Mus musculus (house mouse): 18598
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Entry
18598 CDS
T01002
Symbol
Pdha2, Pdhal
Name
(RefSeq) pyruvate dehydrogenase E1 alpha 2
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu00010
Glycolysis / Gluconeogenesis
mmu00020
Citrate cycle (TCA cycle)
mmu00620
Pyruvate metabolism
mmu00785
Lipoic acid metabolism
mmu01100
Metabolic pathways
mmu01200
Carbon metabolism
mmu01210
2-Oxocarboxylic acid metabolism
mmu04066
HIF-1 signaling pathway
mmu04922
Glucagon signaling pathway
mmu05230
Central carbon metabolism in cancer
mmu05415
Diabetic cardiomyopathy
Module
mmu_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
18598 (Pdha2)
00020 Citrate cycle (TCA cycle)
18598 (Pdha2)
00620 Pyruvate metabolism
18598 (Pdha2)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
18598 (Pdha2)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
18598 (Pdha2)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
18598 (Pdha2)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
18598 (Pdha2)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
18598 (Pdha2)
Enzymes [BR:
mmu01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
18598 (Pdha2)
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GFIT
Motif
Pfam:
E1_dh
TPP_enzyme_C
DXP_synthase_N
Motif
Other DBs
NCBI-GeneID:
18598
NCBI-ProteinID:
NP_032837
MGI:
97533
Ensembl:
ENSMUSG00000047674
UniProt:
P35487
LinkDB
All DBs
Position
3:complement(140915765..140918116)
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AA seq
391 aa
AA seq
DB search
MRKMLTAVLSHVFSGMVQKPALRGLLSSLKFSNDATCDIKKCDLYRLEEGPPTSTVLTRA
EALKYYRTMQVIRRMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPTDHVITSYR
AHGFCYTRGLSVKSILAELTGRKGGCAKGKGGSMHMYGKNFYGGNGIVGAQVPLGAGVAF
ACKYLKNGQVCLALYGDGAANQGQVFEAYNMSALWKLPCVFICENNLYGMGTSNERSAAS
TDYHKKGFIIPGLRVNGMDILCVREATKFAADHCRSGKGPIVMELQTYRYHGHSMSDPGI
SYRSREEVHNVRSKSDPIMLLRERIISNNLSNIEELKEIDADVKKEVEDAAQFATTDPEP
AVEDIANYLYHQDPPFEVRGAHKWLKYKSHS
NT seq
1176 nt
NT seq
+upstream
nt +downstream
nt
atgaggaaaatgctgaccgctgtgctgtctcacgtattttcgggaatggtccaaaagcca
gctctcagaggactgctgtcatctctgaagttctccaacgacgccacctgtgacattaag
aaatgtgacctgtaccggctggaggagggcccaccgacctccaccgtgctcacccgagcc
gaggccctcaagtactaccggaccatgcaggtaattcggcgcatggagttgaaggccgac
cagctgtataagcagaaattcatccgtggtttctgtcacctgtgtgatgggcaggaagcc
tgctgcgtggggctggaggcagggataaatcccacggatcacgtcatcacgtcctaccgg
gctcatggcttctgctacacgcgaggactgtccgtgaagtccattctcgccgagctgact
ggacgcaaaggaggctgtgctaaaggcaagggaggctccatgcacatgtacggcaagaac
ttctacggtggcaatggcattgttggggcccaggtacccctgggagctggtgtggctttt
gcctgtaaatacctgaagaatggtcaggtctgcttggctttgtacggcgatggtgcggct
aaccaagggcaggtattcgaagcatacaatatgtcagccttgtggaaattaccctgtgtt
ttcatctgtgagaataacctctatggaatgggaacctccaacgagagatcagcagccagt
actgattaccacaagaaaggttttattatccccggactgagggtgaatgggatggatatt
ctctgtgttcgggaggcaaccaagtttgcagctgatcactgcagatctggaaaggggccc
attgtgatggagctgcagacctaccgttatcatggacacagtatgagcgacccagggatc
agttatcgttcacgagaagaagttcataacgtgagaagtaagagtgatcctataatgctg
ctccgagagagaattatcagcaacaacctcagcaatattgaagaattgaaagaaattgat
gcagatgtgaagaaagaggtggaggacgcagctcagtttgctacgactgatccagaacca
gctgtggaagatatagccaattacctctaccaccaagatccaccttttgaagtccgtggt
gcacataagtggctcaagtataagtcccacagttag
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