Homo sapiens (human): 9869
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Entry
9869 CDS
T01001
Symbol
SETDB1, ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21
Name
(RefSeq) histone-lysine N-methyltransferase SETDB1 isoform 1
KO
K11421
[histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase [EC:
2.1.1.366
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00310
Lysine degradation
hsa01100
Metabolic pathways
hsa04550
Signaling pathways regulating pluripotency of stem cells
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
9869 (SETDB1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
9869 (SETDB1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
9869 (SETDB1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.366 [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
9869 (SETDB1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
9869 (SETDB1)
Heterochromatin formation proteins
Other heterochromatin formation proteins
9869 (SETDB1)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DUF5604
Tudor_4
SET
Tudor_5
MBD
Pre-SET
Chromo_MORC2_6th
Cic
DUF4537
Chromo
Motif
Other DBs
NCBI-GeneID:
9869
NCBI-ProteinID:
NP_001138887
OMIM:
604396
HGNC:
10761
UniProt:
Q15047
Structure
PDB
PDBj
LinkDB
All DBs
Position
1:150926263..150964737
Genome browser
AA seq
1291 aa
AA seq
DB search
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL
AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS
ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL
LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL
DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN
TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE
CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD
FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE
SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP
PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME
AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT
SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS
EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF
YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTE
LTWDYNYEVGSVEGKELLCCCGAIECRGRLL
NT seq
3876 nt
NT seq
+upstream
nt +downstream
nt
atgtcttcccttcctgggtgcattggtttggatgcagcaacagctacagtggagtctgaa
gagattgcagagctgcaacaggcagtggttgaggaactgggtatctctatggaggaactt
cggcatttcatcgatgaggaactggagaagatggattgtgtacagcaacgcaagaagcag
ctagcagagttagagacatgggtaatacagaaagaatctgaggtggctcacgttgaccaa
ctctttgatgatgcatccagggcagtgactaattgtgagtctttggtgaaggacttctac
tccaagctgggactacaataccgggacagtagctctgaggacgaatcttcccggcctaca
gaaataattgagattcctgatgaagatgatgatgtcctcagtattgattcaggtgatgct
gggagcagaactccaaaagaccagaagctccgtgaagctatggctgccttaagaaagtca
gctcaagatgttcagaagttcatggatgctgtcaacaagaagagcagttcccaggatctg
cataaaggaaccttgagtcagatgtctggagaactaagcaaagatggtgacctgatagtc
agcatgcgaattctgggcaagaagagaactaagacttggcacaaaggcacccttattgcc
atccagacagttgggccagggaagaaatacaaggtgaaatttgacaacaaaggaaagagt
ctactgtcggggaaccatattgcctatgattaccaccctcctgctgacaagctgtatgtg
ggcagtcgggtggtcgccaaatacaaagatgggaatcaggtctggctctatgctggcatt
gtagctgagacaccaaacgtcaaaaacaagctcaggtttctcattttctttgatgatggc
tatgcttcctatgtcacacagtcggaactgtatcccatttgccggccactgaaaaagact
tgggaggacatagaagacatctcctgccgtgacttcatagaggagtatgtcactgcctac
cccaaccgccccatggtactgctcaagagtggccagcttatcaagactgagtgggaaggc
acgtggtggaagtcccgagttgaggaggtggatggcagcctagtcaggatcctcttcctg
gatgacaaaagatgtgagtggatctatcgaggctctacacggctggagcccatgttcagc
atgaaaacatcctcagcctctgcactggagaagaagcaaggacagctcaggacacgtcca
aatatgggtgctgtgaggagcaaaggccctgttgtccagtacacacaggatctgaccggt
actggaacccagttcaagccagtggaacccccacagcctacagctccacctgccccacct
ttcccacctgctccacctctatccccccaagcaggtgacagtgacttggaaagccagctt
gcccagtcacggaagcaggtagccaaaaagagcacgtcctttcgaccaggatctgtgggc
tctggtcattcctcccctacatctcctgcactcagtgaaaatgtctctggtgggaaacct
gggatcaaccagacatatagatcacctttaggctccacagcctctgccccagcaccctca
gcactcccggcccctccagcacccccagtcttccatggcatgctggagcgggccccagca
gagccctcctaccgtgctcccatggagaagcttttctacttacctcatgtctgcagctat
acctgtctgtctcgagtcagacctatgaggaatgagcagtaccggggcaagaaccctctg
ctggtcccgttactatatgacttccggcggatgacagcccggcgtcgagttaaccgcaag
atgggctttcatgttatctataagacaccttgtggtctctgccttcggacaatgcaggag
atagaacgctaccttttcgagactggctgtgacttcctcttcctggagatgttctgtttg
gatccatatgttcttgtggaccgaaagtttcagccctataagcctttttactatattttg
gacatcacttatgggaaggaagatgttcccctatcctgtgtcaatgagattgacacaacc
cctccaccccaggtggcctacagcaaggaacgtatcccgggcaagggtgttttcattaac
acaggccctgaatttctggttggctgtgactgcaaggatgggtgtcgggacaagtccaag
tgtgcctgccatcaactaactatccaggctacagcctgtaccccaggaggccaaatcaac
cctaactctggctaccagtacaagagactagaagagtgtctacccacaggggtatatgag
tgtaacaaacgctgcaaatgtgacccaaacatgtgcacaaaccggttggtgcaacatgga
ctacaagttcggctacagctattcaagacacagaacaagggctggggtatccgctgcttg
gatgacattgccaaaggctcttttgtttgtatttatgcaggcaaaatcctgacagatgac
tttgcagacaaggagggtctggaaatgggtgatgagtactttgcaaatctggaccatatc
gagagcgtggagaacttcaaagaaggatatgagagtgatgccccctgttcctctgacagc
agtggtgtagacttgaaggaccaggaagatggcaacagcggtacagaggaccctgaagag
tccaatgatgatagctcagatgataacttctgtaaggatgaggacttcagcaccagttca
gtgtggcggagctatgctacccggaggcagacccggggccagaaagagaacggactctct
gagacaacttccaaggactcccaccccccagatcttggacccccacatattcctgttcct
ccctcaatccctgtaggtggctgcaatccaccttcctccgaagagacacccaagaacaag
gtggcctcatggttgagctgcaatagtgtcagtgaaggtggttttgctgactctgatagc
cattcatccttcaagactaatgaaggtggggagggccgggctgggggaagccgaatggag
gctgagaaggcctccacctcaggactaggcatcaaggatgagggagacatcaaacaggcc
aagaaagaggacactgacgaccgaaacaagatgtcagtagttactgaaagctctcgaaat
tacggttacaatccttctcctgtgaagcctgaaggacttcgccgcccacctagtaagact
agtatgcatcaaagccgaagactcatggcttctgctcagtccaaccctgatgatgtcctg
acactgtccagcagcacagaaagtgagggggaaagtgggaccagccgaaagcccactgct
ggtcagacttcggctacagcggttgacagtgatgatatccagaccatatcctctggctct
gaaggggatgactttgaggacaagaagaacatgactggtccaatgaagcgtcaagtggca
gtaaaatcaacccgaggctttgctcttaaatcaacccatgggattgcaattaaatcaacc
aacatggcctctgtggacaagggggagagcgcacctgttcgtaagaacacacgccaattc
tatgatggcgaggagtcttgctacatcattgatgccaagcttgaaggcaacctgggccgc
tacctcaaccacagttgcagccccaacctgtttgtccagaatgtcttcgtggatacccat
gatcttcgcttcccctgggtggccttctttgccagcaaaagaatccgggctgggacagaa
cttacttgggactacaactacgaggtgggcagtgtggaaggcaaggagctactctgttgc
tgtggggccattgaatgcagaggacgtcttctttag
DBGET
integrated database retrieval system
