nt   +upstreamnt  +downstreamnt
atgtctggacgagggaagcagggaggaaaagcacgcgccaagtctaagtctcgctcttct
agagcgggtttgcagtttcccgtaggccggatccatcgtctgcttcgtaagggaaactat
gcagagcggataggggcaggcgcaccagtgtatttggcggcagtgttagagtatctcaca
gcagaaatccttgagctggcaggcaatgcgtctcgcgataacaaaaaaactcgcattatt
ccccgccacctgcagctagcgatccgcaatgatgaggaactcaataagcttttgggcggc
gtgaccattgcccagggcggagtcctgcctaacattcaggcagtgctgctgcccaagaag
actgagagtcaccaccataaagcccaaagcaagtaa

KEGG   Homo sapiens (human): 8335
Entry
8335              CDS       T01001                                 
Symbol
H2AC4, H2A/m, H2AC8, H2AFM, HIST1H2AB
Name
(RefSeq) H2A clustered histone 4
  KO
K11251  histone H2A
Organism
hsa  Homo sapiens (human)
Pathway
hsa03082  ATP-dependent chromatin remodeling
hsa04217  Necroptosis
hsa04613  Neutrophil extracellular trap formation
hsa05034  Alcoholism
hsa05322  Systemic lupus erythematosus
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03082 ATP-dependent chromatin remodeling
    8335 (H2AC4)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    8335 (H2AC4)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    8335 (H2AC4)
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    8335 (H2AC4)
  09165 Substance dependence
   05034 Alcoholism
    8335 (H2AC4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    8335 (H2AC4)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    8335 (H2AC4)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Nucleosome assembly factors
   Histones
    8335 (H2AC4)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   8335 (H2AC4)
SSDB
Motif
Pfam: Histone_H2A_C Histone CBFD_NFYB_HMF Ribosomal_L27A
Other DBs
NCBI-GeneID: 8335
NCBI-ProteinID: NP_003504
OMIM: 602795
HGNC: 4734
Ensembl: ENSG00000278463
UniProt: P04908 Q08AJ9
Structure
LinkDB
Position
6:complement(26033092..26033618)
AA seq 130 aa
MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKK
TESHHKAKGK
NT seq 393 nt   +upstreamnt  +downstreamnt
atgtctggtcgcggcaaacaaggcggtaaagctcgcgccaaggctaagactcggtcttct
cgtgcaggtttgcagtttcctgtgggccgagtgcaccgcctgctccgcaaaggcaactac
tccgagcgcgtcggggctggcgcgccggtgtatctcgcggcggtgcttgagtacctgacc
gccgagatcctggagctggcgggcaatgcggcccgcgacaacaagaagacccgcatcatc
ccgcgccacctgcaattggccatccgcaatgacgaggagcttaataaactcttggggcgt
gtgaccatcgcgcagggtggcgttttgcctaatattcaggcggtgctgctgcctaagaaa
actgagagccatcataaggccaagggaaagtga

KEGG   Homo sapiens (human): 7314
Entry
7314              CDS       T01001                                 
Symbol
UBB, HEL-S-50
Name
(RefSeq) ubiquitin B
  KO
K04551  ubiquitin B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
nt06509  DNA replication
nt06523  Epigenetic regulation by Polycomb complexes
nt06532  Autophagy
  Element
N01027  UCHL1-mediated hydrolysis
N01028  Mutation-inactivated UCHL1 to UCHL1-mediated hydrolysis
N01029  26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01464  Fanconi anemia pathway
N01465  Lesion bypass by TLS and DSB formation
N01466  Homologous recombination in ICLR
N01473  DNA replication termination
N01474  TRAIP-dependent replisome disassembly
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
N01636  Loading of the SMC5-SMC6 complex
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    7314 (UBB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    7314 (UBB)
   04137 Mitophagy - animal
    7314 (UBB)
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    7314 (UBB)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    7314 (UBB)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    7314 (UBB)
   05022 Pathways of neurodegeneration - multiple diseases
    7314 (UBB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    7314 (UBB)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    7314 (UBB)
Ubiquitin system [BR:hsa04121]
 Ubiquitins and ubiquitin-like proteins
  Ubiquitins
   7314 (UBB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of breast milk
   7314 (UBB)
  Exosomal proteins of other body fluids (saliva and urine)
   7314 (UBB)
  Exosomal proteins of colorectal cancer cells
   7314 (UBB)
  Exosomal proteins of bladder cancer cells
   7314 (UBB)
SSDB
Motif
Pfam: ubiquitin Rad60-SLD Ubiquitin_2 DUF2604 Rad60-SLD_2 TBK1_ULD Ubiquitin_5 Dsc3_N OTU1_UBXL Sde2_N_Ubi
Other DBs
NCBI-GeneID: 7314
NCBI-ProteinID: NP_001268645
OMIM: 191339
HGNC: 12463
Ensembl: ENSG00000170315
UniProt: P0CG47 Q5U5U6
Structure
LinkDB
Position
17:16380779..16382745
AA seq 229 aa
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLI
FAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKA
KIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGC
NT seq 690 nt   +upstreamnt  +downstreamnt
atgcagatcttcgtgaaaacccttaccggcaagaccatcacccttgaggtggagcccagt
gacaccatcgaaaatgtgaaggccaagatccaggataaggaaggcattccccccgaccag
cagaggctcatctttgcaggcaagcagctggaagatggccgtactctttctgactacaac
atccagaaggagtcgaccctgcacctggtcctgcgtctgagaggtggtatgcagatcttc
gtgaagaccctgaccggcaagaccatcaccctggaagtggagcccagtgacaccatcgaa
aatgtgaaggccaagatccaggataaagaaggcatccctcccgaccagcagaggctcatc
tttgcaggcaagcagctggaagatggccgcactctttctgactacaacatccagaaggag
tcgaccctgcacctggtcctgcgtctgagaggtggtatgcagatcttcgtgaagaccctg
accggcaagaccatcactctggaggtggagcccagtgacaccatcgaaaatgtgaaggcc
aagatccaagataaagaaggcatcccccccgaccagcagaggctcatctttgcaggcaag
cagctggaagatggccgcactctttctgactacaacatccagaaagagtcgaccctgcac
ctggtcctgcgcctgaggggtggctgttaa

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