Loxodonta africana (African savanna elephant): 100676652
Help
Entry
100676652 CDS
T04351
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
KO
K04447
Janus kinase 2 [EC:
2.7.10.2
]
Organism
lav
Loxodonta africana (African savanna elephant)
Pathway
lav01521
EGFR tyrosine kinase inhibitor resistance
lav04062
Chemokine signaling pathway
lav04148
Efferocytosis
lav04151
PI3K-Akt signaling pathway
lav04217
Necroptosis
lav04550
Signaling pathways regulating pluripotency of stem cells
lav04630
JAK-STAT signaling pathway
lav04658
Th1 and Th2 cell differentiation
lav04659
Th17 cell differentiation
lav04725
Cholinergic synapse
lav04917
Prolactin signaling pathway
lav04920
Adipocytokine signaling pathway
lav04933
AGE-RAGE signaling pathway in diabetic complications
lav04935
Growth hormone synthesis, secretion and action
lav05140
Leishmaniasis
lav05145
Toxoplasmosis
lav05152
Tuberculosis
lav05161
Hepatitis B
lav05164
Influenza A
lav05167
Kaposi sarcoma-associated herpesvirus infection
lav05168
Herpes simplex virus 1 infection
lav05200
Pathways in cancer
lav05207
Chemical carcinogenesis - receptor activation
lav05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
lav05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
lav00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
100676652 (JAK2)
04151 PI3K-Akt signaling pathway
100676652 (JAK2)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
100676652 (JAK2)
09143 Cell growth and death
04217 Necroptosis
100676652 (JAK2)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
100676652 (JAK2)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
100676652 (JAK2)
04659 Th17 cell differentiation
100676652 (JAK2)
04062 Chemokine signaling pathway
100676652 (JAK2)
09152 Endocrine system
04920 Adipocytokine signaling pathway
100676652 (JAK2)
04917 Prolactin signaling pathway
100676652 (JAK2)
04935 Growth hormone synthesis, secretion and action
100676652 (JAK2)
09156 Nervous system
04725 Cholinergic synapse
100676652 (JAK2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100676652 (JAK2)
05207 Chemical carcinogenesis - receptor activation
100676652 (JAK2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100676652 (JAK2)
09172 Infectious disease: viral
05161 Hepatitis B
100676652 (JAK2)
05164 Influenza A
100676652 (JAK2)
05168 Herpes simplex virus 1 infection
100676652 (JAK2)
05167 Kaposi sarcoma-associated herpesvirus infection
100676652 (JAK2)
09171 Infectious disease: bacterial
05152 Tuberculosis
100676652 (JAK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
100676652 (JAK2)
05140 Leishmaniasis
100676652 (JAK2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
100676652 (JAK2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
100676652 (JAK2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100676652 (JAK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
lav01001
]
100676652 (JAK2)
Enzymes [BR:
lav01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
100676652 (JAK2)
Protein kinases [BR:
lav01001
]
Non-receptor tyrosine kinases
JAK family [OT]
100676652 (JAK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
FERM_F2
FERM_F1
Jak1_Phl
SH2
ABC1
RIO1
Kinase-like
FERM_C_FAK1
Motif
Other DBs
NCBI-GeneID:
100676652
NCBI-ProteinID:
XP_010598294
LinkDB
All DBs
Position
Unknown
AA seq
1130 aa
AA seq
DB search
MACLTVTDMEGTSTSPVHQNGDIPGPANTVKQVEPVLQVYLYHSLGKAEEDYLRFPAGEY
VAEDICVAASKACGITPVYHNMFALMSETERIWYPPNHVFHVDESASHSVLYRIRFYFPH
WYCNGSNRTYRYGIARGAEAPLLDDFVMSYLFAQWRHDFVCGWIKLPVTHETQEECLGLA
VLDMMRIAKEKGQTPLAIYNSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQFSQ
CKATARNLKLKYLINLEALQAAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSRGK
HKESETLTEQDLQIYCDFPDIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREA
LSFVSVIDGYYRLTADAHHYLCKEVAPPTVLENIQSNCHGPISMDFAISKLKKAGNQTGL
YVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLTGTKKNFNNLKDLLNCYQ
METVRSDSIIFQFIKCCPPKPKDKSNLLVFRTNGVSDVPTSPALQRHNNVNQMVFHKIRN
EDLIFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRSYSESFFEAASMMS
QLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWAMH
FLEEKALIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWAPPE
CIENPKNLSLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTELAN
LINNCMDYGPDFRPSFRAIIRDLNSLFTPDYELLTESDMLPNMRIGALGFSGAFEDRDPT
QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL
KSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICK
GMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYA
PESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELL
KNNGRLPRPEGCPDEIYVIMTECWNNHVNQRPSFRDLALRVDRIRDNMAG
NT seq
3393 nt
NT seq
+upstream
nt +downstream
nt
atggcttgccttacggtgacagacatggaaggaacgtccacatctcctgtacaccagaac
ggtgatattcctggccctgcgaacactgtgaagcaggtagagccagtcctgcaggtgtat
ctttaccattcccttgggaaggctgaagaagattacctgaggtttccagcgggggagtat
gttgctgaagacatttgtgttgctgcttctaaagcttgtggcatcacacctgtgtatcat
aacatgtttgctttaatgagtgaaacagaaaggatctggtatccgcccaaccacgtcttc
cacgtagatgaatcagccagccacagtgtactctacaggataaggttttactttcctcac
tggtattgtaacggcagcaacagaacctatcggtatggaatagctcgaggtgctgaagct
cctctcctggatgactttgtcatgtcttacctgtttgctcagtggcggcacgattttgtc
tgtggctggataaaattaccagtgactcatgaaacacaggaagaatgtcttgggctggcc
gtgttggatatgatgagaatagccaaggaaaagggtcaaaccccactggccatctataac
tccatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagattatcat
attctgacaaggaaacgaataaggtacaggtttcgcagatttattcagcagttcagccaa
tgcaaagccactgccagaaacttgaaacttaagtaccttataaatctggaagcccttcag
gctgccttctacacagagcagtttgaagtaaaagaacctggaagaggtccttcaggtgag
gagatttttgcaaccattataataactggaaacggtggaattcagtggtcaagagggaaa
cataaagaaagtgagacactgacagaacaggatttacagatatattgtgattttcctgat
attattgatgtcagcattaagcaagcaaaccaagaaggctctaatgaaagcagagttgta
actatccataagcaagatggtaaaaatctggaaattgaacttagctccctaagagaagcc
ttgtcttttgtgtcagtgattgatgggtactacagactcactgccgacgcacaccattac
ctctgcaaagaagtggcccccccaacagtgctggaaaatatacagagcaactgtcatggg
ccaatttcaatggattttgccatcagtaaactgaagaaagctggtaatcagactgggctg
tatgtacttcgatgcagtcctaaggactttaataaatattttctcacgtttgctgttgag
cgagaaaatgtcattgaatataagcactgtttgattacaaaaaatgagaatggagaatac
aacctcactgggactaagaagaactttaataatcttaaagatcttctgaactgctatcag
atggaaactgttcgttcagacagtatcattttccagtttattaaatgctgccccccaaag
ccaaaagataaatccaacctcttagtcttcagaacgaacggcgtttctgatgtcccaacc
tcaccagcattacagaggcataataacgtgaaccagatggtgtttcacaaaatcagaaat
gaagatttgatattcaatgaaagtcttggccaaggcacttttacaaaaattttcaaaggt
ataagaagagaagtaggagactacggtcagctgcacgaaaccgaggttctcctcaaagtc
ctggataaagcacacagaagctactccgagtctttctttgaagcggcaagcatgatgagc
cagctttctcacaagcacctggttttaaactatggagtatgtgtctgtggagaggagaat
atcctggttcaagagtttgtaaaatttggatctctagatacatatctgaaaaaaaataaa
aattctataaatatattatggaaacttgaagtggctaaacagttggcatgggccatgcat
tttctcgaagaaaaagcccttattcatgggaacgtgtgtgccaaaaatatcctgctcatc
agagaagaagacaggaagacagggaatccgcctttcatcaaactcagtgaccctggcatt
agtattacggttttgccaaaagacattctccaggagagaataccatgggcacccccagaa
tgtattgaaaatcctaaaaacctaagcttggcaacagataaatggagttttgggactact
ctgtgggaaatctgcagtggaggagacaagcctctcagtgctctagattcccaaaggaag
ctacagttttatgaagacaggcaccagcttcctgcaccaaagtggacagagttagcaaat
cttataaacaattgtatggattacggaccggattttaggccttctttcagagccatcata
cgagatcttaacagcttgtttactccagattatgaactattgacagaaagtgacatgtta
ccaaatatgaggataggtgccctaggattttctggtgcttttgaagacagggaccctaca
cagtttgaagaaagacacttgaaattcttacaacaacttggcaagggtaattttgggagt
gtggagatgtgccggtatgaccctctgcaggacaacactggggaggtggtggccgtgaag
aagctccagcacagtactgaggagcacctccgggactttgaaagggaaattgagatcctt
aaatccctgcagcacgacaacatcgtgaagtacaagggagtgtgctacagtgctggccgg
cgtaatctgagattaattatggagtatttaccatatggaagtttacgagactatctccaa
aaacataaagaacggatagatcataaaaaacttctgcagtacacatctcagatatgcaag
ggtatggaatatcttggtacaaaaaggtacattcacagggatctggcaacaagaaatata
ttggtggagaatgagaacagagttaaaattggggattttggattgactaaagttttgcca
caagacaaagaatactacaaagtgaaagaaccgggtgaaagtcccatattctggtatgcc
ccagaatcactgacagagagcaagttttctgtggcctcggatgtttggagctttggagtg
gttctctatgagcttttcacatacattgagaagagtaaaagtccaccggcggaatttatg
cgtatgattggcaatgacaagcaaggacagatgattgtgttccatttgatagaactcttg
aagaataatggaagattaccaagaccagagggatgcccagatgagatttatgtgatcatg
acagaatgctggaacaatcatgtaaaccagcgcccttccttcagggacctagctcttcga
gtggatcgaataagggacaacatggctggatga
DBGET
integrated database retrieval system
