Mycobacterium tuberculosis CDC1551: MT0581
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Entry
MT0581 CDS
T00053
Symbol
menD
Name
(GenBank) 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase/2-oxoglutarate decarboxylase
KO
K02551
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [EC:
2.2.1.9
]
Organism
mtc
Mycobacterium tuberculosis CDC1551
Pathway
mtc00130
Ubiquinone and other terpenoid-quinone biosynthesis
mtc01100
Metabolic pathways
mtc01110
Biosynthesis of secondary metabolites
mtc01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
mtc00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00130 Ubiquinone and other terpenoid-quinone biosynthesis
MT0581 (menD)
Enzymes [BR:
mtc01000
]
2. Transferases
2.2 Transferring aldehyde or ketonic groups
2.2.1 Transketolases and transaldolases
2.2.1.9 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase
MT0581 (menD)
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Gene cluster
GFIT
Motif
Pfam:
TPP_enzyme_N
Motif
Other DBs
NCBI-ProteinID:
AAK44804
UniProt:
P9WK10
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All DBs
Position
647750..649414
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AA seq
554 aa
AA seq
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MNPSTTQARVVIDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY
LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM
EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP
LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL
AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT
GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA
AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG
AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ
GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR
SSLRQLHAAIKAAL
NT seq
1665 nt
NT seq
+upstream
nt +downstream
nt
gtgaacccctcgacgacacaggcgcgcgtcgtcatcgacgaactgatccgcggcggcgtt
cgcgacgtggtgctgtgtccgggctcgcgcaatgcgccgctggccttcgcgctgcaggac
gccgaccggtccggccggatccggttgcacgttcgcatcgatgaacgcaccgccggctac
ctggccatcgggctggcaatcggggcgggcgcgccggtgtgtgtcgcgatgacatccggc
accgccgtggccaacctcggtccggcggtggtggaggcaaactacgctcgggtgccgctg
atcgtgctgtcagccaatcggccctacgagctgctgggcaccggcgccaaccagaccatg
gaacagctgggctatttcggcacccaggtgcgcgccagcatcagcctggggctggccgag
gacgcacccgagcggacctcggcgctcaacgcgacctggcgatcggctacgtgccgagtg
ttggcggccgccacgggtgctcgcaccgccaacgcgggccccgtgcacttcgacatcccg
ctgcgcgaaccgctggtgcccgatcccgagcccctcggcgcggtcaccccgccgggccgg
cctgctggcaagccgtggacctacacgccgccggtcaccttcgaccagccactggacatc
gacctgtcggtcgacaccgtggtcatctccgggcatggcgctggcgtgcaccccaacctc
gcggcgttgccgaccgtcgcagaaccgacggcgccgcggtccggggacaacccgttgcac
ccgctggcgctgccgctgctgcgccctcaacaggtgatcatgctgggccggccgacactg
catcgtccggtatcggtgctgctggccgacgcagaagtgccggtattcgcattgacaacc
ggtccacgctggccggatgtctcgggtaactcgcaggccaccggcacgcgggcggtcacc
accggcgcgccgcggcccgcgtggctggaccggtgtgcggcgatgaaccggcacgcgatc
gcggcggttcgggaacagctcgcggcgcacccgttgaccaccgggctgcatgtcgcggcg
gcggtgtcgcatgcgctgcggcccggtgaccagctggtgctcggggcatccaatccggtg
cgggatgtggcgttggccggtttggacacccgcggcatccgggtacggtccaaccgtggg
gtcgccggcatcgacggcaccgtgtccaccgcgatcggggcggccctagcttatgagggg
gctcacgagcgcaccggcagcccggactccccgccccgcaccatcgcactgatcggcgac
ctgacgttcgtgcacgacagctccgggctgttgatcgggccgaccgaaccgataccgcgg
tcattgaccatcgtggtgtctaatgacaacggcggcggcatcttcgaattgctcgagcag
ggtgatcccaggttctccgacgtgtcatcgcgaatcttcggcaccccacacgacgtcgat
gtgggcgcattgtgccgcgcctaccacgtggaatctcgccagatcgaggtcgacgaactc
ggaccgaccctcgatcaacccggtgccggcatgcgcgtgctcgaggtcaaggccgaccgg
tcgtcgttgcgacaattgcacgccgccatcaaggcggctctgtga
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