Homo sapiens (human): 3667 Help Entry 3667              CDS       T01001                                  Symbol IRS1, HIRS-1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04068   FoxO signaling pathway hsa04140   Autophagy - animal hsa04150   mTOR signaling pathway hsa04151   PI3K-Akt signaling pathway hsa04152   AMPK signaling pathway hsa04211   Longevity regulating pathway hsa04213   Longevity regulating pathway - multiple species hsa04722   Neurotrophin signaling pathway hsa04910   Insulin signaling pathway hsa04920   Adipocytokine signaling pathway hsa04923   Regulation of lipolysis in adipocytes hsa04930   Type II diabetes mellitus hsa04931   Insulin resistance hsa04932   Non-alcoholic fatty liver disease hsa04935   Growth hormone synthesis, secretion and action hsa04960   Aldosterone-regulated sodium reabsorption hsa05010   Alzheimer disease hsa05206   MicroRNAs in cancer hsa05415   Diabetic cardiomyopathy Network nt06325  Hormone/cytokine signaling   Element N01708   INS-AKT signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     3667 (IRS1)    04022 cGMP-PKG signaling pathway     3667 (IRS1)    04151 PI3K-Akt signaling pathway     3667 (IRS1)    04152 AMPK signaling pathway     3667 (IRS1)    04150 mTOR signaling pathway     3667 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     3667 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     3667 (IRS1)    04923 Regulation of lipolysis in adipocytes     3667 (IRS1)    04920 Adipocytokine signaling pathway     3667 (IRS1)    04935 Growth hormone synthesis, secretion and action     3667 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     3667 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     3667 (IRS1)   09149 Aging    04211 Longevity regulating pathway     3667 (IRS1)    04213 Longevity regulating pathway - multiple species     3667 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     3667 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     3667 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     3667 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     3667 (IRS1)    04932 Non-alcoholic fatty liver disease     3667 (IRS1)    04931 Insulin resistance     3667 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  3667 NCBI-ProteinID:  NP_005535 OMIM:  147545 HGNC:  6125 Ensembl:  ENSG00000169047 UniProt:  P35568 Structure PDB LinkDB All DBs Position 2:complement(226731312..226799820) Genome browser AA seq 1242 aa AA seqDB search MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN GHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRGGHHR PDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVES SGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEP EEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPH LPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIE FGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGV EMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIA AEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPN RNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKR HSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQ PPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ NT seq 3729 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagagcgatggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaaacgcttcttcgtactgcgcgcggccagcgaggctgggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatcccccttgagagctgcttcaacatcaacaagcgggctgactccaagaac aagcacctggtggctctctacacccgggacgagcactttgccatcgcggcggacagcgag gccgagcaagacagctggtaccaggctctcctacagctgcacaaccgtgctaagggccac cacgacggagctgcggccctcggggcgggaggtggtgggggcagctgcagcggcagctcc ggccttggtgaggctggggaggacttgagctacggtgacgtgcccccaggacccgcattc aaagaggtctggcaagtgatcctgaagcccaagggcctgggtcagacaaagaacctgatt ggtatctaccgcctttgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcagcggccgtggtgctgcagctgatgaacatcaggcgctgtggccactcggaaaacttc ttcttcatcgaggtgggccgttctgccgtgacggggcccggggagttctggatgcaggtg gatgactctgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg agtgatgagttccgccctcgcagcaagagccagtcctcgtccaactgctctaaccccatc agcgtccccctgcgccggcaccatctcaacaatcccccgcccagccaggtggggctgacc cgccgatcacgcactgagagcatcaccgccacctccccggccagcatggtgggcgggaag ccaggctccttccgtgtccgcgcctccagtgacggcgaaggcaccatgtcccgcccagcc tcggtggacggcagccctgtgagtcccagcaccaacagaacccacgcccaccggcatcgg ggcagcgcccggctgcaccccccgctcaaccacagccgctccatccccatgccggcttcc cgctgctcgccttcggccaccagcccggtcagtctgtcgtccagtagcaccagtggccat ggctccacctcggattgtctcttcccacggcgatctagtgcttcggtgtctggttccccc agcgatggcggtttcatctcctcggatgagtatggctccagtccctgcgatttccggagt tccttccgcagtgtcactccggattccctgggccacaccccaccagcccgcggtgaggag gagctaagcaactatatctgcatgggtggcaaggggccctccaccctgaccgcccccaac ggtcactacattttgtctcggggtggcaatggccaccgctgcaccccaggaacaggcttg ggcacgagtccagccttggctggggatgaagcagccagtgctgcagatctggataatcgg ttccgaaagagaactcactcggcaggcacatcccctaccattacccaccagaagaccccg tcccagtcctcagtggcttccattgaggagtacacagagatgatgcctgcctacccacca ggaggtggcagtggaggccgactgccgggacacaggcactccgccttcgtgcccacccgc tcctacccagaggagggtctggaaatgcaccccttggagcgtcggggggggcaccaccgc ccagacagctccaccctccacacggatgatggctacatgcccatgtccccaggggtggcc ccagtgcccagtggccgaaagggcagtggagactatatgcccatgagccccaagagcgta tctgccccacagcagatcatcaatcccatcagacgccatccccagagagtggaccccaat ggctacatgatgatgtcccccagcggtggctgctctcctgacattggaggtggccccagc agcagcagcagcagcagcaacgccgtcccttccgggaccagctatggaaagctgtggaca aacggggtagggggccaccactctcatgtcttgcctcaccccaaacccccagtggagagc agcggtggtaagctcttaccttgcacaggtgactacatgaacatgtcaccagtgggggac tccaacaccagcagcccctccgactgctactacggccctgaggacccccagcacaagcca gtcctctcctactactcattgccaagatcctttaagcacacccagcgccccggggagccg gaggagggtgcccggcatcagcacctccgcctttccactagctctggtcgccttctctat gctgcaacagcagatgattcttcctcttccaccagcagcgacagcctgggtgggggatac tgcggggctaggctggagcccagccttccacatccccaccatcaggttctgcagccccat ctgcctcgaaaggtggacacagctgctcagaccaatagccgcctggcccggcccacgagg ctgtccctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagcagcag cagcagcccttgctgcaccctccagagcccaagagcccgggggaatatgtcaatattgaa tttgggagtgatcagtctggctacttgtctggcccggtggctttccacagctcaccttct gtcaggtgtccatcccagctccagccagctcccagagaggaagagactggcactgaggag tacatgaagatggacctggggccgggccggagggcagcctggcaggagagcactggggtc gagatgggcagactgggccctgcacctcccggggctgctagcatttgcaggcctacccgg gcagtgcccagcagccggggtgactacatgaccatgcagatgagttgtccccgtcagagc tacgtggacacctcgccagctgcccctgtaagctatgctgacatgcgaacaggcattgct gcagaggaggtgagcctgcccagggccaccatggctgctgcctcctcatcctcagcagcc tctgcttccccgactgggcctcaaggggcagcagagctggctgcccactcgtccctgctg gggggcccacaaggacctgggggcatgagcgccttcacccgggtgaacctcagtcctaac cgcaaccagagtgccaaagtgatccgtgcagacccacaagggtgccggcggaggcatagc tccgagactttctcctcaacacccagtgccacccgggtgggcaacacagtgccctttgga gcgggggcagcagtagggggcggtggcggtagcagcagcagcagcgaggatgtgaaacgc cacagctctgcttcctttgagaatgtgtggctgaggcctggggagcttgggggagccccc aaggagccagccaaactgtgtggggctgctgggggtttggagaatggtcttaactacata gacctggatttggtcaaggacttcaaacagtgccctcaggagtgcacccctgaaccgcag cctcccccacccccaccccctcatcaacccctgggcagcggtgagagcagctccacccgc cgctcaagtgaggatttaagcgcctatgccagcatcagtttccagaagcagccagaggac cgtcagtag

Homo sapiens (human): 8660 Help Entry 8660              CDS       T01001                                  Symbol IRS2, IRS-2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04068   FoxO signaling pathway hsa04140   Autophagy - animal hsa04152   AMPK signaling pathway hsa04211   Longevity regulating pathway hsa04213   Longevity regulating pathway - multiple species hsa04910   Insulin signaling pathway hsa04920   Adipocytokine signaling pathway hsa04923   Regulation of lipolysis in adipocytes hsa04930   Type II diabetes mellitus hsa04931   Insulin resistance hsa04932   Non-alcoholic fatty liver disease hsa04935   Growth hormone synthesis, secretion and action hsa05010   Alzheimer disease hsa05206   MicroRNAs in cancer Network nt06325  Hormone/cytokine signaling   Element N01708   INS-AKT signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     8660 (IRS2)    04022 cGMP-PKG signaling pathway     8660 (IRS2)    04152 AMPK signaling pathway     8660 (IRS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     8660 (IRS2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     8660 (IRS2)    04923 Regulation of lipolysis in adipocytes     8660 (IRS2)    04920 Adipocytokine signaling pathway     8660 (IRS2)    04935 Growth hormone synthesis, secretion and action     8660 (IRS2)   09149 Aging    04211 Longevity regulating pathway     8660 (IRS2)    04213 Longevity regulating pathway - multiple species     8660 (IRS2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     8660 (IRS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     8660 (IRS2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     8660 (IRS2)    04932 Non-alcoholic fatty liver disease     8660 (IRS2)    04931 Insulin resistance     8660 (IRS2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Motif Other DBs NCBI-GeneID:  8660 NCBI-ProteinID:  NP_003740 OMIM:  600797 HGNC:  6126 Ensembl:  ENSG00000185950 UniProt:  Q9Y4H2 Q9P084 Structure PDB LinkDB All DBs Position 13:complement(109752695..109786583) Genome browser AA seq 1338 aa AA seqDB search MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA TAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE YFAVAAENEQEQEGWYRALTDLVSEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGA EDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTL QLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEF RPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCR VRTASEGDGGAAAGAAAAGARPVSVAGSPLSPGPVRAPLSRSHTLSGGCGGRGSKVALLP AGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPGQR PSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGGGGGEFY GYMTMDRPLSHCGRSYRRVSGDAAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTL MRATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGA ALAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVPSAGPAGPAPTSAAGRTF PASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTGTP PDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLE PQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPS LPSMHEYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGS GTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPR PSASPSSSLQPPPPPPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVA ATPPQPIAAPPKPEAARVASPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADP QGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEP PTSPRQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVRE EPGLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTY ASIDFLSHHLKEATIVKE NT seq 4017 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccgccgcggcacgggccgcccgggccggcgagcggagacggccccaacctc aacaacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag aagcatggccacaagcgcttcttcgtgctgcgcggacccggcgcgggcggcgacgaggcg acggcgggcggggggtcggcgccgcaaccgccgcggctcgagtactacgagagcgagaaa aagtggcggagcaaggcaggcgcgccgaaacgggtgatcgctctcgactgctgcctgaac atcaacaagcgcgccgacgccaagcacaagtacctgatcgccctctacaccaaggacgag tacttcgccgtggccgccgagaacgagcaggagcaggagggctggtaccgcgcgctcacc gacctggtcagcgagggccgcgcggccgccggagacgcgccccccgccgccgcgcccgcc gcgtcctgcagcgcctccctgcccggcgccctgggcggctctgccggcgccgccggggcc gaggacagctacgggctggtggctcccgccacggccgcctaccgtgaggtgtggcaggtg aacctgaagcccaagggtctgggccagagcaagaacctgacgggggtgtaccgtctgtgc ctgtctgcgcgcaccatcggcttcgtgaagctcaactgcgagcagccgtcggtgacgctg cagctcatgaacatccgccgctgcggccactcggacagcttcttcttcatcgaggtgggc cgctcggccgtcacaggccccggcgagctgtggatgcaggcggacgactcggtggtggcg cagaacatccacgagaccatcctggaggccatgaaggcgctcaaggagctcttcgagttc cggccgcgcagtaagagccaatcgtcggggtcgtcggccacgcaccccatcagcgtcccc ggcgcgcgccgccaccaccacctggtcaacctgccccccagccagacgggcctggtgcgc cgctcgcgcaccgacagcctggccgccaccccgccggcggccaagtgcagctcgtgccgg gtgcgcaccgccagcgagggcgacggcggcgcggcggcgggagcggcggccgcgggcgcc aggccggtgtcggtggctgggagccccctgagccccgggccggtgcgcgcgcccctgagc cgctcgcacaccctgagcggcggctgcggcggccgcgggagcaaggtggcgctgctgccg gcagggggcgcgctgcaacacagccgctccatgtccatgcccgtggcgcactcgccgccc gccgccaccagccccggctccctgtcgtccagcagcggccacggctcgggctcctacccg ccgccgcccggcccgcacccgcctctgccgcatccgctgcaccacggccccggccagcgg ccctccagcggcagcgcctccgcctcgggctcccccagcgaccccggcttcatgtccctg gacgagtacggctccagcccaggcgacctgcgcgccttctgcagccaccgaagcaacacg cccgagtccatcgcggagacgcccccggcccgagacggcggcggcggcggtgagttctac gggtacatgaccatggacaggcccctgagccactgtggccgctcctaccgccgggtctcg ggggacgcggcccaggacctggaccgagggctgcgcaagaggacctactccctgaccacg ccagcccggcagcggccggtgccccagccctcctctgcctcgctggatgaatacaccctg atgcgggccaccttctcgggcagcgcgggccgcctctgcccgtcctgccccgcgtcctct cccaaggtggcctaccacccctacccagaggactacggagacatcgagatcggctcccac aggagctccagcagcaacctgggggcagacgacggctacatgcccatgacgcccggcgcg gccctcgcgggcagtgggagcggcagctgcaggagcgacgactacatgcccatgagcccc gccagcgtgtccgcccccaagcagatcttgcagcccagggccgccgccgccgccgccgcc gccgtgccttctgcggggcctgcggggccagcacccacctctgcggcgggcaggacattc ccggcgagcgggggcggctacaaggccagctcgcccgccgagagctcccccgaggacagt gggtacatgcgcatgtggtgcggttccaagctgtccatggagcatgcagatggcaagctg ctgcccaacggggactacctcaacgtgtcccccagcgacgcggtcaccacgggcaccccg cccgacttcttctccgcagccctgcaccccggcggggagccgctcaggggcgttcccggc tgctgctacagctccttgccccgctcctacaaggccccctacacctgtggcggggacagc gaccagtacgtgctcatgagctcccccgtggggcgcatcctggaggaggagcgtctggag cctcaggccacgccagggcccagccaggcggccagcgccttcggggccggccccacgcag ccccctcaccctgtagtgccttcgcccgtgcggcctagcggcggccgcccggagggcttc ttgggccagcgcggccgggcggtgaggcccacgcgcctgtccctggaggggctgcccagc ctgcccagcatgcacgagtacccactgccaccggagcccaagagccccggcgagtacatc aacatcgactttggcgagcccggggcccgcctgtcgccgcccgcgcctcccctgctggcg tcggcggcctcgtcctcctcgctcttgtccgccagcagcccggcctcgtcgctgggctca ggcaccccgggcaccagcagcgacagccggcagcggtctccgctctccgactacatgaac ctcgacttcagctcccccaagtctcctaagccgggcgccccgagcggccaccccgtgggc tccttggacggcctcctgtcccccgaggcctcctccccgtatccgccgttgcccccgcgt ccgtccgcgtccccgtcgtcgtctctgcagccgccgccaccgccgccggccccgggggag ctgtaccgcctgccccccgcctcggccgttgccaccgcccagggcccgggcgccgcctca tcgttgtcctcggacaccggggacaatggtgactacaccgagatggcttttggtgtggcc gccaccccgccgcaacctatcgcggcccccccgaagccagaagctgcccgcgtggccagc ccgacgtcgggcgtgaagaggctgagcctcatggagcaggtgtcgggagtcgaggccttc ctgcaggccagccagcccccggacccccaccgcggcgccaaggtcatccgcgcagacccg caggggggccgccgccgccacagttccgagaccttctcctccaccacgacggtcaccccc gtgtccccgtccttcgcccacaaccccaagcgccacaactcggcctccgtggaaaatgtc tctctcaggaaaagcagcgagggcggcgtgggtgtcggccctggagggggcgacgagccg cccacctccccacgacagttgcagccggcgccccctttggcaccgcagggccggccgtgg accccgggtcagcccgggggcttggtcggttgtcctgggagcggtggatcgcccatgcgc agagagacctctgccggcttccagaatggtctcaactacatcgccatcgacgtgagggag gagcccgggctgccaccccagccgcagccgccgccgccgccgcttcctcagccgggagac aagagctcctggggccggacccgaagcctcgggggtctcatcagcgctgtgggcgtcggc agcaccggcggcgggtgcggggggccgggtcccggtgccctgccccctgccaacacctac gccagcattgacttcttgtcccaccacttgaaggaggccaccatcgtgaaagagtga

Homo sapiens (human): 8471 Help Entry 8471              CDS       T01001                                  Symbol IRS4, CHNG9, IRS-4, PY160 Name (RefSeq) insulin receptor substrate 4   KO K17446   insulin receptor substrate 4 Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04068   FoxO signaling pathway hsa04140   Autophagy - animal hsa04152   AMPK signaling pathway hsa04211   Longevity regulating pathway hsa04213   Longevity regulating pathway - multiple species hsa04910   Insulin signaling pathway hsa04920   Adipocytokine signaling pathway hsa04923   Regulation of lipolysis in adipocytes hsa04930   Type II diabetes mellitus hsa04935   Growth hormone synthesis, secretion and action hsa05010   Alzheimer disease Network nt06325  Hormone/cytokine signaling   Element N01708   INS-AKT signaling pathway Disease H00250   Congenital nongoitrous hypothyroidism (CHNG) Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     8471 (IRS4)    04022 cGMP-PKG signaling pathway     8471 (IRS4)    04152 AMPK signaling pathway     8471 (IRS4)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     8471 (IRS4)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     8471 (IRS4)    04923 Regulation of lipolysis in adipocytes     8471 (IRS4)    04920 Adipocytokine signaling pathway     8471 (IRS4)    04935 Growth hormone synthesis, secretion and action     8471 (IRS4)   09149 Aging    04211 Longevity regulating pathway     8471 (IRS4)    04213 Longevity regulating pathway - multiple species     8471 (IRS4)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     8471 (IRS4)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     8471 (IRS4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH_11 PH PH_8 Motif Other DBs NCBI-GeneID:  8471 NCBI-ProteinID:  NP_003595 OMIM:  300904 HGNC:  6128 Ensembl:  ENSG00000133124 UniProt:  O14654 LinkDB All DBs Position X:complement(108719946..108736563) Genome browser AA seq 1257 aa AA seqDB search MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR NT seq 3774 nt NT seq  +upstreamnt  +downstreamnt atggcgagttgctccttcactcgcgaccaagcgacaagaagactaagaggtgcagcagcg gcggcagcggcagctctagcagcagtggtgaccaccccgcttctttcctcgggaaccccg accgcactcattgggaccgggtcgtcttgtccgggagccatgtggctctccacggccact ggctcccggtcagactccgagtccgaagaggaggacctgcccgtcggggaggaagtctgc aaacgcggctacctgcggaaacagaagcatgggcacaggcgctacttcgtgctcaaactc gagactgctgacgccccagctcggctggaatactacgaaaatgccaggaagttccggcac agtgtccgcgccgcggcggctgcagcagcggcggccgcctctggcgccgcgatccccccg ctcattccaccgcggcgcgtgatcaccctataccagtgcttttccgtgagccagcgagca gatgcaaggtaccgacacctcattgctcttttcacccaagacgaatacttcgcgatggtg gccgagaacgagtcggagcaggaaagctggtacttgctgctcagccgcctcatcctcgag agcaagcgccgccgctgcggcacgctcggcgcgcagccggacggagagccggccgcgctg gcggcggcagcggcggcggagccacccttctataaagatgtgtggcaggtaatagtcaaa cccagggggctggggcacagaaaagagctgagcggcgtgttccggctgtgtctaaccgac gaggaggtcgtgtttgtgaggctgaacaccgaagtggccagcgtggtcgtccagctcctg agcatccgtcgctgtggacactcggagcagtatttcttcttggaagtaggcaggtccact gtcatcggtccgggagagctctggatgcaggtcgatgactgtgtggttgcccaaaacatg catgagctgtttttggagaagatgagagccttgtgtgcagacgaatacagagcccgctgc cgcagctacagcatcagcatcggcgcccacctgttaaccctgctgtccgctaggaggcac ctgggcttggtgccgctcgagccgggaggctggctcagaaggtcccgctttgagcagttt tgccacctcagggccatcggcgacggggaagacgagatgcttttcaccaggcgcttcgta acacccagcgagcctgtggcccactccaggcgaggaagactgcacctgcccagagggcgc aggtcaaggagagcggtttcagtgccggccagcttttttcgccgcttagcacccagccca gcacgtccccggcaccctgcagaagccccgaacaatggagctcgcctgtcttctgaagtg tctggttctggctctggcaactttggggaggaaggcaatccccagggcaaagaagatcag gaaggaagcggaggtgactacatgcctatgaacaattggggctcaggaaatggccggggc tcaggaggtggccagggctcaaatggccaaggctccagtagccatagctcgggaggaaac cagtgttcaggcgagggacagggatcccgaggtggtcagggctcaaatggccagggctca ggaggaaaccagtgctctagagatggccagggcaccgcaggtgggcacggttcaggtggt ggccagagacctggaggtgggcatggctcaggtggtggccagggacctggagatggccat ggctcaggtggtggcaagaactctggggggggcaaaggctcaggaagtgggaaaggatcc gatggtgatggtgaacgtggaaaatctctgaagaaaagatcctattttggcaaattaact caaagcaagcaacagcaaatgccaccacctccaccacctcctcctccacccccaccagct ggaggaactggtggaaaagggaagtctgggggaagattcagactttatttttgtgttgac agaggagccacgaaagaatgcaaagaagccaaagaagtgaaagatgcagagatcccagaa ggtgcagctcgaggtccccacagagccagagcttttgatgaagatgaggatgacccatac gtgccaatgaggccaggggtggccacccctcttgtaagctccagtgattatatgccaatg gctcctcaaaatgtctctgcttcaaaaaagcgccactctcgatccccttttgaagattca agagggtacatgatgatgtttcccagagtgagcccaccacctgctccgagtcctccaaaa gcacctgatactaataaagaggatgactcaaaggacaatgacagtgagagtgactacatg tttatggctcctggagccggtgcaattccaaaaaaccccagaaatcctcagggtggctct tcctccaaaagttggagctcctacttctctctaccaaacccttttcggagctcacctttg ggacagaatgacaacagtgagtatgtgccaatgttacctggaaagttcctggggaggggc ctagacaaagaagtctcctataactgggaccccaaagatgcagcttcaaagccttcaggt gagggatcattctcaaagcctggagatgggggatcaccttcaaagccttcagatcatgag cccccaaagaataaagctaagagacctaaccgactttcttttattacaaaaggatataaa atcaagccaaaaccacaaaagcccacacatgagcagagagaagctgacagctctagtgac tacgtcaacatggacttcactaaaagagagagcaatacaccagctccctctactcaagga ctaccagattcgtggggcataattgctgaacccagacagtcagccttttctaattatgtg aatgttgagtttggagtgccatttccaaatccagcaaacgacctctcagatcttttaaga gctataccacgtgccaaccccttatctctggacagtgctaggtggccacttcctcccctt cccctcagtgctacaggtagcaatgctattgaggaagagggtgactacattgaagtaatt ttcaactcagcaatgacaccagccatggctcttgctgacagtgccattcgctatgatgct gaaacaggtcgaatctatgtggtcgacccattttctgagtgctgtatggatatttctctc tcccccagccgatgttctgaaccaccacctgtagctaggctgctgcaggaagaagagcag gagagaagacgcccacaaagccgttctcaaagtttctttgcagcagccagagccgctgtc tctgcttttccaacagacagcctcgagagagacctttccccatcctcagccccggctgtc gcttcggctgcagagccgactttagccctcagccaagttgtagctgcggcctccgcgctc gccgcagccccgggcatcggcgcagcagccgcagctgctggatttgactccgcctctgcc cgctggtttcaacctgttgctaatgctgctgatgccgaagcagtaaggggagcccaagac gttgccggtggctcgaaccctggagcccacaacccatctgcaaaccttgccagaggtgat aaccaggctggcggggctgccgctgcagctgccgctccggaaccaccacctcgcagtcgc cgggtgccaagacccccggagagagaagattctgacaacgacgacgacactcacgtgaga atggattttgccagacgtgataatcagttcgactctcccaaaagaggtcggtaa

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