Manis javanica (Malayan pangolin): 108393528
Help
Entry
108393528 CDS
T06054
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
mjv
Manis javanica (Malayan pangolin)
Pathway
mjv05012
Parkinson disease
mjv05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
mjv00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
108393528 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
108393528 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mjv01001
]
108393528 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
mjv04131
]
108393528 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
mjv04147
]
108393528 (LRRK2)
Enzymes [BR:
mjv01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
108393528 (LRRK2)
Protein kinases [BR:
mjv01001
]
Serine/threonine kinases: TKL group
LRRK family
108393528 (LRRK2)
Membrane trafficking [BR:
mjv04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
108393528 (LRRK2)
Exosome [BR:
mjv04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
108393528 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
LRR_4
Roc
LRR_8
COR
Ras
LRR_9
Arf
Ank_2
nSTAND3
AAA_22
LRR_6
T2SSE
AAA_7
TrwB_AAD_bind
ABC_tran
MMR_HSR1
Septin
PduV-EutP
NACHT
GTP_EFTU
MobB
ANAPC4_WD40
cobW
AAA_16
SRPRB
G-alpha
Kdo
TsaE
AAA_29
FtsK_SpoIIIE
NB-ARC
TniB
ResIII
AAA_23
SRP54
Motif
Other DBs
NCBI-GeneID:
108393528
NCBI-ProteinID:
XP_036863454
LinkDB
All DBs
Position
Unknown
AA seq
2377 aa
AA seq
DB search
MNRDLTSLPSSLSFPASRLFEGKNVHVPLLIVLESYMRVASVQQVGWSLLCKLIEIYPDT
MQTLMGPQDVGHDWEVLGVHQLILKMLTVHNASVNLSVIGLKVLDHLLTSGKITLLILDE
ESDIFLLIFDAMRTFSANDEVQKLGCKALRVLFETVSDEQLTEFVENKDYMVLLNALKHF
KDEEEIVLHVLYCLHSLAIPCNNVEVLMSGNVRCYNIVVEVMEAFPIHEKIQEVSCCLLH
RLTLGNFFNILVLNEVHEFVVTAVQRYPKNATLQIAALSCLALLTETIFLNQDLEEKSEN
QNDEEEEDKLFWLEACYKALTWHRKNRHVQEAACWALNNLLMYQKGLHEKIGDEDGQFPA
HREVMLSMLMHSSSIEVFQASANALSTLLEQNGRLSRNAMGEEFIGNPGIQKCGLRVLSS
IAHFPDAREALPLEGAMDLVLHTLQMYPDDQEIQCLGLSLIGCLVTKKNLHVGTGHLVAK
ILVSSLQRFKDIAEVQIKGFQTILAILELSVSFSELLVHHSFDSVIFHQMASSIMEQKAQ
QFLHLCCKCFAKLAIDDELKCVMLERACDQNNSIMVECLLLLGADANRTKEGTSLICQVC
EKASSPKLVQLLLNSGSREQDVRKALAISAGKGDSAIVSLLLRRLALDLANNSICLGGFG
LGKIDPAWLGPLFPEKTCNFRKETNIGSTLARMVLRHQRESDVGEGAVSGSDGNLSEVLD
KLDEWTFIPESYVDSVFGQSDDLDSEGSEGSFLVKKKSNSINVGEFYRDAALQRCSPNLQ
RHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQPHMRHSDSISSLASEREYITSLDLS
ANELRDVDALSQKCCISGHLEHLEKLELHQNALTAFPQRLCEILKCLTHLDLHSNKFTSF
PPYLLKMNCIANLDVSRNDIGPSVVLDPGVKCLTLKQFNLSYNQLSSFPENLGDAAETLE
QLTLEGNKIPGICSPLSLKELKILNLSKNHISSLSEDFLEACPKLESFSARMNFLASMPF
LPPSMTSLKLSQNRFTNVPEAILNLPHLRSLDMSGNDIQYLPGPAHWKSLNLRELLFSHN
QISVLDLSEKAFAWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSCNTELRSFPNEMGK
LSKIWDLPLDELRLNFDFKHIGCKAKDVIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTL
LQQLMKTKKSDAGMQSATVGIDVKDWPVQIRGKGKRDLILNVWDFAGREEFYSTHPHFMS
QRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACIGKTT
RELLNKRGFPAIRNYHFVNATEESDALAKLRKTIINESLNFKIRDQPVVGQLIPDCYVEL
EKIILSERKNVPIEFPVIDRKRLLQLVKENQLQLDENELPHAVHFLNESGVLLHFQDPAL
QLSDLYFVEPKWLCKVMAQILTVKVEGYPKHPKGIISRRDVEKFLSKKKRFPKNYMSQYF
KLLEKFQIALPIGEECLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLIN
RLLEISPYMLSGRERVLRPNRMYWRQGIYLNWSPEAYCLVGSEVLDDHPESFLKITVPSC
RKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEECRKILLDDL
MRKAEEGDLLVNPDRPRLTVPISQIAPDLILADLPRNIMLNDDELEFEQAPEFLLGDGSF
GSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLVSLLAAGIRPRMLVMELA
SKGSLDRLLQHDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAA
IIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTG
SRIAEGLKFPNEFDELAIQGKLPDPVKEYGCAPWPTVEKLIKKCLKENPQERPTSAQVFD
ILNSAELICLMRHISIPKNNIVECMVATNHSSKNARIWLGCGFPDKGQLSFLDLNTEKYT
SEEVADSRILCLALVHLPAETESWIVSGTQSGTLLVISTEDGKRRHTLEKMSDSITCLYY
SSFSKQSKQRHFLLVGTADGNLAIFQDKAVKCKGAAPLRILNIGDVSTPLMCLSESMHSN
EKNIMWGGCGTKLFSFTDDFTIQKLIETRTNQLFSYAAFSDSNIIAVVVDTALYVAKKNS
PFVEVRDKKTEKLCELIDCVHFLKEERVKGNKESKHKMSYSGRVKTLCLQKNTALWIGTG
GGHILLLDLSTRRIIRIIHNLCDSVRVMMTAQLGSLKNVMLVLGYNRKSTEGPQHQKEIE
FCLSVWDLNLPHEVQNLEKHIEVRKELAEKMRGISAE
NT seq
7134 nt
NT seq
+upstream
nt +downstream
nt
atgaatcgtgacttgacttctcttccctcatccctttcttttccagcctccaggttattt
gaaggcaaaaatgtgcacgtgcctctgttgatcgtcttggagtcgtacatgagggtcgcc
agcgtgcagcaggttggttggtcacttctctgcaaactgatagaaatctacccggataca
atgcaaaccttaatgggaccccaggatgttggacatgattgggaagttcttggggttcat
caactaattcttaagatgctaacagttcataatgccagtgtcaacttgtcagttattgga
ctgaaggtcttagatcacctcctcacttcaggtaaaatcactttgctgatattggatgaa
gaaagtgatattttcctgttaattttcgatgccatgcgcacattttcagccaatgatgaa
gtccagaaacttggctgcaaagctttacgtgtgctgtttgagacagtttcagatgagcag
ctgacagaatttgttgagaataaagactatatggtattgctaaatgcattaaaacatttt
aaagatgaagaggaaattgtgcttcatgtcctgtactgtttacattccctggcaattcct
tgcaataatgttgaagtcctcatgagcggcaatgtcaggtgttacaatattgtggtagaa
gtcatggaagcattccctattcatgaaaaaattcaagaagtgagttgctgcttgctccac
aggcttacattaggtaattttttcaatatcctggtattaaatgaggtgcatgagtttgtg
gtgaccgccgtacaacggtatccgaagaatgccacgttacagatcgcagccctcagctgt
ttagcactcctcactgagaccattttcttgaatcaagacttagaggagaagagtgagaat
cagaatgacgaggaagaagaggataaattgttttggctggaagcgtgttacaaagcgcta
acatggcacagaaaaaacaggcacgtgcaggaggctgcgtgctgggctctgaacaatctc
ctgatgtaccagaaaggtttacacgagaagattggagatgaagatggccagttcccagct
catagggaagtgatgctgtctatgctgatgcactcctcgtccatagaggtcttccaggca
tccgcaaacgcgttgtccactctcctggaacagaacgggagactttctagaaatgcaatg
ggtgaggagttcattggaaatcctgggattcagaaatgtggattgagagtactgtcttct
atagcgcatttccctgatgcgcgggaggcgttacccctggaaggagctatggatttggtg
ctgcacacgctgcagatgtatccggatgaccaagaaattcagtgtctgggtttgagtctt
ataggatgtttggttacaaagaagaatttacatgtaggaactggacatctggtggcaaaa
attctggtttccagtttacagcgatttaaggatattgctgaagtacagattaaaggattt
cagacaatattggcaatactggaattgtcagtgtctttttctgagctgctggtgcatcat
tcctttgactcagtgatattccatcagatggcttccagcatcatggaacaaaaggctcaa
cagtttctacacctttgttgcaagtgcttcgcaaaattagctatcgatgatgagttaaaa
tgtgtgatgctagagagagcatgtgatcagaataacagcatcatggtggaatgcctgctt
ctgttgggagcggatgccaacagaacaaaggaaggaacttctttaatttgtcaggtatgt
gagaaagcgagcagtcccaaactggtgcaactgctcttaaatagcgggtcccgtgagcaa
gatgttcggaaagcgctggcgattagtgccgggaaaggtgacagcgccatcgtcagctta
ctcctacggaggcttgccctggatctggccaataacagcatttgcctaggaggatttggc
ttaggaaaaatcgaccctgcttggcttggtcctttatttccggaaaagacatgtaatttc
agaaaagaaacgaatatcggatccaccctcgcaagaatggtgctcaggcatcagagggag
agtgacgtgggggagggggcagtctcaggcagcgacgggaacctgtccgaagtccttgat
aaacttgatgaatggaccttcattcctgagtcttacgtggacagtgtgtttggtcaaagt
gatgacctggacagtgaaggaagcgaaggctcatttcttgtgaaaaagaagtcaaattca
attaatgtaggagaattttaccgagatgctgctttgcagcgctgctcgccaaatttgcaa
aggcattccaattcactgggacccatttttgatcatgaagatttactgaagcgaaaaaga
aaaatactgtcttcagatgattcactcaggtcatcaaaacttcaaccccacatgaggcat
tcagacagcatttcttccctggcttctgagagagaatatattacatcattagacctttca
gcaaatgagctaagagatgttgatgccctaagtcagaaatgctgtataagtggtcatttg
gagcatcttgaaaagctggagcttcaccagaacgcactcacggcctttccgcagcgacta
tgtgaaattctgaagtgtttgacacatttggacctgcacagtaataaatttacatcattt
ccgccttacttgctgaaaatgaattgtattgccaaccttgatgtttctcgaaatgacatt
ggcccctcggtagttttggatcctggggtgaagtgcttgaccttgaagcagtttaacctg
tcctataatcagctgtcatctttccccgagaacctgggcgatgcggcagagacgctggaa
cagctgactttggaaggaaataaaataccaggaatttgttcccccttgagcctgaaggag
ctgaagattttaaatcttagtaaaaaccacatttcttccctatcagaggactttcttgag
gcatgtcctaaactggagagtttcagcgccagaatgaatttccttgcttctatgcctttt
ttgcctccttccatgacaagcctaaaattatctcaaaacagatttacaaatgttccagaa
gcaattttaaatctcccacacttgcggtccttagatatgagcggcaatgatattcagtat
ctgccgggtcctgcgcactggaagtctttgaacttgagggaactcctctttagtcataat
cagatcagcgtcttggacttgagtgaaaaagcgtttgcatggtctagagtagagaagctt
catctttctcataataaactgaaagagattcctcctgagattggctgtcttgaaaatctg
acatctcttgatgtcagttgcaacacggaactgagatcctttcccaacgaaatggggaag
ttaagcaaaatatgggatcttcctttggatgaactgcgtcttaattttgattttaaacat
ataggatgtaaagctaaagacgtcataaggttccttcagcagaggttaaaaaaggcagta
ccctataaccgtatgaaacttatgattgtgggaaatactgggagtgggaaaaccacctta
ttgcagcaattaatgaaaaccaagaaatccgatgctgggatgcagagcgctaccgttggc
atagacgtgaaagactggcctgtccagataagaggcaaaggaaagagggacctcattcta
aatgtgtgggattttgcagggcgcgaggagttctacagcactcacccccacttcatgagc
cagcgggccctgtacctggctgtctatgacctcagcaaagggcaggccgaagtggacgcc
atgaagccctggctcttcaatataaaggcgcgagcttcgtcctcccccgtgattcttgtc
ggcacccacttggacgtctcggatgagaagcagcggaaggcctgcatcggcaagaccacg
agggagctcctcaacaagaggggctttcctgcaatacggaattaccatttcgtaaatgcc
acggaggaatcggacgctttggccaaacttcggaaaaccatcatcaacgagagccttaat
ttcaagatccgagatcagcctgttgtggggcagctgattccagactgctatgtagaactt
gagaaaatcattttatcggagcgtaaaaatgtgccaattgaatttcctgtaattgaccgg
aaacgattattacagctggtgaaagaaaatcagctgcagttggatgaaaacgagcttcct
catgcagttcacttcctaaatgaatcaggggtccttcttcattttcaagacccagcactg
cagttaagtgacttatattttgtggaacccaagtggctttgtaaagtcatggcccagatt
ttgacagtgaaagtggaaggttatccaaaacaccctaaaggaattatttcacggagagat
gtggaaaaatttctttccaagaaaaagagatttccaaagaactacatgtcacagtatttt
aaacttctagaaaaattccagattgccttgccaataggagaagaatgtttgctggttcca
agcagtttgtctgaccataggccagtgatagagcttccccattgtgagaactctgaaatt
atcattcgactatacgaaatgccttattttccaatgggattttggtcgagattaatcaat
cgattgcttgaaatttcaccttacatgctttcaggaagagagcgagtacttcgcccaaac
agaatgtactggcgacagggcatctacttgaactggtctcctgaagcttattgtctggtg
ggatctgaagtcttagatgatcatccagagagtttcttaaaaattacagttccttcttgt
agaaaaggttgcatccttttgggccaagttgtggaccacattgattctctcatggaggaa
tggtttcctggactactggagatcgatatttgtggtgaaggagaaactctgttgaagaag
tgggcattatatagttttaatgatggtgaagagtgccgaaaaatcttgcttgatgacttg
atgaggaaggcagaggaaggagacctcctggtaaatccagaccggccgaggctcaccgtt
cctatatctcagatcgctcctgacttgatcttggctgacctgcctagaaatattatgttg
aatgatgatgaactggaatttgaacaagctccggagtttctcctaggtgatggcagtttt
ggatctgtttatcgagcagcctatgaaggagaagaagtggctgtgaagatttttaataag
catacatcacttagactgttgcgacaagagctggtggtgctgtgccatctccaccacccc
agcctggtgtctctgctggccgccgggattcgccctcgcatgctggtgatggagctggcc
tccaagggttccctggatcgcctgcttcagcacgacaaggccagtctcaccagaaccctg
cagcacaggatcgcgctgcatgtggctgatggtttgagatacctccactcagccatgatc
atataccgcgacttaaagccccacaacgtgctgcttttcaccctgtatccgaatgccgcc
atcatcgcaaagattgctgactatgggattgcccagtactgctgtagaatggggataaaa
acgtcggagggcacgccagggtttcgtgcacctgaagttgccagaggaaatgttatttat
aaccaacaggctgatgtttattcattcggtttactactgtatgacattttgacaactgga
agtagaatagcagagggtttgaaatttccaaatgagtttgatgaattggcaatacaagga
aaattgcctgatccagttaaagaatatggttgtgccccatggcctacggttgagaagtta
attaaaaagtgtctgaaagagaatcctcaagaaaggcctacttctgcccaggtctttgac
attttgaattctgctgagttaatctgtctgatgagacatatatcaatacccaaaaacaat
attgttgaatgcatggtcgctacaaaccatagcagcaagaatgcgcgcatctggctgggc
tgcgggttccctgacaaaggacagctctcgtttcttgacttaaatactgaaaaatacact
tccgaggaagttgctgatagtagaatactgtgcctagctttggtgcaccttcctgctgag
acggagagctggatcgtgtctgggacacagtctggcaccctcctggtcatcagtactgaa
gatgggaagaggagacacacccttgagaagatgagtgactccatcacctgcttgtattac
agttccttttccaagcaaagcaagcaaaggcattttcttttggtgggcactgctgatggt
aacttagcaatttttcaagataaagctgttaagtgtaaaggggctgctcctctgaggatc
ctgaatataggtgatgtcagcactccactgatgtgtctgagtgaatccatgcattcaaac
gaaaaaaacatcatgtggggaggatgcggtacaaaacttttctcatttactgatgatttc
accattcagaaactgattgagaccaggacaaaccagttgttctcttatgcagctttcagt
gattccaacatcatagccgtggtggtagacacagctctctacgtcgcgaagaagaatagc
ccatttgtggaagtgcgggataagaaaactgaaaagctctgcgaactaatagactgtgtg
cactttttaaaggaggaaagagtaaaaggaaacaaagaatcaaaacacaaaatgtcttat
tctgggagagtgaaaactctctgcctccagaagaacaccgctctctggataggaactgga
ggaggccatatcttactgctggatctttcaactcgtcggattattcgtataattcacaat
ttatgcgattctgttagagtcatgatgacagcacagttaggtagccttaaaaatgtcatg
ctggttttggggtataaccggaaaagtactgaaggtccacaacaccaaaaagagatagag
ttttgcttgtctgtttgggacctcaatcttccacatgaagtgcaaaatttagaaaaacat
attgaagtaaggaaagaattagctgaaaaaatgagaggaatatctgctgaatag
DBGET
integrated database retrieval system
