Leptonychotes weddellii (Weddell seal): 102743413
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Entry
102743413 CDS
T08708
Symbol
PDHA1
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X1
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
lww
Leptonychotes weddellii (Weddell seal)
Pathway
lww00010
Glycolysis / Gluconeogenesis
lww00020
Citrate cycle (TCA cycle)
lww00620
Pyruvate metabolism
lww00785
Lipoic acid metabolism
lww01100
Metabolic pathways
lww01200
Carbon metabolism
lww01210
2-Oxocarboxylic acid metabolism
lww04066
HIF-1 signaling pathway
lww04922
Glucagon signaling pathway
lww05230
Central carbon metabolism in cancer
lww05415
Diabetic cardiomyopathy
Module
lww_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
lww00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
102743413 (PDHA1)
00020 Citrate cycle (TCA cycle)
102743413 (PDHA1)
00620 Pyruvate metabolism
102743413 (PDHA1)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
102743413 (PDHA1)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
102743413 (PDHA1)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
102743413 (PDHA1)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
102743413 (PDHA1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
102743413 (PDHA1)
Enzymes [BR:
lww01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
102743413 (PDHA1)
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GFIT
Motif
Pfam:
E1_dh
DXP_synthase_N
TPP_enzyme_C
Motif
Other DBs
NCBI-GeneID:
102743413
NCBI-ProteinID:
XP_006740577
UniProt:
A0A2U3YA27
LinkDB
All DBs
Position
Unknown
AA seq
390 aa
AA seq
DB search
MRKMLAAVSRVLSGVAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLRYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLSVREILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSIS
NT seq
1173 nt
NT seq
+upstream
nt +downstream
nt
atgaggaaaatgctcgccgctgtgtctcgcgtgttgtcgggcgtcgcccagaagccggca
agcagagtgctcgtggcctcccgtaattttgcaaatgatgctacatttgaaattaagaaa
tgcgatcttcatcggctagaagagggccctcctgtcaccacagtgctcaccagggaggac
gggctcaggtactataggatgatgcagactgttcgccggatggagttaaaggcagatcag
ctgtataaacagaaaattattcgtggtttctgtcacttgtgtgatggtcaggaagcttgt
tgtgtgggcctggaggccggcataaatcccacagaccatcttatcacagcctatcgggct
catggctttacctttactcgtggactttctgtccgagaaattcttgcagagcttacagga
cgaagaggaggctgtgctaagggaaaaggtggatcaatgcatatgtatgccaagaacttc
tatgggggcaatggcatcgttggagctcaggtgcccctgggagcagggattgctctggcc
tgtaagtataacggaaaggatgaggtctgtttgactttatatggtgatggtgctgccaat
cagggtcagatatttgaagcttacaacatggcagctttgtggaaattgccgtgtattttc
atctgtgagaataaccgctatggaatgggaacgtctgttgagagagcagcggccagcact
gattactacaagagaggcgacttcattcctgggctgagggtggatggaatggatatcttg
tgtgtccgggaggcaacaaggtttgcagctgcttactgtagatctggaaaggggcccata
ctgatggagctacagacttaccgttaccatggacacagcatgagcgaccctggcgtcagt
taccgtacacgagaagagattcaggaagtaagaagtaagagtgaccctattatgcttctc
aaggataggatggtgaacagcaatctggccagtgttgaagaattaaaggaaattgatgtt
gaagtgaggaaagaaattgaggatgctgcccagtttgccactgctgatcctgaaccgcct
ttggaagaactaggctatcacatttacagcagcgatccgccttttgaagttcggggtgca
aatcagtggatcaagtttaagtccatcagttaa
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