Kluyveromyces marxianus: KLMA_80299
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Entry
KLMA_80299 CDS
T05269
Symbol
LYS2
Name
(RefSeq) L-aminoadipate-semialdehyde dehydrogenase
KO
K00143
L-2-aminoadipate reductase [EC:
1.2.1.95
]
Organism
kmx
Kluyveromyces marxianus
Pathway
kmx00300
Lysine biosynthesis
kmx01100
Metabolic pathways
kmx01110
Biosynthesis of secondary metabolites
kmx01230
Biosynthesis of amino acids
Module
kmx_M00030
Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
Brite
KEGG Orthology (KO) [BR:
kmx00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
KLMA_80299 (LYS2)
Enzymes [BR:
kmx01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.1 With NAD+ or NADP+ as acceptor
1.2.1.95 L-2-aminoadipate reductase
KLMA_80299 (LYS2)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
NAD_binding_4
AMP-binding
PP-binding
Epimerase
Condensation
3Beta_HSD
AMP-binding_C
GDP_Man_Dehyd
Polysacc_synt_2
Motif
Other DBs
NCBI-GeneID:
34718491
NCBI-ProteinID:
XP_022678348
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All DBs
Position
8:complement(659594..663754)
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AA seq
1386 aa
AA seq
DB search
MTALSAWASKLDNPTISVLPHDYLRPQQEPFVKQDELAFQLPQLEAASANSNSSAYEIVL
AAWASLIYRLTGDDDIVLLVRDGKVIRFTIQPTWSFEELCKTVSEELAAVASLDSVDFDE
LSQHIKTQNELEVQPQLFRLGFVTEPGFSLATYKSSILDVALTLTGNQAQIVYNSLLYSK
DRIAILADQITQFVSQVLENPQDIITKVSLITSSSESIIPDPTKNLGWCDFRGCIHDIFQ
DNAEKFPERTCVVETPATGSNESRVFTYKDINYASNIVAHYLINTGIKRGDIVMIYSSRG
VDLMVCVMGVLKAGATFSVIDPAYPPVRQTVYLDVAKPKGLIVIKAAGTLDQFVEDFITE
KLNVVSRIPSIAIQNDGSILGGKLPQQDQDCLAPYEHLKTKRTGIVVGPDSNPTLSFTSG
SEGIPKGVLGRHFSLAYYFDWMAKEFNLSENDKFAMLSGIAHDPIQRDMFTPLFLGAQLL
VPTQDDIGTPGQLASWMAKYGATVTHLTPAMGQLLAAQATTPFPKLHHAFFVGDILTKRD
CLRLQTLAENVNIVNMYGTTETQRAVSYFTVKSRSEDANFLKKLKDVIPAGKGMYNVQLL
VVNRYDRSQICGVGEVGEIYVRAGGLAAEYRGLPELNKEKFVNNWFVEEGHWKSLDKDNG
EPWREFWLGPRDRLYRTGDLGRYLPDGNTECCGRADDQVKIRGFRIELGEIDTHISQYPL
VRENITLVRNNSDNEKTLITFMVPRFDKPDELSKLSSDVPEGVANDPVVSGMIRYRHLVK
DIKEFLKKRLASYAIPTVIIVLNKLPLNPNGKVDKPKLQFPTVKQLNLVAENSSVEVNDA
DFTKTEKEVRDLWLGVLPSRPASISPEDSFFDLGGHSIIATRMIFGLRNTLQVDLPLGTI
FKYPTIRAFAGEIDRVKNSGLSSSDEVKTADYANDAKQLTESLLPKRFESRDALISSSAN
TGKTDLNVFVTGVTGFLGSYILADLLNRPTDSFSIKVFAHVRAKSEEAGLERLKQAGITY
GTWSDKFTDKIEVVLGDLSKEKFGLDTEKWSKLTDQIDVIIHNGALVHWVYPYSKLRDPN
VISTINVMSLASSGKAKYFTFVSSTSTIDTEHYFSLSDKLVAEGKTGILESDDLSGSATG
LTSGYGQSKWAAEYIIRRAGERGLRGCIVRPGYVTGNSSNGSSNTDDFLLRFLKGVVQLG
KIPDIENTVNMVPVDHVARVVTATAFNPPNEKELVVAHVTGHPRILFKDYLYQLKKYGYN
VEVQPYSEWKISLEHSVISRGEENALYPLLHMCLDGLPENTRAPELDDTNATLSLKKDEK
LTHVDVSSGKGATPEQIGIYIAFLNKVGFLPPPPSKGELSLPEVSLSEEQIKLVSSGAGA
RSSAAA
NT seq
4161 nt
NT seq
+upstream
nt +downstream
nt
atgacggcattaagtgcatgggcaagcaagttggacaatccaacgattagtgtgctacca
cacgactatttgagaccacaacaggaaccatttgtgaaacaggatgaactggctttccag
ttgccacagctagaagctgcatctgcgaatagcaatagtagtgcgtacgaaattgtgctg
gctgcctgggctagtcttatctacaggttgaccggcgatgacgacattgttttgcttgtt
agagacggtaaggtgattaggttcacaattcagccgacttggtcctttgaggagttgtgc
aagacggtgagtgaagagctggccgccgtagcgtctcttgattctgttgattttgatgag
ctttctcaacatattaagacacagaatgagttagaggtacagccgcaacttttccgtcta
gggtttgttacggagccagggttctcattagccacttacaagagctcaattttggacgtg
gctcttactttgaccggtaaccaggcgcaaattgtgtacaattctttgctatattccaag
gatagaatagccatattggcagaccaaattacgcagttcgtatctcaagttttggagaat
cctcaagacataatcaccaaggtttctttgatcaccagctcatcagaatctatcattcca
gaccctaccaagaacttgggatggtgcgatttccgtggatgtatccatgacatcttccag
gataacgcagagaagttcccagaaagaacttgcgttgtggaaaccccagctactggatcc
aacgagtcgcgtgttttcacttacaaagacattaattacgcatctaatatcgtggcccac
tacttgataaatactggaatcaagaggggggatatagtgatgatttactcttcccgtggt
gttgatttaatggtctgcgttatgggtgttttaaaggccggtgcaaccttctccgttatt
gacccagcttatccacctgtaagacaaactgtgtatcttgacgttgccaaaccaaaggga
ttgatcgttatcaaagcagcaggaacgctagaccagtttgtcgaagatttcatcactgaa
aagcttaatgtggtctccagaattccatcaattgctatccaaaatgatggttcgatactt
gggggtaaattgccacagcaggatcaagattgtcttgcaccttacgaacatttgaagacc
aaaagaactggtattgttgtcggcccagacagcaatcctacattatcctttacatcaggt
tccgaaggtattccaaagggtgtgctaggaaggcatttctcattggcctactactttgat
tggatggccaaggaatttaacttatctgagaatgataaattcgccatgctcagtggtatt
gcccatgaccctatccaaagagatatgttcaccccattattcttaggagctcaattgctt
gtaccaacacaggatgacattggtaccccaggtcaattggcttcgtggatggctaaatat
ggcgcaaccgttactcatttgacaccagctatgggtcaattgttggctgcccaggcaact
actccattccctaaacttcaccacgctttcttcgtaggtgacatcttaactaagagagac
tgtttgagattgcaaactttggcagaaaatgtcaacattgttaatatgtatggtaccact
gaaacccaacgtgccgtctcctacttcacagtcaaatctagatcggaggatgctaatttc
ttaaagaagctaaaggatgtcatacctgctggtaaaggtatgtacaacgtacaacttttg
gttgttaatagatacgacagatcccaaatttgtggggttggtgaagtcggagaaatctac
gtacgtgcaggtggtctagcagccgaataccgtggtttaccagaactaaacaaggaaaag
tttgtcaataactggttcgttgaagaaggtcattggaaaagtcttgataaggacaatggt
gagccttggagagaattttggctaggtccaagagacagattatacagaactggtgattta
ggtcgttatcttcctgatggaaatacagagtgctgtgggcgtgctgatgatcaggtgaag
atcagaggtttcagaattgagctaggtgaaattgacacacatatctcccaatatccttta
gttcgtgaaaacattacgttggttcgtaacaatagcgataatgagaaaaccttaataacc
tttatggtgccaagatttgataaaccagacgaattgtcaaagctatcttccgatgtccca
gaaggtgttgcaaatgatccagtggttagtggcatgattcgctatcgccacttggttaag
gatataaaggaattcttgaagaaaaggttggcaagttatgcaattccaactgtaataatt
gttctaaacaagctaccactaaaccctaacgggaaagttgataaacctaagttgcaattc
cctacagttaagcaattgaatcttgtagctgagaattcatccgtagaagtaaacgacgca
gattttaccaaaaccgaaaaagaagttagagatctctggttaggtgttttaccctcgaga
cctgcttctatttctccagaggattctttctttgaccttggtggtcactccattattgct
actagaatgatctttggattgagaaacactctgcaagttgatcttcctttaggaactatt
ttcaagtaccccacaattagagcatttgccggagaaattgacagagttaaaaactcaggt
ttgtcttcatctgacgaagttaagacagctgattatgcaaacgacgcaaaacagctaacc
gaatctcttcttccaaagagatttgaatccagagacgctttgatttcgtcatctgctaac
acaggtaaaaccgatctaaatgtgtttgtcactggtgtaacgggtttcttaggttcgtac
atcttggctgaccttctcaatcgtccaactgattctttcagcattaaggtgtttgctcat
gtcagagccaagagcgaagaagctggtttagagagattgaaacaagctggaattacatac
ggaacgtggtcagacaagttcaccgacaagatagaagtagtcttaggtgatttgtctaag
gaaaagttcggattggacacggagaaatggtctaaactaacggaccaaattgatgttatt
attcacaatggtgctttagttcactgggtttatccatactctaagctaagagatccaaac
gtgatttcaactatcaatgtgatgtcattagcatcatccggaaaggcaaagtacttcact
ttcgtatcatccacttccactattgatactgaacattacttctccctatctgacaaatta
gttgcagagggtaaaacaggtattttggagtcggatgatttatctggttcagcaactggt
ttaacgagtggctatggtcaatcgaaatgggccgcagaatatatcattagaagggcagga
gaacgtggtcttcgcggttgtatagtaagaccagggtacgtcactggtaattcatcaaat
ggttcatctaacacagatgatttccttttgagattcctaaagggtgttgttcaattagga
aagattcctgacattgaaaacactgtgaacatggttcctgtcgatcatgttgctcgtgtt
gttacagcaactgcattcaatccaccaaatgaaaaagaattggtggttgctcatgtcacc
ggacatccacgtatcttgttcaaagattacctatatcaattgaaaaagtatggctacaat
gttgaggttcaaccttactcggaatggaaaatatccttggaacattccgtcatctctaga
ggagaagaaaatgctttgtatccattattgcacatgtgcttagacggtttaccagaaaac
accagagctccagagttagatgataccaatgccactttatcattgaaaaaagatgagaaa
ctaacacatgtagacgtttcaagtggtaaaggtgctactccagaacagattggtatttac
attgctttcttgaataaggttggatttttgcccccacctccttcaaagggcgaactttct
cttcctgaagtatctttgtcagaagaacaaataaagctagtatcttctggtgcaggtgcc
cgtagttcagcagcagcttaa
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