Homo sapiens (human): 23418
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Entry
23418 CDS
T01001
Symbol
CRB1, CRB1-A, CRB1-B, CRB1-C, LCA8, RP12
Name
(RefSeq) protein crumbs homolog 1 isoform 1 precursor
KO
K16681
protein crumbs
Organism
hsa
Homo sapiens (human)
Pathway
hsa04390
Hippo signaling pathway
Disease
H00527
Retinitis pigmentosa
H00837
Leber congenital amaurosis
H01088
Pigmented paravenous chorioretinal atrophy
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04390 Hippo signaling pathway
23418 (CRB1)
SSDB
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Paralog
GFIT
Motif
Pfam:
EGF
Laminin_G_2
hEGF
EGF_TEN
Laminin_G_1
EGF_CA
EGF_3
EGF_2
EGF_Teneurin
JAG1-like_EGF2
SH3_6
Motif
Other DBs
NCBI-GeneID:
23418
NCBI-ProteinID:
NP_957705
OMIM:
604210
HGNC:
2343
Ensembl:
ENSP00000356370.3
UniProt:
P82279
A0A7D6VM04
Structure
PDB
PDBj
LinkDB
All DBs
Position
1:197201504..197478455
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AA seq
1406 aa
AA seq
DB search
MALKNINYLLIFYLSFSLLIYIKNSFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTA
NNLDKDCDNMKDPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQ
HGGICHQDPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQG
RHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQ
DALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCET
LMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSE
KQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYT
CHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLC
EIATTLSFEGDGFLWVKSGSVTTKGSVCNIALRFQTVQPMALLLFRSNRDVFVKLELLSG
YIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLE
SDQSICAFQNSFLGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISS
GSSLNVKAGCVRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDD
STGYVIFTLDESYGDTISLSMFVRTLQPSGLLLALENSTYQYIRVWLERGRLAMLTPNSP
KLVVKFVLNDGNVHLISLKIKPYKIELYQSSQNLGFISASTWKIEKGDVIYIGGLPDKQE
TELNGGFFKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQGCAGDNSCKSNPCHNGG
VCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQCQPVLQGFECIANAVFNGQSGQ
ILFRSNGNITRELTNITFGFRTRDANVIILHAEKEPEFLNISIQDSRLFFQLQSGNSFYM
LSLTSLQSVNDGTWHEVTLSMTDPLSQTSRWQMEVDNETPFVTSTIATGSLNFLKDNTDI
YVGDRAIDNIKGLQGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNSVVTGCLQL
NVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAYHC
TCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCG
NEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQ
CLCDVAFAGERCEVDLADDLISDIFTTIGSVTVALLLILLLAIVASVVTSNKRATQGTYS
PSRQEKEGSRVEMWNLMPPPAMERLI
NT seq
4221 nt
NT seq
+upstream
nt +downstream
nt
atggcacttaagaacattaactaccttctcatcttctacctcagtttctcactgcttatc
tacataaaaaattccttttgcaataaaaacaacaccaggtgcctctcaaattcttgccaa
aacaattctacatgcaaagatttttcaaaagacaatgattgttcttgttcagacacagcc
aataatttggacaaagactgtgacaacatgaaagacccttgcttctccaatccctgtcaa
ggaagtgccacttgtgtgaacaccccaggagaaaggagctttctgtgcaaatgtcctcct
gggtacagtgggacaatctgtgaaactaccattggttcctgtggcaagaactcctgccaa
catggaggtatttgccatcaggaccctatttatcctgtctgcatctgccctgctggatat
gctggaagattctgtgagatagatcacgatgagtgtgcttccagcccttgccaaaatggg
gccgtgtgccaggatggaattgatggttactcctgcttctgtgtcccaggatatcaaggc
agacactgcgacttggaagtggatgaatgtgcttcagatccctgcaagaacgaggctaca
tgcctcaatgaaataggaagatatacttgtatctgtccccacaattattctggtgtaaac
tgtgaattggaaattgacgaatgttggtcccagccttgtttaaatggtgcaacttgtcag
gatgctctgggggcctatttctgcgactgtgcccctggattcctgggggatcactgtgaa
ctcaacactgatgagtgtgccagtcaaccttgtctccatggagggctgtgtgtggatgga
gaaaacagatatagctgtaactgcacgggtagtggattcacagggacacactgtgagacc
ttgatgcctctttgttggtcaaaaccttgtcacaataatgctacatgtgaggacagtgtt
gacaattacacttgtcactgctggcctggatacacaggtgcccagtgtgagatcgacctc
aatgaatgcaatagtaacccctgccagtccaatggggaatgtgtggagctgtcctcagag
aaacaatatggacgcatcactggactgccttcttctttcagctaccatgaagcctcaggt
tatgtctgtatctgtcagcctggattcacaggaatccactgcgaagaagacgtcaatgaa
tgttcttcaaacccttgccaaaatggtggtacttgtgagaacttgcctgggaattatact
tgccattgcccatttgataacctttctagaactttttatggaggaagggactgttctgat
attctcctgggctgtacccatcagcaatgtctaaataatggaacatgcatccctcacttc
caagatggccagcatggattcagctgcctatgtccatctggctacaccgggtccctgtgt
gaaatcgcaaccacactttcatttgagggcgatggcttcctgtgggtcaaaagtggctca
gtgacaaccaagggctcagtttgtaacatagccctcaggtttcagactgttcagccaatg
gctcttctacttttccgaagcaacagggatgtgtttgtgaagctggagctgctaagtggc
tacattcacttatcaattcaggtcaataatcagtcaaaggtgcttctgttcatttcccac
aacaccagcgatggagagtggcatttcgtggaggtaatatttgcagaggctgtgaccctt
accttaatcgacgactcctgtaaggagaaatgcatcgcgaaagctcctactccacttgaa
agtgatcaatcaatatgtgcttttcagaactcctttttgggtggtttaccagtgggaatg
accagcaatggtgttgctctgcttaacttctataatatgccatccacaccttcgtttgta
ggctgtctccaagacattaaaattgattggaatcacattaccctggagaacatctcgtct
ggctcatcattaaatgtcaaggcaggctgtgtgagaaaggattggtgtgaaagccaacct
tgtcaaagcagaggacgctgcatcaacttgtggctgagttaccagtgtgactgccacagg
ccctatgaaggccccaactgtctgagagagtatgtggcaggcagatttggccaggatgac
tccactggttatgtcatctttactcttgatgagagctatggagacaccatcagcctctcc
atgtttgtccgaacgcttcaaccatcaggcttacttctagctttggaaaacagcacttat
caatatatccgtgtctggctagagcgcggcagactagcaatgctgactccaaactctccc
aaattagtagtaaaatttgttcttaatgatggaaatgtccacttgatatctttgaaaatc
aagccatataaaattgaactgtatcagtcttcacaaaacctaggatttatttctgcttct
acgtggaaaatcgaaaagggagatgtcatctacattggtggcctacctgacaagcaagag
actgaacttaatggtggattcttcaaaggctgtatccaagatgtaagactaaacaaccaa
aatctggaattctttccaaatccaacaaacaatgcatctctcaatccagttcttgtcaat
gtaacccaaggctgtgctggagacaacagctgcaagtccaacccctgtcacaatggaggt
gtttgccattcccggtgggatgacttctcctgttcctgtcctgccctcacaagtgggaaa
gcctgtgaggaggttcagtggtgtggattcagcccgtgtcctcacggagcccagtgccag
ccggtgcttcaaggatttgaatgtattgcaaatgctgtttttaatggacaaagcggtcaa
atattattcagaagcaatgggaatattaccagagaactcaccaatatcacatttggtttc
agaacaagggatgcaaatgtaataatattgcatgcagaaaaagagcctgaatttcttaat
attagcattcaagattccagattattctttcaattgcaaagtggcaacagcttttatatg
ctaagtctgacaagtttgcagtcagtgaatgatggcacatggcacgaagtgaccctttcc
atgacagacccactgtcccagacctccaggtggcaaatggaagtggacaacgaaacacct
tttgtgaccagcacaattgctactggaagcctcaactttttgaaggataatacagatatt
tatgtgggagacagagctattgacaatataaagggcctgcaagggtgtctaagtacaata
gaaatcggaggcatttatctctcttactttgaaaatgttcatggtttcattaataaacct
caggaagagcaatttctcaaaatctctaccaattcagtggtcactggctgtttgcagtta
aatgtctgcaactccaacccctgtttgcatggaggaaactgtgaagacatctatagctct
tatcattgctcctgtcccttgggatggtcagggaaacactgtgaactcaacatcgatgaa
tgcttttcaaacccctgtatccatggcaactgctctgacagagttgcagcctaccactgc
acatgtgagcctggatacactggtgtgaactgtgaagtggatatagacaactgccagagt
caccagtgtgcaaatggagccacctgcattagtcatactaatggctattcttgcctctgt
tttggaaattttacaggaaaattttgcagacagagcagattaccctcaacagtctgtggg
aatgagaagacaaatctcacttgctacaatggaggcaactgcacagagttccagactgaa
ttaaaatgtatgtgccggccaggttttactggagaatggtgtgaaaaggacattgatgag
tgtgcctctgatccgtgtgtcaatggaggtctgtgccaggacttactcaacaaattccag
tgcctctgtgatgttgcctttgctggcgagcgctgcgaggtggacttggcagatgacttg
atctccgacattttcaccactattggctcagtgactgtcgccttgttactgatcctcttg
ctggccattgttgcttctgttgtcacctccaacaaaagggcaactcagggaacctacagc
cccagccgtcaggagaaggagggctcccgagtggaaatgtggaacttgatgccaccccct
gcaatggagagactgatttag
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