Homo sapiens (human): 84464
Help
Entry
84464 CDS
T01001
Symbol
SLX4, BTBD12, FANCP, MUS312
Name
(RefSeq) SLX4 structure-specific endonuclease subunit
KO
K10484
structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Organism
hsa
Homo sapiens (human)
Pathway
hsa03460
Fanconi anemia pathway
Network
nt06506
Double-strand break repair
nt06508
Interstrand crosslink repair
Element
N01448
Double Holliday junction resolution
N01465
Lesion bypass by TLS and DSB formation
Disease
H00238
Fanconi anemia
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09124 Replication and repair
03460 Fanconi anemia pathway
84464 (SLX4)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:
hsa04121
]
84464 (SLX4)
03400 DNA repair and recombination proteins [BR:
hsa03400
]
84464 (SLX4)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
Multi subunit Ring-finger type E3
Cul3 complex
Adoptor and target recognizing subunit (BTB)
84464 (SLX4)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic type
DSBR (double strand breaks repair)
HR (homologous recombination)
Other HR factors
84464 (SLX4)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Slx4
BTB
Motif
Other DBs
NCBI-GeneID:
84464
NCBI-ProteinID:
NP_115820
OMIM:
613278
HGNC:
23845
Ensembl:
ENSG00000188827
UniProt:
Q8IY92
Structure
PDB
LinkDB
All DBs
Position
16:complement(3581181..3611606)
Genome browser
AA seq
1834 aa
AA seq
DB search
MKLSVNEAQLGFYLGSLSHLSACPGIDPRSSEDQPESLKTGQMMDESDEDFKELCASFFQ
RVKKHGIKEVSGERKTQKAASNGTQIRSKLKRTKQTATKTKTLQGPAEKKPPSGSQAPRT
KKQRVTKWQASEPAHSVNGEGGVLASAPDPPVLRETAQNTQTGNQQEPSPNLSREKTREN
VPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAAREEN
VPKDPQEEMMAGNVYGLGPPAPESDAAVALTLQQEFARVGASAHDDSLEEKGLFFCQICQ
KNLSAMNVTRREQHVNRCLDEAEKTLRPSVPQIPECPICGKPFLTLKSRTSHLKQCAVKM
EVGPQLLLQAVRLQTAQPEGSSSPPMFSFSDHSRGLKRRGPTSKKEPRKRRKVDEAPSED
LLVAMALSRSEMEPGAAVPALRLESAFSERIRPEAENKSRKKKPPVSPPLLLVQDSETTG
RQIEDRVALLLSEEVELSSTPPLPASRILKEGWERAGQCPPPPERKQSFLWEGSALTGAW
AMEDFYTARLVPPLVPQRPAQGLMQEPVPPLVPPEHSELSERRSPALHGTPTAGCGSRGP
SPSASQREHQALQDLVDLAREGLSASPWPGSGGLAGSEGTAGLDVVPGGLPLTGFVVPSQ
DKHPDRGGRTLLSLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQY
VNNEGFSAVEDGVLTQRVLLGDVSTEAARTFLHYLYTADTGLPPGLSSELSSLAHRFGVS
ELVHLCEQVPIATDSEGKPWEEKEAENCESRAENFQELLRSMWADEEEEAETLLKSKDHE
EDQENVNEAEMEEIYEFAATQRKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQVQKQW
DKVEEMEPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSS
PSRDCQAERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITSEPEEQSGAVRERGLEVSH
RLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGSSLSTPRSRGGTSQVGSPTLLSPAVPS
KQKRDRSILTLSKEPGHQKGKERRSVLECRNKGVLMFPEKSPSIDLTQSNPDHSSSRSQK
SSSKLNEEDEVILLLDSDEELELEQTKMKSISSDPLEEKKALEISPRSCELFSIIDVDAD
QEPSQSPPRSEAVLQQEDEGALPENRGSLGRRGAPWLFCDRESSPSEASTTDTSWLVPAT
PLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNREGNEVAQKFSVIRPQTPPPQT
PSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISGDRAHFSRRFLKHSPPG
PSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDH
WNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGN
SRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPI
TPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDESQSSQPL
LQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKGPRHQRKHHESITPPSR
SPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAGEEEGEGEV
SASQAAVQAADTDEALRCYIRSKPALYQKVLLYQPFELRELQAELRQNGLRVSSRRLLDF
LDTHCITFTTAATRREKLQGRRRQPRGKKKVERN
NT seq
5505 nt
NT seq
+upstream
nt +downstream
nt
atgaaactgagtgtgaatgaggctcagctaggcttctacttgggttcactttctcatctg
tctgcctgtcctgggattgaccctcgctcctctgaagaccagcctgaaagccttaaaact
ggtcagatgatggatgagtctgatgaggactttaaagaactctgcgctagctttttccaa
agggtgaaaaaacatggaatcaaggaagtgtcaggagaaaggaagacacaaaaggctgcc
tcaaacggcactcagataagaagcaaattgaaaaggaccaaacaaactgctaccaagacc
aaaacccttcaaggccctgcagagaagaaacctccgtctggcagccaggcccctaggact
aaaaagcaaagggtaaccaaatggcaagcaagtgaaccggcccactctgtgaatggggag
gggggtgtgcttgcctctgctccagatccacctgtgctccgggaaacagcacaaaacacc
cagacgggtaaccagcaagaaccatcgccaaacctttccagagagaaaaccagagagaat
gtgcccaacagcgactcccagcctcctccttcctgtttgacaacagcagtgccaagtccc
tccaaaccccgcacagcacaattggtcctacagcgaatgcagcagttcaagagagcagac
cccgagcgtttgagacacgcttcagaagagtgctccctcgaggctgcgcgggaagaaaat
gtcccaaaggatcctcaagaggagatgatggcggggaatgtgtatgggcttgggccccct
gccccagagagcgacgctgcggtggccttgaccctgcagcaggagtttgcacgggtagga
gcatcggcacatgatgatagcctggaggaaaagggtttgttcttctgccagatttgtcaa
aagaacctctcagccatgaacgtgacccgaagggaacagcatgtgaacaggtgcttggat
gaagctgaaaagacactaagaccttctgtgcctcagatccctgagtgcccgatttgtggg
aaaccgtttcttaccttaaagagcagaaccagtcacttgaagcagtgtgctgtgaagatg
gaggttggcccccagctcctgcttcaggctgtgcggctgcagacagcacagcctgagggt
agcagcagcccacccatgttcagcttcagtgatcacagtagaggtctgaaacggagagga
cccaccagcaagaaggagccacggaagaggcggaaggtggacgaggcaccgtccgaggac
ctgctggtggccatggctctgtcccggtcggagatggagccgggtgcggctgtaccagcg
ctcaggctggaaagtgccttttctgagaggataagaccagaagcagagaataaaagtcgc
aagaagaaacccccggtatcccccccattgttgttagtccaggactctgaaaccacaggc
cgacagatagaggaccgtgtggccctgctcctctctgaggaagtggaattgtctagcacg
ccaccacttcctgccagcaggattttaaaggaagggtgggaaagagcgggccagtgtcct
cctccacctgaacgcaagcagagctttctgtgggagggcagcgcactgactggggcctgg
gccatggaggacttctacacggccaggctggtccctcctctcgtgccccagcggcctgcc
cagggccttatgcaggagcccgtgccgcctctggtgccacctgagcactcagagctgagc
gagcgaaggtcacccgctctccacggcacccccactgcaggctgtggctccaggggcccg
tcgccttcggccagccagagggagcaccaggccctgcaggacctcgtggacctggcgagg
gagggactgagcgccagcccgtggcccggcagtgggggcctggctggctcggaagggact
gcagggttggacgtggtgcccggcggccttcctctgactgggtttgtggtgccatcgcag
gacaagcacccggacaggggcggccgcaccttgctctccctcgggctgctggttgctgac
tttggcgccatggtcaataacccacacctgagtgatgtccagtttcagacggacagcggg
gaggtgctttacgcccacaagttcgtgctttatgcccgatgcccgctcctcatccagtat
gtgaacaatgaaggcttctccgctgtagaggacggggttctgacccagcgtgtcctgctg
ggtgacgtgagcaccgaggccgcccgcacgttcctgcactatctctacactgcggacact
ggccttcctcctggccttagctctgagctgagctccctggcccacaggtttggcgtgagt
gagctcgttcacctgtgcgaacaggtgcctattgccactgactcagagggcaaaccatgg
gaggagaaggaagcagagaattgcgaaagcagggccgagaatttccaggaactcttgagg
tcaatgtgggcagatgaagaggaggaagcggagactttgttgaaatccaaggaccacgaa
gaagatcaagaaaacgtgaatgaagcagaaatggaagaaatttatgaatttgcagctact
cagcgaaagcttctccaggaagaaagggcagcgggtgccggcgaggacgctgactggctg
gagggtggcagtccggtttctgggcaactcctagcaggtgtccaggtgcagaaacagtgg
gacaaggtggaggagatggagccgttggagccaggaagagatgaggccgccaccacctgg
gagaagatgggacagtgcgctctcccgccaccccagggccagcactcaggggcacgggga
gcagaggcccctgagcaggaggcgccagaggaggcgcttggccattccagctgctccagc
ccttccagggactgccaggcagagagaaaagaaggctctcttccgcactcagatgatgcc
ggggattacgaacagctcttctcatcaactcagggagagatctcagagccgtcccaaata
acaagtgagcccgaggaacaaagtggcgctgtcagggaaagggggctggaggtttctcat
cgcctggctccctggcaggcatctccaccgcacccgtgccgcttcctattggggcctccc
cagggcgggagtccccgcgggtctcatcacacaagtgggtcgtccctgtcaacaccccgg
tcccgtggcggaacttcccaggtgggctccccaaccttgctgtctccagctgtgccatca
aagcagaaaagggacaggagcatcctcacgctgtctaaagagccagggcaccagaaaggc
aaagagcgtcggtccgtgctggagtgcagaaataagggggtcctgatgttcccagaaaaa
tctccgtctattgacctaacccagtcaaatcctgaccattcgagctccagatctcagaaa
tcttcatccaaactgaacgaagaagatgaggtcatcctcttactggactcggatgaggag
ctggagctagaacaaaccaaaatgaagtccatttctagtgatcctctggaagaaaagaaa
gctctagaaattagccctaggtcctgtgagctgttttccatcattgatgttgatgcagat
caggaaccttcccagagcccaccaagaagcgaagctgtgctgcagcaggaggatgagggg
gcgctgccggagaatcggggctctttgggcaggagaggggctccctggctgttctgtgac
cgtgagagcagccccagcgaggccagcaccacagacacctcgtggctggtgcccgccacc
ccgctggccagcagaagccgtgactgttcttcccagacccaaatcagcagcctcaggagc
gggctggccgtgcaggcggtgactcagcacacgcccagggcctcagtaggaaacagggaa
gggaacgaagtcgcacagaagttttctgtcatcaggccccagacaccaccgccccagaca
ccgtcctcatgcctcactcccgtctctccaggaacttctgacggcagaaggcaaggccac
agaagcccttcccgtccccaccccgggggccacccgcactcctctccgctggctccacat
cccatctcaggggaccgcgcccacttcagcaggcggttcctgaaacactcgccgcctggg
ccaagcttcctgaaccagaccccagcgggtgaagtggtggaagtcggagacagtgacgat
gagcaggaggtggcctcccatcaggccaacagaagccccccactggacagtgacccccca
attccaattgacgactgctgctggcacatggagcccctctcgccaattcccattgaccac
tggaacctggagcggaccggccccctgagcaccagcagccccagccgcaggatgaacgag
gccgccgacagccgtgactgtcgctccccgggactcctggacaccacccccatccgagga
agctgcactacccagaggaaattgcaagagaagtcctcgggcgcgggctccctggggaat
agcaggccgagctttctgaattcggctctgtgggacgtttgggacggggaagagcagagg
cctccagagacccctcctccggcccagatgccaagcgctggtggagctcagaagcccgaa
gggttagagacacccaaaggtgctaatcggaagaagaacttgccccccaaagtgcccata
acgccgatgccacagtattccattatggagacgccggtgctgaagaaggaactggatagg
tttggagtccgccctctgcctaaacgccagatggttctgaagctgaaggagatattccag
tacactcaccagaccctggactcagactccgaggacgagagccagtcctcacagccgctg
ttgcaggcgcctcactgccagaccctcgcctcccagacctacaagccttcaagggcaggg
gtccatgcccagcaggaggccaccacaggacctggggcccataggcccaagggacctgct
aagaccaagggcccccgacatcaaaggaagcatcatgaaagcatcacacccccaagcagg
tcgcccaccaaggaggcacctccaggcctcaatgatgacgcccagatcccagcctctcaa
gaatccgtggccacctctgtggatggcagtgacagctccttgagctcacagagttcttcc
tcctgtgagtttggagcggcatttgagtctgcaggtgaagaggagggcgagggggaggtc
agtgcctcgcaggcagccgtgcaggcggcggacacagacgaggcgctgaggtgctacatc
cgctccaagccggccctgtaccagaaggtgctgctgtaccagccctttgagctgcgggag
ctgcaggcagagctgaggcagaacggcctccgtgtgtcctcgcgcaggctgttggacttc
ctggacacccactgtatcaccttcaccactgccgccacccgcagggagaagctccagggc
aggaggcggcagcctcggggcaagaagaaggtggagcggaactga
DBGET
integrated database retrieval system
