Homo sapiens (human): 9817
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Entry
9817 CDS
T01001
Symbol
KEAP1, INrf2, KLHL19
Name
(RefSeq) kelch like ECH associated protein 1
KO
K10456
kelch-like protein 19
Organism
hsa
Homo sapiens (human)
Pathway
hsa04120
Ubiquitin mediated proteolysis
hsa05012
Parkinson disease
hsa05200
Pathways in cancer
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05225
Hepatocellular carcinoma
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06226
KEAP1-NRF2 signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06463
Parkinson disease
Element
N00243
KEAP1-NRF2 signaling pathway
N00244
Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245
Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01413
Metals to KEAP1-NRF2 signalig pathway
Disease
H00048
Hepatocellular carcinoma
Drug target
Dimethyl fumarate:
D03846
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
9817 (KEAP1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
9817 (KEAP1)
05208 Chemical carcinogenesis - reactive oxygen species
9817 (KEAP1)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
9817 (KEAP1)
09164 Neurodegenerative disease
05012 Parkinson disease
9817 (KEAP1)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
9817 (KEAP1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:
hsa04121
]
9817 (KEAP1)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
Multi subunit Ring-finger type E3
Cul3 complex
Adoptor and target recognizing subunit (BTB)
9817 (KEAP1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Kelch_1
Kelch_6
Kelch_3
Kelch_2
BACK
BTB
Kelch_4
KLHL33-like_BTB_POZ
Motif
Other DBs
NCBI-GeneID:
9817
NCBI-ProteinID:
NP_036421
OMIM:
606016
HGNC:
23177
Ensembl:
ENSG00000079999
UniProt:
Q14145
Structure
PDB
LinkDB
All DBs
Position
19:complement(10486125..10503356)
Genome browser
AA seq
624 aa
AA seq
DB search
MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
NT seq
1875 nt
NT seq
+upstream
nt +downstream
nt
atgcagccagatcccaggcctagcggggctggggcctgctgccgattcctgcccctgcag
tcacagtgccctgagggggcaggggacgcggtgatgtacgcctccactgagtgcaaggcg
gaggtgacgccctcccagcatggcaaccgcaccttcagctacaccctggaggatcatacc
aagcaggcctttggcatcatgaacgagctgcggctcagccagcagctgtgtgacgtcaca
ctgcaggtcaagtaccaggatgcaccggccgcccagttcatggcccacaaggtggtgctg
gcctcatccagccctgtcttcaaggccatgttcaccaacgggctgcgggagcagggcatg
gaggtggtgtccattgagggtatccaccccaaggtcatggagcgcctcattgaattcgcc
tacacggcctccatctccatgggcgagaagtgtgtcctccacgtcatgaacggtgctgtc
atgtaccagatcgacagcgttgtccgtgcctgcagtgacttcctggtgcagcagctggac
cccagcaatgccatcggcatcgccaacttcgctgagcagattggctgtgtggagttgcac
cagcgtgcccgggagtacatctacatgcattttggggaggtggccaagcaagaggagttc
ttcaacctgtcccactgccaactggtgaccctcatcagccgggacgacctgaacgtgcgc
tgcgagtccgaggtcttccacgcctgcatcaactgggtcaagtacgactgcgaacagcga
cggttctacgtccaggcgctgctgcgggccgtgcgctgccactcgttgacgccgaacttc
ctgcagatgcagctgcagaagtgcgagatcctgcagtccgactcccgctgcaaggactac
ctggtcaagatcttcgaggagctcaccctgcacaagcccacgcaggtgatgccctgccgg
gcgcccaaggtgggccgcctgatctacaccgcgggcggctacttccgacagtcgctcagc
tacctggaggcttacaaccccagtgacggcacctggctccggttggcggacctgcaggtg
ccgcggagcggcctggccggctgcgtggtgggcgggctgttgtacgccgtgggcggcagg
aacaactcgcccgacggcaacaccgactccagcgccctggactgttacaaccccatgacc
aatcagtggtcgccctgcgcccccatgagcgtgccccgtaaccgcatcggggtgggggtc
atcgatggccacatctatgccgtcggcggctcccacggctgcatccaccacaacagtgtg
gagaggtatgagccagagcgggatgagtggcacttggtggccccaatgctgacacgaagg
atcggggtgggcgtggctgtcctcaatcgtctcctttatgccgtggggggctttgacggg
acaaaccgccttaattcagctgagtgttactacccagagaggaacgagtggcgaatgatc
acagcaatgaacaccatccgaagcggggcaggcgtctgcgtcctgcacaactgtatctat
gctgctgggggctatgatggtcaggaccagctgaacagcgtggagcgctacgatgtggaa
acagagacgtggactttcgtagcccccatgaagcaccggcgaagtgccctggggatcact
gtccaccaggggagaatctacgtccttggaggctatgatggtcacacgttcctggacagt
gtggagtgttacgacccagatacagacacctggagcgaggtgacccgaatgacatcgggc
cggagtggggtgggcgtggctgtcaccatggagccctgccggaagcagattgaccagcag
aactgtacctgttga
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