Manis javanica (Malayan pangolin): 108385046
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Entry
108385046 CDS
T06054
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
KO
K04369
mitogen-activated protein kinase kinase 2 [EC:
2.7.12.2
]
Organism
mjv
Manis javanica (Malayan pangolin)
Pathway
mjv01521
EGFR tyrosine kinase inhibitor resistance
mjv01522
Endocrine resistance
mjv04010
MAPK signaling pathway
mjv04012
ErbB signaling pathway
mjv04014
Ras signaling pathway
mjv04015
Rap1 signaling pathway
mjv04022
cGMP-PKG signaling pathway
mjv04024
cAMP signaling pathway
mjv04066
HIF-1 signaling pathway
mjv04068
FoxO signaling pathway
mjv04071
Sphingolipid signaling pathway
mjv04072
Phospholipase D signaling pathway
mjv04140
Autophagy - animal
mjv04148
Efferocytosis
mjv04150
mTOR signaling pathway
mjv04151
PI3K-Akt signaling pathway
mjv04210
Apoptosis
mjv04218
Cellular senescence
mjv04270
Vascular smooth muscle contraction
mjv04370
VEGF signaling pathway
mjv04371
Apelin signaling pathway
mjv04540
Gap junction
mjv04550
Signaling pathways regulating pluripotency of stem cells
mjv04613
Neutrophil extracellular trap formation
mjv04620
Toll-like receptor signaling pathway
mjv04650
Natural killer cell mediated cytotoxicity
mjv04660
T cell receptor signaling pathway
mjv04662
B cell receptor signaling pathway
mjv04664
Fc epsilon RI signaling pathway
mjv04720
Long-term potentiation
mjv04722
Neurotrophin signaling pathway
mjv04730
Long-term depression
mjv04810
Regulation of actin cytoskeleton
mjv04910
Insulin signaling pathway
mjv04912
GnRH signaling pathway
mjv04915
Estrogen signaling pathway
mjv04916
Melanogenesis
mjv04917
Prolactin signaling pathway
mjv04919
Thyroid hormone signaling pathway
mjv04921
Oxytocin signaling pathway
mjv04926
Relaxin signaling pathway
mjv04929
GnRH secretion
mjv04934
Cushing syndrome
mjv04935
Growth hormone synthesis, secretion and action
mjv05010
Alzheimer disease
mjv05022
Pathways of neurodegeneration - multiple diseases
mjv05132
Salmonella infection
mjv05135
Yersinia infection
mjv05160
Hepatitis C
mjv05161
Hepatitis B
mjv05163
Human cytomegalovirus infection
mjv05164
Influenza A
mjv05165
Human papillomavirus infection
mjv05166
Human T-cell leukemia virus 1 infection
mjv05167
Kaposi sarcoma-associated herpesvirus infection
mjv05170
Human immunodeficiency virus 1 infection
mjv05200
Pathways in cancer
mjv05205
Proteoglycans in cancer
mjv05206
MicroRNAs in cancer
mjv05207
Chemical carcinogenesis - receptor activation
mjv05208
Chemical carcinogenesis - reactive oxygen species
mjv05210
Colorectal cancer
mjv05211
Renal cell carcinoma
mjv05213
Endometrial cancer
mjv05214
Glioma
mjv05215
Prostate cancer
mjv05216
Thyroid cancer
mjv05218
Melanoma
mjv05219
Bladder cancer
mjv05220
Chronic myeloid leukemia
mjv05221
Acute myeloid leukemia
mjv05223
Non-small cell lung cancer
mjv05224
Breast cancer
mjv05225
Hepatocellular carcinoma
mjv05226
Gastric cancer
mjv05230
Central carbon metabolism in cancer
mjv05231
Choline metabolism in cancer
mjv05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
mjv00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
108385046 (MAP2K2)
04012 ErbB signaling pathway
108385046 (MAP2K2)
04014 Ras signaling pathway
108385046 (MAP2K2)
04015 Rap1 signaling pathway
108385046 (MAP2K2)
04370 VEGF signaling pathway
108385046 (MAP2K2)
04371 Apelin signaling pathway
108385046 (MAP2K2)
04066 HIF-1 signaling pathway
108385046 (MAP2K2)
04068 FoxO signaling pathway
108385046 (MAP2K2)
04072 Phospholipase D signaling pathway
108385046 (MAP2K2)
04071 Sphingolipid signaling pathway
108385046 (MAP2K2)
04024 cAMP signaling pathway
108385046 (MAP2K2)
04022 cGMP-PKG signaling pathway
108385046 (MAP2K2)
04151 PI3K-Akt signaling pathway
108385046 (MAP2K2)
04150 mTOR signaling pathway
108385046 (MAP2K2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
108385046 (MAP2K2)
04148 Efferocytosis
108385046 (MAP2K2)
09143 Cell growth and death
04210 Apoptosis
108385046 (MAP2K2)
04218 Cellular senescence
108385046 (MAP2K2)
09144 Cellular community - eukaryotes
04540 Gap junction
108385046 (MAP2K2)
04550 Signaling pathways regulating pluripotency of stem cells
108385046 (MAP2K2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
108385046 (MAP2K2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
108385046 (MAP2K2)
04620 Toll-like receptor signaling pathway
108385046 (MAP2K2)
04650 Natural killer cell mediated cytotoxicity
108385046 (MAP2K2)
04660 T cell receptor signaling pathway
108385046 (MAP2K2)
04662 B cell receptor signaling pathway
108385046 (MAP2K2)
04664 Fc epsilon RI signaling pathway
108385046 (MAP2K2)
09152 Endocrine system
04910 Insulin signaling pathway
108385046 (MAP2K2)
04929 GnRH secretion
108385046 (MAP2K2)
04912 GnRH signaling pathway
108385046 (MAP2K2)
04915 Estrogen signaling pathway
108385046 (MAP2K2)
04917 Prolactin signaling pathway
108385046 (MAP2K2)
04921 Oxytocin signaling pathway
108385046 (MAP2K2)
04926 Relaxin signaling pathway
108385046 (MAP2K2)
04935 Growth hormone synthesis, secretion and action
108385046 (MAP2K2)
04919 Thyroid hormone signaling pathway
108385046 (MAP2K2)
04916 Melanogenesis
108385046 (MAP2K2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
108385046 (MAP2K2)
09156 Nervous system
04720 Long-term potentiation
108385046 (MAP2K2)
04730 Long-term depression
108385046 (MAP2K2)
04722 Neurotrophin signaling pathway
108385046 (MAP2K2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
108385046 (MAP2K2)
05206 MicroRNAs in cancer
108385046 (MAP2K2)
05205 Proteoglycans in cancer
108385046 (MAP2K2)
05207 Chemical carcinogenesis - receptor activation
108385046 (MAP2K2)
05208 Chemical carcinogenesis - reactive oxygen species
108385046 (MAP2K2)
05230 Central carbon metabolism in cancer
108385046 (MAP2K2)
05231 Choline metabolism in cancer
108385046 (MAP2K2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
108385046 (MAP2K2)
09162 Cancer: specific types
05210 Colorectal cancer
108385046 (MAP2K2)
05225 Hepatocellular carcinoma
108385046 (MAP2K2)
05226 Gastric cancer
108385046 (MAP2K2)
05214 Glioma
108385046 (MAP2K2)
05216 Thyroid cancer
108385046 (MAP2K2)
05221 Acute myeloid leukemia
108385046 (MAP2K2)
05220 Chronic myeloid leukemia
108385046 (MAP2K2)
05218 Melanoma
108385046 (MAP2K2)
05211 Renal cell carcinoma
108385046 (MAP2K2)
05219 Bladder cancer
108385046 (MAP2K2)
05215 Prostate cancer
108385046 (MAP2K2)
05213 Endometrial cancer
108385046 (MAP2K2)
05224 Breast cancer
108385046 (MAP2K2)
05223 Non-small cell lung cancer
108385046 (MAP2K2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
108385046 (MAP2K2)
05170 Human immunodeficiency virus 1 infection
108385046 (MAP2K2)
05161 Hepatitis B
108385046 (MAP2K2)
05160 Hepatitis C
108385046 (MAP2K2)
05164 Influenza A
108385046 (MAP2K2)
05163 Human cytomegalovirus infection
108385046 (MAP2K2)
05167 Kaposi sarcoma-associated herpesvirus infection
108385046 (MAP2K2)
05165 Human papillomavirus infection
108385046 (MAP2K2)
09171 Infectious disease: bacterial
05132 Salmonella infection
108385046 (MAP2K2)
05135 Yersinia infection
108385046 (MAP2K2)
09164 Neurodegenerative disease
05010 Alzheimer disease
108385046 (MAP2K2)
05022 Pathways of neurodegeneration - multiple diseases
108385046 (MAP2K2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
108385046 (MAP2K2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
108385046 (MAP2K2)
01522 Endocrine resistance
108385046 (MAP2K2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mjv01001
]
108385046 (MAP2K2)
Enzymes [BR:
mjv01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
108385046 (MAP2K2)
Protein kinases [BR:
mjv01001
]
Serine/threonine kinases: STE group
STE7 family
108385046 (MAP2K2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
CAMSAP_CC1
Kdo
APH
Motif
Other DBs
NCBI-GeneID:
108385046
NCBI-ProteinID:
XP_036874423
LinkDB
All DBs
Position
Unknown
AA seq
400 aa
AA seq
DB search
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGAEGEPHSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGIFTQDFQEFVNKCLIKNPAERADL
KMLMNHTFIKRSEAEEVDFAGWLCKTLRLNQPSTPTRAAV
NT seq
1203 nt
NT seq
+upstream
nt +downstream
nt
atgctggcccgtaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgaa
ggcccgtcccccaccagcgagggcgcctccgaagccaacttggtggacctccagaagaag
ctagaggagctggaactcgatgagcagcagaagaagcggctagaagctttcctcacccag
aaggccaaggtcggggagctcaaggatgatgacttcgagcggatctcagagctgggagct
gggaacggcggggtggtcaccaaggtccagcatagaccttcgggcctcatcatggcaagg
aagttgattcacctggagatcaagccggccatccggaaccagatcatccgagagctacag
gtgctgcacgagtgtaactcgccgtacatcgtgggcttctacggggccttctacagcgac
ggggagatcagcatctgcatggagcacatggacggcggctctctggaccaggtgttgaaa
gaagccaagagaattcccgaggagatcctgggcaaggtcagcatcgcggtcctgcggggc
ttggcgtatctccgggaaaagcaccagatcatgcaccgagacgtgaaaccgtcgaacatc
ctcgtcaactcccgaggggagatcaagctgtgcgattttggggtgagcgggcaactcatt
gactcaatggccaactccttcgtgggaacgcggtcctacatgtctccagagcggttgcaa
ggtactcactactccgtgcagtcagacatctggagcatgggcctgtccctggtggagctg
tccatcggaaggtaccccatccccccaccagatgccaaggagctggaagccatatttggc
cggcccatggtcgatggggcggaaggagagccacacagcatctcgccacggccgagaccc
cccggacgccccatcagcggtcacgggatggacagccggccggccatggctatcttcgag
ctgctggactatattgtgaatgagccacctcccaagctgcccagcggcattttcacccag
gacttccaggagtttgtaaataaatgcctgattaagaacccagcagagcgagccgatctg
aagatgctcatgaaccacaccttcatcaaacggtccgaggcggaagaagtcgattttgcc
ggctggttgtgtaaaacgctgcggctgaaccagcccagcacgcccacacgcgctgccgtg
tga
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