KEGG   Leptonychotes weddellii (Weddell seal): 102751193
Entry
102751193         CDS       T08708                                 
Symbol
TPH1
Name
(RefSeq) tryptophan 5-hydroxylase 1
  KO
K00502  tryptophan 5-monooxygenase [EC:1.14.16.4]
Organism
lww  Leptonychotes weddellii (Weddell seal)
Pathway
lww00380  Tryptophan metabolism
lww00790  Folate biosynthesis
lww01100  Metabolic pathways
lww04726  Serotonergic synapse
Module
lww_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin
Brite
KEGG Orthology (KO) [BR:lww00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    102751193 (TPH1)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    102751193 (TPH1)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    102751193 (TPH1)
Enzymes [BR:lww01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.4  tryptophan 5-monooxygenase
     102751193 (TPH1)
SSDB
Motif
Pfam: Biopterin_H ACT TH_ACT ACT_4 zf-C2HE DUF5370 DUF262
Other DBs
NCBI-GeneID: 102751193
NCBI-ProteinID: XP_006749322
UniProt: A0A2U3YZY9
LinkDB
Position
Unknown
AA seq 456 aa
MATTVRELHQLTMIEDNKENKDHSLERGRATLIFSLKNEVGGLIKALKIFQEKHVNLLHI
ESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNPPDSFTVKENGMETVPWF
PKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTE
EEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFS
IRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQ
FSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHSLSGH
AKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSI
QILKDTKSITSAMNELQHDLDVVSDALAKVSRQPSI
NT seq 1371 nt   +upstreamnt  +downstreamnt
atggccacaactgtgagagaactacaccaattgaccatgattgaagacaataaggaaaat
aaagaccattccttagaaagaggaagagcaactctcattttttccttaaagaatgaagtt
ggtggacttataaaagcactgaaaatcttccaggagaagcatgtgaacctgttacatatt
gagtcccgaaaatcaaagagaagaaactcagaatttgagatttttgttgactgtgatatc
aacagagaacaattgaatgatatttttcatctgttgaagtcccatactaacgttctctct
gtgaatccaccagacagttttactgtgaaggaaaatggtatggaaactgttccttggttt
ccaaagaagatttctgacctggaccattgtgccaacagagttctgatgtatggttctgaa
ctggatgcagatcatcctggcttcaaagacaatgtctaccgtaaaagacggaagtatttt
gcagacttggctatgaactataaacatggagaccccattcccaaggttgaattcactgaa
gaggagattaagacctggggaactgtgttccaagagctcaacaaactttacccaacccat
gcctgcagagagtatctcaaaaacttacctttgctttctaaatattgtgggtaccgggaa
gataatatcccacaattggaagatgtctcaaactttttaaaagagcgcacgggtttttcc
atccgtcccgtggctggttacttatcaccaagagatttcttatcaggtttagccttccgg
gtttttcactgcacacagtatgtgagacacagttcagaccctctctataccccagagcca
gatacttgccatgaactcttaggtcacgtcccccttttggctgaacctagttttgcgcaa
ttctcccaggaaattggcctggcttcccttggagcttcagaggaggctgttcaaaaactg
gcaacgtgctactttttcactgtggagtttggtctctgtaaacaagatgggcaattgcga
gtctttggtgctggattactttcttctatcagtgaacttaagcattcactttctggacat
gccaaagtaaagccctttgatcccaagattacctgcaaacaggagtgtctcatcacaact
tttcaggatgtctactttgtatctgaaagctttgaagatgcaaaggagaagatgagagaa
tttaccaaaacaattaagcgtccatttggagtgaagtataatccatacacacggagtatt
cagatcttgaaagacaccaagagcataaccagcgccatgaatgagctgcagcatgatctc
gatgtcgtcagtgatgcccttgcgaaggtcagcagacagccaagcatctga

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