Mycobacterium tuberculosis H37Rv: Rv0555
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Entry
Rv0555 CDS
T00015
Symbol
menD
Name
(RefSeq) bifunctional 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase/2-oxoglutarate decarboxylase
KO
K02551
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [EC:
2.2.1.9
]
Organism
mtu
Mycobacterium tuberculosis H37Rv
Pathway
mtu00130
Ubiquinone and other terpenoid-quinone biosynthesis
mtu01100
Metabolic pathways
mtu01110
Biosynthesis of secondary metabolites
mtu01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
mtu00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00130 Ubiquinone and other terpenoid-quinone biosynthesis
Rv0555 (menD)
Enzymes [BR:
mtu01000
]
2. Transferases
2.2 Transferring aldehyde or ketonic groups
2.2.1 Transketolases and transaldolases
2.2.1.9 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase
Rv0555 (menD)
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Gene cluster
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Motif
Pfam:
TPP_enzyme_N
Motif
Other DBs
NCBI-GeneID:
887554
NCBI-ProteinID:
NP_215069
TubercuList:
Rv0555
UniProt:
P9WK11
Structure
PDB
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Position
646298..647962
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AA seq
554 aa
AA seq
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MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY
LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM
EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP
LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL
AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT
GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA
AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG
AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ
GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR
SSLRQLHAAIKAAL
NT seq
1665 nt
NT seq
+upstream
nt +downstream
nt
gtgaacccctcgacgacacaggcgcgcgtcgtcgtcgacgaactgatccgcggcggcgtt
cgcgacgtggtgctgtgtccgggctcgcgcaatgcgccgctggccttcgcgctgcaggac
gccgaccggtccggccggatccggttgcacgttcgcatcgatgaacgcaccgccggctac
ctggccatcgggctggcaatcggggcgggcgcgccggtgtgtgtcgcgatgacatccggc
accgccgtggccaacctcggtccggcggtggtggaggcaaactacgctcgggtgccgctg
atcgtgctgtcagccaatcggccctacgagctgctgggcaccggcgccaaccagaccatg
gaacagctgggctatttcggcacccaggtgcgcgccagcatcagcctggggctggccgag
gacgcacccgagcggacctcggcgctcaacgcgacctggcgatcggctacgtgccgagtg
ttggcggccgccacgggtgctcgcaccgccaacgcgggccccgtgcacttcgacatcccg
ctgcgcgaaccgctggtgcccgatcccgagcccctcggcgcggtcaccccgccgggccgg
cctgctggcaagccgtggacctacacgccgccggtcaccttcgaccagccactggacatc
gacctgtcggtcgacaccgtggtcatctccgggcatggcgctggcgtgcaccccaacctc
gcggcgttgccgaccgtcgcagaaccgacggcgccgcggtccggggacaacccgttgcac
ccgctggcgctgccgctgctgcgccctcaacaggtgatcatgctgggccggccgacactg
catcgtccggtatcggtgctgctggccgacgcagaagtgccggtattcgcattgacaacc
ggtccacgctggccggatgtctcgggtaactcgcaggccaccggcacgcgggcggtcacc
accggcgcgccgcggcccgcgtggctggaccggtgtgcggcgatgaaccggcacgcgatc
gcggcggttcgggaacagctcgcggcgcacccgttgaccaccgggctgcatgtcgcggcg
gcggtgtcgcatgcgctgcggcccggtgaccagctggtgctcggggcatccaatccggtg
cgggatgtggcgttggccggtttggacacccgcggcatccgggtacggtccaaccgtggg
gtcgccggcatcgacggcaccgtgtccaccgcgatcggggcggccctagcttatgagggg
gctcacgagcgcaccggcagcccggactccccgccccgcaccatcgcactgatcggcgac
ctgacgttcgtgcacgacagctccgggctgttgatcgggccgaccgaaccgataccgcgg
tcattgaccatcgtggtgtctaatgacaacggcggcggcatcttcgaattgctcgagcag
ggtgatcccaggttctccgacgtgtcatcgcgaatcttcggcaccccacacgacgtcgat
gtgggcgcattgtgccgcgcctaccacgtggaatctcgccagatcgaggtcgacgaactc
ggaccgaccctcgatcaacccggtgccggcatgcgcgtgctcgaggtcaaggccgaccgg
tcgtcgttgcgacaattgcacgccgccatcaaggcggctctgtga
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