VARIANT: 1019v1
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Entry
1019v1 Variant
Name
CDK4 amplification
Gene
CDK4
cyclin dependent kinase 4 [KO:
K02089
]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar:
268075
150740
dbVar:
nsv917029
Network
nt06230
Cell cycle (cancer)
nt06273
Glioma
Disease
H00042
Glioma
Reference
PMID:
7987821
Authors
Schmidt EE, Ichimura K, Reifenberger G, Collins VP
Title
CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.
Journal
Cancer Res 54:6321-4 (1994)
Reference
PMID:
8044775
Authors
Reifenberger G, Reifenberger J, Ichimura K, Meltzer PS, Collins VP
Title
Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2.
Journal
Cancer Res 54:4299-303 (1994)
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