KEGG   Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise): 112394646
Entry
112394646         CDS       T08872                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
nasi  Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Pathway
nasi01522  Endocrine resistance
nasi04010  MAPK signaling pathway
nasi04015  Rap1 signaling pathway
nasi04068  FoxO signaling pathway
nasi04071  Sphingolipid signaling pathway
nasi04114  Oocyte meiosis
nasi04148  Efferocytosis
nasi04218  Cellular senescence
nasi04261  Adrenergic signaling in cardiomyocytes
nasi04370  VEGF signaling pathway
nasi04380  Osteoclast differentiation
nasi04550  Signaling pathways regulating pluripotency of stem cells
nasi04611  Platelet activation
nasi04613  Neutrophil extracellular trap formation
nasi04620  Toll-like receptor signaling pathway
nasi04621  NOD-like receptor signaling pathway
nasi04622  RIG-I-like receptor signaling pathway
nasi04625  C-type lectin receptor signaling pathway
nasi04657  IL-17 signaling pathway
nasi04658  Th1 and Th2 cell differentiation
nasi04659  Th17 cell differentiation
nasi04660  T cell receptor signaling pathway
nasi04664  Fc epsilon RI signaling pathway
nasi04668  TNF signaling pathway
nasi04670  Leukocyte transendothelial migration
nasi04714  Thermogenesis
nasi04722  Neurotrophin signaling pathway
nasi04723  Retrograde endocannabinoid signaling
nasi04728  Dopaminergic synapse
nasi04750  Inflammatory mediator regulation of TRP channels
nasi04912  GnRH signaling pathway
nasi04914  Progesterone-mediated oocyte maturation
nasi04917  Prolactin signaling pathway
nasi04926  Relaxin signaling pathway
nasi04932  Non-alcoholic fatty liver disease
nasi04933  AGE-RAGE signaling pathway in diabetic complications
nasi04935  Growth hormone synthesis, secretion and action
nasi04936  Alcoholic liver disease
nasi05014  Amyotrophic lateral sclerosis
nasi05020  Prion disease
nasi05022  Pathways of neurodegeneration - multiple diseases
nasi05132  Salmonella infection
nasi05133  Pertussis
nasi05135  Yersinia infection
nasi05140  Leishmaniasis
nasi05142  Chagas disease
nasi05145  Toxoplasmosis
nasi05152  Tuberculosis
nasi05161  Hepatitis B
nasi05163  Human cytomegalovirus infection
nasi05167  Kaposi sarcoma-associated herpesvirus infection
nasi05169  Epstein-Barr virus infection
nasi05170  Human immunodeficiency virus 1 infection
nasi05171  Coronavirus disease - COVID-19
nasi05205  Proteoglycans in cancer
nasi05208  Chemical carcinogenesis - reactive oxygen species
nasi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
nasi05415  Diabetic cardiomyopathy
nasi05417  Lipid and atherosclerosis
nasi05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nasi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112394646 (MAPK12)
   04015 Rap1 signaling pathway
    112394646 (MAPK12)
   04370 VEGF signaling pathway
    112394646 (MAPK12)
   04668 TNF signaling pathway
    112394646 (MAPK12)
   04068 FoxO signaling pathway
    112394646 (MAPK12)
   04071 Sphingolipid signaling pathway
    112394646 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    112394646 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    112394646 (MAPK12)
   04218 Cellular senescence
    112394646 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    112394646 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112394646 (MAPK12)
   04613 Neutrophil extracellular trap formation
    112394646 (MAPK12)
   04620 Toll-like receptor signaling pathway
    112394646 (MAPK12)
   04621 NOD-like receptor signaling pathway
    112394646 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    112394646 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    112394646 (MAPK12)
   04660 T cell receptor signaling pathway
    112394646 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    112394646 (MAPK12)
   04659 Th17 cell differentiation
    112394646 (MAPK12)
   04657 IL-17 signaling pathway
    112394646 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    112394646 (MAPK12)
   04670 Leukocyte transendothelial migration
    112394646 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    112394646 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    112394646 (MAPK12)
   04917 Prolactin signaling pathway
    112394646 (MAPK12)
   04926 Relaxin signaling pathway
    112394646 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    112394646 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    112394646 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    112394646 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    112394646 (MAPK12)
   04722 Neurotrophin signaling pathway
    112394646 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    112394646 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    112394646 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    112394646 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    112394646 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    112394646 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112394646 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    112394646 (MAPK12)
   05161 Hepatitis B
    112394646 (MAPK12)
   05171 Coronavirus disease - COVID-19
    112394646 (MAPK12)
   05163 Human cytomegalovirus infection
    112394646 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112394646 (MAPK12)
   05169 Epstein-Barr virus infection
    112394646 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112394646 (MAPK12)
   05135 Yersinia infection
    112394646 (MAPK12)
   05133 Pertussis
    112394646 (MAPK12)
   05152 Tuberculosis
    112394646 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    112394646 (MAPK12)
   05140 Leishmaniasis
    112394646 (MAPK12)
   05142 Chagas disease
    112394646 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    112394646 (MAPK12)
   05020 Prion disease
    112394646 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    112394646 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112394646 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    112394646 (MAPK12)
   05415 Diabetic cardiomyopathy
    112394646 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    112394646 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    112394646 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    112394646 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    112394646 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nasi01001]
    112394646 (MAPK12)
Enzymes [BR:nasi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     112394646 (MAPK12)
Protein kinases [BR:nasi01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   112394646 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Kinase-like Haspin_kinase
Other DBs
NCBI-GeneID: 112394646
NCBI-ProteinID: XP_024593241
UniProt: A0A341ARK2
LinkDB
Position
Unknown
AA seq 424 aa
MSSPPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPNETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMITGETLFKGSDRILYLELGAG
EACLTPGAGCGGGLPYTCGGQARRTARAGWVGELCPLAPRCAPDLSQDLDQLKEIMKVTG
TPPAEFVQRLQSAEAQNYMNGLPELEKKDFAAILTNASPLAVNLLEKMLVLDAERRVTAA
KALTHPYFESLHDTEDEPKAQKYDESFDDVDRTLEEWKRVTYREVLSFKPPRQLGAKVSK
ETAL
NT seq 1275 nt   +upstreamnt  +downstreamnt
atgagctctccgccgcccgcccgcaagggcttttaccgccaggaggtgaccaagacggcc
tgggaggtgcgcgccgtgtaccaggacctgcagcccgtaggctcgggcgcctatggcgcc
gtgtgctcggcggtggacagccgcacgggcgccaaggtggccataaagaagctgtaccgg
cccttccagtccgagctgttcgccaagcgcgcctaccgcgagctgcgcctgctcaagcac
atgcgccatgagaacgtaattgggctgctggatgtgttcacacccaatgagaccctggat
gatttcacagacttttacctggtgatgccgttcatgggcaccgacctggggaagctcatg
aagcacgagaagctgagtgaggaccgaatccagttcctcgtctaccagatgctcaagggg
ctgaagtacatccatgctgctggcatcatccacagggacctgaagcccggcaacctggcc
gtgaacgaggactgtgagctcaagatcctggactttggcctggcccggcaggcagatagc
gagatgactgggtacgtggtgacccggtggtaccgggcgcctgaggtcatcttgaattgg
atgcactacacacagacggtggacatctggtcagtgggctgcatcatggctgagatgatc
acaggggagacgctcttcaaaggcagcgaccgtatcctatacctggagctgggtgcgggg
gaggcttgccttacacctggagctgggtgcgggggaggcttgccctacacctgcgggggg
caggccaggcgcactgcccgggctgggtgggtaggtgagctctgccctctggccccgcgc
tgtgctcctgacctcagccaagacctggaccagctgaaggagatcatgaaggtgacgggg
acgcctcccgccgagttcgtgcagaggctgcagagtgccgaggctcagaactacatgaac
ggcctccccgagctagagaaaaaggattttgccgccatcctgaccaacgcaagccctctg
gccgtgaacctcctggagaagatgctcgtgctggatgcggagcggcgggtgacggcggcc
aaggcgctgacccacccctacttcgagtcgctgcacgacacggaggacgagcccaaagcc
caaaagtacgatgaatcctttgatgacgtggaccgcacgctggaagagtggaagcgcgtc
acatacagagaggtgctcagcttcaagcctccccgacagctgggggccaaggtctccaag
gagacggccctgtga

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