Homo sapiens (human): 4860 Help Entry 4860              CDS       T01001                                  Symbol PNP, NP, PRO1837, PUNP Name (RefSeq) purine nucleoside phosphorylase   KO K03783   purine-nucleoside phosphorylase [EC:2.4.2.1] Organism hsa  Homo sapiens (human) Pathway hsa00230   Purine metabolism hsa00760   Nicotinate and nicotinamide metabolism hsa01100   Metabolic pathways hsa01232   Nucleotide metabolism Module hsa_M00958   Adenine ribonucleotide degradation, AMP => Urate hsa_M00959   Guanine ribonucleotide degradation, GMP => Urate Network nt06027  Purine salvage pathway   Element N01418   Purine salvage pathway, adenine to AMP N01421   Purine salvage pathway, hypoxanthine/guanine to IMP/GMP Disease H00093   Combined immunodeficiency Drug target Forodesine (DG01392):  D04245<JP> D06596 Peldesine:  D05396 Ulodesine (DG01881):  D10431 D10432 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     4860 (PNP)   09108 Metabolism of cofactors and vitamins    00760 Nicotinate and nicotinamide metabolism     4860 (PNP) Enzymes [BR:hsa01000]  2. Transferases   2.4  Glycosyltransferases    2.4.2  Pentosyltransferases     2.4.2.1  purine-nucleoside phosphorylase      4860 (PNP) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PNP_UDP_1 Motif Other DBs NCBI-GeneID:  4860 NCBI-ProteinID:  NP_000261 OMIM:  164050 HGNC:  7892 Ensembl:  ENSG00000198805 UniProt:  P00491 V9HWH6 Structure PDB LinkDB All DBs Position 14:20469406..20477089 Genome browser AA seq 289 aa AA seqDB search MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS NT seq 870 nt NT seq  +upstreamnt  +downstreamnt atggagaacggatacacctatgaagattataagaacactgcagaatggcttctgtctcac actaagcaccgacctcaagttgcaataatctgtggttctggattaggaggtctgactgat aaattaactcaggcccagatctttgactacggtgaaatccccaactttccccgaagtaca gtgccaggtcatgctggccgactggtgtttgggttcctgaatggcagggcctgtgtgatg atgcagggcaggttccacatgtatgaagggtacccactctggaaggtgacattcccagtg agggttttccaccttctgggtgtggacaccctggtagtcaccaatgcagcaggagggctg aaccccaagtttgaggttggagatatcatgctgatccgtgaccatatcaacctacctggt ttcagtggtcagaaccctctcagagggcccaatgatgaaaggtttggagatcgtttccct gccatgtctgatgcctacgaccggactatgaggcagagggctctcagtacctggaaacaa atgggggagcaacgtgagctacaggaaggcacctatgtgatggtggcaggccccagcttt gagactgtggcagaatgtcgtgtgctgcagaagctgggagcagacgctgttggcatgagt acagtaccagaagttatcgttgcacggcactgtggacttcgagtctttggcttctcactc atcactaacaaggtcatcatggattatgaaagcctggagaaggccaaccatgaagaagtc ttagcagctggcaaacaagctgcacagaaattggaacagtttgtctccattcttatggcc agcattccactccctgacaaagccagttga

Homo sapiens (human): 144811 Help Entry 144811            CDS       T01001                                  Symbol LACC1, C13orf31, FAMIN, JUVAR Name (RefSeq) laccase domain containing 1   KO K05810   purine-nucleoside/S-methyl-5'-thioadenosine phosphorylase / adenosine deaminase [EC:2.4.2.1 2.4.2.28 3.5.4.4] Organism hsa  Homo sapiens (human) Pathway hsa00230   Purine metabolism hsa00270   Cysteine and methionine metabolism hsa01100   Metabolic pathways hsa01232   Nucleotide metabolism Module hsa_M00034   Methionine salvage pathway hsa_M00958   Adenine ribonucleotide degradation, AMP => Urate hsa_M00959   Guanine ribonucleotide degradation, GMP => Urate Network nt06027  Purine salvage pathway   Element N01418   Purine salvage pathway, adenine to AMP N01421   Purine salvage pathway, hypoxanthine/guanine to IMP/GMP Disease H01672   Juvenile idiopathic arthritis Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     144811 (LACC1)   09105 Amino acid metabolism    00270 Cysteine and methionine metabolism     144811 (LACC1) Enzymes [BR:hsa01000]  2. Transferases   2.4  Glycosyltransferases    2.4.2  Pentosyltransferases     2.4.2.1  purine-nucleoside phosphorylase      144811 (LACC1)     2.4.2.28  S-methyl-5'-thioadenosine phosphorylase      144811 (LACC1)  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.4  In cyclic amidines     3.5.4.4  adenosine deaminase      144811 (LACC1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Cu-oxidase_4 Motif Other DBs NCBI-GeneID:  144811 NCBI-ProteinID:  NP_001121775 OMIM:  613409 HGNC:  26789 Ensembl:  ENSG00000179630 UniProt:  Q8IV20 LinkDB All DBs Position 13:43879178..43893932 Genome browser AA seq 430 aa AA seqDB search MAEAVLIDLFGLKLNSQKNCHQTLLKTLNAVQYHHAAKAKFLCIMCCSNISYERDGEQDN CEIETSNGLSALLEEFEIVSCPSMAATLYTIKQKIDEKNLSSIKVIVPRHRKTLMKAFID QLFTDVYNFEFEDLQVTFRGGLFKQSIEINVITAQELRGIQNEIETFLRSLPALRGKLTI ITSSLIPDIFIHGFTTRTGGISYIPTLSSFNLFSSSKRRDPKVVVQENLRRLANAAGFNV EKFYRIKTHHSNDIWIMGRKEPDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVA HAGWKGTLLGVAMATVNAMIAEYGCSLEDIVVVLGPSVGPCCFTLPRESAEAFHNLHPAC VQLFDSPNPCIDIRKATRILLEQGGILPQNIQDQNQDLNLCTSCHPDKFFSHVRDGLNFG TQIGFISIKE NT seq 1293 nt NT seq  +upstreamnt  +downstreamnt atggcagaagctgttttgattgatctttttggtttgaaattgaactctcaaaaaaactgc catcagacattactgaagactttgaatgctgtccaataccaccatgctgccaaggccaag tttctctgtataatgtgttgcagtaacatcagctatgaaagggatggagaacaagataat tgtgaaatagaaacaagcaatggattatcagctctcttggaagaatttgagattgttagc tgtcccagcatggctgccactttgtataccattaaacagaaaattgatgaaaaaaatctg agcagcattaaggtaattgtacccaggcacaggaagacattaatgaaagcttttattgat caactcttcactgatgtttacaattttgaatttgaagatttgcaagtgacttttagggga gggctttttaaacagtccattgaaataaacgtaatcacagctcaagaactaagaggaatt cagaatgaaatagaaacatttttgagaagtctgccagcactgagaggaaaattaactatt atcacttcttctttgatcccagatattttcatacatggatttactacaagaacaggtggg atatcttatataccaactcttagctcattcaatctcttcagtagttccaaacggagagat cccaaggtagtggttcaagaaaatctgcgtaggttggcgaatgctgcaggatttaatgtg gagaaattttaccgaataaagactcatcattccaatgacatctggattatgggaagaaag gagcctgactcttatgatggaataaccacaaatcagagaggagtcacaatagcagctctt ggtgcagactgtataccgatagtttttgcagatccagtcaaaaaagcatgtggggttgct cacgctggttggaaaggtactttgttgggtgttgctatggctacagtgaatgctatgata gcagaatatggctgcagtttggaagacattgttgttgtacttggaccttcagtaggacct tgctgttttactcttccaagggaatcagcagaggcatttcataatcttcatcctgcatgt gtacaactatttgattcaccaaatccctgtatcgacatccgtaaagccacaaggattctt ctagaacagggaggaattcttccacagaatattcaggaccagaaccaagatctcaacctc tgtacatcttgccatcctgacaagtttttctcccatgtccgagatggccttaattttggt acacagattggcttcatatcaattaaagaatga

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