Leishmania donovani: LDBPK_181360
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Entry
LDBPK_181360 CDS
T02289
Name
(RefSeq) pyruvate dehydrogenase E1 component alpha subunit, putative
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
ldo
Leishmania donovani
Pathway
ldo00010
Glycolysis / Gluconeogenesis
ldo00020
Citrate cycle (TCA cycle)
ldo00620
Pyruvate metabolism
ldo00785
Lipoic acid metabolism
ldo01100
Metabolic pathways
ldo01110
Biosynthesis of secondary metabolites
ldo01200
Carbon metabolism
ldo01210
2-Oxocarboxylic acid metabolism
Module
ldo_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
ldo00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
LDBPK_181360
00020 Citrate cycle (TCA cycle)
LDBPK_181360
00620 Pyruvate metabolism
LDBPK_181360
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
LDBPK_181360
Enzymes [BR:
ldo01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
LDBPK_181360
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Motif
Pfam:
E1_dh
DXP_synthase_N
SCD
Motif
Other DBs
NCBI-GeneID:
13393449
NCBI-ProteinID:
XP_003860150
UniProt:
A0A3Q8IB83
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Position
18:596567..597703
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AA seq
378 aa
AA seq
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MFKCATRCLLDTKTVPLKPQRPFKLHTAGRTDMAPLPTQAAYDAEQLKKSLALMFRIRRM
ESLCDQSYKLKKIRGFCHLYIGQEAIPAGMENVLTFEDPIVTGYRDHGWYISRGGKPEDV
FAEMFGRQGGCSKGKGGSMHMYKVGNGFYGGNGIVGAQVSIGAGLAWRFAMENRDSPKHV
AVTFYGDGAANQGQIYESMNIAALQRLPVIFAVENNHFGMGTSAARGSYQAEFYRRGDYI
PGIKVDGMDVLAVQEGTRYARDHCMSGKGPIVMELDCYRYMGHSMSDPDNQYRTKSDIQH
VKQERDCIRKMREFMATEGIMTEDEMSKMEKDVKKEVDQDLQKAQKQPMTKLDELFTDIY
VGEQYEHRTCQGTVYHKP
NT seq
1137 nt
NT seq
+upstream
nt +downstream
nt
atgttcaagtgcgcgactcgctgccttctggacaccaagacggtgccgctgaagccgcag
cgcccattcaagctacacacggctggccgcaccgacatggcaccacttccgacgcaggcg
gcgtacgacgcagagcagctgaagaagagtcttgccctgatgttccgcatccgccgcatg
gagtctctgtgcgatcagtcctacaagctaaagaagattcgcggcttctgccacctctac
atcgggcaggaggccattccggctggcatggagaacgttctgaccttcgaggaccccatc
gtcactggctaccgcgatcacggctggtacatctctcgcggtggcaagcccgaggatgtc
ttcgctgaaatgttcggccgtcagggcggctgcagcaagggcaagggtggctcgatgcac
atgtacaaggtgggtaacggcttctacggcggtaatggcatcgtgggtgcgcaggtctcg
atcggcgctggccttgcctggcgcttcgcgatggagaaccgcgacagcccgaagcacgtt
gcggtcaccttctacggcgacggtgctgccaaccagggccagatctacgagtccatgaac
attgccgctctgcagcgcctccccgtcatcttcgcagtggagaacaaccacttcggtatg
ggcactagcgccgctcgcggctcctatcaggcggagttttaccgccgtggtgactacatc
cctggtatcaaggtcgatggcatggacgtgctcgcggtgcaggagggcacccgctacgca
cgcgaccactgcatgtcgggcaagggcccgattgtgatggagctggactgctaccgctac
atgggtcatagcatgtcggaccccgacaaccagtaccgcaccaagagcgacatccagcac
gtgaagcaggagcgtgactgcattcgcaagatgcgcgagttcatggcgaccgagggcatc
atgaccgaggacgagatgagcaagatggagaaagacgtgaagaaggaggtggaccaggac
ctgcagaaggcccagaaacaacctatgacaaagttggatgagctcttcacggacatctac
gtgggtgagcagtacgagcaccgcacctgccagggtaccgtgtaccacaagccctaa
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