KEGG T01001: 7153

Homo sapiens (human): 7153

Entry

7153              CDS       T01001

Symbol

TOP2A, TOP2, TOP2alpha, TOPIIA, TP2A

Name

(RefSeq) DNA topoisomerase II alpha

K03164

DNA topoisomerase II [EC:5.6.2.2]

Organism

hsa Homo sapiens (human)

Pathway

hsa01524

Platinum drug resistance

Network

nt06512 Chromosome cohesion and segregation

Element

N01497

Condensin loading

Drug target

Aclarubicin (DG00699):

D01911<JP> D02756

Aldoxorubicin (DG01726):

D10383 D10384

Amonafide (DG01268):

D10090 D10091

Amrubicin (DG00703):

D07100<JP> D08854

Amsacrine:

D02321

Becatecarin:

D03220

Berubicin hydrochloride:

D08871

Crisnatol mesylate:

D03602

Daunorubicin (DG00697):

D01264<JP/US> D07776 D10787

Dexrazoxane (DG01162):

D03730<JP/US> D07807<US>

Doxorubicin (DG00696):

D01275<JP/US> D03899

Elsamitrucin:

D03977

Epirubicin (DG00698):

D02214<JP/US> D07901

Etoposide (DG00693):

D00125<JP/US> D04107<US>

Fostriecin sodium:

D04262

Idarubicin (DG00700):

D01747<JP/US> D08062

Idronoxil:

D04498

Ledoxantrone trihydrochloride:

D04685

Losoxantrone hydrochloride:

D04783

Menogaril:

D04914

Mitindomide:

D05054

Mitoxantrone (DG00701):

D02166<JP/US> D08224

Naxtarubicin:

D12844

Pirarubicin (DG00702):

D01885 D08386<JP>

Piroxantrone hydrochloride:

D05510

Pixantrone (DG00704):

D05522 D09654

Quarfloxin:

D08981

Sobuzoxane:

D01404<JP>

Teloxantrone hydrochloride:

Teniposide:

Tirapazamine:

Topixantrone:

Valrubicin:

D02697<US>

Vosaroxin:

D08024

Zorubicin:

D06386

Brite

KEGG Orthology (KO) [BR:hsa00001]
09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    7153 (TOP2A)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    7153 (TOP2A)
   03036 Chromosome and associated proteins [BR:hsa03036]
    7153 (TOP2A)
Enzymes [BR:hsa01000]
5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     7153 (TOP2A)
DNA replication proteins [BR:hsa03032]
Eukaryotic type
  DNA Topoisomerases
   7153 (TOP2A)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    7153 (TOP2A)
  Centrosome formation proteins
   Centriole proteins
    7153 (TOP2A)

SSDB

Motif

Pfam:

DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

17:complement(40388525..40417896)

AA seq 1531 aa
MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

NT seq 4596 nt +upstreamnt +downstreamnt
atggaagtgtcaccattgcagcctgtaaatgaaaatatgcaagtcaacaaaataaagaaa
aatgaagatgctaagaaaagactgtctgttgaaagaatctatcaaaagaaaacacaattg
gaacatattttgctccgcccagacacctacattggttctgtggaattagtgacccagcaa
atgtgggtttacgatgaagatgttggcattaactatagggaagtcacttttgttcctggt
ttgtacaaaatctttgatgagattctagttaatgctgcggacaacaaacaaagggaccca
aaaatgtcttgtattagagtcacaattgatccggaaaacaatttaattagtatatggaat
aatggaaaaggtattcctgttgttgaacacaaagttgaaaagatgtatgtcccagctctc
atatttggacagctcctaacttctagtaactatgatgatgatgaaaagaaagtgacaggt
ggtcgaaatggctatggagccaaattgtgtaacatattcagtaccaaatttactgtggaa
acagccagtagagaatacaagaaaatgttcaaacagacatggatggataatatgggaaga
gctggtgagatggaactcaagcccttcaatggagaagattatacatgtatcacctttcag
cctgatttgtctaagtttaaaatgcaaagcctggacaaagatattgttgcactaatggtc
agaagagcatatgatattgctggatccaccaaagatgtcaaagtctttcttaatggaaat
aaactgccagtaaaaggatttcgtagttatgtggacatgtatttgaaggacaagttggat
gaaactggtaactccttgaaagtaatacatgaacaagtaaaccacaggtgggaagtgtgt
ttaactatgagtgaaaaaggctttcagcaaattagctttgtcaacagcattgctacatcc
aagggtggcagacatgttgattatgtagctgatcagattgtgactaaacttgttgatgtt
gtgaagaagaagaacaagggtggtgttgcagtaaaagcacatcaggtgaaaaatcacatg
tggatttttgtaaatgccttaattgaaaacccaacctttgactctcagacaaaagaaaac
atgactttacaacccaagagctttggatcaacatgccaattgagtgaaaaatttatcaaa
gctgccattggctgtggtattgtagaaagcatactaaactgggtgaagtttaaggcccaa
gtccagttaaacaagaagtgttcagctgtaaaacataatagaatcaagggaattcccaaa
ctcgatgatgccaatgatgcagggggccgaaactccactgagtgtacgcttatcctgact
gagggagattcagccaaaactttggctgtttcaggccttggtgtggttgggagagacaaa
tatggggttttccctcttagaggaaaaatactcaatgttcgagaagcttctcataagcag
atcatggaaaatgctgagattaacaatatcatcaagattgtgggtcttcagtacaagaaa
aactatgaagatgaagattcattgaagacgcttcgttatgggaagataatgattatgaca
gatcaggaccaagatggttcccacatcaaaggcttgctgattaattttatccatcacaac
tggccctctcttctgcgacatcgttttctggaggaatttatcactcccattgtaaaggta
tctaaaaacaagcaagaaatggcattttacagccttcctgaatttgaagagtggaagagt
tctactccaaatcataaaaaatggaaagtcaaatattacaaaggtttgggcaccagcaca
tcaaaggaagctaaagaatactttgcagatatgaaaagacatcgtatccagttcaaatat
tctggtcctgaagatgatgctgctatcagcctggcctttagcaaaaaacagatagatgat
cgaaaggaatggttaactaatttcatggaggatagaagacaacgaaagttacttgggctt
cctgaggattacttgtatggacaaactaccacatatctgacatataatgacttcatcaac
aaggaacttatcttgttctcaaattctgataacgagagatctatcccttctatggtggat
ggtttgaaaccaggtcagagaaaggttttgtttacttgcttcaaacggaatgacaagcga
gaagtaaaggttgcccaattagctggatcagtggctgaaatgtcttcttatcatcatggt
gagatgtcactaatgatgaccattatcaatttggctcagaattttgtgggtagcaataat
ctaaacctcttgcagcccattggtcagtttggtaccaggctacatggtggcaaggattct
gctagtccacgatacatctttacaatgctcagctctttggctcgattgttatttccacca
aaagatgatcacacgttgaagtttttatatgatgacaaccagcgtgttgagcctgaatgg
tacattcctattattcccatggtgctgataaatggtgctgaaggaatcggtactgggtgg
tcctgcaaaatccccaactttgatgtgcgtgaaattgtaaataacatcaggcgtttgatg
gatggagaagaacctttgccaatgcttccaagttacaagaacttcaagggtactattgaa
gaactggctccaaatcaatatgtgattagtggtgaagtagctattcttaattctacaacc
attgaaatctcagagcttcccgtcagaacatggacccagacatacaaagaacaagttcta
gaacccatgttgaatggcaccgagaagacacctcctctcataacagactatagggaatac
catacagataccactgtgaaatttgttgtgaagatgactgaagaaaaactggcagaggca
gagagagttggactacacaaagtcttcaaactccaaactagtctcacatgcaactctatg
gtgctttttgaccacgtaggctgtttaaagaaatatgacacggtgttggatattctaaga
gacttttttgaactcagacttaaatattatggattaagaaaagaatggctcctaggaatg
cttggtgctgaatctgctaaactgaataatcaggctcgctttatcttagagaaaatagat
ggcaaaataatcattgaaaataagcctaagaaagaattaattaaagttctgattcagagg
ggatatgattcggatcctgtgaaggcctggaaagaagcccagcaaaaggttccagatgaa
gaagaaaatgaagagagtgacaacgaaaaggaaactgaaaagagtgactccgtaacagat
tctggaccaaccttcaactatcttcttgatatgcccctttggtatttaaccaaggaaaag
aaagatgaactctgcaggctaagaaatgaaaaagaacaagagctggacacattaaaaaga
aagagtccatcagatttgtggaaagaagacttggctacatttattgaagaattggaggct
gttgaagccaaggaaaaacaagatgaacaagtcggacttcctgggaaaggggggaaggcc
aaggggaaaaaaacacaaatggctgaagttttgccttctccgcgtggtcaaagagtcatt
ccacgaataaccatagaaatgaaagcagaggcagaaaagaaaaataaaaagaaaattaag
aatgaaaatactgaaggaagccctcaagaagatggtgtggaactagaaggcctaaaacaa
agattagaaaagaaacagaaaagagaaccaggtacaaagacaaagaaacaaactacattg
gcatttaagccaatcaaaaaaggaaagaagagaaatccctggtctgattcagaatcagat
aggagcagtgacgaaagtaattttgatgtccctccacgagaaacagagccacggagagca
gcaacaaaaacaaaattcacaatggatttggattcagatgaagatttctcagattttgat
gaaaaaactgatgatgaagattttgtcccatcagatgctagtccacctaagaccaaaact
tccccaaaacttagtaacaaagaactgaaaccacagaaaagtgtcgtgtcagaccttgaa
gctgatgatgttaagggcagtgtaccactgtcttcaagccctcctgctacacatttccca
gatgaaactgaaattacaaacccagttcctaaaaagaatgtgacagtgaagaagacagca
gcaaaaagtcagtcttccacctccactaccggtgccaaaaaaagggctgccccaaaagga
actaaaagggatccagctttgaattctggtgtctctcaaaagcctgatcctgccaaaacc
aagaatcgccgcaaaaggaagccatccacttctgatgattctgactctaattttgagaaa
attgtttcgaaagcagtcacaagcaagaaatccaagggggagagtgatgacttccatatg
gactttgactcagctgtggctcctcgggcaaaatctgtacgggcaaagaaacctataaag
tacctggaagagtcagatgaagatgatctgttttaa

Homo sapiens (human): 24137

Entry

24137             CDS       T01001

Symbol

KIF4A, KIF4, KIF4G1, MRX100, TMDI, XLID100

Name

(RefSeq) kinesin family member 4A

K10395

kinesin family member 4

Organism

hsa Homo sapiens (human)

Pathway

hsa04814

Motor proteins

Network

nt06512 Chromosome cohesion and segregation

Element

N01497

Condensin loading

Disease

H00480

X-linked intellectual developmental disorder

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    24137 (KIF4A)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    24137 (KIF4A)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Kinesins
     24137 (KIF4A)

SSDB

Motif

Pfam:

Kinesin Microtub_bd

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

X:70290104..70420886

AA seq 1232 aa
MKEEVKGIPVRVALRCRPLVPKEISEGCQMCLSFVPGEPQVVVGTDKSFTYDFVFDPSTE
QEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGVIPRVIQ
LLFKEIDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKT
VLVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISLEQRKKSDKNSSFRSKLHLVD
LAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGGFVPYRDSKLTRLLQDS
LGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIVNIDPQTAELNHLKQQVQQ
LQVLLLQAHGGTLPGSITVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERI
ILTEQANEKMNAKLEELRQHAACKLDLQKLVETLEDQELKENVEIICNLQQLITQLSDET
VACMAAAIDTAVEQEAQVETSPETSRSSDAFTTQHALRQAQMSKELVELNKALALKEALA
RKMTQNDSQLQPIQYQYQDNIKELELEVINLQKEKEELVLELQTAKKDANQAKLSERRRK
RLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIRMMKNQRVQLMRQMKEDAEK
FRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQK
QREVADKRKETQSRGMEGTAARVKNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVAQ
LKEKKESGENPPPKLRRRTFSLTEVRGQVSESEDSITKQIESLETEMEFRSAQIADLQQK
LLDAESEDRPKQRWENIATILEAKCALKYLIGELVSSKIQVSKLESSLKQSKTSCADMQK
MLFEERNHFAEIETELQAELVRMEQQHQEKVLYLLSQLQQSQMAEKQLEESVSEKEQQLL
STLKCQDEELEKMREVCEQNQQLLRENEIIKQKLTLLQVASRQKHLPKDTLLSPDSSFEY
VPPKPKPSRVKEKFLEQSMDIEDLKYCSEHSVNEHEDGDGDDDEGDDEEWKPTKLVKVSR
KNIQGCSCKGWCGNKQCGCRKQKSDCGVDCCCDPTKCRNRQQGKDSLGTVERTQDSEGSF
KLEDPTEVTPGLSFFNPVCATPNSKILKEMCDVEQVLSKKTPPAPSPFDLPELKHVATEY
QENKAPGKKKKRALASNTSFFSGCSPIEEEAH

NT seq 3699 nt +upstreamnt +downstreamnt
atgaaggaagaggtgaagggaattcccgtaagagtggcgctgcgttgtcgccctctggtc
cccaaagagattagcgagggctgccagatgtgcctttccttcgtgcccggagagcctcag
gtggtggttggtacagataaatccttcacctacgattttgtatttgatccctctactgaa
caggaagaagtcttcaatacagcagtagcgccactcataaaaggtgtatttaaaggatat
aatgcaacggtcctggcctatgggcagactggctctggaaaaacctattcaatgggaggt
gcatatactgcagagcaagagaatgaaccaacagttggggttattcctagggtaatacaa
ctgctcttcaaagaaattgataaaaagagtgactttgaatttactctgaaagtgtcttac
ttagagatttacaatgaagaaattttggatcttctatgcccatctcgtgagaaagctcaa
ataaatatacgagaggatcctaaggaaggcataaagattgtgggactcactgagaagact
gttttggttgccttggatactgtttcctgtttggaacagggcaacaactctaggactgtg
gcctccacggctatgaactcccagtcgtcccgatctcatgccatctttacaatctcctta
gagcaaagaaagaaaagtgacaagaatagcagctttcgctccaagctgcatcttgtagac
ctcgctggatcagaaagacagaagaaaaccaaggctgaaggggatcgtctaaaagagggt
attaatattaaccgaggcctcctatgcttgggaaatgtaatcagtgctcttggagatgac
aaaaagggtggctttgtgccctacagagattccaagttgactcgactgcttcaagattct
ctaggaggtaatagccatactcttatgatagcctgtgtgagtcctgctgactccaatcta
gaggaaacattaaatacccttcgctatgctgacagagcaagaaaaatcaagaacaaacct
attgttaatattgatccccagacagctgaacttaatcatctaaagcaacaggtacaacag
ctacaagtcttgttgctacaggcccatggaggtaccctgcctggatctataactgtggaa
ccatcagagaatctacaatccctgatggagaagaatcagtccctggtagaggagaatgaa
aaattaagtcgtggtctgagcgaggcagctggtcagacagcccagatgttggagaggatc
attttgacagagcaagcgaatgaaaaaatgaacgccaagctagaagagctcaggcagcat
gcggcctgcaaactggatcttcaaaagctagtggagactttggaagaccaggaattgaaa
gaaaatgtagagataatttgtaacctgcagcaattgattacccagttatcggatgaaact
gttgcttgcatggctgcagccattgatactgcggtggagcaagaagcccaagtagaaacc
agtccagagacgagcaggtcttctgacgcttttaccactcagcatgctctccgtcaagcg
cagatgtctaaggagctggttgagttgaataaagcgcttgcactgaaagaggccctggct
aggaagatgactcagaatgacagccaactgcagcccattcagtaccaataccaggataac
ataaaagagctagaattagaagtcatcaatctgcaaaaggaaaaggaagaattggttctt
gaacttcagacagcaaagaaggatgccaaccaagccaagttgagtgagcgccgccgcaaa
cgtctccaggagctggagggtcaaattgctgatctgaagaagaaactgaatgagcagtcc
aaacttctgaaactaaaggaatccacagagcgtactgtctccaaactgaaccaggagata
cggatgatgaaaaaccagcgggtacagttaatgcgtcaaatgaaagaagatgctgagaag
tttagacagtggaagcagaaaaaagacaaagaagtaatacagttaaaagaacgagaccgt
aagaggcaatatgagctgctgaaacttgaaagaaacttccagaaacaatccaatgtgctc
agacgtaaaacggaggaggcagcagctgccaacaagcgtctcaaggatgctctccagaaa
caacgggaggttgcagataagcggaaagagactcagagccgtggaatggaaggcactgca
gctcgagtgaagaattggcttggaaacgaaattgaggttatggtcagtactgaggaagcc
aaacgccatctgaatgacctccttgaagatagaaagatcctggctcaagatgtggctcaa
ctcaaagaaaaaaaggaatctggggagaatccacctcctaaactccggaggcgtacattc
tcccttactgaagtgcgtggtcaagtttcggagtcagaagattctattacaaagcagatt
gaaagcctagagactgaaatggaattcaggagtgctcagattgctgacctacagcagaag
ctgctggatgcagaaagtgaagacagaccaaaacaacgctgggagaatattgccaccatt
ctggaagccaagtgtgccctgaaatatttgattggagagctggtctcctccaaaatacag
gtcagcaaacttgaaagcagcctgaaacagagcaagaccagctgtgctgacatgcagaag
atgctgtttgaggaacgaaatcattttgccgagatagagacagagttacaagctgagctg
gtcagaatggagcaacagcaccaagagaaggtgctgtaccttctcagccagctgcagcaa
agccaaatggcagagaagcagttagaggaatcagtcagtgaaaaggaacagcagctgctg
agcacactgaagtgtcaggatgaagaacttgagaaaatgcgagaagtgtgtgagcaaaat
cagcagcttctccgagagaatgaaatcatcaagcagaaactgaccctcctccaggtagcc
agcagacagaaacatcttcctaaggatacccttctatctccagactcttcttttgaatat
gtcccacctaagccaaaaccttctcgtgttaaagaaaagttcctggagcaaagcatggac
atcgaggatctaaaatattgttcagagcattctgtgaatgagcatgaggatggtgatggt
gatgatgatgagggggatgacgaggaatggaagccaacaaaattagttaaggtgtccagg
aagaacatccaagggtgttcctgcaagggctggtgtggaaacaagcagtgtgggtgcagg
aagcaaaagtcagactgtggtgtggactgttgctgtgaccccacaaagtgtcggaaccgc
cagcaaggcaaggatagcttgggcactgttgaacggacccaggattccgaaggctccttc
aaactggaggatcctaccgaggtgaccccaggattgagcttctttaatcccgtctgtgcc
acccccaatagcaagatcctgaaagagatgtgcgatgtggagcaggtgctgtcaaagaag
actcccccagctccctccccttttgacctcccagagttgaaacatgtagcaacagaatac
caagaaaacaaggctccagggaagaaaaagaaacgggctctggccagcaacaccagcttc
ttctctggctgctcccctatcgaagaagaggcccactga

Homo sapiens (human): 1789

Entry

1789              CDS       T01001

Symbol

DNMT3B, FSHD4, ICF, ICF1, M.HsaIIIB

Name

(RefSeq) DNA methyltransferase 3 beta

K17399

DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]

Organism

hsa Homo sapiens (human)

Pathway

hsa00270

Cysteine and methionine metabolism

hsa01100

Metabolic pathways

hsa05206

MicroRNAs in cancer

Module

hsa_M00035

Methionine degradation

Network

nt06030 Methionine metabolism
nt06512 Chromosome cohesion and segregation

Element

N01497

Condensin loading

N01607

Methionine degradation

Disease

H00087

Other humoral immunodeficiencies

H00591

Facioscapulohumeral muscular dystrophy

H02308

Immunodeficiency-centromeric instability-facial anomalies syndrome

Drug target

Azacitidine:

D03021<JP/US>

Decitabine:

D03665<US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    1789 (DNMT3B)
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    1789 (DNMT3B)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1789 (DNMT3B)
   03032 DNA replication proteins [BR:hsa03032]
    1789 (DNMT3B)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1789 (DNMT3B)
Enzymes [BR:hsa01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     1789 (DNMT3B)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Zinc finger
   Cys4 GATA-factors
    1789 (DNMT3B)
DNA replication proteins [BR:hsa03032]
Eukaryotic type
  DNA Replication Termination Factors
   DNA methylation enzymes
    1789 (DNMT3B)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    1789 (DNMT3B)

SSDB

Motif

Pfam:

ADD_DNMT3 ADDz_Dnmt3b DNA_methylase PWWP

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

20:32762385..32809356

AA seq 853 aa
MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
HLFAPLKDYFACE

NT seq 2562 nt +upstreamnt +downstreamnt
atgaagggagacaccaggcatctcaatggagaggaggacgccggcgggagggaagactcg
atcctcgtcaacggggcctgcagcgaccagtcctccgactcgcccccaatcctggaggct
atccgcaccccggagatcagaggccgaagatcaagctcgcgactctccaagagggaggtg
tccagtctgctaagctacacacaggacttgacaggcgatggcgacggggaagatggggat
ggctctgacaccccagtcatgccaaagctcttccgggaaaccaggactcgttcagaaagc
ccagctgtccgaactcgaaataacaacagtgtctccagccgggagaggcacaggccttcc
ccacgttccacccgaggccggcagggccgcaaccatgtggacgagtcccccgtggagttc
ccggctaccaggtccctgagacggcgggcaacagcatcggcaggaacgccatggccgtcc
cctcccagctcttaccttaccatcgacctcacagacgacacagaggacacacatgggacg
ccccagagcagcagtaccccctacgcccgcctagcccaggacagccagcaggggggcatg
gagtccccgcaggtggaggcagacagtggagatggagacagttcagagtatcaggatggg
aaggagtttggaataggggacctcgtgtggggaaagatcaagggcttctcctggtggccc
gccatggtggtgtcttggaaggccacctccaagcgacaggctatgtctggcatgcggtgg
gtccagtggtttggcgatggcaagttctccgaggtctctgcagacaaactggtggcactg
gggctgttcagccagcactttaatttggccaccttcaataagctcgtctcctatcgaaaa
gccatgtaccatgctctggagaaagctagggtgcgagctggcaagaccttccccagcagc
cctggagactcattggaggaccagctgaagcccatgttggagtgggcccacgggggcttc
aagcccactgggatcgagggcctcaaacccaacaacacgcaaccagtggttaataagtcg
aaggtgcgtcgtgcaggcagtaggaaattagaatcaaggaaatacgagaacaagactcga
agacgcacagctgacgactcagccacctctgactactgccccgcacccaagcgcctcaag
acaaattgctataacaacggcaaagaccgaggggatgaagatcagagccgagaacaaatg
gcttcagatgttgccaacaacaagagcagcctggaagatggctgtttgtcttgtggcagg
aaaaaccccgtgtccttccaccctctctttgagggggggctctgtcagacatgccgggat
cgcttccttgagctgttttacatgtatgatgacgatggctatcagtcttactgcactgtg
tgctgcgagggccgagagctgctgctttgcagcaacacgagctgctgccggtgtttctgt
gtggagtgcctggaggtgctggtgggcacaggcacagcggccgaggccaagcttcaggag
ccctggagctgttacatgtgtctcccgcagcgctgtcatggcgtcctgcggcgccggaag
gactggaacgtgcgcctgcaggccttcttcaccagtgacacggggcttgaatatgaagcc
cccaagctgtaccctgccattcccgcagcccgaaggcggcccattcgagtcctgtcattg
tttgatggcatcgcgacaggctacctagtcctcaaagagttgggcataaaggtaggaaag
tacgtcgcttctgaagtgtgtgaggagtccattgctgttggaaccgtgaagcacgagggg
aatatcaaatacgtgaacgacgtgaggaacatcacaaagaaaaatattgaagaatggggc
ccatttgacttggtgattggcggaagcccatgcaacgatctctcaaatgtgaatccagcc
aggaaaggcctgtatgagggtacaggccggctcttcttcgaattttaccacctgctgaat
tactcacgccccaaggagggtgatgaccggccgttcttctggatgtttgagaatgttgta
gccatgaaggttggcgacaagagggacatctcacggttcctggagtgtaatccagtgatg
attgatgccatcaaagtttctgctgctcacagggcccgatacttctggggcaacctaccc
gggatgaacaggcccgtgatagcatcaaagaatgataaactcgagctgcaggactgcttg
gaatacaataggatagccaagttaaagaaagtacagacaataaccaccaagtcgaactcg
atcaaacaggggaaaaaccaacttttccctgttgtcatgaatggcaaagaagatgttttg
tggtgcactgagctcgaaaggatctttggctttcctgtgcactacacagacgtgtccaac
atgggccgtggtgcccgccagaagctgctgggaaggtcctggagcgtgcctgtcatccga
cacctcttcgcccctctgaaggactactttgcatgtgaatag

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