Homo sapiens (human): 27232
Help
Entry
27232 CDS
T01001
Symbol
GNMT, HEL-S-182mP
Name
(RefSeq) glycine N-methyltransferase
KO
K00552
glycine N-methyltransferase [EC:
2.1.1.20
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00260
Glycine, serine and threonine metabolism
hsa00270
Cysteine and methionine metabolism
hsa01100
Metabolic pathways
Module
hsa_M00035
Methionine degradation
Network
nt06030
Methionine metabolism
Element
N01607
Methionine degradation
Disease
H00184
Hypermethioninemia
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
27232 (GNMT)
00270 Cysteine and methionine metabolism
27232 (GNMT)
Enzymes [BR:
hsa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.20 glycine N-methyltransferase
27232 (GNMT)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Methyltransf_25
Methyltransf_31
Methyltransf_23
Methyltransf_12
Methyltransf_11
TehB
Ubie_methyltran
MTS
Methyltransf_15
PCMT
TPMT
CMAS
Motif
Other DBs
NCBI-GeneID:
27232
NCBI-ProteinID:
NP_061833
OMIM:
606628
HGNC:
4415
Ensembl:
ENSG00000124713
UniProt:
Q14749
V9HW60
Structure
PDB
LinkDB
All DBs
Position
6:42960754..42963880
Genome browser
AA seq
295 aa
AA seq
DB search
MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQR
VLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMT
LDKDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNY
DHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGSPGLSK
FRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKRTD
NT seq
888 nt
NT seq
+upstream
nt +downstream
nt
atggtggacagcgtgtaccggacccgctccctgggggtggcggccgaagggctcccggac
cagtacgcggacggggaggcggcgcgcgtgtggcagctgtatatcggagacacccgcagc
cgcaccgccgagtacaaggcatggctgcttgggctgctgcgccagcacggctgccagcgg
gtgctcgacgtagcctgtggcactggggtggactccattatgctggtggaagagggcttc
agtgtgacgagtgtggatgccagtgacaagatgctgaagtatgcacttaaggagcgctgg
aaccggcggcacgagcccgccttcgacaagtgggtcatcgaagaagccaactggatgact
ctggacaaagatgtgccccagtcagcagagggtggctttgatgctgtcatctgccttgga
aacagtttcgctcacttgccagactgcaaaggggaccagagtgagcaccggctggcgctg
aaaaacattgcgagcatggtgcgggcagggggcctactggtcattgatcatcgcaactac
gaccacatcctcagtacaggctgtgcacccccagggaagaacatctactataagagtgac
ttgaccaaggacgtcacaacatcagtgctgatagtgaacaacaaggcccacatggtgacc
ctggactatacggtgcaggtgccgggggctggccaggatggctctcctggcttgagtaag
ttccggctctcctactacccacactgtctggcatccttcacggagctgctccaagcagcc
ttcggaggtaagtgccagcacagcgtcctgggcgacttcaagccttacaagccaggccaa
acctacattccctgctacttcatccacgtgctcaagaggacagactga
Homo sapiens (human): 1786
Help
Entry
1786 CDS
T01001
Symbol
DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI
Name
(RefSeq) DNA methyltransferase 1
KO
K00558
DNA (cytosine-5)-methyltransferase 1 [EC:
2.1.1.37
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00270
Cysteine and methionine metabolism
hsa01100
Metabolic pathways
hsa05206
MicroRNAs in cancer
Module
hsa_M00035
Methionine degradation
Network
nt06030
Methionine metabolism
Element
N01607
Methionine degradation
Disease
H00265
Hereditary sensory and autonomic neuropathy
Drug target
Azacitidine:
D03021
<JP/US>
Decitabine:
D03665
<US>
Roducitabine:
D11740
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
1786 (DNMT1)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
1786 (DNMT1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
1786 (DNMT1)
03032 DNA replication proteins [BR:
hsa03032
]
1786 (DNMT1)
03036 Chromosome and associated proteins [BR:
hsa03036
]
1786 (DNMT1)
09183 Protein families: signaling and cellular processes
02048 Prokaryotic defense system [BR:
hsa02048
]
1786 (DNMT1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.37 DNA (cytosine-5-)-methyltransferase
1786 (DNMT1)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Zinc finger
CXXC CpG-binding proteins
1786 (DNMT1)
DNA replication proteins [BR:
hsa03032
]
Eukaryotic type
DNA Replication Termination Factors
DNA methylation enzymes
1786 (DNMT1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Heterochromatin formation proteins
Other heterochromatin formation proteins
1786 (DNMT1)
Prokaryotic defense system [BR:
hsa02048
]
Restriction and modification system (R-M system)
Type II R-M system
DNA methyltransferases
1786 (DNMT1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
BAH
DNMT1-RFD
DNA_methylase
DMAP_binding
zf-CXXC
HTH_12
Motif
Other DBs
NCBI-GeneID:
1786
NCBI-ProteinID:
NP_001370
OMIM:
126375
HGNC:
2976
Ensembl:
ENSG00000130816
UniProt:
P26358
I6L9H2
Structure
PDB
LinkDB
All DBs
Position
19:complement(10133346..10194953)
Genome browser
AA seq
1616 aa
AA seq
DB search
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQ
LCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRV
GMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP
QEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEK
EEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPE
EKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKTHPPKCIQCGQYL
DDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLC
PIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFS
TSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGL
NLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQAR
RQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQ
QPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQ
GKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVT
ALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPS
ENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLA
EMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPR
KEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNK
FYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSMGGP
NRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLPKLR
TLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMA
GETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRP
RFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAP
GEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNG
ASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLP
NIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNTLIPWCL
PHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFP
DTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKEEEAAKD
NT seq
4851 nt
NT seq
+upstream
nt +downstream
nt
atgccggcgcgtaccgccccagcccgggtgcccacactggccgtcccggccatctcgctg
cccgacgatgtccgcaggcggctcaaagatttggaaagagacagcttaacagaaaaggaa
tgtgtgaaggagaaattgaatctcttgcacgaatttctgcaaacagaaataaagaatcag
ttatgtgacttggaaaccaaattacgtaaagaagaattatccgaggagggctacctggct
aaagtcaaatcccttttaaataaagatttgtccttggagaacggtgctcatgcttacaac
cgggaagtgaatggacgtctagaaaacgggaaccaagcaagaagtgaagcccgtagagtg
ggaatggcagatgccaacagcccccccaaacccctttccaaacctcgcacgcccaggagg
agcaagtccgatggagaggctaagcctgaaccttcacctagccccaggattacaaggaaa
agcaccaggcaaaccaccatcacatctcattttgcaaagggccctgccaaacggaaacct
caggaagagtctgaaagagccaaatcggatgagtccatcaaggaagaagacaaagaccag
gatgagaagagacgtagagttacatccagagaacgagttgctagaccgcttcctgcagaa
gaacctgaaagagcaaaatcaggaacgcgcactgaaaaggaagaagaaagagatgaaaaa
gaagaaaagagactccgaagtcaaaccaaagaaccaacacccaaacagaaactgaaggag
gagccggacagagaagccagggcaggcgtgcaggctgacgaggacgaagatggagacgag
aaagatgagaagaagcacagaagtcaacccaaagatctagctgccaaacggaggcccgaa
gaaaaagaacctgaaaaagtaaatccacagatttctgatgaaaaagacgaggatgaaaag
gaggagaagagacgcaaaacgacccccaaagaaccaacggagaaaaaaatggctcgcgcc
aaaacagtcatgaactccaagacccaccctcccaagtgcattcagtgcgggcagtacctg
gacgaccctgacctcaaatatgggcagcacccaccagacgcggtggatgagccacagatg
ctgacaaatgagaagctgtccatctttgatgccaacgagtctggctttgagagttatgag
gcgcttccccagcacaaactgacctgcttcagtgtgtactgtaagcacggtcacctgtgt
cccatcgacaccggcctcatcgagaagaatatcgaactcttcttttctggttcagcaaaa
ccaatctatgatgatgacccatctcttgaaggtggtgttaatggcaaaaatcttggcccc
ataaatgaatggtggatcactggctttgatggaggtgaaaaggccctcatcggcttcagc
acctcatttgccgaatacattctgatggatcccagtcccgagtatgcgcccatatttggg
ctgatgcaggagaagatctacatcagcaagattgtggtggagttcctgcagagcaattcc
gactcgacctatgaggacctgatcaacaagatcgagaccacggttcctccttctggcctc
aacttgaaccgcttcacagaggactccctcctgcgacacgcgcagtttgtggtggagcag
gtggagagttatgacgaggccggggacagtgatgagcagcccatcttcctgacaccctgc
atgcgggacctgatcaagctggctggggtcacgctgggacagaggcgagcccaggcgagg
cggcagaccatcaggcattctaccagggagaaggacaggggacccacgaaagccaccacc
accaagctggtctaccagatcttcgatactttcttcgcagagcaaattgaaaaggatgac
agagaagacaaggagaacgcctttaagcgccggcgatgtggcgtctgtgaggtgtgtcag
cagcctgagtgtgggaaatgtaaagcctgcaaggacatggttaaatttggtggcagtgga
cggagcaagcaggcttgccaagagcggaggtgtcccaatatggccatgaaggaggcagat
gacgatgaggaagtcgatgataacatcccagagatgccgtcacccaaaaaaatgcaccag
gggaagaagaagaaacagaacaagaatcgcatctcttgggtcggagaagccgtcaagact
gatgggaagaagagttactataagaaggtgtgcattgatgcggaaaccctggaagtgggg
gactgtgtctctgttattccagatgattcctcaaaaccgctgtatctagcaagggtcacg
gcgctgtgggaggacagcagcaacgggcagatgtttcacgcccactggttctgcgctggg
acagacacagtcctcggggccacgtcggaccctctggagctgttcttggtggatgaatgt
gaggacatgcagctttcatatatccacagcaaagtgaaagtcatctacaaagccccctcc
gaaaactgggccatggagggaggcatggatcccgagtccctgctggagggggacgacggg
aagacctacttctaccagctgtggtatgatcaagactacgcgagattcgagtcccctcca
aaaacccagccaacagaggacaacaagttcaaattctgtgtgagctgtgcccgtctggct
gagatgaggcaaaaagaaatccccagggtcctggagcagctcgaggacctggatagccgg
gtcctctactactcagccaccaagaacggcatcctgtaccgagttggtgatggtgtgtac
ctgccccctgaggccttcacgttcaacatcaagctgtccagtcccgtgaaacgcccacgg
aaggagcccgtggatgaggacctgtacccagagcactaccggaaatactccgactacatc
aaaggcagcaacctggatgcccctgagccctaccgaattggccggatcaaagagatcttc
tgtcccaagaagagcaacggcaggcccaatgagactgacatcaaaatccgggtcaacaag
ttctacaggcctgagaacacccacaagtccactccagcgagctaccacgcagacatcaac
ctgctctactggagcgacgaggaggccgtggtggacttcaaggctgtgcagggccgctgc
accgtggagtatggggaggacctgcccgagtgcgtccaggtgtactccatgggcggcccc
aaccgcttctacttcctcgaggcctataatgcaaagagcaaaagctttgaagatcctccc
aaccatgcccgtagccctggaaacaaagggaagggcaagggaaaagggaagggcaagccc
aagtcccaagcctgtgagccgagcgagccagagatagagatcaagctgcccaagctgcgg
accctggatgtgttttctggctgcggggggttgtcggagggattccaccaagcaggcatc
tctgacacgctgtgggccatcgagatgtgggaccctgcggcccaggcgttccggctgaac
aaccccggctccacagtgttcacagaggactgcaacatcctgctgaagctggtcatggct
ggggagaccaccaactcccgcggccagcggctgccccagaagggagacgtggagatgctg
tgcggcgggccgccctgccagggcttcagcggcatgaaccgcttcaattcgcgcacctac
tccaagttcaaaaactctctggtggtttccttcctcagctactgcgactactaccggccc
cggttcttcctcctggagaatgtcaggaactttgtctccttcaagcgctccatggtcctg
aagctcaccctccgctgcctggtccgcatgggctatcagtgcaccttcggcgtgctgcag
gccggtcagtacggcgtggcccagactaggaggcgggccatcatcctggccgcggcccct
ggagagaagctccctctgttcccggagccactgcacgtgtttgctccccgggcctgccag
ctgagcgtggtggtggatgacaagaagtttgtgagcaacataaccaggttgagctcgggt
cctttccggaccatcacggtgcgagacacgatgtccgacctgccggaggtgcggaatgga
gcctcggcactggagatctcctacaacggggagcctcagtcctggttccagaggcagctc
cggggcgcacagtaccagcccatcctcagggaccacatctgtaaggacatgagtgcattg
gtggctgcccgcatgcggcacatccccttggccccagggtcagactggcgcgatctgccc
aacatcgaggtgcggctctcagacggcaccatggccaggaagctgcggtatacccaccat
gacaggaagaacggccgcagcagctctggggccctccgtggggtctgctcctgcgtggaa
gccggcaaagcctgcgaccccgcagccaggcagttcaacaccctcatcccctggtgcctg
ccccacaccgggaaccggcacaaccactgggctggcctctatggaaggctcgagtgggac
ggcttcttcagcacaaccgtcaccaaccccgagcccatgggcaagcagggccgcgtgctc
cacccagagcagcaccgtgtggtgagcgtgcgggagtgtgcccgctcccagggcttccct
gacacctaccggctcttcggcaacatcctggacaagcaccggcaggtgggcaatgccgtg
ccaccgcccctggccaaagccattggcttggagatcaagctttgtatgttggccaaagcc
cgagagagtgcctcagctaaaataaaggaggaggaagctgctaaggactag
Homo sapiens (human): 1788
Help
Entry
1788 CDS
T01001
Symbol
DNMT3A, DNMT3A2, HESJAS, M.HsaIIIA, TBRS
Name
(RefSeq) DNA methyltransferase 3 alpha
KO
K17398
DNA (cytosine-5)-methyltransferase 3A [EC:
2.1.1.37
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00270
Cysteine and methionine metabolism
hsa01100
Metabolic pathways
hsa04148
Efferocytosis
hsa05206
MicroRNAs in cancer
Module
hsa_M00035
Methionine degradation
Network
nt06030
Methionine metabolism
nt06535
Efferocytosis
Element
N01607
Methionine degradation
N01773
PTGS2-PGE2-TGFB1 pathway
N01774
ERK-DUSP4 negative feedback pathway
Disease
H00003
Acute myeloid leukemia
H01892
Peripheral T cell lymphoma
H02294
Tatton-Brown-Rahman syndrome
H02410
Myelodysplastic/myeloproliferative neoplasms
H02411
Chronic myelomonocytic leukemia
H02668
Heyn-Sproul-Jackson syndrome
Drug target
Azacitidine:
D03021
<JP/US>
Decitabine:
D03665
<US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
1788 (DNMT3A)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
1788 (DNMT3A)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
1788 (DNMT3A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
1788 (DNMT3A)
03032 DNA replication proteins [BR:
hsa03032
]
1788 (DNMT3A)
03036 Chromosome and associated proteins [BR:
hsa03036
]
1788 (DNMT3A)
Enzymes [BR:
hsa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.37 DNA (cytosine-5-)-methyltransferase
1788 (DNMT3A)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Zinc finger
Cys4 GATA-factors
1788 (DNMT3A)
DNA replication proteins [BR:
hsa03032
]
Eukaryotic type
DNA Replication Termination Factors
DNA methylation enzymes
1788 (DNMT3A)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Heterochromatin formation proteins
Other heterochromatin formation proteins
1788 (DNMT3A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ADD_DNMT3
ADDz_Dnmt3b
DNA_methylase
PWWP
Motif
Other DBs
NCBI-GeneID:
1788
NCBI-ProteinID:
NP_072046
OMIM:
602769
HGNC:
2978
Ensembl:
ENSG00000119772
UniProt:
Q9Y6K1
Structure
PDB
LinkDB
All DBs
Position
2:complement(25227874..25342590)
Genome browser
AA seq
912 aa
AA seq
DB search
MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV
ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG
AAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSL
RQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE
EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKL
RGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYN
KQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPK
GLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLV
YEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTIC
CGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRRED
WPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRY
IASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPAR
KGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMI
DAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSI
KQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRH
LFAPLKEYFACV
NT seq
2739 nt
NT seq
+upstream
nt +downstream
nt
atgcccgccatgccctccagcggccccggggacaccagcagctctgctgcggagcgggag
gaggaccgaaaggacggagaggagcaggaggagccgcgtggcaaggaggagcgccaagag
cccagcaccacggcacggaaggtggggcggcctgggaggaagcgcaagcaccccccggtg
gaaagcggtgacacgccaaaggaccctgcggtgatctccaagtccccatccatggcccag
gactcaggcgcctcagagctattacccaatggggacttggagaagcggagtgagccccag
ccagaggaggggagccctgctggggggcagaagggcggggccccagcagagggagagggt
gcagctgagaccctgcctgaagcctcaagagcagtggaaaatggctgctgcacccccaag
gagggccgaggagcccctgcagaagcgggcaaagaacagaaggagaccaacatcgaatcc
atgaaaatggagggctcccggggccggctgcggggtggcttgggctgggagtccagcctc
cgtcagcggcccatgccgaggctcaccttccaggcgggggacccctactacatcagcaag
cgcaagcgggacgagtggctggcacgctggaaaagggaggctgagaagaaagccaaggtc
attgcaggaatgaatgctgtggaagaaaaccaggggcccggggagtctcagaaggtggag
gaggccagccctcctgctgtgcagcagcccactgaccccgcatcccccactgtggctacc
acgcctgagcccgtggggtccgatgctggggacaagaatgccaccaaagcaggcgatgac
gagccagagtacgaggacggccggggctttggcattggggagctggtgtgggggaaactg
cggggcttctcctggtggccaggccgcattgtgtcttggtggatgacgggccggagccga
gcagctgaaggcacccgctgggtcatgtggttcggagacggcaaattctcagtggtgtgt
gttgagaagctgatgccgctgagctcgttttgcagtgcgttccaccaggccacgtacaac
aagcagcccatgtaccgcaaagccatctacgaggtcctgcaggtggccagcagccgcgcg
gggaagctgttcccggtgtgccacgacagcgatgagagtgacactgccaaggccgtggag
gtgcagaacaagcccatgattgaatgggccctggggggcttccagccttctggccctaag
ggcctggagccaccagaagaagagaagaatccctacaaagaagtgtacacggacatgtgg
gtggaacctgaggcagctgcctacgcaccacctccaccagccaaaaagccccggaagagc
acagcggagaagcccaaggtcaaggagattattgatgagcgcacaagagagcggctggtg
tacgaggtgcggcagaagtgccggaacattgaggacatctgcatctcctgtgggagcctc
aatgttaccctggaacaccccctcttcgttggaggaatgtgccaaaactgcaagaactgc
tttctggagtgtgcgtaccagtacgacgacgacggctaccagtcctactgcaccatctgc
tgtgggggccgtgaggtgctcatgtgcggaaacaacaactgctgcaggtgcttttgcgtg
gagtgtgtggacctcttggtggggccgggggctgcccaggcagccattaaggaagacccc
tggaactgctacatgtgcgggcacaagggtacctacgggctgctgcggcggcgagaggac
tggccctcccggctccagatgttcttcgctaataaccacgaccaggaatttgaccctcca
aaggtttacccacctgtcccagctgagaagaggaagcccatccgggtgctgtctctcttt
gatggaatcgctacagggctcctggtgctgaaggacttgggcattcaggtggaccgctac
attgcctcggaggtgtgtgaggactccatcacggtgggcatggtgcggcaccaggggaag
atcatgtacgtcggggacgtccgcagcgtcacacagaagcatatccaggagtggggccca
ttcgatctggtgattgggggcagtccctgcaatgacctctccatcgtcaaccctgctcgc
aagggcctctacgagggcactggccggctcttctttgagttctaccgcctcctgcatgat
gcgcggcccaaggagggagatgatcgccccttcttctggctctttgagaatgtggtggcc
atgggcgttagtgacaagagggacatctcgcgatttctcgagtccaaccctgtgatgatt
gatgccaaagaagtgtcagctgcacacagggcccgctacttctggggtaaccttcccggt
atgaacaggccgttggcatccactgtgaatgataagctggagctgcaggagtgtctggag
catggcaggatagccaagttcagcaaagtgaggaccattactacgaggtcaaactccata
aagcagggcaaagaccagcattttcctgtcttcatgaatgagaaagaggacatcttatgg
tgcactgaaatggaaagggtatttggtttcccagtccactatactgacgtctccaacatg
agccgcttggcgaggcagagactgctgggccggtcatggagcgtgccagtcatccgccac
ctcttcgctccgctgaaggagtattttgcgtgtgtgtaa
Homo sapiens (human): 1789
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Entry
1789 CDS
T01001
Symbol
DNMT3B, FSHD4, ICF, ICF1, M.HsaIIIB
Name
(RefSeq) DNA methyltransferase 3 beta
KO
K17399
DNA (cytosine-5)-methyltransferase 3B [EC:
2.1.1.37
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00270
Cysteine and methionine metabolism
hsa01100
Metabolic pathways
hsa05206
MicroRNAs in cancer
Module
hsa_M00035
Methionine degradation
Network
nt06030
Methionine metabolism
nt06512
Chromosome cohesion and segregation
Element
N01497
Condensin loading
N01607
Methionine degradation
Disease
H00087
Other humoral immunodeficiencies
H00591
Facioscapulohumeral muscular dystrophy
H02308
Immunodeficiency-centromeric instability-facial anomalies syndrome
Drug target
Azacitidine:
D03021
<JP/US>
Decitabine:
D03665
<US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
1789 (DNMT3B)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
1789 (DNMT3B)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
1789 (DNMT3B)
03032 DNA replication proteins [BR:
hsa03032
]
1789 (DNMT3B)
03036 Chromosome and associated proteins [BR:
hsa03036
]
1789 (DNMT3B)
Enzymes [BR:
hsa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.37 DNA (cytosine-5-)-methyltransferase
1789 (DNMT3B)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Zinc finger
Cys4 GATA-factors
1789 (DNMT3B)
DNA replication proteins [BR:
hsa03032
]
Eukaryotic type
DNA Replication Termination Factors
DNA methylation enzymes
1789 (DNMT3B)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Heterochromatin formation proteins
Other heterochromatin formation proteins
1789 (DNMT3B)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ADD_DNMT3
ADDz_Dnmt3b
DNA_methylase
PWWP
Motif
Other DBs
NCBI-GeneID:
1789
NCBI-ProteinID:
NP_008823
OMIM:
602900
HGNC:
2979
Ensembl:
ENSG00000088305
UniProt:
Q9UBC3
Structure
PDB
LinkDB
All DBs
Position
20:32762385..32809356
Genome browser
AA seq
853 aa
AA seq
DB search
MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
HLFAPLKDYFACE
NT seq
2562 nt
NT seq
+upstream
nt +downstream
nt
atgaagggagacaccaggcatctcaatggagaggaggacgccggcgggagggaagactcg
atcctcgtcaacggggcctgcagcgaccagtcctccgactcgcccccaatcctggaggct
atccgcaccccggagatcagaggccgaagatcaagctcgcgactctccaagagggaggtg
tccagtctgctaagctacacacaggacttgacaggcgatggcgacggggaagatggggat
ggctctgacaccccagtcatgccaaagctcttccgggaaaccaggactcgttcagaaagc
ccagctgtccgaactcgaaataacaacagtgtctccagccgggagaggcacaggccttcc
ccacgttccacccgaggccggcagggccgcaaccatgtggacgagtcccccgtggagttc
ccggctaccaggtccctgagacggcgggcaacagcatcggcaggaacgccatggccgtcc
cctcccagctcttaccttaccatcgacctcacagacgacacagaggacacacatgggacg
ccccagagcagcagtaccccctacgcccgcctagcccaggacagccagcaggggggcatg
gagtccccgcaggtggaggcagacagtggagatggagacagttcagagtatcaggatggg
aaggagtttggaataggggacctcgtgtggggaaagatcaagggcttctcctggtggccc
gccatggtggtgtcttggaaggccacctccaagcgacaggctatgtctggcatgcggtgg
gtccagtggtttggcgatggcaagttctccgaggtctctgcagacaaactggtggcactg
gggctgttcagccagcactttaatttggccaccttcaataagctcgtctcctatcgaaaa
gccatgtaccatgctctggagaaagctagggtgcgagctggcaagaccttccccagcagc
cctggagactcattggaggaccagctgaagcccatgttggagtgggcccacgggggcttc
aagcccactgggatcgagggcctcaaacccaacaacacgcaaccagtggttaataagtcg
aaggtgcgtcgtgcaggcagtaggaaattagaatcaaggaaatacgagaacaagactcga
agacgcacagctgacgactcagccacctctgactactgccccgcacccaagcgcctcaag
acaaattgctataacaacggcaaagaccgaggggatgaagatcagagccgagaacaaatg
gcttcagatgttgccaacaacaagagcagcctggaagatggctgtttgtcttgtggcagg
aaaaaccccgtgtccttccaccctctctttgagggggggctctgtcagacatgccgggat
cgcttccttgagctgttttacatgtatgatgacgatggctatcagtcttactgcactgtg
tgctgcgagggccgagagctgctgctttgcagcaacacgagctgctgccggtgtttctgt
gtggagtgcctggaggtgctggtgggcacaggcacagcggccgaggccaagcttcaggag
ccctggagctgttacatgtgtctcccgcagcgctgtcatggcgtcctgcggcgccggaag
gactggaacgtgcgcctgcaggccttcttcaccagtgacacggggcttgaatatgaagcc
cccaagctgtaccctgccattcccgcagcccgaaggcggcccattcgagtcctgtcattg
tttgatggcatcgcgacaggctacctagtcctcaaagagttgggcataaaggtaggaaag
tacgtcgcttctgaagtgtgtgaggagtccattgctgttggaaccgtgaagcacgagggg
aatatcaaatacgtgaacgacgtgaggaacatcacaaagaaaaatattgaagaatggggc
ccatttgacttggtgattggcggaagcccatgcaacgatctctcaaatgtgaatccagcc
aggaaaggcctgtatgagggtacaggccggctcttcttcgaattttaccacctgctgaat
tactcacgccccaaggagggtgatgaccggccgttcttctggatgtttgagaatgttgta
gccatgaaggttggcgacaagagggacatctcacggttcctggagtgtaatccagtgatg
attgatgccatcaaagtttctgctgctcacagggcccgatacttctggggcaacctaccc
gggatgaacaggcccgtgatagcatcaaagaatgataaactcgagctgcaggactgcttg
gaatacaataggatagccaagttaaagaaagtacagacaataaccaccaagtcgaactcg
atcaaacaggggaaaaaccaacttttccctgttgtcatgaatggcaaagaagatgttttg
tggtgcactgagctcgaaaggatctttggctttcctgtgcactacacagacgtgtccaac
atgggccgtggtgcccgccagaagctgctgggaaggtcctggagcgtgcctgtcatccga
cacctcttcgcccctctgaaggactactttgcatgtgaatag
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integrated database retrieval system