KEGG   Homo sapiens (human): 27232
Entry
27232             CDS       T01001                                 
Symbol
GNMT, HEL-S-182mP
Name
(RefSeq) glycine N-methyltransferase
  KO
K00552  glycine N-methyltransferase [EC:2.1.1.20]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00260  Glycine, serine and threonine metabolism
hsa00270  Cysteine and methionine metabolism
hsa01100  Metabolic pathways
Module
hsa_M00035  Methionine degradation
Network
nt06030  Methionine metabolism
  Element
N01607  Methionine degradation
Disease
H00184  Hypermethioninemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    27232 (GNMT)
   00270 Cysteine and methionine metabolism
    27232 (GNMT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.20  glycine N-methyltransferase
     27232 (GNMT)
SSDB
Motif
Pfam: Methyltransf_25 Methyltransf_31 Methyltransf_23 Methyltransf_12 Methyltransf_11 TehB Ubie_methyltran MTS Methyltransf_15 PCMT TPMT CMAS
Other DBs
NCBI-GeneID: 27232
NCBI-ProteinID: NP_061833
OMIM: 606628
HGNC: 4415
Ensembl: ENSG00000124713
UniProt: Q14749 V9HW60
Structure
LinkDB
Position
6:42960754..42963880
AA seq 295 aa
MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQR
VLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMT
LDKDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNY
DHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGSPGLSK
FRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKRTD
NT seq 888 nt   +upstreamnt  +downstreamnt
atggtggacagcgtgtaccggacccgctccctgggggtggcggccgaagggctcccggac
cagtacgcggacggggaggcggcgcgcgtgtggcagctgtatatcggagacacccgcagc
cgcaccgccgagtacaaggcatggctgcttgggctgctgcgccagcacggctgccagcgg
gtgctcgacgtagcctgtggcactggggtggactccattatgctggtggaagagggcttc
agtgtgacgagtgtggatgccagtgacaagatgctgaagtatgcacttaaggagcgctgg
aaccggcggcacgagcccgccttcgacaagtgggtcatcgaagaagccaactggatgact
ctggacaaagatgtgccccagtcagcagagggtggctttgatgctgtcatctgccttgga
aacagtttcgctcacttgccagactgcaaaggggaccagagtgagcaccggctggcgctg
aaaaacattgcgagcatggtgcgggcagggggcctactggtcattgatcatcgcaactac
gaccacatcctcagtacaggctgtgcacccccagggaagaacatctactataagagtgac
ttgaccaaggacgtcacaacatcagtgctgatagtgaacaacaaggcccacatggtgacc
ctggactatacggtgcaggtgccgggggctggccaggatggctctcctggcttgagtaag
ttccggctctcctactacccacactgtctggcatccttcacggagctgctccaagcagcc
ttcggaggtaagtgccagcacagcgtcctgggcgacttcaagccttacaagccaggccaa
acctacattccctgctacttcatccacgtgctcaagaggacagactga

KEGG   Homo sapiens (human): 1786
Entry
1786              CDS       T01001                                 
Symbol
DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI
Name
(RefSeq) DNA methyltransferase 1
  KO
K00558  DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa01100  Metabolic pathways
hsa05206  MicroRNAs in cancer
Module
hsa_M00035  Methionine degradation
Network
nt06030  Methionine metabolism
  Element
N01607  Methionine degradation
Disease
H00265  Hereditary sensory and autonomic neuropathy
Drug target
Azacitidine: D03021<JP/US>
Decitabine: D03665<US>
Roducitabine: D11740
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    1786 (DNMT1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    1786 (DNMT1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1786 (DNMT1)
   03032 DNA replication proteins [BR:hsa03032]
    1786 (DNMT1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1786 (DNMT1)
  09183 Protein families: signaling and cellular processes
   02048 Prokaryotic defense system [BR:hsa02048]
    1786 (DNMT1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     1786 (DNMT1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    1786 (DNMT1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   DNA methylation enzymes
    1786 (DNMT1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    1786 (DNMT1)
Prokaryotic defense system [BR:hsa02048]
 Restriction and modification system (R-M system)
  Type II R-M system
   DNA methyltransferases
    1786 (DNMT1)
SSDB
Motif
Pfam: BAH DNMT1-RFD DNA_methylase DMAP_binding zf-CXXC HTH_12
Other DBs
NCBI-GeneID: 1786
NCBI-ProteinID: NP_001370
OMIM: 126375
HGNC: 2976
Ensembl: ENSG00000130816
UniProt: P26358 I6L9H2
Structure
LinkDB
Position
19:complement(10133346..10194953)
AA seq 1616 aa
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQ
LCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRV
GMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP
QEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEK
EEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPE
EKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKTHPPKCIQCGQYL
DDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLC
PIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFS
TSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGL
NLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQAR
RQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQ
QPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQ
GKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVT
ALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPS
ENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLA
EMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPR
KEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNK
FYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSMGGP
NRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLPKLR
TLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMA
GETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRP
RFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAP
GEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNG
ASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLP
NIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNTLIPWCL
PHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFP
DTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKEEEAAKD
NT seq 4851 nt   +upstreamnt  +downstreamnt
atgccggcgcgtaccgccccagcccgggtgcccacactggccgtcccggccatctcgctg
cccgacgatgtccgcaggcggctcaaagatttggaaagagacagcttaacagaaaaggaa
tgtgtgaaggagaaattgaatctcttgcacgaatttctgcaaacagaaataaagaatcag
ttatgtgacttggaaaccaaattacgtaaagaagaattatccgaggagggctacctggct
aaagtcaaatcccttttaaataaagatttgtccttggagaacggtgctcatgcttacaac
cgggaagtgaatggacgtctagaaaacgggaaccaagcaagaagtgaagcccgtagagtg
ggaatggcagatgccaacagcccccccaaacccctttccaaacctcgcacgcccaggagg
agcaagtccgatggagaggctaagcctgaaccttcacctagccccaggattacaaggaaa
agcaccaggcaaaccaccatcacatctcattttgcaaagggccctgccaaacggaaacct
caggaagagtctgaaagagccaaatcggatgagtccatcaaggaagaagacaaagaccag
gatgagaagagacgtagagttacatccagagaacgagttgctagaccgcttcctgcagaa
gaacctgaaagagcaaaatcaggaacgcgcactgaaaaggaagaagaaagagatgaaaaa
gaagaaaagagactccgaagtcaaaccaaagaaccaacacccaaacagaaactgaaggag
gagccggacagagaagccagggcaggcgtgcaggctgacgaggacgaagatggagacgag
aaagatgagaagaagcacagaagtcaacccaaagatctagctgccaaacggaggcccgaa
gaaaaagaacctgaaaaagtaaatccacagatttctgatgaaaaagacgaggatgaaaag
gaggagaagagacgcaaaacgacccccaaagaaccaacggagaaaaaaatggctcgcgcc
aaaacagtcatgaactccaagacccaccctcccaagtgcattcagtgcgggcagtacctg
gacgaccctgacctcaaatatgggcagcacccaccagacgcggtggatgagccacagatg
ctgacaaatgagaagctgtccatctttgatgccaacgagtctggctttgagagttatgag
gcgcttccccagcacaaactgacctgcttcagtgtgtactgtaagcacggtcacctgtgt
cccatcgacaccggcctcatcgagaagaatatcgaactcttcttttctggttcagcaaaa
ccaatctatgatgatgacccatctcttgaaggtggtgttaatggcaaaaatcttggcccc
ataaatgaatggtggatcactggctttgatggaggtgaaaaggccctcatcggcttcagc
acctcatttgccgaatacattctgatggatcccagtcccgagtatgcgcccatatttggg
ctgatgcaggagaagatctacatcagcaagattgtggtggagttcctgcagagcaattcc
gactcgacctatgaggacctgatcaacaagatcgagaccacggttcctccttctggcctc
aacttgaaccgcttcacagaggactccctcctgcgacacgcgcagtttgtggtggagcag
gtggagagttatgacgaggccggggacagtgatgagcagcccatcttcctgacaccctgc
atgcgggacctgatcaagctggctggggtcacgctgggacagaggcgagcccaggcgagg
cggcagaccatcaggcattctaccagggagaaggacaggggacccacgaaagccaccacc
accaagctggtctaccagatcttcgatactttcttcgcagagcaaattgaaaaggatgac
agagaagacaaggagaacgcctttaagcgccggcgatgtggcgtctgtgaggtgtgtcag
cagcctgagtgtgggaaatgtaaagcctgcaaggacatggttaaatttggtggcagtgga
cggagcaagcaggcttgccaagagcggaggtgtcccaatatggccatgaaggaggcagat
gacgatgaggaagtcgatgataacatcccagagatgccgtcacccaaaaaaatgcaccag
gggaagaagaagaaacagaacaagaatcgcatctcttgggtcggagaagccgtcaagact
gatgggaagaagagttactataagaaggtgtgcattgatgcggaaaccctggaagtgggg
gactgtgtctctgttattccagatgattcctcaaaaccgctgtatctagcaagggtcacg
gcgctgtgggaggacagcagcaacgggcagatgtttcacgcccactggttctgcgctggg
acagacacagtcctcggggccacgtcggaccctctggagctgttcttggtggatgaatgt
gaggacatgcagctttcatatatccacagcaaagtgaaagtcatctacaaagccccctcc
gaaaactgggccatggagggaggcatggatcccgagtccctgctggagggggacgacggg
aagacctacttctaccagctgtggtatgatcaagactacgcgagattcgagtcccctcca
aaaacccagccaacagaggacaacaagttcaaattctgtgtgagctgtgcccgtctggct
gagatgaggcaaaaagaaatccccagggtcctggagcagctcgaggacctggatagccgg
gtcctctactactcagccaccaagaacggcatcctgtaccgagttggtgatggtgtgtac
ctgccccctgaggccttcacgttcaacatcaagctgtccagtcccgtgaaacgcccacgg
aaggagcccgtggatgaggacctgtacccagagcactaccggaaatactccgactacatc
aaaggcagcaacctggatgcccctgagccctaccgaattggccggatcaaagagatcttc
tgtcccaagaagagcaacggcaggcccaatgagactgacatcaaaatccgggtcaacaag
ttctacaggcctgagaacacccacaagtccactccagcgagctaccacgcagacatcaac
ctgctctactggagcgacgaggaggccgtggtggacttcaaggctgtgcagggccgctgc
accgtggagtatggggaggacctgcccgagtgcgtccaggtgtactccatgggcggcccc
aaccgcttctacttcctcgaggcctataatgcaaagagcaaaagctttgaagatcctccc
aaccatgcccgtagccctggaaacaaagggaagggcaagggaaaagggaagggcaagccc
aagtcccaagcctgtgagccgagcgagccagagatagagatcaagctgcccaagctgcgg
accctggatgtgttttctggctgcggggggttgtcggagggattccaccaagcaggcatc
tctgacacgctgtgggccatcgagatgtgggaccctgcggcccaggcgttccggctgaac
aaccccggctccacagtgttcacagaggactgcaacatcctgctgaagctggtcatggct
ggggagaccaccaactcccgcggccagcggctgccccagaagggagacgtggagatgctg
tgcggcgggccgccctgccagggcttcagcggcatgaaccgcttcaattcgcgcacctac
tccaagttcaaaaactctctggtggtttccttcctcagctactgcgactactaccggccc
cggttcttcctcctggagaatgtcaggaactttgtctccttcaagcgctccatggtcctg
aagctcaccctccgctgcctggtccgcatgggctatcagtgcaccttcggcgtgctgcag
gccggtcagtacggcgtggcccagactaggaggcgggccatcatcctggccgcggcccct
ggagagaagctccctctgttcccggagccactgcacgtgtttgctccccgggcctgccag
ctgagcgtggtggtggatgacaagaagtttgtgagcaacataaccaggttgagctcgggt
cctttccggaccatcacggtgcgagacacgatgtccgacctgccggaggtgcggaatgga
gcctcggcactggagatctcctacaacggggagcctcagtcctggttccagaggcagctc
cggggcgcacagtaccagcccatcctcagggaccacatctgtaaggacatgagtgcattg
gtggctgcccgcatgcggcacatccccttggccccagggtcagactggcgcgatctgccc
aacatcgaggtgcggctctcagacggcaccatggccaggaagctgcggtatacccaccat
gacaggaagaacggccgcagcagctctggggccctccgtggggtctgctcctgcgtggaa
gccggcaaagcctgcgaccccgcagccaggcagttcaacaccctcatcccctggtgcctg
ccccacaccgggaaccggcacaaccactgggctggcctctatggaaggctcgagtgggac
ggcttcttcagcacaaccgtcaccaaccccgagcccatgggcaagcagggccgcgtgctc
cacccagagcagcaccgtgtggtgagcgtgcgggagtgtgcccgctcccagggcttccct
gacacctaccggctcttcggcaacatcctggacaagcaccggcaggtgggcaatgccgtg
ccaccgcccctggccaaagccattggcttggagatcaagctttgtatgttggccaaagcc
cgagagagtgcctcagctaaaataaaggaggaggaagctgctaaggactag

KEGG   Homo sapiens (human): 1788
Entry
1788              CDS       T01001                                 
Symbol
DNMT3A, DNMT3A2, HESJAS, M.HsaIIIA, TBRS
Name
(RefSeq) DNA methyltransferase 3 alpha
  KO
K17398  DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa01100  Metabolic pathways
hsa04148  Efferocytosis
hsa05206  MicroRNAs in cancer
Module
hsa_M00035  Methionine degradation
Network
nt06030  Methionine metabolism
nt06535  Efferocytosis
  Element
N01607  Methionine degradation
N01773  PTGS2-PGE2-TGFB1 pathway
N01774  ERK-DUSP4 negative feedback pathway
Disease
H00003  Acute myeloid leukemia
H01892  Peripheral T cell lymphoma
H02294  Tatton-Brown-Rahman syndrome
H02410  Myelodysplastic/myeloproliferative neoplasms
H02411  Chronic myelomonocytic leukemia
H02668  Heyn-Sproul-Jackson syndrome
Drug target
Azacitidine: D03021<JP/US>
Decitabine: D03665<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    1788 (DNMT3A)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    1788 (DNMT3A)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    1788 (DNMT3A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1788 (DNMT3A)
   03032 DNA replication proteins [BR:hsa03032]
    1788 (DNMT3A)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1788 (DNMT3A)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     1788 (DNMT3A)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 GATA-factors
    1788 (DNMT3A)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   DNA methylation enzymes
    1788 (DNMT3A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    1788 (DNMT3A)
SSDB
Motif
Pfam: ADD_DNMT3 ADDz_Dnmt3b DNA_methylase PWWP
Other DBs
NCBI-GeneID: 1788
NCBI-ProteinID: NP_072046
OMIM: 602769
HGNC: 2978
Ensembl: ENSG00000119772
UniProt: Q9Y6K1
Structure
LinkDB
Position
2:complement(25227874..25342590)
AA seq 912 aa
MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV
ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG
AAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSL
RQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE
EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKL
RGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYN
KQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPK
GLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLV
YEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTIC
CGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRRED
WPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRY
IASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPAR
KGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMI
DAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSI
KQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRH
LFAPLKEYFACV
NT seq 2739 nt   +upstreamnt  +downstreamnt
atgcccgccatgccctccagcggccccggggacaccagcagctctgctgcggagcgggag
gaggaccgaaaggacggagaggagcaggaggagccgcgtggcaaggaggagcgccaagag
cccagcaccacggcacggaaggtggggcggcctgggaggaagcgcaagcaccccccggtg
gaaagcggtgacacgccaaaggaccctgcggtgatctccaagtccccatccatggcccag
gactcaggcgcctcagagctattacccaatggggacttggagaagcggagtgagccccag
ccagaggaggggagccctgctggggggcagaagggcggggccccagcagagggagagggt
gcagctgagaccctgcctgaagcctcaagagcagtggaaaatggctgctgcacccccaag
gagggccgaggagcccctgcagaagcgggcaaagaacagaaggagaccaacatcgaatcc
atgaaaatggagggctcccggggccggctgcggggtggcttgggctgggagtccagcctc
cgtcagcggcccatgccgaggctcaccttccaggcgggggacccctactacatcagcaag
cgcaagcgggacgagtggctggcacgctggaaaagggaggctgagaagaaagccaaggtc
attgcaggaatgaatgctgtggaagaaaaccaggggcccggggagtctcagaaggtggag
gaggccagccctcctgctgtgcagcagcccactgaccccgcatcccccactgtggctacc
acgcctgagcccgtggggtccgatgctggggacaagaatgccaccaaagcaggcgatgac
gagccagagtacgaggacggccggggctttggcattggggagctggtgtgggggaaactg
cggggcttctcctggtggccaggccgcattgtgtcttggtggatgacgggccggagccga
gcagctgaaggcacccgctgggtcatgtggttcggagacggcaaattctcagtggtgtgt
gttgagaagctgatgccgctgagctcgttttgcagtgcgttccaccaggccacgtacaac
aagcagcccatgtaccgcaaagccatctacgaggtcctgcaggtggccagcagccgcgcg
gggaagctgttcccggtgtgccacgacagcgatgagagtgacactgccaaggccgtggag
gtgcagaacaagcccatgattgaatgggccctggggggcttccagccttctggccctaag
ggcctggagccaccagaagaagagaagaatccctacaaagaagtgtacacggacatgtgg
gtggaacctgaggcagctgcctacgcaccacctccaccagccaaaaagccccggaagagc
acagcggagaagcccaaggtcaaggagattattgatgagcgcacaagagagcggctggtg
tacgaggtgcggcagaagtgccggaacattgaggacatctgcatctcctgtgggagcctc
aatgttaccctggaacaccccctcttcgttggaggaatgtgccaaaactgcaagaactgc
tttctggagtgtgcgtaccagtacgacgacgacggctaccagtcctactgcaccatctgc
tgtgggggccgtgaggtgctcatgtgcggaaacaacaactgctgcaggtgcttttgcgtg
gagtgtgtggacctcttggtggggccgggggctgcccaggcagccattaaggaagacccc
tggaactgctacatgtgcgggcacaagggtacctacgggctgctgcggcggcgagaggac
tggccctcccggctccagatgttcttcgctaataaccacgaccaggaatttgaccctcca
aaggtttacccacctgtcccagctgagaagaggaagcccatccgggtgctgtctctcttt
gatggaatcgctacagggctcctggtgctgaaggacttgggcattcaggtggaccgctac
attgcctcggaggtgtgtgaggactccatcacggtgggcatggtgcggcaccaggggaag
atcatgtacgtcggggacgtccgcagcgtcacacagaagcatatccaggagtggggccca
ttcgatctggtgattgggggcagtccctgcaatgacctctccatcgtcaaccctgctcgc
aagggcctctacgagggcactggccggctcttctttgagttctaccgcctcctgcatgat
gcgcggcccaaggagggagatgatcgccccttcttctggctctttgagaatgtggtggcc
atgggcgttagtgacaagagggacatctcgcgatttctcgagtccaaccctgtgatgatt
gatgccaaagaagtgtcagctgcacacagggcccgctacttctggggtaaccttcccggt
atgaacaggccgttggcatccactgtgaatgataagctggagctgcaggagtgtctggag
catggcaggatagccaagttcagcaaagtgaggaccattactacgaggtcaaactccata
aagcagggcaaagaccagcattttcctgtcttcatgaatgagaaagaggacatcttatgg
tgcactgaaatggaaagggtatttggtttcccagtccactatactgacgtctccaacatg
agccgcttggcgaggcagagactgctgggccggtcatggagcgtgccagtcatccgccac
ctcttcgctccgctgaaggagtattttgcgtgtgtgtaa

KEGG   Homo sapiens (human): 1789
Entry
1789              CDS       T01001                                 
Symbol
DNMT3B, FSHD4, ICF, ICF1, M.HsaIIIB
Name
(RefSeq) DNA methyltransferase 3 beta
  KO
K17399  DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa01100  Metabolic pathways
hsa05206  MicroRNAs in cancer
Module
hsa_M00035  Methionine degradation
Network
nt06030  Methionine metabolism
nt06512  Chromosome cohesion and segregation
  Element
N01497  Condensin loading
N01607  Methionine degradation
Disease
H00087  Other humoral immunodeficiencies
H00591  Facioscapulohumeral muscular dystrophy
H02308  Immunodeficiency-centromeric instability-facial anomalies syndrome
Drug target
Azacitidine: D03021<JP/US>
Decitabine: D03665<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    1789 (DNMT3B)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    1789 (DNMT3B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1789 (DNMT3B)
   03032 DNA replication proteins [BR:hsa03032]
    1789 (DNMT3B)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1789 (DNMT3B)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     1789 (DNMT3B)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 GATA-factors
    1789 (DNMT3B)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   DNA methylation enzymes
    1789 (DNMT3B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    1789 (DNMT3B)
SSDB
Motif
Pfam: ADD_DNMT3 ADDz_Dnmt3b DNA_methylase PWWP
Other DBs
NCBI-GeneID: 1789
NCBI-ProteinID: NP_008823
OMIM: 602900
HGNC: 2979
Ensembl: ENSG00000088305
UniProt: Q9UBC3
Structure
LinkDB
Position
20:32762385..32809356
AA seq 853 aa
MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
HLFAPLKDYFACE
NT seq 2562 nt   +upstreamnt  +downstreamnt
atgaagggagacaccaggcatctcaatggagaggaggacgccggcgggagggaagactcg
atcctcgtcaacggggcctgcagcgaccagtcctccgactcgcccccaatcctggaggct
atccgcaccccggagatcagaggccgaagatcaagctcgcgactctccaagagggaggtg
tccagtctgctaagctacacacaggacttgacaggcgatggcgacggggaagatggggat
ggctctgacaccccagtcatgccaaagctcttccgggaaaccaggactcgttcagaaagc
ccagctgtccgaactcgaaataacaacagtgtctccagccgggagaggcacaggccttcc
ccacgttccacccgaggccggcagggccgcaaccatgtggacgagtcccccgtggagttc
ccggctaccaggtccctgagacggcgggcaacagcatcggcaggaacgccatggccgtcc
cctcccagctcttaccttaccatcgacctcacagacgacacagaggacacacatgggacg
ccccagagcagcagtaccccctacgcccgcctagcccaggacagccagcaggggggcatg
gagtccccgcaggtggaggcagacagtggagatggagacagttcagagtatcaggatggg
aaggagtttggaataggggacctcgtgtggggaaagatcaagggcttctcctggtggccc
gccatggtggtgtcttggaaggccacctccaagcgacaggctatgtctggcatgcggtgg
gtccagtggtttggcgatggcaagttctccgaggtctctgcagacaaactggtggcactg
gggctgttcagccagcactttaatttggccaccttcaataagctcgtctcctatcgaaaa
gccatgtaccatgctctggagaaagctagggtgcgagctggcaagaccttccccagcagc
cctggagactcattggaggaccagctgaagcccatgttggagtgggcccacgggggcttc
aagcccactgggatcgagggcctcaaacccaacaacacgcaaccagtggttaataagtcg
aaggtgcgtcgtgcaggcagtaggaaattagaatcaaggaaatacgagaacaagactcga
agacgcacagctgacgactcagccacctctgactactgccccgcacccaagcgcctcaag
acaaattgctataacaacggcaaagaccgaggggatgaagatcagagccgagaacaaatg
gcttcagatgttgccaacaacaagagcagcctggaagatggctgtttgtcttgtggcagg
aaaaaccccgtgtccttccaccctctctttgagggggggctctgtcagacatgccgggat
cgcttccttgagctgttttacatgtatgatgacgatggctatcagtcttactgcactgtg
tgctgcgagggccgagagctgctgctttgcagcaacacgagctgctgccggtgtttctgt
gtggagtgcctggaggtgctggtgggcacaggcacagcggccgaggccaagcttcaggag
ccctggagctgttacatgtgtctcccgcagcgctgtcatggcgtcctgcggcgccggaag
gactggaacgtgcgcctgcaggccttcttcaccagtgacacggggcttgaatatgaagcc
cccaagctgtaccctgccattcccgcagcccgaaggcggcccattcgagtcctgtcattg
tttgatggcatcgcgacaggctacctagtcctcaaagagttgggcataaaggtaggaaag
tacgtcgcttctgaagtgtgtgaggagtccattgctgttggaaccgtgaagcacgagggg
aatatcaaatacgtgaacgacgtgaggaacatcacaaagaaaaatattgaagaatggggc
ccatttgacttggtgattggcggaagcccatgcaacgatctctcaaatgtgaatccagcc
aggaaaggcctgtatgagggtacaggccggctcttcttcgaattttaccacctgctgaat
tactcacgccccaaggagggtgatgaccggccgttcttctggatgtttgagaatgttgta
gccatgaaggttggcgacaagagggacatctcacggttcctggagtgtaatccagtgatg
attgatgccatcaaagtttctgctgctcacagggcccgatacttctggggcaacctaccc
gggatgaacaggcccgtgatagcatcaaagaatgataaactcgagctgcaggactgcttg
gaatacaataggatagccaagttaaagaaagtacagacaataaccaccaagtcgaactcg
atcaaacaggggaaaaaccaacttttccctgttgtcatgaatggcaaagaagatgttttg
tggtgcactgagctcgaaaggatctttggctttcctgtgcactacacagacgtgtccaac
atgggccgtggtgcccgccagaagctgctgggaaggtcctggagcgtgcctgtcatccga
cacctcttcgcccctctgaaggactactttgcatgtgaatag

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