ORTHOLOGY: K02089
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Entry
K02089 KO
Symbol
CDK4
Name
cyclin-dependent kinase 4 [EC:
2.7.11.22
]
Pathway
map01522
Endocrine resistance
map04110
Cell cycle
map04115
p53 signaling pathway
map04151
PI3K-Akt signaling pathway
map04218
Cellular senescence
map04530
Tight junction
map04660
T cell receptor signaling pathway
map04933
AGE-RAGE signaling pathway in diabetic complications
map04934
Cushing syndrome
map05160
Hepatitis C
map05162
Measles
map05163
Human cytomegalovirus infection
map05164
Influenza A
map05165
Human papillomavirus infection
map05166
Human T-cell leukemia virus 1 infection
map05167
Kaposi sarcoma-associated herpesvirus infection
map05169
Epstein-Barr virus infection
map05200
Pathways in cancer
map05203
Viral carcinogenesis
map05212
Pancreatic cancer
map05214
Glioma
map05218
Melanoma
map05219
Bladder cancer
map05220
Chronic myeloid leukemia
map05222
Small cell lung cancer
map05223
Non-small cell lung cancer
map05224
Breast cancer
map05225
Hepatocellular carcinoma
Disease
H00030
Cervical cancer
H00038
Melanoma
H00042
Glioma
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09130 Environmental Information Processing
09132 Signal transduction
04151 PI3K-Akt signaling pathway
K02089 CDK4; cyclin-dependent kinase 4
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
K02089 CDK4; cyclin-dependent kinase 4
04115 p53 signaling pathway
K02089 CDK4; cyclin-dependent kinase 4
04218 Cellular senescence
K02089 CDK4; cyclin-dependent kinase 4
09144 Cellular community - eukaryotes
04530 Tight junction
K02089 CDK4; cyclin-dependent kinase 4
09150 Organismal Systems
09151 Immune system
04660 T cell receptor signaling pathway
K02089 CDK4; cyclin-dependent kinase 4
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K02089 CDK4; cyclin-dependent kinase 4
05203 Viral carcinogenesis
K02089 CDK4; cyclin-dependent kinase 4
09162 Cancer: specific types
05212 Pancreatic cancer
K02089 CDK4; cyclin-dependent kinase 4
05225 Hepatocellular carcinoma
K02089 CDK4; cyclin-dependent kinase 4
05214 Glioma
K02089 CDK4; cyclin-dependent kinase 4
05220 Chronic myeloid leukemia
K02089 CDK4; cyclin-dependent kinase 4
05218 Melanoma
K02089 CDK4; cyclin-dependent kinase 4
05219 Bladder cancer
K02089 CDK4; cyclin-dependent kinase 4
05224 Breast cancer
K02089 CDK4; cyclin-dependent kinase 4
05222 Small cell lung cancer
K02089 CDK4; cyclin-dependent kinase 4
05223 Non-small cell lung cancer
K02089 CDK4; cyclin-dependent kinase 4
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
K02089 CDK4; cyclin-dependent kinase 4
05160 Hepatitis C
K02089 CDK4; cyclin-dependent kinase 4
05164 Influenza A
K02089 CDK4; cyclin-dependent kinase 4
05162 Measles
K02089 CDK4; cyclin-dependent kinase 4
05163 Human cytomegalovirus infection
K02089 CDK4; cyclin-dependent kinase 4
05167 Kaposi sarcoma-associated herpesvirus infection
K02089 CDK4; cyclin-dependent kinase 4
05169 Epstein-Barr virus infection
K02089 CDK4; cyclin-dependent kinase 4
05165 Human papillomavirus infection
K02089 CDK4; cyclin-dependent kinase 4
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
K02089 CDK4; cyclin-dependent kinase 4
04934 Cushing syndrome
K02089 CDK4; cyclin-dependent kinase 4
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
K02089 CDK4; cyclin-dependent kinase 4
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases
K02089 CDK4; cyclin-dependent kinase 4
Enzymes [BR:
ko01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.22 cyclin-dependent kinase
K02089 CDK4; cyclin-dependent kinase 4
Protein kinases [BR:
ko01001
]
Serine/threonine kinases: CMGC group
CDK family
K02089 CDK4; cyclin-dependent kinase 4
BRITE hierarchy
Other DBs
GO:
0004693
Genes
HSA:
1019
(CDK4)
PTR:
452025
(CDK4)
PPS:
100976294
(CDK4)
GGO:
101147065
(CDK4)
PON:
100443314
(CDK4)
NLE:
100594967
(CDK4)
HMH:
116480850
(CDK4)
MCC:
715650
(CDK4)
MCF:
101925733
(CDK4)
MTHB:
126930400
MNI:
105474081
(CDK4)
CSAB:
103238589
(CDK4)
CATY:
105587240
(CDK4)
PANU:
101011004
(CDK4)
TGE:
112634055
(CDK4)
MLEU:
105545589
(CDK4)
RRO:
104682344
(CDK4)
RBB:
108524397
(CDK4)
TFN:
117089862
(CDK4)
PTEH:
111541790
(CDK4)
CANG:
105500487
(CDK4)
CJC:
100408304
(CDK4)
SBQ:
101040767
(CDK4)
CIMI:
108304334
108309741
(CDK4)
108313247
CSYR:
103264423
(CDK4)
MMUR:
105877995
(CDK4)
LCAT:
123639589
(CDK4)
PCOQ:
105816738
(CDK4)
OGA:
100960589
(CDK4)
MMU:
12567
(Cdk4)
MCAL:
110303132
(Cdk4)
MPAH:
110326196
(Cdk4)
RNO:
94201
(Cdk4)
MCOC:
116075684
(Cdk4)
ANU:
117696408
(Cdk4)
MUN:
110561245
(Cdk4)
CGE:
100760122
(Cdk4)
MAUA:
101839492
(Cdk4)
PROB:
127215685
(Cdk4)
PLEU:
114704814
(Cdk4)
MORG:
121461982
121463961
(Cdk4)
MFOT:
126514774
AAMP:
119803317
(Cdk4)
NGI:
103742900
(Cdk4)
HGL:
101702608
(Cdk4)
CPOC:
100717960
(Cdk4)
CCAN:
109686224
(Cdk4)
DORD:
105989896
(Cdk4)
DSP:
122124085
(Cdk4)
PLOP:
125362060
(Cdk4)
NCAR:
124983907
MMMA:
107140113
(Cdk4)
OCU:
100009039
OPI:
101530437
(CDK4)
TUP:
102493291
(CDK4)
GVR:
103609174
(CDK4)
CFA:
481131
(CDK4)
612475
CLUD:
112654545
112677962
(CDK4)
VVP:
112922331
(CDK4)
VLG:
121490703
(CDK4)
NPO:
129511485
(CDK4)
AML:
100481236
(CDK4)
UMR:
103656694
(CDK4)
UAH:
113256363
(CDK4)
UAR:
123787201
(CDK4)
ELK:
111160230
LLV:
125106397
MPUF:
101673063
(CDK4)
MNP:
132019857
(CDK4)
MLK:
131838541
(CDK4)
NVS:
122892356
(CDK4)
ORO:
101362330
(CDK4)
EJU:
114214999
(CDK4)
ZCA:
113921783
(CDK4)
MLX:
118008659
(CDK4)
NSU:
110577858
(CDK4)
LWW:
102746891
(CDK4)
FCA:
101097903
(CDK4)
PYU:
121040857
(CDK4)
PCOO:
112863780
(CDK4)
PBG:
122473830
(CDK4)
PVIV:
125170174
(CDK4)
LRUF:
124501159
PTG:
102970281
(CDK4)
PPAD:
109270390
(CDK4)
PUC:
125919257
AJU:
106975871
HHV:
120248012
(CDK4)
BTA:
510618
(CDK4)
BOM:
102278545
(CDK4)
BIU:
109559308
(CDK4)
BBUB:
102412787
(CDK4)
BBIS:
104988133
(CDK4)
CHX:
102171306
(CDK4)
OAS:
100144756
(CDK4)
BTAX:
128047322
(CDK4)
ODA:
120857506
(CDK4)
CCAD:
122427215
(CDK4)
MBEZ:
129536501
(CDK4)
SSC:
100144492
(CDK4)
CFR:
102522300
(CDK4)
CBAI:
105062140
(CDK4)
CDK:
105100330
(CDK4)
VPC:
102532580
(CDK4)
BACU:
103000540
(CDK4)
103010593
BMUS:
118902505
(CDK4)
LVE:
103084826
(CDK4)
OOR:
101283760
(CDK4)
DLE:
111173824
(CDK4)
PCAD:
102985179
(CDK4)
PSIU:
116760381
(CDK4)
NASI:
112394295
(CDK4)
ECB:
100051005
(CDK4)
EPZ:
103553644
(CDK4)
EAI:
106833016
(CDK4)
MYB:
102261527
(CDK4)
MYD:
102758995
(CDK4)
MMYO:
118651037
(CDK4)
MLF:
102431798
(CDK4)
PKL:
118730275
(CDK4)
EFUS:
103292479
(CDK4)
MNA:
107546223
(CDK4)
DRO:
112319119
(CDK4)
SHON:
118975891
(CDK4)
AJM:
119065244
(CDK4)
PDIC:
114512697
(CDK4)
PHAS:
123812897
(CDK4)
MMF:
118624208
(CDK4)
PPAM:
129075823
(CDK4)
HAI:
109390747
(CDK4)
RFQ:
117029166
(CDK4)
PALE:
102894222
(CDK4)
PGIG:
120604974
(CDK4)
PVP:
105307393
(CDK4)
RAY:
107501504
(CDK4)
MJV:
108387631
(CDK4)
TOD:
119248102
(CDK4)
SARA:
101559274
(CDK4)
SETR:
126022235
(CDK4)
LAV:
104847103
(CDK4)
TMU:
101355276
ETF:
101654378
(CDK4)
DNM:
101416305
(CDK4)
GAS:
123251284
(CDK4)
SHR:
100932899
(CDK4)
AFZ:
127538222
PCW:
110210989
(CDK4)
CJO:
107325825
(CDK4)
PHI:
102103942
(CDK4)
PMAJ:
107199280
SVG:
106862647
(CDK4)
TALA:
116960867
116963701
(CDK4)
AGEN:
126037403
RTD:
128903864
AAM:
106492770
NPD:
112952245
(CDK4)
DNE:
112983405
(CDK4)
ASN:
102387479
(CDK4)
AMJ:
102572556
(CDK4)
CPOO:
109324458
(CDK4)
CMY:
102945436
(CDK4)
CCAY:
125627703
(CDK4)
DCC:
119845815
(CDK4)
CPIC:
101943854
(CDK4)
TST:
117888590
(CDK4)
CABI:
116828541
(CDK4)
MRV:
120391006
(CDK4)
ACS:
100559515
(cdk4)
ASAO:
132767651
(CDK4)
PVT:
110074435
(CDK4)
SUND:
121920842
(CDK4)
PBI:
103058869
(CDK4)
PMUR:
107291540
(CDK4)
CTIG:
120309963
(CDK4)
TSR:
106540822
(CDK4)
PGUT:
117662680
(CDK4)
APRI:
131192160
(CDK4)
PTEX:
113445556
(CDK4)
NSS:
113418439
(CDK4)
VKO:
123029774
(CDK4)
PMUA:
114593035
(CDK4)
PRAF:
128405821
(CDK4)
ZVI:
118078968
(CDK4)
HCG:
128347326
(CDK4)
GJA:
107119665
(CDK4)
EMC:
129346578
(CDK4)
XLA:
379406
(cdk4.S)
496334
(cdk6.L)
XTR:
549496
(cdk4)
NPR:
108795357
(CDK4)
RTEM:
120929442
(CDK4)
BBUF:
120996181
(CDK4)
BGAR:
122932515
(CDK4)
MUO:
115465825
(CDK4)
GSH:
117357532
(CDK4)
DRE:
777730
(cdk4)
SRX:
107737134
107747701
SANH:
107684003
107701179
SGH:
107567936
CCAR:
109069976
109089968
CAUA:
113054912
113068151
CGIB:
127968260
128022703
PTET:
122353952
122354325
(cdk4)
LROH:
127173464
(cdk4)
OMC:
131549489
(cdk4)
PPRM:
120460707
(cdk4)
RKG:
130086284
(cdk4)
MAMB:
125256866
(cdk4)
CIDE:
127522801
MASI:
127425969
TROS:
130571158
(cdk4)
TDW:
130410017
(cdk4)
MANU:
129427530
(cdk4)
IPU:
108255186
IFU:
128625273
(cdk4)
PHYP:
113525662
SMEO:
124401943
(cdk4)
TFD:
113639050
(cdk4)
TVC:
132838231
(cdk4)
TRN:
134301572
(cdk4)
AMEX:
103034254
(cdk4)
CMAO:
118799717
(cdk4)
EEE:
113572459
(cdk4)
CHAR:
105907246
(cdk4)
TRU:
101063081
(cdk4)
TFS:
130524612
TNG:
GSTEN00033818G001
LCO:
104929049
(cdk4)
NCC:
104955917
(cdk4)
TBEN:
117489719
(cdk4)
CGOB:
115008789
(cdk4)
PGEO:
117441083
(cdk4)
GACU:
117534213
(cdk4)
EMAC:
134883274
(cdk4)
ELY:
117257485
(cdk4)
EFO:
125893517
(cdk4)
PLEP:
121953305
(cdk4)
SLUC:
116066212
(cdk4)
ECRA:
117942897
(cdk4)
ESP:
116679825
116687243
PFLV:
114554047
(cdk4)
GAT:
120835334
(cdk4)
PPUG:
119194053
(cdk4)
AFB:
129105372
(cdk4)
CLUM:
117730594
(cdk4)
PSWI:
130208515
(cdk4)
MSAM:
119886384
(cdk4)
SCHU:
122888471
(cdk4)
CUD:
121507439
(cdk4)
ALAT:
119020857
(cdk4)
MZE:
101475315
ONL:
100710125
(cdk4)
OAU:
116326635
(cdk4)
OLA:
101172808
(cdk4)
OML:
112145080
(cdk4)
CSAI:
133448713
(cdk4)
XMA:
102220323
(cdk4)
XCO:
114135419
(cdk4)
XHE:
116710170
(cdk4)
PRET:
103465328
(cdk4)
PFOR:
103129587
(cdk4)
PLAI:
106961113
PMEI:
106923269
GAF:
122833741
(cdk4)
PPRL:
129358305
(cdk4)
CVG:
107082148
(cdk4)
CTUL:
119795488
(cdk4)
GMU:
124856981
NFU:
107385649
(cdk4)
KMR:
108235797
(cdk4)
ALIM:
106518078
NWH:
119412589
(cdk4)
AOCE:
111587634
(cdk4)
MCEP:
125007293
(cdk4)
CSEM:
103386052
(cdk4)
POV:
109629352
(cdk4)
SSEN:
122768740
(cdk4)
HHIP:
117761425
(cdk4)
HSP:
118104894
(cdk4)
PPLT:
128454022
(cdk4)
SMAU:
118309388
(cdk4)
LCF:
108898964
SDU:
111221753
(cdk4)
SLAL:
111667889
(cdk4)
XGL:
120807598
(cdk4)
HCQ:
109522590
(cdk4)
SSCV:
125976797
SBIA:
133507496
(cdk4)
PEE:
133408435
(cdk4)
PTAO:
133483625
(cdk4)
BPEC:
110171259
(cdk4)
MALB:
109956190
(cdk4)
BSPL:
114855460
(cdk4)
SJO:
128355116
(cdk4)
SASA:
106565448
106583286
STRU:
115150473
115207950
OTW:
112216345
(cdk4)
112254694
OMY:
110494214
110528217
OGO:
124003111
124031204
ONE:
115140953
115143085
OKI:
109882619
109894658
OKE:
118388669
118400364
SALP:
111965632
111970188
111970190
SNH:
120062000
120065264
CCLU:
121575165
121577842
ELS:
105016970
(cdk4)
SFM:
108918175
(cdk4)
PKI:
111854375
(cdk4)
111856032
AANG:
118210620
(cdk4)
LOC:
102686530
(cdk4)
PSPA:
121308988
(cdk4)
ARUT:
117401103
117962597
PSEX:
120524842
(cdk4)
LCM:
102363370
(CDK4)
CMK:
103191316
(cdk4)
RTP:
109925336
CPLA:
122543277
(cdk4)
HOC:
132805820
(cdk4)
LERI:
129714770
(cdk4)
LRJ:
133361523
133362026
133362062
133362134
133362705
AJC:
117108070
DME:
Dmel_CG5072
(Cdk4)
DER:
6548425
DSE:
6609465
DSI:
Dsimw501_GD11207
(Dsim_GD11207)
DYA:
Dyak_GE11805
DAN:
6494260
DSR:
110187091
DPO:
4803571
DPE:
6591061
DMN:
108158559
117191375
117191615
117191617
DWI:
6639792
DGR:
6559243
DMO:
Dmoj_GI20474
DAZ:
108615638
DNV:
108653601
DHE:
111593550
DVI:
6625181
CCAT:
101454916
BOD:
106621434
BDR:
105229369
RZE:
108365867
AOQ:
129245337
TDA:
119674095
MDE:
101892496
131801631
SCAC:
106086684
LCQ:
111675356
LSQ:
119603043
GFS:
119638637
ECOE:
129952173
CLON:
129610982
HIS:
119646348
AGA:
1276486
ACOZ:
120947623
AARA:
120905759
AMER:
121593463
ASTE:
118511494
AFUN:
125768019
AMOU:
128300948
AALI:
118464842
AAG:
5570506
AALB:
109406441
ASUA:
134218523
CQU:
CpipJ_CPIJ015895
CPII:
120425591
CNS:
116345736
BCOO:
119079833
CCAL:
108633063
SOC:
105196992
MPHA:
105838129
AEC:
105153633
PBAR:
105433444
VEM:
105561026
HST:
105187057
DQU:
106744310
CFO:
105249672
FEX:
115233314
LHU:
105675373
PGC:
109855281
NVI:
100122192
(Cdk4)
CSOL:
105361031
TPRE:
106648062
TCA:
663975
DPA:
109545808
SOY:
115875203
AGRG:
126736132
126736532
ATD:
109601734
109602185
AGB:
108914646
LDC:
111502212
DVV:
114328612
NVL:
108558807
PPYR:
116159688
OTU:
111413066
BMOR:
100316860
BMAN:
114250235
MSEX:
115444537
DPL:
KGM_201733
KGM_201734
BANY:
112056244
MJU:
123879175
NIQ:
126779296
VCD:
124541084
MCIX:
123667797
PMAC:
106709519
PPOT:
106101314
PXU:
106124670
PRAP:
110993439
PBX:
123718879
PNAP:
125062674
ZCE:
119836525
CCRC:
123704180
LSIN:
126971444
AAGE:
121738280
HAW:
110381856
HZE:
124643481
TNL:
113499972
SLIU:
111350035
OFU:
114359631
ATRA:
106138565
PXY:
105389917
PGW:
126378481
LGLY:
125238710
CFEL:
113389462
PJA:
122253490
PCLA:
123759664
CQD:
128689293
ABRU:
129978396
UDV:
129217040
129235238
SDM:
118180084
CRQ:
GCK72_000989
LOA:
LOAG_17283
TSP:
Tsp_00762
AOR:
AO090026000290
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Taxonomy
UniProt
Reference
PMID:
18414028
Authors
Blain SW
Title
Switching cyclin D-Cdk4 kinase activity on and off.
Journal
Cell Cycle 7:892-8 (2008)
DOI:
10.4161/cc.7.7.5637
Reference
PMID:
7652577
Authors
Wolfel T, Hauer M, Schneider J, Serrano M, Wolfel C, Klehmann-Hieb E, De Plaen E, Hankeln T, Meyer zum Buschenfelde KH, Beach D
Title
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.
Journal
Science 269:1281-4 (1995)
DOI:
10.1126/science.7652577
Sequence
[hsa:
1019
]
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