Entry Name Intestinal immune network for IgA production
Description The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ko04672 Intestinal immune network for IgA production
Ortholog table Other DBs Orthology K10784 T cell receptor alpha chain V region
K10785 T-cell receptor beta chain V region
K13375 transforming growth factor beta-1
K05475 tumor necrosis factor ligand superfamily member 13
K05476 tumor necrosis factor ligand superfamily member 13B
K05150 tumor necrosis factor receptor superfamily member 13B
K05153 tumor necrosis factor receptor superfamily member 17
K05151 tumor necrosis factor receptor superfamily member 13C
K06856 immunoglobulin heavy chain
K03160 tumor necrosis factor receptor superfamily member 5
K03161 tumor necrosis factor ligand superfamily member 5
K06713 inducible T-cell co-stimulator
K06710 inducible T-cell co-stimulator ligand
K04184 C-C chemokine receptor type 9
K10031 C-X-C motif chemokine 12
K04189 C-X-C chemokine receptor type 4
K04185 C-C chemokine receptor type 10
K06779 mucosal vascular addressin cell adhesion molecule 1
K03159 lymphotoxin beta receptor TNFR superfamily member 3
K05074 interleukin 15 receptor alpha
K13073 polymeric immunoglobulin receptor
Compound Reference Authors Fagarasan S, Honjo T
Title Intestinal IgA synthesis: regulation of front-line body defences.
Journal Reference Authors Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P
Title The immune geography of IgA induction and function.
Journal Reference Authors Kunisawa J, Kiyono H
Title A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.
Journal Reference Authors Cerutti A, Rescigno M
Title The biology of intestinal immunoglobulin A responses.
Journal Reference Authors Tsuji M, Suzuki K, Kinoshita K, Fagarasan S
Title Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis.
Journal Reference Authors Corthesy B
Title Roundtrip ticket for secretory IgA: role in mucosal homeostasis?
Journal Reference Authors Suzuki K, Fagarasan S
Title How host-bacterial interactions lead to IgA synthesis in the gut.
Journal Reference Authors Mora JR, von Andrian UH
Title Differentiation and homing of IgA-secreting cells.
Journal Reference Authors Suzuki K, Ha SA, Tsuji M, Fagarasan S
Title Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.
Journal Reference Authors Cerutti A
Title The regulation of IgA class switching.
Journal Related ko04612 Antigen processing and presentation
ko04660 T cell receptor signaling pathway
ko04662 B cell receptor signaling pathway
ko04670 Leukocyte transendothelial migration
LinkDB All DBs
