KEGG   PATHWAY: ko00965
Entry
ko00965                     Pathway                                
Name
Betalain biosynthesis
Description
Betalains are water-soluble nitrogen-containing pigments that are present in plants belonging to the order Caryophyllales (such as cactus and amaranth families) and in higher fungi. They contain betalamic acid as the chromophore and are classified into two types: betacyanins and betaxanthins. Betacyanins contain a cyclo-DOPA residue and exhibit red/violet coloration, while betaxanthins contain different amino acids or amino side chains and exhibit a yellow/orange coloration. The condensation of betalamic acid with amino acids (including cyclo-DOPA or amines) in plants is a spontaneous reaction, not an enzyme-catalyzed reaction.
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
ko00965  Betalain biosynthesis
ko00965

Module
M00961  Betacyanin biosynthesis, L-tyrosine => amaranthin [PATH:ko00965]
Orthology
K26037  tyrosine hydroxylase / L-DOPA oxygenase [EC:1.14.-.-]
K15777  4,5-DOPA dioxygenase extradiol [EC:1.13.11.-]
K01593  aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]
K00545  catechol O-methyltransferase [EC:2.1.1.6]
K15776  cyclo-DOPA 5-O-glucosyltransferase [EC:2.4.1.-]
K15774  betanidin 5-O-glucosyltransferase [EC:2.4.1.-]
K26038  amaranthin synthetase [EC:2.4.1.-]
K15775  betanidin 6-O-glucosyltransferase [EC:2.4.1.-]
Compound
C00082  L-Tyrosine
C00355  3,4-Dihydroxy-L-phenylalanine
C03758  Dopamine
C05587  3-Methoxytyramine
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C08537  Amaranthin
C08538  Betalamic acid
C08539  Betanidin
C08540  Betanin
C08542  Celosianin II
C08543  Dopaxanthin
C08544  Gomphrenin-I
C08552  Lampranthin II
C08557  Miraxanthin-V
C08565  Portulacaxanthin II
C17751  cyclo-Dopa 5-O-glucoside
C17752  cyclo-Dopa-glucuronylglucoside
C17753  Dopaxanthin quinone
C17754  3-Methoxytyramine-betaxanthin
C17755  Dopamine quinone
C17756  2-Descarboxy-cyclo-dopa
C17757  2-Descarboxy-betanidin
C17758  4,5-seco-Dopa
Reference
  Authors
Gandia-Herrero F, Escribano J, Garcia-Carmona F
  Title
Betaxanthins as substrates for tyrosinase. An approach to the role of tyrosinase in the biosynthetic pathway of betalains.
  Journal
Plant Physiol 138:421-32 (2005)
DOI:10.1104/pp.104.057992
Reference
  Authors
Sasaki N, Abe Y, Wada K, Koda T, Goda Y, Adachi T, Ozeki Y
  Title
Amaranthin in feather cockscombs is synthesized via glucuronylation at the cyclo-DOPA glucoside step in the betacyanin biosynthetic pathway.
  Journal
J Plant Res 118:439-42 (2005)
DOI:10.1007/s10265-005-0237-z
Reference
  Authors
Strack D, Vogt T, Schliemann W
  Title
Recent advances in betalain research.
  Journal
Phytochemistry 62:247-69 (2003)
DOI:10.1016/S0031-9422(02)00564-2
Reference
  Authors
Vogt T
  Title
Substrate specificity and sequence analysis define a polyphyletic origin of betanidin 5- and 6-O-glucosyltransferase from Dorotheanthus bellidiformis.
  Journal
Planta 214:492-5 (2002)
DOI:10.1007/s00425-001-0685-1
Related
pathway
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
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