Homo sapiens (human): 6999 Help Entry 6999              CDS       T01001                                  Symbol TDO2, HYPTRP, TDO, TO, TPH2, TRPO Name (RefSeq) tryptophan 2,3-dioxygenase   KO K00453   tryptophan 2,3-dioxygenase [EC:1.13.11.11] Organism hsa  Homo sapiens (human) Pathway hsa00380   Tryptophan metabolism hsa01100   Metabolic pathways hsa01240   Biosynthesis of cofactors Module hsa_M00038   Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate hsa_M00912   NAD biosynthesis, tryptophan => quinolinate => NAD Network nt06036  Lysine degradation   Element N01723   NAD biosynthesis Disease H02545   Hypertryptophanemia Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09105 Amino acid metabolism    00380 Tryptophan metabolism     6999 (TDO2) Enzymes [BR:hsa01000]  1. Oxidoreductases   1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)    1.13.11  With incorporation of two atoms of oxygen     1.13.11.11  tryptophan 2,3-dioxygenase      6999 (TDO2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Trp_dioxygenase DUF3107 Motif Other DBs NCBI-GeneID:  6999 NCBI-ProteinID:  NP_005642 OMIM:  191070 HGNC:  11708 Ensembl:  ENSG00000151790 UniProt:  P48775 Structure PDB LinkDB All DBs Position 4:155903696..155920406 Genome browser AA seq 406 aa AA seqDB search MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD NT seq 1221 nt NT seq  +upstreamnt  +downstreamnt atgagtgggtgcccatttttaggaaacaactttggatatacttttaaaaaactccccgta gaaggcagcgaagaagacaaatcacaaactggtgtgaatagagccagcaaaggaggtctt atctatgggaactacctgcatttggaaaaagttttgaatgcacaagaactgcaaagtgaa acaaaaggaaataaaatccatgatgaacatctttttatcataactcatcaagcttatgaa ctctggtttaagcaaatcctctgggagttggattctgttcgagagatctttcagaatggc catgtcagagatgaaaggaacatgcttaaggttgtttctcggatgcaccgagtgtcagtg atcctgaaactgctggtgcagcagttttccattctggagacgatgacagccttggacttc aatgacttcagagagtacttatctccagcatcaggcttccagagtttgcaattccgacta ttagaaaacaagataggtgttcttcagaacatgagagtcccttataacagaagacattat cgtgataacttcaaaggagaagaaaatgaactgctacttaaatctgagcaggaaaagaca cttctggaattagtggaggcatggctggaaagaactccaggtttagagccacatggattt aacttctggggaaagcttgaaaaaaatatcaccagaggcctggaagaggaattcataagg attcaggctaaagaagagtctgaagaaaaagaggaacaggtggctgaatttcagaagcaa aaagaggtgctactgtccttatttgatgagaaacgtcatgaacatctccttagtaaaggt gaaagacggctgtcatacagagcacttcagggagcattgatgatatatttttacagggaa gagcctaggttccaggtgccttttcagttgctgacttctcttatggacatagattcactg atgaccaaatggagatataaccatgtgtgcatggtgcacagaatgctgggcagcaaagct ggcaccggtggttcctcaggctatcactacctgcgatcaactgtgagtgataggtacaag gtatttgtagatttatttaatctttcaacatacctgattccccgacactggataccgaag atgaacccaaccattcacaaatttctatatacagcagaatactgtgatagctcctacttc agcagtgatgaatcagattaa

Homo sapiens (human): 169355 Help Entry 169355            CDS       T01001                                  Symbol IDO2, INDOL1 Name (RefSeq) indoleamine 2,3-dioxygenase 2   KO K00463   indoleamine 2,3-dioxygenase [EC:1.13.11.52] Organism hsa  Homo sapiens (human) Pathway hsa00380   Tryptophan metabolism hsa01100   Metabolic pathways hsa01240   Biosynthesis of cofactors hsa05143   African trypanosomiasis Module hsa_M00038   Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate hsa_M00912   NAD biosynthesis, tryptophan => quinolinate => NAD Network nt06036  Lysine degradation   Element N01723   NAD biosynthesis Drug target Indoximod:  D10640 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09105 Amino acid metabolism    00380 Tryptophan metabolism     169355 (IDO2)  09160 Human Diseases   09174 Infectious disease: parasitic    05143 African trypanosomiasis     169355 (IDO2) Enzymes [BR:hsa01000]  1. Oxidoreductases   1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)    1.13.11  With incorporation of two atoms of oxygen     1.13.11.52  indoleamine 2,3-dioxygenase      169355 (IDO2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IDO PrnB Motif Other DBs NCBI-GeneID:  169355 NCBI-ProteinID:  NP_919270 OMIM:  612129 HGNC:  27269 Ensembl:  ENSG00000188676 UniProt:  Q6ZQW0 LinkDB All DBs Position 8:39934651..40016392 Genome browser AA seq 407 aa AA seqDB search MEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQ AHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSR NLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVP GIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSG WKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYM PPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAA KAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG NT seq 1224 nt NT seq  +upstreamnt  +downstreamnt atggagccccacagaccgaatgtgaagacagcagtgccattgtctttggaaagctatcac atatctgaagagtatggctttcttcttccagattctctgaaagaacttccagatcattat aggccttggatggaaattgccaacaaacttcctcaattgattgatgctcaccagcttcaa gctcatgtggacaagatgcccctgctgagctgccagttcctgaagggtcaccgggagcag cgcctggcccacctggtcctgagcttcctcaccatgggttatgtctggcaggaaggagag gcgcagcctgcagaggtcctgccaaggaatcttgcccttccatttgtcgaagtctccagg aacttggggctccctcctatcctggtccactcagacttggtgctgacgaactggaccaaa aaagatccagacggattcctggaaattgggaacctggagaccatcatctcatttcctggg ggagagagcctgcatggttttatactggtgactgctttggtagagaaagaagcagtgcct gggataaaggctcttgttcaggccacgaatgctatcttgcagcccaaccaggaggccctg ctccaagccctgcagcgactgagactgtctattcaggacatcaccaaaaccttaggacag atgcatgattatgtagatccagacatattttatgcaggcatccggatctttctctctgga tggaaagacaacccagcaatgcctgcagggctgatgtatgaaggagtttcccaagagccc ctgaaatactccggcgggagtgcagctcagagcacagtgcttcatgcctttgatgagttc ttaggcattcgtcatagcaaggaaagtggtgactttctgtacagaatgagggattacatg cctccttcccataaggccttcatagaagacatccactcagcaccttccctgagggactac atcctgtcatctggacaggaccacttgctgacagcttataaccagtgtgtgcaggccctg gcagagctgcggagctatcacatcaccatggtcaccaaatacctcatcacagctgcagcc aaggcaaagcatgggaagccaaaccatctcccagggcctcctcaggctttaaaagacagg ggcacaggtggaaccgcagttatgagctttcttaagagtgtcagggataagaccttggag tcaatccttcacccacgtggttag

Homo sapiens (human): 3620 Help Entry 3620              CDS       T01001                                  Symbol IDO1, IDO, IDO-1, INDO Name (RefSeq) indoleamine 2,3-dioxygenase 1   KO K00463   indoleamine 2,3-dioxygenase [EC:1.13.11.52] Organism hsa  Homo sapiens (human) Pathway hsa00380   Tryptophan metabolism hsa01100   Metabolic pathways hsa01240   Biosynthesis of cofactors hsa05143   African trypanosomiasis Module hsa_M00038   Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate hsa_M00912   NAD biosynthesis, tryptophan => quinolinate => NAD Network nt06036  Lysine degradation   Element N01723   NAD biosynthesis Drug target Epacadostat:  D11049 Indoximod:  D10640 Linrodostat (DG03010):  D11412 D11413 Navoximod:  D11255 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09105 Amino acid metabolism    00380 Tryptophan metabolism     3620 (IDO1)  09160 Human Diseases   09174 Infectious disease: parasitic    05143 African trypanosomiasis     3620 (IDO1) Enzymes [BR:hsa01000]  1. Oxidoreductases   1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)    1.13.11  With incorporation of two atoms of oxygen     1.13.11.52  indoleamine 2,3-dioxygenase      3620 (IDO1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IDO PrnB Meckelin Motif Other DBs NCBI-GeneID:  3620 NCBI-ProteinID:  NP_002155 OMIM:  147435 HGNC:  6059 Ensembl:  ENSG00000131203 UniProt:  P14902 A0A348GSI3 Structure PDB LinkDB All DBs Position 8:39913891..39928790 Genome browser AA seq 403 aa AA seqDB search MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG NT seq 1212 nt NT seq  +upstreamnt  +downstreamnt atggcacacgctatggaaaactcctggacaatcagtaaagagtaccatattgatgaagaa gtgggctttgctctgccaaatccacaggaaaatctacctgatttttataatgactggatg ttcattgctaaacatctgcctgatctcatagagtctggccagcttcgagaaagagttgag aagttaaacatgctcagcattgatcatctcacagaccacaagtcacagcgccttgcacgt ctagttctgggatgcatcaccatggcatatgtgtggggcaaaggtcatggagatgtccgt aaggtcttgccaagaaatattgctgttccttactgccaactctccaagaaactggaactg cctcctattttggtttatgcagactgtgtcttggcaaactggaagaaaaaggatcctaat aagcccctgacttatgagaacatggacgttttgttctcatttcgtgatggagactgcagt aaaggattcttcctggtctctctattggtggaaatagcagctgcttctgcaatcaaagta attcctactgtattcaaggcaatgcaaatgcaagaacgggacactttgctaaaggcgctg ttggaaatagcttcttgcttggagaaagcccttcaagtgtttcaccaaatccacgatcat gtgaacccaaaagcatttttcagtgttcttcgcatatatttgtctggctggaaaggcaac ccccagctatcagacggtctggtgtatgaagggttctgggaagacccaaaggagtttgca gggggcagtgcaggccaaagcagcgtctttcagtgctttgacgtcctgctgggcatccag cagactgctggtggaggacatgctgctcagttcctccaggacatgagaagatatatgcca ccagctcacaggaacttcctgtgctcattagagtcaaatccctcagtccgtgagtttgtc ctttcaaaaggtgatgctggcctgcgggaagcttatgacgcctgtgtgaaagctctggtc tccctgaggagctaccatctgcaaatcgtgactaagtacatcctgattcctgcaagccag cagccaaaggagaataagacctctgaagacccttcaaaactggaagccaaaggaactgga ggcactgatttaatgaatttcctgaagactgtaagaagtacaactgagaaatcccttttg aaggaaggttaa

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