KEGG T02918: 102125852

Macaca fascicularis (crab-eating macaque): 102125852

Entry

102125852         CDS       T02918

Symbol

PDHA1

Name

(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

K00161

pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]

Organism

mcf Macaca fascicularis (crab-eating macaque)

Pathway

mcf00010

Glycolysis / Gluconeogenesis

mcf00020

Citrate cycle (TCA cycle)

mcf00620

Pyruvate metabolism

mcf00785

Lipoic acid metabolism

mcf01100

Metabolic pathways

mcf01200

Carbon metabolism

mcf01210

2-Oxocarboxylic acid metabolism

mcf04066

HIF-1 signaling pathway

mcf04922

Glucagon signaling pathway

mcf05230

Central carbon metabolism in cancer

mcf05415

Diabetic cardiomyopathy

Module

mcf_M00307

Pyruvate oxidation, pyruvate => acetyl-CoA

Brite

KEGG Orthology (KO) [BR:mcf00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    102125852 (PDHA1)
   00020 Citrate cycle (TCA cycle)
    102125852 (PDHA1)
   00620 Pyruvate metabolism
    102125852 (PDHA1)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    102125852 (PDHA1)
09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    102125852 (PDHA1)
09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    102125852 (PDHA1)
09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    102125852 (PDHA1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    102125852 (PDHA1)
Enzymes [BR:mcf01000]
1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1  pyruvate dehydrogenase (acetyl-transferring)
     102125852 (PDHA1)

SSDB

Motif

Pfam:

E1_dh DXP_synthase_N TPP_enzyme_C

Other DBs

NCBI-GeneID:

102125852

NCBI-ProteinID:

XP_045240247

Ensembl:

ENSMFAG00000043170

LinkDB

Position

X:join(19211884..19211940,19217131..19217190,19217731..19217904,19219025..19219151,19220810..19220901,19222218..19222310,19223391..19223546,19223720..19223791,19225946..19226013,19227187..19227295,19227763..19227927)

AA seq 390 aa
MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSVS

NT seq 1173 nt +upstreamnt +downstreamnt
atgaggaagatgctcgccgccgtctcccgcgtgttgtctggcgcttctcagaagccggca
agcagagtgctggtagcatcccgtaattttgcaaatgatgctacatttgaaattaagaaa
tgtgaccttcaccgactggaagaaggccctcctgtcacaacagtgctcaccagggaggat
gggctcaaatactacaggatgatgcagactgtgcgccgaatggagttgaaagcagatcag
ctgtataaacagaaaattattcgtggtttctgtcacttgtgtgatggtcaggaagcttgc
tgtgtgggcctggaagccggcatcaaccccacagaccatctcataacagcctaccgggct
catggctttaccttcacccggggcctttccgtccgagaaattctcgcagagcttacagga
cgaaaaggaggttgtgctaaagggaaaggaggatcgatgcacatgtatgccaagaacttc
tacgggggcaatggcatcgtgggagcgcaggtgcccctgggcgctgggattgctctagcc
tgtaagtataatggaaaagatgaggtctgcctgactttatatggcgatggtgctgctaac
cagggccagatatttgaagcttacaacatggcagctttgtggaaattaccttgtattttc
atctgtgagaataatcgctatggaatgggaacatctgttgagagagcagcagccagcact
gattactacaagagaggcgatttcattcctgggctgagagtggatggaatggatatcttg
tgcgtccgagaggcgacaaggtttgctgccgcctattgtagatctgggaaggggcccatc
ctgatggagctgcagacttatcgttaccacggacacagtatgagtgatcctggagtcagt
taccgtacacgagaagaaattcaggaagtaagaagtaagagtgaccctattatgcttctc
aaggacaggatggtgaacagcaatcttgccagtgtggaagaactaaaggaaattgatgtg
gaagtgaggaaggagattgaggatgctgcccagtttgccacggccgatcctgagccacct
ttggaggagctgggctaccacatctactccagcgacccacctttcgaagttcgtggtgcc
aatcagtggatcaagtttaagtcagtcagttaa

DBGET integrated database retrieval system