Neomonachus schauinslandi (Hawaiian monk seal): 110575058
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Entry
110575058 CDS
T08474
Symbol
PDHA1
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X1
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
nsu
Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu00010
Glycolysis / Gluconeogenesis
nsu00020
Citrate cycle (TCA cycle)
nsu00620
Pyruvate metabolism
nsu00785
Lipoic acid metabolism
nsu01100
Metabolic pathways
nsu01200
Carbon metabolism
nsu01210
2-Oxocarboxylic acid metabolism
nsu04066
HIF-1 signaling pathway
nsu04922
Glucagon signaling pathway
nsu05230
Central carbon metabolism in cancer
nsu05415
Diabetic cardiomyopathy
Module
nsu_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
nsu00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
110575058 (PDHA1)
00020 Citrate cycle (TCA cycle)
110575058 (PDHA1)
00620 Pyruvate metabolism
110575058 (PDHA1)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
110575058 (PDHA1)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
110575058 (PDHA1)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
110575058 (PDHA1)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
110575058 (PDHA1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
110575058 (PDHA1)
Enzymes [BR:
nsu01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
110575058 (PDHA1)
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GFIT
Motif
Pfam:
E1_dh
DXP_synthase_N
TPP_enzyme_C
Motif
Other DBs
NCBI-GeneID:
110575058
NCBI-ProteinID:
XP_021539595
EnsemblRapid:
ENSNSCG00000003177
UniProt:
A0A2Y9GNX2
LinkDB
All DBs
Position
X:complement(111251220..111265702)
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AA seq
390 aa
AA seq
DB search
MRKMLAAVSRVLSGVAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLRYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLSVREILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSIS
NT seq
1173 nt
NT seq
+upstream
nt +downstream
nt
atgaggaaaatgctcgccgctgtgtctcgcgtgttgtcgggcgtcgcccagaagccggca
agcagagtgctcgtggcctcccgtaattttgcaaatgatgctacatttgaaattaagaaa
tgcgatcttcatcggctagaagagggccctcctgtcaccacagtgctcaccagggaggac
gggctcaggtactataggatgatgcagactgttcgccggatggagttaaaggcagatcag
ctgtataaacagaaaattattcgtggtttctgtcacttgtgtgatggtcaggaagcttgt
tgtgtgggcctggaggccggcataaatcccacagaccatcttatcacagcctatcgggct
catggctttacctttactcgtggactttctgtccgagaaattcttgcagagcttacagga
cgaagaggaggctgtgctaagggaaaaggtggatcaatgcatatgtatgccaagaacttc
tatgggggcaatggcatcgttggagctcaggtacccctgggagcagggattgctctggcc
tgtaagtataacggaaaggatgaggtctgtttgactttatatggtgatggtgctgccaat
cagggtcagatatttgaagcttacaacatggcagctttgtggaaattgccgtgtattttc
atctgtgagaataaccgctatggaatgggaacgtctgttgagagagcagcggccagcact
gattactacaagagaggcgacttcattcctgggctgagggtggatggaatggatatcttg
tgtgtccgggaggcaacaaggtttgcagctgcttactgtagatctggaaaggggcccata
ctgatggagctacagacttaccgttaccatggacacagcatgagcgaccctggcgtcagt
taccgtacacgagaagagattcaggaagtaagaagtaagagtgaccctattatgcttctc
aaggataggatggtgaacagcaatctggccagtgttgaagaattaaaggaaattgatgtt
gaagtgaggaaagaaattgaggatgctgcccagtttgccactgctgatcctgaaccgcct
ttggaagaactaggctatcacatttacagcagcgatccgccttttgaagttcggggtgca
aatcagtggatcaagtttaagtccatcagttaa
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