| Entry |
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| Symbol |
ESPL1, ESP1, SEPA
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| Name |
(RefSeq) extra spindle pole bodies like 1, separase
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| KO |
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| Organism |
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| Pathway |
| hsa05166 | Human T-cell leukemia virus 1 infection |
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| Network |
nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06230 Cell cycle (cancer) nt06512 Chromosome cohesion and segregation |
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| Element |
| N00221 | HTLV-1 Tax to spindle assembly checkpoint signaling |
| N00493 | Spindle assembly checkpoint signaling |
| N01486 | Cohesin dissociation in anaphase |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
9700 (ESPL1)
04114 Oocyte meiosis
9700 (ESPL1)
09160 Human Diseases
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
9700 (ESPL1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:hsa01002]
9700 (ESPL1)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:hsa03036]
9700 (ESPL1)
Enzymes [BR:hsa01000]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.49 separase
9700 (ESPL1)
Peptidases and inhibitors [BR:hsa01002]
Cysteine peptidases
Family C50: separase family
9700 (ESPL1)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Sister chromatid separation proteins
Separase
9700 (ESPL1)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
12:53268299..53293638
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| AA seq |
2120 aa
MRSFKRVNFGTLLSSQKEAEELLPALKEFLSNPPAGFPSSRSDAERRQACDAILRACNQQ
LTAKLACPRHLGSLLELAELACDGYLVSTPQRPPLYLERILFVLLRNAAAQGSPEATLRL
AQPLHACLVQCSREAAPQDYEAVARGSFSLLWKGAEALLERRAAFAARLKALSFLVLLED
ESTPCEVPHFASPTACRAVAAHQLFDASGHGLNEADADFLDDLLSRHVIRALVGERGSSS
GLLSPQRALCLLELTLEHCRRFCWSRHHDKAISAVEKAHSYLRNTNLAPSLQLCQLGVKL
LQVGEEGPQAVAKLLIKASAVLSKSMEAPSPPLRALYESCQFFLSGLERGTKRRYRLDAI
LSLFAFLGGYCSLLQQLRDDGVYGGSSKQQQSFLQMYFQGLHLYTVVVYDFAQGCQIVDL
ADLTQLVDSCKSTVVWMLEALEGLSGQELTDHMGMTASYTSNLAYSFYSHKLYAEACAIS
EPLCQHLGLVKPGTYPEVPPEKLHRCFRLQVESLKKLGKQAQGCKMVILWLAALQPCSPE
HMAEPVTFWVRVKMDAARAGDKELQLKTLRDSLSGWDPETLALLLREELQAYKAVRADTG
QERFNIICDLLELSPEETPAGAWARATHLVELAQVLCYHDFTQQTNCSALDAIREALQLL
DSVRPEAQARDQLLDDKAQALLWLYICTLEAKMQEGIERDRRAQAPGNLEEFEVNDLNYE
DKLQEDRFLYSNIAFNLAADAAQSKCLDQALALWKELLTKGQAPAVRCLQQTAASLQILA
ALYQLVAKPMQALEVLLLLRIVSERLKDHSKAAGSSCHITQLLLTLGCPSYAQLHLEEAA
SSLKHLDQTTDTYLLLSLTCDLLRSQLYWTHQKVTKGVSLLLSVLRDPALQKSSKAWYLL
RVQVLQLVAAYLSLPSNNLSHSLWEQLCAQGWQTPEIALIDSHKLLRSIILLLMGSDILS
TQKAAVETSFLDYGENLVQKWQVLSEVLSCSEKLVCHLGRLGSVSEAKAFCLEALKLTTK
LQIPRQCALFLVLKGELELARNDIDLCQSDLQQVLFLLESCTEFGGVTQHLDSVKKVHLQ
KGKQQAQVPCPPQLPEEELFLRGPALELVATVAKEPGPIAPSTNSSPVLKTKPQPIPNFL
SHSPTCDCSLCASPVLTAVCLRWVLVTAGVRLAMGHQAQGLDLLQVVLKGCPEAAERLTQ
ALQASLNHKTPPSLVPSLLDEILAQAYTLLALEGLNQPSNESLQKVLQSGLKFVAARIPH
LEPWRASLLLIWALTKLGGLSCCTTQLFASSWGWQPPLIKSVPGSEPSKTQGQKRSGRGR
QKLASAPLRLNNTSQKGLEGRGLPCTPKPPDRIRQAGPHVPFTVFEEVCPTESKPEVPQA
PRVQQRVQTRLKVNFSDDSDLEDPVSAEAWLAEEPKRRGTASRGRGRARKGLSLKTDAVV
APGSAPGNPGLNGRSRRAKKVASRHCEERRPQRASDQARPGPEIMRTIPEEELTDNWRKM
SFEILRGSDGEDSASGGKTPAPGPEAASGEWELLRLDSSKKKLPSPCPDKESDKDLGPRL
RLPSAPVATGLSTLDSICDSLSVAFRGISHCPPSGLYAHLCRFLALCLGHRDPYATAFLV
TESVSITCRHQLLTHLHRQLSKAQKHRGSLEIADQLQGLSLQEMPGDVPLARIQRLFSFR
ALESGHFPQPEKESFQERLALIPSGVTVCVLALATLQPGTVGNTLLLTRLEKDSPPVSVQ
IPTGQNKLHLRSVLNEFDAIQKAQKENSSCTDKREWWTGRLALDHRMEVLIASLEKSVLG
CWKGLLLPSSEEPGPAQEASRLQELLQDCGWKYPDRTLLKIMLSGAGALTPQDIQALAYG
LCPTQPERAQELLNEAVGRLQGLTVPSNSHLVLVLDKDLQKLPWESMPSLQALPVTRLPS
FRFLLSYSIIKEYGASPVLSQGVDPRSTFYVLNPHNNLSSTEEQFRANFSSEAGWRGVVG
EVPRPEQVQEALTKHDLYIYAGHGAGARFLDGQAVLRLSCRAVALLFGCSSAALAVRGNL
EGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLGAGPGAPLLYYVNQARQAP
RLKYLIGAAPIAYGLPVSLR |
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| NT seq |
6363 nt +upstreamnt +downstreamnt
atgaggagcttcaaaagagtcaactttgggactctgctaagcagccagaaggaggctgaa
gagttgctgcccgccttgaaggagttcctgtccaaccctccagctggttttcccagcagc
cgatctgatgctgagaggagacaagcttgtgatgccatcctgagggcttgcaaccagcag
ctgactgctaagctagcttgccctaggcatctggggagcctgctggagctggcagagctg
gcctgtgatggctacttagtgtctaccccacagcgtcctcccctctacctggaacgaatt
ctctttgtcttactgcggaatgctgctgcacaaggaagcccagaggccacactccgcctt
gctcagcccctccatgcctgcttggtgcagtgctctcgcgaggctgctccccaggactat
gaggccgtggctcggggcagcttttctctgctttggaagggggcagaagccctgttggaa
cggcgagctgcatttgcagctcggctgaaggccttgagcttcctagtactcttggaggat
gaaagtaccccttgtgaggttcctcactttgcttctccaacagcctgtcgagcggtagct
gcccatcagctatttgatgccagtggccatggtctaaatgaagcagatgctgatttccta
gatgacctgctctccaggcacgtgatcagagccttggtgggtgagagagggagctcttct
gggcttctttctccccagagggccctctgcctcttggagctcaccttggaacactgccgt
cgcttttgctggagccgccaccatgacaaagccatcagcgcagtggagaaggctcacagt
tacctaaggaacaccaatctagcccctagccttcagctatgtcagctgggggttaagctg
ctgcaggttggggaggaaggacctcaggcagtggccaagcttctgatcaaggcatcagct
gtcctgagcaagagtatggaggcaccatcacccccacttcgggcattgtatgagagctgc
cagttcttcctttcaggcctggaacgaggcaccaagaggcgctatagacttgatgccatt
ctgagcctctttgcttttcttggagggtactgctctcttctgcagcagctgcgggatgat
ggtgtgtatgggggctcctccaagcaacagcagtcttttcttcagatgtactttcaggga
cttcacctctacactgtggtggtttatgactttgcccaaggctgtcagatagttgatttg
gctgacctgacccaactagtggacagttgtaaatctaccgttgtctggatgctggaggcc
ttagagggcctgtcgggccaagagctgacggaccacatggggatgaccgcttcttacacc
agtaatttggcctacagcttctatagtcacaagctctatgccgaggcctgtgccatctct
gagccgctctgtcagcacctgggtttggtgaagccaggcacttatcccgaggtgcctcct
gagaagttgcacaggtgcttccggctacaagtagagagtttgaagaaactgggtaaacag
gcccagggctgcaagatggtgattttgtggctggcagccctgcaaccctgtagccctgaa
cacatggctgagccagtcactttctgggttcgggtcaagatggatgcggccagggctgga
gacaaggagctacagctaaagactctgcgagacagcctcagtggctgggacccggagacc
ctggccctcctgctgagggaggagctgcaggcctacaaggcggtgcgggccgacactgga
caggaacgcttcaacatcatctgtgacctcctggagctgagccccgaggagacaccagcc
ggggcctgggcacgagccacccacctggtagaactggctcaggtgctctgctaccacgac
tttacgcagcagaccaactgctctgctctggatgctatccgggaagccctgcagcttctg
gactctgtgaggcctgaggcccaggccagagatcagcttctggacgataaagcacaggcc
ttgctgtggctttacatctgtactctggaagccaaaatgcaggaaggtatcgagcgggat
cggagagcccaggcccctggtaacttggaggaatttgaagtcaatgacctgaactatgaa
gataaactccaggaagatcgtttcctatacagtaacattgccttcaacctggctgcagat
gctgctcagtccaaatgcctggaccaagccctggccctgtggaaggagctgcttacaaag
gggcaggccccagctgtacggtgtctccagcagacagcagcctcactgcagatcctagca
gccctctaccagctggtggcaaagcccatgcaggctctggaggtcctcctgctgctacgg
attgtctctgagagactgaaggaccactcgaaggcagctggctcctcctgccacatcacc
cagctcctcctgaccctcggctgtcccagctatgcccagttacacctggaagaggcagca
tcgagcctgaagcatctcgatcagactactgacacatacctgctcctttccctgacctgt
gatctgcttcgaagtcaactctactggactcaccagaaggtgaccaagggtgtctctctg
ctgctgtctgtgcttcgggatcctgccctccagaagtcctccaaggcttggtacttgctg
cgtgtccaggtcctgcagctggtggcagcttaccttagcctcccgtcaaacaacctctca
cactccctgtgggagcagctctgtgcccaaggctggcagacacctgagatagctctcata
gactcccataagctcctccgaagcatcatcctcctgctgatgggcagtgacattctctca
actcagaaagcagctgtggagacatcgtttttggactatggtgaaaatctggtacaaaaa
tggcaggttctttcagaggtgctgagctgctcagagaagctggtctgccacctgggccgc
ctgggtagtgtgagtgaagccaaggccttttgcttggaggccctaaaacttacaacaaag
ctgcagataccacgccagtgtgccctgttcctggtgctgaagggcgagctggagctggcc
cgcaatgacattgatctctgtcagtcggacctgcagcaggttctgttcttgcttgagtct
tgcacagagtttggtggggtgactcagcacctggactctgtgaagaaggtccacctgcag
aaggggaagcagcaggcccaggtcccctgtcctccacagctcccagaggaggagctcttc
ctaagaggccctgctctagagctggtggccactgtggccaaggagcctggccccatagca
ccttctacaaactcctccccagtcttgaaaaccaagccccagcccatacccaacttcctg
tcccattcacccacctgtgactgctcgctctgcgccagccctgtcctcacagcagtctgt
ctgcgctgggtattggtcacggcaggggtgaggctggccatgggccaccaagcccagggt
ctggatctgctgcaggtcgtgctgaagggctgtcctgaagccgctgagcgcctcacccaa
gctctccaagcttccctgaatcataaaacacccccctccttggttccaagcctcttggat
gagatcttggctcaagcatacacactgttggcactggagggcctgaaccagccatcaaac
gagagcctgcagaaggttctacagtcagggctgaagtttgtagcagcacggataccccac
ctagagccctggcgagccagcctgctcttgatttgggccctcacaaaactaggtggcctc
agctgctgtactacccaactttttgcaagctcctggggctggcagccaccattaataaaa
agtgtccctggctcagagccctctaagactcagggccaaaaacgttctggacgagggcgc
caaaagttagcctctgctcccctgcgcctcaataatacctctcagaaaggtctggaaggt
agaggactgccctgcacacctaaacccccagaccggatcaggcaagctggccctcatgtc
cccttcacggtgtttgaggaagtctgccctacagagagcaagcctgaagtaccccaggcc
cccagggtacaacagagagtccagacgcgcctcaaggtgaacttcagtgatgacagtgac
ttggaagaccctgtctcagctgaggcctggctggcagaggagcctaagagacggggcact
gcttcccggggccgggggcgagcaaggaagggcctgagcctaaagacggatgccgtggtt
gccccaggtagtgcccctgggaaccctggcctgaatggcaggagccggagggccaagaag
gtggcatcaagacattgtgaggagcggcgtccccagagggccagtgaccaggccaggcct
ggccctgagatcatgaggaccatccctgaggaagaactgactgacaactggagaaaaatg
agctttgagatcctcaggggctctgacggggaagactcagcctcaggtgggaagactcca
gctccgggccctgaggcagcttctggagaatgggagctgctgaggctggattccagcaag
aagaagctgcccagcccatgcccagacaaggagagtgacaaggaccttggtcctcggctc
cggctcccctcagcccccgtagccactggtctttctaccctggactccatctgtgactcc
ctgagtgttgctttccggggcattagtcactgtcctcctagtgggctctatgcccacctc
tgccgcttcctggccttgtgcctgggccaccgggatccttatgccactgctttccttgtc
accgagtctgtctccatcacctgtcgccaccagctgctcacccacctccacagacagctc
agcaaggcccagaagcaccgaggatcacttgaaatagcagaccagctgcaggggctgagc
cttcaggagatgcctggagatgtccccctggcccgcatccagcgcctcttttccttcagg
gctttggaatctggccacttcccccagcctgaaaaggagagtttccaggagcgcctggct
ctgatccccagtggggtgactgtgtgtgtgttggccctggccaccctccagcccggaacc
gtgggcaacaccctcctgctgacccggctggaaaaggacagtcccccagtcagtgtgcag
attcccactggccagaacaagcttcatctgcgttcagtcctgaatgagtttgatgccatc
cagaaggcacagaaagagaacagcagctgtactgacaagcgagaatggtggacagggcgg
ctggcactggaccacaggatggaggttctcatcgcttccctagagaagtctgtgctgggc
tgctggaaggggctgctgctgccgtccagtgaggagcccggccctgcccaggaggcctcc
cgcctacaggagctgctacaggactgtggctggaaatatcctgaccgcactctgctgaaa
atcatgctcagtggtgccggtgccctcacccctcaggacattcaggccctggcctacggg
ctgtgcccaacccagccagagcgagcccaggagctcctgaatgaggcagtaggacgtcta
cagggcctgacagtaccaagcaatagccaccttgtcttggtcctagacaaggacttgcag
aagctgccgtgggaaagcatgcccagcctccaagcactgcctgtcacccggctgccctcc
ttccgcttcctactcagctactccatcatcaaagagtatggggcctcgccagtgctgagt
caaggggtggatccacgaagtaccttctatgtcctgaaccctcacaataacctgtcaagc
acagaggagcaatttcgagccaatttcagcagtgaagctggctggagaggagtggttggg
gaggtgccaagacctgaacaggtgcaggaagccctgacaaagcatgatttgtatatctat
gcagggcatggggctggtgcccgcttccttgatgggcaggctgtcctgcggctgagctgt
cgggcagtggccctgctgtttggctgtagcagtgcggccctggctgtgcgtggaaacctg
gagggggctggcatcgtgctcaagtacatcatggctggttgccccttgtttctgggtaat
ctctgggatgtgactgaccgcgacattgaccgctacacggaagctctgctgcaaggctgg
cttggagcaggcccaggggccccccttctctactatgtaaaccaggcccgccaagctccc
cgactcaagtatcttattggggctgcacctatagcctatggcttgcctgtctctctgcgg
taa |
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