Mycolicibacterium alvei: MALV_27350
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Entry
MALV_27350 CDS
T06961
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
malv
Mycolicibacterium alvei
Pathway
malv00860
Porphyrin metabolism
malv01100
Metabolic pathways
malv01110
Biosynthesis of secondary metabolites
malv01120
Microbial metabolism in diverse environments
malv01240
Biosynthesis of cofactors
Module
malv_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
malv_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
malv00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MALV_27350 (hemD)
Enzymes [BR:
malv01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MALV_27350 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MALV_27350 (hemD)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
BBX27610
UniProt:
A0A6N4URU0
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All DBs
Position
complement(2810764..2812440)
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AA seq
558 aa
AA seq
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MTMRGRKAKPGRITFVGSGPGDPGLLTARAQTVLAHAELVFTDPDVPEAVLALIGTELPP
ASGPAPAEPAKAAAAGDDATGTPDAAQAAVIAGGPEVRPALGDPAEVAKTLVSEARHGYD
VVRLVAGDPLSVDAVITEIGALARSHVNFEIVPGLPATSAVPTYAGLPLGSSHTVADVRG
DVDWAALAAAPGPLILHATASHLPDAARTLIEFGLAENTPAVVTASGTTCQQRSVETSLG
GLTDKAVLEKPAGSELAGPLAGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKDQA
GEMSDRLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK
FNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPFDEVFDP
VNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAQTREMIKTGGFDAVCFT
SSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPETATVGPLVDALAEHAA
RLRAEGALPPPRKKSRRR
NT seq
1677 nt
NT seq
+upstream
nt +downstream
nt
atgaccatgcgaggtcgcaaggccaagcccggccgcatcacatttgtgggttcgggcccg
ggagatccggggctgctgacggcacgggcgcagactgtactggcgcacgccgagttggtg
ttcaccgatcccgacgtcccagaagccgtactggcgctgatcggcacggagctgcccccg
gcgtccggcccggcaccggctgagccggccaaggccgccgccgcaggcgatgacgccacc
ggaacccccgacgcggcgcaagccgccgtcatcgcgggtggtcccgaggtgcgccccgcg
ctgggcgatcccgccgaggtggccaagacactggtctccgaggcccgccacggctacgac
gtggtgcgcctggtcgccggtgacccgctgtccgtggacgccgtcatcaccgagatcggt
gcgctggccaggtcccatgtgaacttcgagatcgtccccggtctgcccgccaccagcgca
gtgcccacctacgcgggcctgccgctcgggtcgtcgcacaccgtggccgacgtccgcggt
gacgtggactgggcggcgctggccgccgcacccgggccgctgatcctgcacgcgaccgcg
tcgcacctgccggacgccgcgcgcaccctgatcgaattcggtctggccgagaacactccg
gcggtggtgaccgcgagcggtaccacctgccagcagcgttcggtggagaccagcctcggt
ggactgaccgacaaggcggtgctggagaagccggccggcagtgagctggcgggcccgctg
gccgggccgctggtggtcaccatcggcaagaccgtggccaaccgggccaagctgaactgg
tgggagagccgcgccctgtacggctggaccgtgctggtgccgcgtaccaaggatcaggcc
ggcgagatgagcgaccggttggtgggccacggcgccctgccgatcgaggtgccgaccatc
gcggtcgagccgccgcgcagccccgcccagatggagcgcgcagtcaagggtctggtcgac
ggccggttccagtgggtggtgttcacctcgaccaacgccgtgcgtgcggtctgggagaag
ttcaacgagttcggtctggatgcgcgggccttctccggggtgaagatcgcctgtgtcgga
caggccaccgccgacaaggtgcgggcgttcggcatcaaccccgagctggtgccgtcgggg
gagcagtcctcgctgggtctgctcgacgagttcccgccgttcgacgaggttttcgatccg
gtgaaccgggtgctgctgccgcgcgccgacatcgccaccgagacgctggccgagggcctg
cgtgagcgcgggtgggagatcgaggatgtcacggcctaccgcaccgtgcgtgccgctccg
ccaccggcgcagacccgcgagatgatcaagaccggcgggttcgacgcggtctgcttcacc
tccagttcgacggtgcgcaacctggtcggtatcgccggcaagccgcacgcccggaccatc
gtggcctgcatcgggccgaaaactgctgaaaccgcagcggaattcggcctgcgggtggat
gtgcagcccgagacggccaccgtggggccgctggtcgacgcgctcgccgagcacgccgct
cgactgcgggccgaaggggcactgcccccgccgcgcaagaagagccgccgcaggtag
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