KEGG   VARIANT: 1019v1
Entry
1019v1                      Variant                                
Name
CDK4 amplification
Gene
CDK4  cyclin dependent kinase 4 [KO:K02089]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar: 268075 150740
dbVar: nsv917029
Network
nt06230  Cell cycle (cancer)
nt06273  Glioma
Disease
H00042  Glioma
Reference
PMID:7987821
  Authors
Schmidt EE, Ichimura K, Reifenberger G, Collins VP
  Title
CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.
  Journal
Cancer Res 54:6321-4 (1994)
Reference
PMID:8044775
  Authors
Reifenberger G, Reifenberger J, Ichimura K, Meltzer PS, Collins VP
  Title
Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2.
  Journal
Cancer Res 54:4299-303 (1994)
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